In India, the tradition of marrying within the kin is known as endogamy. It has been a cultural cornerstone. However, this widespread practice, while deeply rooted in societal norms, is increasingly linked to a surge of inherited health conditions across the country.

As per the National Family Health Survey 2005-06, only 10% marriages in India were inter-caste and just 2.1% were interreligious. This highlights how the majority of people practice endogamy. Even, a recent genome mapping study from India's Genome Project confirmed that trend remained strong. All 83 population groups studied showed high levels of endogamy, which has led to population specific genetic mutations and disorders.

How Endogamy Contributes to Genetic Disorders?

Endogamy has increased the chances of genetic disorders, especially when it overlaps with consanguineous marriages, which means marriages between close relatives. This is much more common in the southern parts of India.

Doctors have explained that when both parents carry the same recessive gene mutation, their children have a greater risk of inheriting two copies of the faulty gene. This is also the case with thalassemia cases in India. This can also lead to the manifestation of genetic disorders, even if the parents are asymptomatic carriers.

Over generations, such selective mating within communities has further allowed rare mutations to persist and concentrate. This is resulted to what researchers refer to as "population-specific mutations". These can affect various bodily systems, including the heart, joints, and reproductive health.

What All Disorders Could Happen?

As per the study published in Nature Genetics, Dr Kumaraswamy Thangaraj, Principal Investigator of the Genome India Project, highlighted how these mutations are directly linked to early-onset cardiac issues, particularly in South India.

Unlike the North, where cardiac problems come later in life, due to lifestyle issues, people in southern parts of India are affected by population-specific mutations from a younger age.

Another health concern that the study highlighted was ankylosing spondylitis, which is a type of arthritis that affects the spine and is more common in genetically homogenous populations.

A different study in journal Nature also revealed that consanguineous marriages raise the risk of spontaneous abortions, stillbirths, neonatal and child mortality.

Another study published in the Journal of Genetics and Genomics in 2005, titled: Endogamy and high prevalence of deleterious mutations in India: evidence from strong founder events, reads: "Several Indian populations have experienced significant founder events due to strict endogamy. However, the clinical implications of it remain underexplored. Therefore, we perform whole-exome sequencing of 281 individuals from four South Indian populations, characterized by high IBD scores. Our study reveals a high inbreeding rate of 59% across the populations. We identify ∼29.2% of the variants that are exclusively present in a single population and uncover 1284 unreported exonic variants, underscoring the underrepresentation of Indian populations in global databases."

What Can Be Done to Avoid This?

Experts from time and again have stressed the need for widespread education and awareness as well as genetic counselling. Promoting inter-community marriages can also dilute the concentration of harmful genetic mutations, and also reduce the incidence of hereditary diseases.

Doctors can also play a role in advising couples on their health risks, especially if it is with regards to consanguineous marriages and encouraging genetic screening before marriage or conception.

The Genome India Project offers hope for future solutions. By mapping the genomes of more than 10,000 individuals, the project aims to identify mutations that are widespread due to endogamy. According to Dr. Thangaraj, these findings could help make diagnostics and treatments more affordable and tailored to India’s unique genetic landscape.

As per the World Health Organization (WHO), globally, over 1.2 billion people ages 30 to 79 have hypertension. The number has increased from 650 million in 1990 to 1.2 billion in 2021. This increase is attributed to many factors, including lifestyle factors, which include salty indulgence, stress, and screen time which has been increased. These three impact your blood pressure levels, know how.

What Are The Three S Worsening Your Blood Pressure?

Salt

As per the Harvard Heart Publishing, an average American consumes the equivalent of about 1 1/2 teaspoon of salt per day, which is 50% more than the recommended amount.

About a third of healthy people and about 60% of people with high blood pressure are salt sensitive.

How does salt affects blood pressure?

When you consume too much sodium, your body holds on to extra water to balance the sodium levels. This added fluid increases the volume of blood in your vessels, which in turn raises your blood pressure and forces your heart to work harder. High sodium intake can also reduce the effectiveness of certain blood pressure medications. For example, diuretics help eliminate excess sodium and water, while vasodilators work by relaxing the blood vessels. However, a high-sodium diet makes your body retain fluid again, refilling those relaxed vessels and undoing the medication's effects.

Stress

As per the official publication of State Medical Society of Wisconsin, stress can cause hypertension through repeated blood pressure elevations as well as by stimulation of the nervous system to produce large amounts of vasoconstricting hormones that increase blood pressure. Factors affecting blood pressure through stress include white coat hypertension, job strain, race, social environment, and emotional distress.

As per National Health and Nutrition Examination Survey, around 50 million American adults live with hypertension, defined as a systolic blood pressure over 139 mm Hg or diastolic pressure over 89 mm Hg. In about 95% of these cases, the condition is classified as "essential" hypertension, meaning there’s no single identifiable cause. However, experts agree that multiple factors—including stress—can contribute to rising blood pressure in these individuals.

Screentime

As per a 2024 study published in Cureus, hypertension is a major risk factor for coronary artery disease. The study links the increased accessibility of smartphones with the increasing hypertension.

This study explored the relationship between screen time and blood pressure (BP) among young adults.

The study also noted that higher screen time was more common among individuals using multiple devices. The prevalence of elevated BP in the sample was 35.8%, aligning with national data and raising concerns about the cardiovascular health of young adults.

Previous studies support these concerns. For instance, Nang et al. and Martinez-Gomez et al. linked prolonged TV viewing to higher BP and an adverse cardiovascular risk profile in adolescents. However, these relied on self-reported data. Other risk factors, such as age, gender, obesity, inactivity, and substance use, have also been linked to hypertension.

Women’s reproductive health is a sensitive subject. Even though there have been many advancements in women’s healthcare, large gaps in research and medical well-being of women have been observed. The general lack of information regarding women’s healthcare and education have also been highlighted in the recent years.

While you may think it is not a matter of urgency, a new report found a very concerning toxin in tampons, levels of which were higher than what is even allowed in drinking water.

A new report from two groups, the Women's Environmental Network (WEN) and Pesticide Action Network UK, has raised serious concerns. They found harmful chemicals in many of the menstrual products sold in regular stores across Britain. The study was particularly worried about finding pesticides, especially glyphosate, which is the most common weed killer used worldwide, in these products that women use in a very sensitive part of their bodies.

Disturbing Levels of Pesticides Detected

The findings are quite shocking. Tampons are a largely used menstruation product, which soaks the menstrual blood by insertion in the vaginal canal. The World Health Organization, a global health authority, has said that glyphosate probably causes cancer. Even more alarmingly, one box of tampons had levels of glyphosate that were 40 times higher than what's legally allowed in drinking water!

It's thought this happens because the pesticide might be sprayed on the cotton crops that are used to make tampons. The report also found another dangerous chemical called chlorpyrifos in some tampons. This is an insecticide that's actually banned in the UK because it can harm the brain and nervous system.

The report was very clear about how serious this is: they said that for some chemicals, there's no safe amount, so any trace found in period products should be less than what can even be detected.

Direct Threat to Health

There's worry about how these chemicals might affect health. This is because a part of the body that absorbs things very easily, the vagina, lets chemicals skip the body's natural cleaning systems and go straight into the blood. People are saying this isn't just careless, it's actually dangerous. They also feel it's wrong that these kinds of chemicals are still in period products today.

Lack of Regulation and Impact on Farmers

The report pointed out a major problem: there are no specific rules in the UK for these products. Manufacturers don't have to tell you what's in their products, and there are no laws to stop pesticide residue from ending up in the final product you buy.

The issue also affects cotton farmers. The report highlighted that "cotton farmers are being exposed to toxic pesticides at concerning levels." Many of these farmers are women, and they face health risks every day from working with these dangerous pesticides both on their farms and even in their homes.

Demands for Clearer Information and Change

People are strongly demanding that the industry be more open. It's simply not okay that users don't know what's in products they use on such private parts of their bodies. There's an urgent need for companies to be transparent (show all ingredients), take accountability (be responsible for their products), and make real changes in how things are done. This is because everyone who has a period deserves better and safer products.

The report asks the government to act quickly:

• Test period products very strictly.
• Make it a legal rule for companies to list every ingredient and extra chemical.
• Include organic, disposable period products in free school programs.

Concern regarding pollution and how it affects our health is a worry that affects many of us worldwide. As years pass on by, the pollution levels are also increasing, and so is our mortality risk. The World Health Organization (WHO) explains that exposure to air pollution is strongly linked with stroke, ischaemic heart disease, lung diseases etc. However, these are not the only things you must worry about when it comes to air pollution exposure. A new study shows that it could also affect the way our brain functions.

A study from Italy, published in a science journal called iScience, found a really important clue in our genes. It seems that when we breathe in polluted air, it can actually change how our genes work in the brain. Think of it like flipping a switch that creates the perfect conditions for diseases like Alzheimer's and Parkinson's to start growing.

Early Warning Signs and High-Risk Groups

The researchers saw some worrying changes even in young adults. Their brain tissue showed signs of DNA damage that looked a lot like what you'd see in someone with Alzheimer's – but decades before they would normally be diagnosed. This is a huge red flag.

Certain jobs also put people at a higher risk. If you're a miner, factory worker, or driver, you're exposed to more polluted air. Even people who work with plastics face a hidden danger from tiny particles called nanoparticles that can get into their brains.

But here's some good news: this discovery could mean doctors can check for these changes without needing to do anything invasive, like surgery. They might be able to test for something called extracellular vesicles. These are like tiny packages that carry material from damaged brain cells. So, if we can test for these packages, it could give us an early warning sign from the brain itself.

Understanding the Complexities and Taking Precautions

It's clear that being generally unhealthy and breathing polluted air from a young age can increase your risk of these brain conditions. However, we still need a lot more research to fully understand how everything is connected. Experts from News Medical have pointed out that studying air pollution is tricky because the air we breathe in the real world is a mix of many different pollutants.

To help protect yourself on days when pollution levels are high, organizations like Asthma + Lung UK suggest some simple steps:

• Stay indoors as much as possible.
• Avoid exercising outside, especially vigorous activity.
• If you're walking, try to stay away from busy roads with heavy traffic.
• Keep your car windows closed when driving in traffic.
• If you do want to be active outdoors, try to do it earlier in the day, as the air tends to be cleaner then.

Looking Ahead: Prevention and Policy

There's a big call for more research to understand how air pollution affects younger people and other parts of our brain's thinking abilities. The results of this research could lead to exciting new ways to prevent these diseases. It could also push for better safety rules in workplaces, stricter environmental standards to clean up our air, and even new laws to protect public health from air pollution.