Cancer is a disease that has ripped many families apart from their loved ones. Often showing less or no signs, cancer cells grow in the form of tumours, and if not detected can consume the person whole! Breast cancer is one of the most common forms of cancer worldwide. Slowly but surely breast cancer survival rates have increased and this has given people hope with advances in breast cancer screening and early detection.

With many breast cancer awareness weeks, workshops and lectures, people are more educated on the matter and how to talk about it. In India, many women face the stigma of not speaking about the matter as it is considered shameful and degrading. The only way to battle this issue is to keep speaking about and not treating this as a ‘women’s issue’ as anyone who has breast tissue is susceptible to cancer. There are many at-home steps you can utilize to keep a check on yourself if you are worried about going to the hospital on a whim. Signs you should look for are lumps and thickened area of skin that feels different from the surrounding tissue. If your nipples look flattened or tuned inwards and there is a change in the colour of your breast skin, you must visit your healthcare professional for a check-up.

Many brave survivors have shared their stories and what they went through during the trying times. One such survivor has shared her story with us. *Sunita Rai, a 41-year-old woman from Bangalore spoke about her diagnosis and her treatment after.

How It Began

“So, I felt a lump at the end of February, around 24th, then I felt a lump at my right breast. I thought it might be an abscess or maybe mastitis or something of that sort or maybe PMS. So, I booked an appointment with my gynaecologist on the following Monday, which was the 26th of February. And her initial thought was also probably an abscess or a lump, mastitis or something of that sort because when I was breastfeeding my child about 4-5 years ago, I had some blocked ducts. So, I thought maybe something unhealthy occurred. However, she also said on physical examination, she noticed some discolouration of my skin.”

With the prompt response of her doctor's availability of the correct equipment, Sunita was able to get a sonogram and an X-ray mammogram. The results however did not put Sunita at ease, she was quickly referred to a surgical oncologist. The following days brought forth the diagnosis that the masses were carcinogenic initially with invasive ductal carcinoma, which prompted a deep biopsy, which confirmed the presence of invasive papillary carcinoma.

Family History and Genetic Tests

When there are breast cancer detections, it immediately prompts the question of whether there is a family history. Sunita’s doctors recommended these tests to her as 41 is still a very young age to get breast cancer, citing that it is more common in women above the age of 61. “He recommended that we do the genetic testing specifically for the BRCA1 and 2 gene. But we decided to go ahead and test for the entire genome mapping. We did check for my child's risk because the TP53 also has, I mean, there are multiple childhood cancers which are associated with the TP53 gene which could manifest. So, we did go ahead and get an exemption for my child and get her tested. Other than that, my parents gave it to me for testing, but the result has not yet come out. So, I did it.”

Sunita expressed that she had to take some time to explain why everyone in her immediate family needs to get tested. There was pushback, but eventually, they did send the samples. The reason why it was important for them to get tested as it may have been a new mutation, or it may have been inherited from someone in the family, “We were in touch with somebody from the Strand Life Sciences Team, who specialise in advanced genomic technologies that drive breakthroughs in clinical diagnostics, personalise treatment plans, and research. They had a very quick response, they immediately came and took the samples. They were very supportive to help us get my daughter tested and get the results for us. In fact, they went out of the way to send me the result quite late in the night because they knew that I was worried.”

How it is Going

Sunita is still fighting her cancer vigorously and keeping her spirits high. Currently, she is going through targeted therapy and radiation. Going through stage 2 cancer she is under robust monitoring, especially after the diagnosis of TP53 mutation. As a last piece of advice for the people who are still on the fence about getting diagnosed or not going to the doctors, Sunita shares, “I would say it is okay to feel all the emotions that you're feeling. It's very natural and normal to feel shocked, anger, disappointment, and also fear. Because depending on your family circumstances, if you have children especially, it becomes a big worry for you. Because a cancer diagnosis, no matter what stage you are, is quite a bit of a shock. So it's okay to feel whatever emotions you are feeling. You shouldn't feel like, oh, I have to be strong, I shouldn't cry, I shouldn't speak about what I'm feeling. I think it's better to be able to speak out what you're feeling than bottle everything up. Because that helps a lot. And it's also very important to have a very strong support system around you, whether it's your family or friends.”

*Name has been changed for anonymity

That sudden tightness after washing your face, the redness that won’t calm down, or the stinging from a product you’ve used for years—those aren’t just random flare-ups. They’re signals. Quiet, persistent warnings from your skin barrier, your body’s frontline defense system.

Most people don’t even realize they’ve been slowly breaking it down. From over-cleansing to layering too many actives, modern skincare trends often leave the barrier confused, stripped, and vulnerable. But the good news? This protective layer is also incredibly responsive. When you treat it right, it bounces back—stronger, smoother, and more resilient than before.

“The skin barrier is your body’s natural shield, protecting against pollution, bacteria, and moisture loss,” says dermatologist Dr. Rupika Singh. “When it’s healthy, your skin looks and feels balanced. But when it’s damaged—often due to over-cleansing, too many actives, or skipping moisturizer—your skin can become dry, red, sensitive, or breakout-prone.”

What Is The Skin Barrier?

Your skin barrier lives in the stratum corneum, the outermost layer of your skin, and it functions much like a brick wall. The "bricks" are made up of dead skin cells, while the "mortar" that holds them together consists of lipids—specifically fatty acids, ceramides, and cholesterol. These lipids are essential for maintaining the skin’s structure and integrity. Inside the cells, Natural Moisturizing Factors (NMFs) act like water magnets, pulling in and retaining moisture to keep the skin hydrated. This highly organized system isn’t just for structure—it plays a crucial role in protection.

A healthy barrier keeps out irritants, allergens, bacteria, and pollution, while locking in hydration and essential nutrients. When functioning properly, your skin feels smooth, resilient, and balanced. But when this barrier is compromised, your skin quickly begins to send warning signs like dryness, tightness, redness, or increased sensitivity.

How to Know If Your Skin Barrier Is Damaged?

Here’s the tricky part, the first clue your barrier is under stress might be subtle—just a little dehydration. But if ignored, this can spiral into:

• Persistent dryness and flakiness
• Tightness after cleansing
• Redness or inflammation
• Breakouts or rough texture
• Increased sensitivity to your go-to products

“Your skin doesn’t need more products—just smarter ones,” says Dr. Singh. “A resilient barrier means fewer flare-ups, faster recovery, and that healthy, glowing texture we’re all after.”

What Damaged Skin Barrier Looks Like?

While environmental stressors like UV radiation, air pollution, and extreme weather are well-known culprits in weakening the skin barrier, the real damage often begins much closer to home—right at your bathroom sink. Daily skincare habits, when not done mindfully, can erode your skin’s natural defenses over time.

Over-exfoliating, for instance, strips away protective oils that are essential for barrier function. Using harsh cleansers can disrupt your skin’s natural pH, making it more vulnerable to irritants. Skipping moisturizer allows precious water to escape through transepidermal water loss, leaving your skin dry and more prone to damage. Overusing potent actives like retinol, AHAs, or BHAs may seem like a fast track to glowing skin, but they can actually compromise healthy cell turnover if not balanced properly. Even less obvious factors—like emotional stress or lack of sleep—can trigger inflammation that silently breaks down your barrier from within.

How Long Does It Take to Repair Your Skin Barrier?

A healthy skin cycle typically lasts about 28 days, so with proper care, most skin barrier issues can start to improve within 2 to 4 weeks. That said, even a few days of barrier-friendly habits can bring relief from tightness and irritation but consistency is key. Think of barrier repair like physical rehab—it requires patience, the right tools, and a slow, methodical approach.

Step-by-Step Guide To Building A Protective Skin Barrier

1. Simplify and Reset

Dr. Singh advises starting by scaling back:

“The first step toward healing? Simplify your routine. Switch to a gentle, hydrating cleanser and reduce exfoliation to once or twice a week. Give your skin a break from strong actives like retinol or acids until it feels calmer.”

Stick to essentials: a cleanser, moisturizer, and sunscreen. Once your skin stabilizes, you can slowly reintroduce actives.

2. Cleanse Gently

Use cleansers with a pH between 5.5 and 6.5, which match your skin’s natural acidity. Cream and oil-based formulas tend to be less disruptive than foam cleansers. Always wash with lukewarm water and pat dry instead of rubbing.

3. Hydrate and Moisturize in Layers

Hydration is about more than just applying moisturizer. Start with a hydrating serum containing hyaluronic acid or glycerin. While skin is still damp, apply a nourishing moisturizer with barrier-building ingredients like:

• Ceramides
• Niacinamide
• Panthenol
• Squalane

Dr. Singh emphasizes, “A nourishing moisturizer, applied twice a day, helps restore hydration and comfort.”

4. Don't Skip Sunscreen—Ever

Even mild sun exposure silently chips away at your skin’s barrier integrity. A broad-spectrum SPF 30 or higher helps prevent this, while antioxidants like vitamin C or E add an extra layer of defense against environmental stressors.

When your barrier is strong, your skin naturally fends off signs of premature aging, inflammation, and sensitivity. But when it’s weak?

• You’re more vulnerable to fine lines and wrinkles
• Inflammation triggers uneven skin tone
• Hydration loss makes skin look dull and tired

In other words, barrier health is the foundation of all good skincare. You can’t glow if your skin is busy trying to protect itself from further harm.

Most skin barrier issues are reversible. But you need to stay tuned in. If your skin suddenly feels off, flaky, or reacts to a product you’ve used for years, that’s your cue to reassess and recalibrate.

“So the next time your skin feels off, take it as a sign to slow down and tune in,” says Dr. Singh. “Often, what your skin really needs is less stress and more support—and that starts with protecting your barrier.”

Much like your gut or your immune system, your skin barrier is a living, breathing part of your health. Respect it, support it, and respond when it speaks up.

With a few thoughtful changes and a barrier-first mindset, you can transform not just how your skin looks, but how it behaves—resilient, calm, and confident in the face of whatever the world throws at it.

Dr. Rupika Singh is a Dermatologist and Founder at Akiya Aesthetics in India

Plastic is everywhere. On mountaintops, in oceans, inside our bodies, and according to a new expert review published in The Lancet, it is silently wreaking havoc on human health from the womb to old age.

The review, first reported by The Guardian, calls the global surge in plastic production and pollution a full-blown “plastics crisis,” attributing at least $1.5 trillion a year in health-related damages to it.

The problem isn't just environmental, it’s deeply human.

The report warns of long-term consequences, ranging from infertility and birth defects to heart attacks and strokes. Vulnerable groups, especially infants and children, bear the brunt of the burden. “The impacts fall most heavily on vulnerable populations,” said Prof. Philip Landrigan, a paediatrician and epidemiologist at Boston College in the US, and the report’s lead author. “It is incumbent on us to act in response.”

A Rapidly Escalating Threat

Plastic production has skyrocketed, by more than 200 times since 1950, and if current trends continue, it's expected to almost triple again by 2060, exceeding one billion tonnes annually. While plastics have undeniable value in medicine and technology, the most explosive growth has been in single-use items: plastic bottles, food packaging, and disposable cutlery. These are the very things that crowd our landfills, rivers, and oceans.

Less than 10% of all plastic is recycled. The rest? It seeps into every corner of our ecosystem—from the deepest ocean trench to the peak of Mount Everest. In total, an estimated 8 billion tonnes of plastic waste now pollute the planet.

Harm at Every Stage: From Extraction to Disposal

What makes this crisis uniquely harmful is that plastics pose risks at every stage of their life cycle. They're derived almost entirely from fossil fuels: oil, gas, and coal, whose extraction and processing pollute air and water and fuel the climate crisis. Manufacturing plastic releases about 2 billion tonnes of CO₂ annually, more than Russia's total emissions.

Once produced, plastics expose people to thousands of chemicals, over 16,000, including flame retardants, fillers, and stabilizers. Many are toxic, and worryingly, many more haven’t even been fully studied. The lack of transparency from manufacturers makes it difficult to know exactly what we’re being exposed to.

As plastics degrade, they break down into micro- and nano-plastics, minuscule particles that can infiltrate nearly every organ of the human body. These particles have been detected in blood, placentas, breast milk, semen, and even brain tissue. Though long-term health effects are still being researched, early links suggest increased risks of strokes, heart attacks, and cancer.

A Crisis Hidden in Plain Sight

In many ways, plastic has become too familiar to question. Its pervasiveness masks its cost. While it's often treated as a cheap material, the true cost, once health impacts are accounted for, is staggering. The report notes that just three plastic chemicals (PBDE, BPA, and DEHP) are responsible for $1.5 trillion in damages annually across 38 countries.

The danger also extends to the environment in unexpected ways. Discarded plastics become breeding grounds for mosquitoes, potentially accelerating the spread of diseases like dengue and malaria.

A Turning Point: Can the World Act?

This latest report comes ahead of the sixth and likely final round of UN treaty negotiations aimed at creating a legally binding global agreement to address the plastics crisis. Over 100 countries support capping plastic production, while petrostates, particularly Saudi Arabia, and powerful industry lobbyists are pushing back, insisting that the focus should be on recycling, reported the Guardian.

But the report is clear: "The world cannot recycle its way out of the plastic pollution crisis."

Margaret Spring, a co-author and senior legal expert, said this analysis marks the beginning of a series of reports that will track plastic’s impact on human and planetary health. “These reports will offer decision-makers a robust and independent data source,” she said, “to inform the development of effective policies.”

As the world waits for action, the message from the medical and scientific community is becoming increasingly urgent: we cannot afford to ignore the cost of plastic any longer.

If you're planning or experiencing the emotional and physical rollercoaster of IVF while living with Polycystic Ovary Syndrome (PCOS) you're not overthinking about the added complexity. While IVF is often painted as the silver bullet for infertility, women with PCOS quickly discover that one-size-fits-all protocols often fall short for them. The diagnosis of PCOS introduces a unique set of biological challenges that can’t be managed with standard IVF plans.

So, what makes IVF more complicated for people with PCOS? And how can treatments be tailored to fit these more complex bodies? We asked three top fertility specialists to break it down—and their answers underscore the importance of a highly personalized approach.

"Polycystic Ovary Syndrome (PCOS) is especially difficult to manage with IVF due to its combination of endocrine disturbance, insulin resistance, and a diffuse number of antral follicles," says Dr. Nishi Singh, Head of Fertility at Prime IVF.

According to Dr. Singh, women with PCOS often show an increased ovarian reserve, which may sound like a good thing. But in reality, it sets the stage for them to become hyper-responders—women who react too strongly to standard IVF stimulation, putting them at risk for Ovarian Hyperstimulation Syndrome (OHSS).

To mitigate these risks, Dr. Singh relies on individualized ovarian stimulation using low-dose therapy and GnRH antagonist protocols. “Oocyte quality is also an issue in PCOS. Although numerous eggs can be retrieved, they may have less developmental potential,” she notes. For this reason, the dosage must be carefully calculated to avoid overstimulation while still supporting optimal outcomes.

But it’s not just about the medication. “Successful IVF in PCOS goes beyond medical management,” Dr. Singh emphasizes. “Therapy would necessitate an approach that includes a lifestyle reaching a peak of metabolic health.”

That includes weight control, lifestyle modifications, insulin-sensitizing agents, and targeted supplements—all of which can improve ovulatory function and egg quality. Dr. Singh stresses that personalized care must be embedded in every stage of the IVF cycle, from initial stimulation to embryo freezing.

“If done with accuracy, IVF in PCOS patients is not a limitation but a promise,” she concludes. “The solution is individualized, regulatory, and based on individualistic knowledge of each patient's reproductive plan.”

Balancing High Ovarian Reserve, Low Egg Quality for Women with PCOS

Dr. Kaberi Banerjee, Founder and Medical Director of Advance Fertility & Gynecology Centre, agrees that PCOS requires a meticulous and integrated approach. "PCOS presents a special challenge in reproductive medicine since its impact on ovarian function is multidimensional," she says.

She explains that while high ovarian reserve is common in PCOS, as indicated by higher AMH and antral follicle counts, the quality of those eggs can be subpar. "Ovulation can be irregular or even cease to occur. Even mild stimulation can bring about an exaggerated ovarian response, increasing the risk of OHSS," she notes.

To counter this, Dr. Banerjee emphasizes pre-treatment optimization. Addressing insulin resistance, hormonal imbalances, and weight management before starting IVF can greatly improve results. She recommends lifestyle adjustments such as low glycemic diets, moderate physical activity, and supplements like inositols and CoQ10. Metformin also plays a central role in managing insulin resistance and improving ovarian response.

Her go-to strategy during IVF includes starting with low-dose gonadotropins, using GnRH antagonist protocols, and employing GnRH agonist triggers. “In high responders, we commonly follow a ‘freeze-all’ policy to prevent compromising endometrial receptivity,” she explains.

For younger PCOS patients, early preconception counseling and ovulation monitoring are vital. “First-line therapy such as letrozole, usually taken in combination with metformin, is very effective,” she says. And if that doesn’t work? IVF with a tailored approach is the next logical step.

“Achievement in treating PCOS-related infertility is a harmonious, evidence-based measure that benefits safety and long-term reproductive health,” Dr. Banerjee concludes.

What is The Role of Insulin, Hormones And Weight in IVF Success?

"The management of PCOS and IVF requires an extremely individualized approach," says Dr Shweta Mishra, Gynecologist and Obstetrician at Trulife Family Health Clinic in Ghaziabad, underscores the need for ultra-personalized care.

Dr. Mishra points out that PCOS affects nearly 70–80% of women with insulin resistance and presents with high antral follicle counts—often exceeding 24 per ovary. This makes conventional stimulation protocols not just ineffective but risky. “PCOS women may have a normal ovarian reserve but are susceptible to hyperstimulation,” she says. That means patient-specific regimens like low-dose stimulation and GnRH antagonist protocols are non-negotiable.

Egg quality is another critical piece of the puzzle. “Although numerous eggs can be retrieved from PCOS patients, the developmental potential of those eggs may be compromised,” she warns. Improving egg quality involves not just medication but also addressing hormonal balance through weight management, insulin sensitization, and supplements. “Enhancement of metabolism is critically important for success in IVF,” she adds.

Her message to younger women is clear: early diagnosis and a comprehensive plan can make all the difference. “PCOS need not be viewed as a disadvantage. It is an aspect that needs caution. Success rates significantly increase when IVF is treated with a personalized, specifically designed method.”

Does PCOS Make IVF More Complicated?

Yes, but it also opens the door to more personalized, effective treatments. As all three experts make clear, success with IVF and PCOS isn’t about pushing harder or using more medications. It’s about understanding the body’s unique biochemistry and crafting a treatment plan that respects its complexity.

IVF in the context of PCOS demands more than a protocol—it demands a philosophy of care rooted in customization, evidence-based medicine, and long-term reproductive health. And when that’s done right, PCOS isn’t a limitation. It’s a roadmap to smarter fertility care.

Before beginning any IVF treatment, consult a fertility specialist who understands the nuances of PCOS. The road may be more complex, but with the right plan, it can also lead to lasting success.