Paracetamol or Tylenol is a popular pain and fever medication for decades for all and especially for pregnant women. Its safety record has for many years stood above the rest of the over-the-counter medications and is therefore used as the first-line medication for headache, fever, and mild pain in pregnancy. But new studies at Mount Sinai and Harvard T.H. Chan School of Public Health have opened the door to an important discussion: is prenatal exposure to acetaminophen associated with neurodevelopmental disorders including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in children?

A study led by Andrea Baccarelli, dean of Harvard T.H. Chan School of Public Health’s faculty of environmental health, published on August 14 in BMC Environmental Health, systematically reviewed 46 previous studies encompassing data from more than 100,000 participants. The aim was to investigate whether acetaminophen use during pregnancy correlates with neurodevelopmental disorders in children.

Applying the Navigation Guide Systematic Review method—a strict, gold-standard approach to assessing environmental health evidence—the study team evaluated the quality, risk of bias, and strength of evidence of all included research. By doing so, it was possible to conduct a solid synthesis of available scientific literature, and what emerged was a pattern: better-quality studies more often showed an association between prenatal acetaminophen exposure and offspring increased risk of ADHD and autism.

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Researchers at the Icahn School of Medicine at Mount Sinai reiterated these alarms. The research highlighted that acetaminophen is not without risk, particularly considering its heavy use—more than half of pregnant women worldwide reportedly use it. Although the research does not establish causation, biological pathways may provide some insight. Acetaminophen passes through the placental membrane, which may initiate oxidative stress, hormonal disruption, and epigenetic changes that can disrupt fetal brain development.

Dr. Diddier Prada, a population health science and policy and environmental medicine assistant professor at Mount Sinai, pointed to the larger picture: "With so many people taking this drug, even a modest increase in risk could have huge public health implications."

How To Balance Risks and Usage?

What this actually indicates is not that pregnant women should never take acetaminophen—not at all. Fever and unrelieved pain during pregnancy are actually risks to the fetus as well, risks of miscarriage, preterm labor, and developmental problems. Rather, researchers at both Harvard and Mount Sinai simply suggest the use of acetaminophen with restraint: the minimum dose that will be effective, for as short a period as possible, always under a physician's care.

Clinical practice guidelines in the U.S., such as those of the American College of Obstetricians and Gynecologists, still favor acetaminophen over nonsteroidal anti-inflammatory agents such as ibuprofen, which are usually avoided in the second and third trimesters. The focus is on personalized risk-benefit evaluation, not blanket bans.

Although the new evidence raised some eyebrows, not all research supports an association. For example, in 2024, the Swedish cohort of about 2 million children, of which more than 180,000 were exposed to acetaminophen during pregnancy, identified no evidence of association with autism, ADHD, or intellectual disability. Likewise, previously, the FDA and the Society for Maternal-Fetal Medicine suggested that current studies are inconclusive or too small in number to change recommendations.

These contradictory findings demonstrate the nuance of research on prenatal effects of medication. Neurodevelopmental conditions such as autism and ADHD are affected by a wide range of genetic, environmental, and lifestyle variables. Separating the effect of acetaminophen from these elements is difficult, and large-scale, high-quality longitudinal studies are needed.

Why Is Tylenol A Concern For Pregnant Women?

Scientists investigating biological mechanisms have observed that acetaminophen has the potential to affect fetal brain growth through several mechanisms:

Oxidative Stress: Metabolism of acetaminophen can produce reactive oxygen species that could interfere with usual neural development.

Hormonal Disruption: Changes in maternal hormone levels may indirectly influence fetal neurodevelopment.

Epigenetic Changes: Exposure can induce changes in gene expression without changing DNA sequences, which can impact cognitive and behavioral outcomes.

Though these mechanisms are still being studied, they are a reasonable hypothesis for why some have seen associations with ADHD and autism.

How Does It Affect Future Prenatal Care?

The results have important public health consequences. Acetaminophen is the most widely used over-the-counter medication among pregnant women, so even a modest increase in risk of neurodevelopment would impact huge populations worldwide. The study highlights the necessity of new clinical guidelines, improved patient education, and investment in safer alternatives for pain and fever management for pregnant women.

Researchers emphasize that pregnant women should not stop taking acetaminophen on their own. Rather, open communication between healthcare providers and pregnant women is essential, comparing untreated pain and fever risk against possible neurodevelopmental issues. Non-pharmacologic pain relief, rest, and hydration can be considered when appropriate.

As ADHD and autism diagnoses surge globally, knowing the environmental and drug causes of neurodevelopment becomes ever more pressing. This research contributes to mounting evidence calling for caution in prenatal use of acetaminophen, while continuing to support further study to establish causation, dose-response, and alternative safer medicines.

Tylenol is still widely used as a suggested painkiller and fever reducer during pregnancy. However, recent research has shown possible associations with ADHD and autism in kids, which has led scientists to recommend careful, short-term use under medical guidance. Women in pregnancy should consult their doctor concerning any pain relief plan, weighing current needs against possible long-term impacts on child development.

As artificial intelligence becomes a go-to source for quick answers, a new University of Oxford-led study on AI chatbots and medical advice is raising serious concerns about how safe it is to rely on these tools for health guidance.

The research suggests that while AI chatbots can provide medical information, their advice is often inaccurate, inconsistent, and difficult for users to interpret, potentially putting people at risk—especially when dealing with symptoms that need urgent care.

What the Oxford Study Found

The study involved 1,300 participants who were given realistic health scenarios, such as experiencing a severe headache or being a new mother feeling constantly exhausted. Participants were divided into two groups: one group used AI chatbots to understand their symptoms and decide next steps, while the other did not.

Researchers then assessed whether participants correctly identified what might be wrong and whether they made appropriate decisions, such as seeing a GP or visiting A&E.

The results were troubling. People who relied on AI frequently failed to identify the severity of their condition and were often unsure about when to seek professional medical help.

Why Chatbot Advice Can Go Wrong

According to the researchers, one major issue is that people don’t always know what to ask. The study found that chatbot responses varied widely depending on how questions were phrased. Even small changes in wording could lead to completely different answers.

The AI often produced a mix of helpful and misleading information, leaving users to decide which advice mattered. Many participants struggled to distinguish between reliable guidance and unnecessary or confusing details.

As one of the study’s authors explained, when an AI lists multiple possible conditions, users are left guessing which one applies to them—precisely the moment where mistakes can happen.

A Dangerous Gap in Symptom Interpretation

Dr Rebecca Payne, lead medical practitioner on the study, warned that asking chatbots about symptoms could be “dangerous”, particularly when users delay seeking professional care based on AI responses.

Dr Adam Mahdi, the study’s senior author, noted that while AI can share medical facts, people often share information gradually and leave out key details—something chatbots struggle to manage effectively.

Bias, Data, and the Limits of AI

Experts also point out that chatbots are trained on existing medical data, which means they may repeat long-standing biases baked into healthcare systems. As one psychiatry expert put it, a chatbot is only as accurate as human clinicians—and humans are far from perfect.

That said, not everyone is pessimistic.

What Comes Next for AI in Healthcare

Digital health experts argue the technology is evolving. Health-specific versions of general AI chatbots have recently been released by major developers, and these could perform differently in future studies.

The consensus among experts is clear: AI in healthcare should focus on improvement, regulation, and guardrails, not replacement of doctors. Used responsibly, it may support healthcare—but without safeguards, it risks doing more harm than good.

This common pregnancy drug could be linked to cancer. Wes Streeting has been urged to launch a public inquiry into a miscarriage drug called Diethylstilbestrol, which, reports say has "ruined and devastated" the lives of countless women. On Monday, the Health Secretary Streeting met victims of the pregnancy drugs, which has been linked to cancer, early menopause and infertility.

What Is Diethylstilbestrol?

Diethylstilbestrol, commonly known as DES, is a synthetic form of female hormone estrogen, which was prescribed to thousands of pregnant women from 1940 to 1970s.

The drug was used to prevent miscarriage, premature labor and complications of pregnancy. This was also used to suppress breast milk production, as an emergency contraception and to treat symptoms of menopause.

What Is The DES Controversy?

In 1971, Diethylstilbestrol (DES) was linked to a rare cancer of the cervix and vagina known as clear cell adenocarcinoma, prompting US regulators to advise that it should no longer be prescribed to pregnant women. Despite this, the drug continued to be given to expectant mothers across parts of Europe until 1978. DES has also since been associated with other cancers, including breast, pancreatic and cervical cancers, The Telegraph reported.

Campaign group DES Justice UK (DJUK) is now urging Health Secretary Wes Streeting to order a public inquiry and introduce an NHS screening programme to identify people who may have been exposed to the drug before birth.

Victims described DES as “one of the biggest pharmaceutical scandals this country has ever seen,” warning that “the impact of this terrible drug cannot be underestimated as it has ruined and devastated so many lives,” according to The Telegraph.

In November, Streeting acknowledged that the “state got it wrong” and issued an apology to those affected. He also advised anyone who believes they may have been exposed to DES to speak to their GP.

Susie Martin, 55, from Manchester, whose mother was prescribed DES during pregnancy, told The Telegraph she has undergone between 20 and 30 operations as a result of the drug’s effects.

“The impact of this terrible drug cannot be underestimated as it has ruined and devastated so many lives, including my own,” she said. “The physical and emotional pain has been unbearable. I live with a constant fear that I will need more surgery or develop cancer—and I am far from the only one.”

Calling DES a “silent scandal,” Martin said she hopes the government’s engagement will lead to concrete action. “While I welcome Mr Streeting meeting us, it will only matter if he commits to meaningful steps for victims of this shameful chapter in British medical history, including a screening programme and a full statutory public inquiry,” she added.

What Is Happening With The DES Victims?

The Telegraph reported that compensation schemes have been set up for DES victims in the US and Netherlands, however, UK does not have one yet.

"There are harrowing accounts of harm caused by the historic use of Diethylstilbestrol (DES). Some women and their relatives are still suffering from the associated risks of this medicine which have been passed down a generation, and haven’t been supported. The Secretary of State has been looking seriously at this legacy issue and carefully considering what more the government can do to better support women and their families who have been impacted. NHS England has alerted all cancer alliances to this issue so that healthcare professionals are aware of the impacts of DES and the existing NHS screening guidance which sets out the arrangements for those who show signs and symptoms of exposure,” said a Department of Health and Social Care spokesman to The Telegraph.

The World Health Organization (WHO)'s Montreal meeting focused on wearable technology like smartwatches and activity trackers as a reliable source of health tracking. The meeting discussed that wearables could in fact generate objective real-time data, which helps governments design targeted and evidence-based health interventions.

Physicians in the Montreal meetings discussed that wrist-worn devices are more reliable than traditional self-reported surveys. This is because the self-reported surveys could underestimate the levels of physical inactivity.

“Metrics such as step count, moderate-to-vigorous physical activity and sedentary time directly correlate with cardiovascular disease, diabetes and mental health outcomes. Having population-level data allows for early and preventive strategies,” said Dr Venkat Nani Kumar, consultant in internal medicine.

WHO Montreal Meeting: How Have Doctors Reacted The Shift To Wearables?

Doctors in India have welcomed this shift to wearable devices as a better way to generate data and make policies. Dr Kiran Madhala, professor at Gandhi Medical College, Secunderabad, said WHO’s shift reflects rapid advances in artificial intelligence and digital health tools, calling it a progressive step towards improved monitoring of physical activity worldwide.

City-based doctors also underlined the need for inclusive validation of devices. “Wearables must recognise varied movement patterns and step equivalents, especially in ageing populations,” a physician said, while stressing the importance of data privacy and ethical use of health information.

WHO Montreal Meeting: What Are Wearable Health Devices?

As per a 2022 study published in JMIR MHealth and UHealth, wearables refer to devices that are worn by individuals. In health care field, they assist with individual monitoring and diagnosis. Wearables are “seamlessly embedded portable computers...worn on the body," notes another 2018 study published in Telematics Informatics.

A 2018 study published in the journal Sensors noted that wearable health devices are increasingly helping people to better monitor their health status both at an activity/fitness level for self health tracking and at a medical level providing more data to clinicians with a potential for earlier diagnostic and guidance of treatment.

WHO Montreal Meeting: What Are Some Examples Of Wearables?

Blood Pressure Monitor

This is a blood pressure monitor that consists of a cuff that is placed in upper arm with a digital display that provides real time reading of systolic and diastolic blood pressure.

Glucose Monitoring Device

This device estimates your glucose levels in every few minutes. It can be worn in upper arm, with a phone sensor connected to measure readings. It also includes real time glucose alarms to make informed decisions.

Wearable ECG Monitor

ECG patches are interconnected with smartphones, where one can see their readings. They not only measure electrocardiograms, but also detect any abnormalities.

Fitness Tracker

Smartwatches or fitbits that could be worn on your wrist. They help track real time data of your health, steps, heart rate, calorie consumptions, and even sleep patterns. It can also help keep track of oxygen levels.

Integrated Activewear

These activewears come with microscopic sensors to safeguard wearer's body or assist them in reaching their fitness objective.