The Kardashians have lately covered plenty of medical drama, from Kris Jenner's hysterectomy to Kim Kardashian breaking the tip of her finger in an accident. Now, in the latest episode of The Kardashians, Kim, Kris, Khloé Kardashian, and Scott Disick took the groundbreaking 'Horvath test' to determine their biological ages. The test, which measures cellular aging, revealed that 40-year-old Khloé has the cellular age of a 28-year-old. While Kim, 43, has the biological age of 35 and 68-year-old Kris is at a cellular age of 64. These results shocked the Kardashians as well. Khloe, who was visibly surprised said, "Never in a million years! If I had to bet money, I would’ve never bet on myself... Kim is livid, by the way."

What is biological age?

Biological age differs from chronological age, reflecting how old a person seems at a cellular level. There are a lot of factors that influence biological age which include genetics, lifestyle, environment, and health conditions. Tests like the Horvath test offer insights into one's aging process and may prompt lifestyle changes aimed at healthier aging.

But how does the test work?

These tests analyze DNA methylation patterns by collecting a blood sample and examining it in a lab. Techniques include measuring telomere length, evaluating biomarkers in blood, and assessing overall health functions. Dr. Shrinidhi Nathany from Fortis Memorial Research Institute explains that AI-powered software compares the results with population data to assess aging speed and potential health risks.

Is it available in India?

The Horvath test is not available in India, however, similar tests including Meand32 test, are offered by diagnostic labs and wellness centers such as Dr Lal PathLabs and SRL Diagnostics. However, the tests are expensive, with costs ranging from Rs 1-3 lakh, due to advanced techniques and the nascent stage of the field. Dr. Basavaraj S Kumbar of Aster Whitefield Hospital notes that high costs and uncertain accuracy, as these tests are still developing, pose significant barriers.

While biological age tests offer intriguing insights, they cannot reverse aging. To look younger, experts advise focusing on healthy living practices such as a balanced diet, regular exercise, and stress management over worrying about test results.

Laughing gas or nitrous oxide is making headlines not for its role in dental clinics or surgical procedures, but as a potential treatment for depression. Once only considered a part of short-term anaesthetics used to relieve pain or anxiety during surgical procedures, like childbirth, nitrous oxide is now gaining attention in the world of mental health research for its potential to alleviate symptoms of depression, especially in people who have not responded to traditional treatments.

Even A Low Dose Of Laughing Gas Provides Rapid Relief From Depression

Several studies in recent years have shown that even a low dose of laughing gas can provide rapid relief from depressive symptoms. Unlike conventional antidepressants, which can take weeks to show results, nitrous oxide has demonstrated an almost immediate impact in some patients. Scientists believe this fast-acting effect could be a game-changer in managing treatment-resistant depression.

How Was The Research Conducted?

Researchers at Washington University School of Medicine and the University of Chicago conducted clinical trials on people with severe depression who had not responded well to typical medications. Participants were given a single one-hour inhalation session of nitrous oxide. Remarkably, many reported relief from symptoms within just a few hours, and in some cases, the effects lasted for several days.

Laughing gas is thought to work differently from traditional antidepressants, which usually act on serotonin and other neurotransmitters. Nitrous oxide instead affects the NMDA receptors in the brain, which are involved in mood regulation and cognitive functions. This is similar to how ketamine—another fast-acting antidepressant—works. However, nitrous oxide has the added advantage of being less intense and more manageable in terms of side effects.

Patients who received nitrous oxide in the study experienced a noticeable reduction in their depression scores, even when given low concentrations of the gas. Researchers found that a 25% concentration of nitrous oxide was nearly as effective as the 50% dose but caused fewer side effects, such as nausea or dissociation.

Nitrous Oxide Has Advantage Over Others-Its Long Term Medical Use

One of the reasons nitrous oxide is being seriously explored as a depression treatment is its accessibility and long-standing safety profile. It has been used in medical settings for over 150 years, primarily for pain relief. Its safety, low cost, and ease of administration make it an appealing option for rapid intervention in psychiatric emergencies, particularly for those at risk of suicide.

Still, experts caution that laughing gas is not a magic bullet. While it shows promise, more research is needed to understand its long-term effects and how often it can be safely administered without causing dependency or neurological issues. It also needs to be administered under medical supervision. Mental health professionals are optimistic, though. With increasing cases of depression worldwide and many patients not responding to current treatments, the medical community is on the lookout for new and effective therapies. Laughing gas may not be the ultimate cure, but it represents a promising step forward.

Scientists at the University of Pittsburgh School of Medicine are making significant progress toward developing a brain-computer interface (BCI) that could help people with tetraplegia (paralysis) restore their lost sense of touch. In the new study published in Nature Communications, participants explored digitally represented objects using an artificially created sense of touch. Through the interface, they described sensations as vivid as the warm fur of a purring cat, the smooth, rigid surface of a door key, and the cool roundness of an apple. This collaborative effort between the University of Pittsburgh and the University of Chicago represents a major step forward in neuroprosthetics.

Unlike earlier experiments—where artificial touch often felt like undifferentiated buzzing or tingling—this study introduced a novel feature: BCI users had control over the details of the electrical stimulation that generated their tactile sensations. By enabling participants to personalise their sensory input, scientists were able to help them recreate intuitive and meaningful experiences.

"Touch is an important part of nonverbal social communication; it is a sensation that is personal and that carries a lot of meaning," said lead author Ceci Verbaarschot, Ph.D., assistant professor of neurological surgery and biomedical engineering at the University of Texas-Southwestern and a former postdoctoral fellow at Pitt’s Rehab Neural Engineering Labs. "Designing their own sensations allows BCI users to make interactions with objects feel more realistic and meaningful, which gets us closer to creating a neuroprosthetic that feels pleasant and intuitive to use."

BCI converts Brain Activity Into Signals

A brain-computer interface converts brain activity into signals that can replace, restore, or enhance bodily functions normally controlled by the brain, such as movement. BCIs can also be used to restore lost sensations by directly stimulating the brain, essentially bypassing damaged neural pathways. Over the last decade, Pitt researchers have shown that a paralysed individual can feel sensation using a mind-controlled robotic arm. However, those sensations lacked nuance—touching a person’s hand felt no different than grasping a hard rock.

In this new study, researchers moved closer to creating a realistic, intuitive sense of touch. BCI users were able to "design" different tactile experiences for objects displayed on a screen and could identify objects based on sensation alone—though not perfectly. Participants, all of whom had lost hand sensation due to spinal cord injuries, were challenged to match stimulation settings with sensations like petting a cat or touching an apple, key, towel, or toast.

Sensations Were Subjective

Describing their sensations in rich and subjective detail, one participant noted a cat felt "warm and tappy," while another described it as "smooth and silky." Even when images were removed and participants had to rely solely on touch, they correctly identified the objects 35% of the time—better than chance. "We designed this study to shoot for the moon and made it into orbit," said senior author Robert Gaunt, Ph.D., associate professor of physical medicine and rehabilitation at Pitt. "Participants had a really hard task... and they were quite successful.

Vanellope Hope Wilkins made medical history in 2017 when she was born with her heart outside her body—a condition so rare it's described by experts as "one of a kind." Recently, she underwent a procedure wherein doctors split open her ribs to insert her heart back into her chest cavity. After the successful operation, they shared how they performed the seemingly impossible surgeries.

Born in the UK with a condition known as ectopia cordis, Vanellope underwent three major operations at Glenfield Hospital in Leicester to place her heart back inside her chest. The hospital says it knows of no other case in the UK where a baby with this condition has survived. Now seven years old, Vanellope has undergone groundbreaking surgery to reconstruct a protective cage around her heart—using her own ribs. Since then, she has worn a brace around her chest for protection.

She lives with complex medical needs and requires one-to-one care 24 hours a day. Vanellope is autistic and non-verbal, but according to her mother, Naomi Findlay, 39, from Clifton, Nottingham, she is "a happy little thing" who "brings a lot of joy and happiness." Speaking to the BBC, Naomi said she is extremely proud of the fact that her daughter has not only survived her rare medical condition but also achieved. "It makes me extremely proud to see how far she's come, what she's overcome, and what she's achieving. It's a real journey of strength and bravery... she's so brave," Naomi said, adding that saying goodbye at the theatre door before surgery is always emotional.

How Was It Done?

The surgical team carefully decided that the timing was right for this next step. Vanellope was placed on a bypass machine, which temporarily took over the function of her heart and lungs. This allowed her heart to deflate, making it easier to perform the “very tricky” procedure.

Surgeons first detached part of her heart—the right ventricular outflow tract—and the pulmonary artery from where it had fused to her skin. Then came the bilateral rib osteotomy, a procedure involving breaking her ribs on both sides. The ribs were then repositioned to create a protective cage around her heart.

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