Health and Me

Itisha Arya

Norovirus 2025: Is There A Vaccine For The Stomach Bug Spreading This Year?

norovirus vaccine

Dozens of norovirus outbreaks have been recorded nationwide over the past few weeks, and as people deal with intense vomiting, diarrhea, and other uncomfortable or even risky symptoms, a common question keeps coming up: why is there still no vaccine for such a widespread infection. 

The Centers for Disease Control and Prevention (CDC) says norovirus cases are increasing toward the end of 2025, with higher activity reported in both the US and the UK. Health officials note that a new, highly infectious strain known as GII.17 is partly driving this rise. Because many people have little or no immunity to it, outbreaks are being seen more often in schools and shared public spaces. While overall case numbers remain within typical seasonal ranges, recent weeks have shown a clear upward trend.

Norovirus is an extremely contagious virus that leads to gastroenteritis. It commonly causes symptoms such as vomiting, diarrhea, nausea, and stomach cramps, and may also bring fever and body aches. It is often referred to as the ‘stomach flu,’ though it has no connection to influenza. 

The virus spreads quickly through contaminated food or water, shared surfaces, or direct contact with an infected person’s vomit or stool. Crowded settings like cruise ships are especially vulnerable. Most people recover within one to three days with rest and enough fluids, according to the CDC.

Norovirus usually comes on suddenly, causing vomiting, watery diarrhea, nausea, and abdominal pain. Fever, headaches, and body aches are also common. Symptoms typically appear 12 to 48 hours after exposure and last for one to three days. Because it spreads so easily, infections can move fast through families and communities. 

While most cases improve on their own, dehydration is a concern, so warning signs such as intense thirst or reduced urination should not be ignored, as noted by the Cleveland Clinic.

<h2>Do We Have A <span rel="noindex">Norovirus Vaccine</span>?</h2>

At present, there is no widely available vaccine for norovirus. That said, research has made meaningful strides. Experimental oral vaccines have shown encouraging results in clinical studies, suggesting they may offer protection against multiple fast-changing strains and help reduce how much virus an infected person sheds. Scientists are hopeful that an effective, broadly protective vaccine may become available in the coming years, according to the National Institutes of Health.

<h2>Why Don’t We Have a Norovirus Vaccine Yet?</h2>

Developing a vaccine for norovirus has proven especially difficult, largely because of how quickly the virus changes. “It really is evolving extremely rapidly, and that’s a big problem,” Patricia Foster, PhD, professor emerita of biology at Indiana University Bloomington, told Health.

Norovirus also exists in dozens of subtypes, with several dominant strains circulating at any given time. This is why people can catch norovirus more than once in their lives. Even if immunity develops against one strain, either after infection or through vaccination, another strain can still cause illness. Centers for Disease Control and Prevention. About norovirus.

<h2>Norovirus: Multiple Vaccines Are In The Works</h2>

Despite these obstacles, vaccine research is moving forward. Progress has accelerated in part because of newer technologies developed over the past decade. In 2016, Mary Estes, PhD, a researcher at Baylor College of Medicine, and her team found a way to grow norovirus outside the human body. This breakthrough made it possible to test vaccine approaches and treatments more effectively. This step was crucial because common lab animals like mice do not typically get sick from human norovirus.

Today, scientists are testing several experimental vaccines. One example is a 2023 vaccine developed at Washington University School of Medicine in St. Louis that combines protection against norovirus with an existing rotavirus vaccine. Several pharmaceutical companies are also developing candidates, many of which are now in clinical trials, said Amesh Adalja, MD, senior scholar at the Johns Hopkins Center for Health Security, in comments to *Health*.

HilleVax, a Boston-based company, has been testing a norovirus vaccine originally developed by Japan’s Takeda. However, that candidate did not succeed in a phase II trial in June 2024. Meanwhile, a tablet-style norovirus vaccine from San Francisco-based Vaxart has completed phase I testing. Among the most promising efforts is Moderna’s vaccine, which is currently being tested in human volunteers.

<h2>Preventing Norovirus, Even Without a Vaccine</h2>

Norovirus spreads so easily that stopping it once someone falls ill can be very challenging. This is linked to the virus’s structure. Norovirus is a nonenveloped virus, similar to polio and other stomach-related infections. Because of this, neither hand sanitizers nor soap and water actually destroy the virus, Foster explained. “Handwashing helps because you’re physically rinsing the virus away,” she said.

As a result, basic hygiene practices, especially thorough handwashing, remain some of the most effective ways to lower risk, said Ming Tan, PhD, an infectious disease researcher and associate professor of pediatrics at Cincinnati Children’s Hospital Medical Center, speaking to *Health*.

If norovirus does strike, treatment options are limited. Staying hydrated is essential to avoid complications from fluid loss. Some people may also use medicines to control nausea or diarrhea, either over the counter or by prescription, such as Zofran. If severe symptoms develop, including confusion, high fever, or intense abdominal pain, medical care should be sought right away.

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Dozens of norovirus outbreaks have been recorded nationwide over the past few weeks, and as people deal with intense vomiting, diarrhea, and other uncomfortable or even risky symptoms, a common question keeps coming up: why is there still no vaccine for such a widespread infection. The Centers for Disease Control and Prevention (CDC) says norovirus cases are increasing toward the end of 2025, with higher activity reported in both the US and the UK. Health officials note that a new, highly infectious strain known as GII.17 is partly driving this rise. Because many people have little or no immunity to it, outbreaks are being seen more often in schools and shared public spaces. While overall case numbers remain within typical seasonal ranges, recent weeks have shown a clear upward trend.What Is Norovirus?Norovirus is an extremely contagious virus that leads to gastroenteritis. It commonly causes symptoms such as vomiting, diarrhea, nausea, and stomach cramps, and may also bring fever and body aches. It is often referred to as the ‘stomach flu,’ though it has no connection to influenza. The virus spreads quickly through contaminated food or water, shared surfaces, or direct contact with an infected person’s vomit or stool. Crowded settings like cruise ships are especially vulnerable. Most people recover within one to three days with rest and enough fluids, according to the CDC.Norovirus Symptoms 2025Norovirus usually comes on suddenly, causing vomiting, watery diarrhea, nausea, and abdominal pain. Fever, headaches, and body aches are also common. Symptoms typically appear 12 to 48 hours after exposure and last for one to three days. Because it spreads so easily, infections can move fast through families and communities. While most cases improve on their own, dehydration is a concern, so warning signs such as intense thirst or reduced urination should not be ignored, as noted by the Cleveland Clinic.Do We Have A Norovirus Vaccine?At present, there is no widely available vaccine for norovirus. That said, research has made meaningful strides. Experimental oral vaccines have shown encouraging results in clinical studies, suggesting they may offer protection against multiple fast-changing strains and help reduce how much virus an infected person sheds. Scientists are hopeful that an effective, broadly protective vaccine may become available in the coming years, according to the National Institutes of Health.Why Don’t We Have a Norovirus Vaccine Yet?Developing a vaccine for norovirus has proven especially difficult, largely because of how quickly the virus changes. “It really is evolving extremely rapidly, and that’s a big problem,” Patricia Foster, PhD, professor emerita of biology at Indiana University Bloomington, told Health.Norovirus also exists in dozens of subtypes, with several dominant strains circulating at any given time. This is why people can catch norovirus more than once in their lives. Even if immunity develops against one strain, either after infection or through vaccination, another strain can still cause illness. Centers for Disease Control and Prevention. About norovirus.Norovirus: Multiple Vaccines Are In The WorksDespite these obstacles, vaccine research is moving forward. Progress has accelerated in part because of newer technologies developed over the past decade. In 2016, Mary Estes, PhD, a researcher at Baylor College of Medicine, and her team found a way to grow norovirus outside the human body. This breakthrough made it possible to test vaccine approaches and treatments more effectively. This step was crucial because common lab animals like mice do not typically get sick from human norovirus.Today, scientists are testing several experimental vaccines. One example is a 2023 vaccine developed at Washington University School of Medicine in St. Louis that combines protection against norovirus with an existing rotavirus vaccine. Several pharmaceutical companies are also developing candidates, many of which are now in clinical trials, said Amesh Adalja, MD, senior scholar at the Johns Hopkins Center for Health Security, in comments to *Health*.HilleVax, a Boston-based company, has been testing a norovirus vaccine originally developed by Japan’s Takeda. However, that candidate did not succeed in a phase II trial in June 2024. Meanwhile, a tablet-style norovirus vaccine from San Francisco-based Vaxart has completed phase I testing. Among the most promising efforts is Moderna’s vaccine, which is currently being tested in human volunteers.Preventing Norovirus, Even Without a VaccineNorovirus spreads so easily that stopping it once someone falls ill can be very challenging. This is linked to the virus’s structure. Norovirus is a nonenveloped virus, similar to polio and other stomach-related infections. Because of this, neither hand sanitizers nor soap and water actually destroy the virus, Foster explained. “Handwashing helps because you’re physically rinsing the virus away,” she said.As a result, basic hygiene practices, especially thorough handwashing, remain some of the most effective ways to lower risk, said Ming Tan, PhD, an infectious disease researcher and associate professor of pediatrics at Cincinnati Children’s Hospital Medical Center, speaking to *Health*.If norovirus does strike, treatment options are limited. Staying hydrated is essential to avoid complications from fluid loss. Some people may also use medicines to control nausea or diarrhea, either over the counter or by prescription, such as Zofran. If severe symptoms develop, including confusion, high fever, or intense abdominal pain, medical care should be sought right away.