Air pollution levels in Delhi rises after the festive celebrations in October, and due to the cold weather, the polluted air looms around us. While all of us are aware of the respiratory illnesses caused by air pollution, a new study has now shown that it could also trigger rheumatoid arthritis. At the 40th annual conference of the Indian Rheumatology Association (IRACON 2025), which was held at the Yashobhoomi in Dwarka, with leading rheumatologists present there, revealed that there is plenty evidence that shows how toxic air and PM2.5 pollution could fuel a surge in cases of rheumatoid arthritis across Delhi-NCR. What is rheumatoid arthritis?It is a chronic autoimmune disease that causes pain, swelling, stiffness, and warmth in the joints and affects mostly small joints of hands and feet in a symmetrical pattern. It occurs when the immune system attacks the body's own tissue, particularly the lining of the joints and leads to inflammation or even damage to cartilage and bones.What Are The Experts Saying?The experts have pointed out that autoimmune diseases like rheumatoid arthritis was traditionally linked to genetics and immune system dysfunction. However, now it is increasingly being associated with environmental factors too. One of the biggest trigger is air pollution. As per the current estimates, the condition affects 1% of India's adult, and pollution adds fuel to the fire. The experts suggested with pollution being on the rise, the cases are expected to increase too. "When pollution levels are high, the patients who do well otherwise, their condition also worsen… We are observing a rise in RA cases in patients living in polluted areas with no family history or genetic predisposition to autoimmune disease,” said Dr Uma Kumar, Head of Rheumatology at AIIMS Delhi. She also pointed out that most of these patients are between the age 20 to 50. “This is a public health emergency we can no longer ignore,” she said.Dr Pulin Gupta, who is a professor and rheumatologist at the Dr Ram Manohar Lohia Hospital said, “What we are witnessing is not just a increase in cases of RA but these cases are also more severe… Reduced green spaces in urban areas are worsening the problem, depriving residents of protective environmental buffers.”He also said that studies have now shown a strong association between exposure to PM2.5, nitrogen oxides, and ozone with increased risk of rheumatoid arthritis cases. "Living near busy roads, which means constant traffic-related pollution, has also been linked to higher RA risk,” he said. What Is The Study Experts Are Basing Their Opinions At?Dr Gupta pointed out the study that was the base of this claim of the relationship between pollution and rheumatoid arthritis. The 'landmark study' is published in the European Medical Journal, 2025, which has provided strong genetic evidence that connect air pollution to autoimmune diseases, including rheumatoid arthritis. The study has used two-sample Mendelian randomisation approach and identified significant causal links between common pollutants and immune system dysfunction. It has also highlighted environmental damage as a crucial driver in the rise of these diseases. Dr Gupta pointed out that Delhi is one of the top 10 most polluted cities in the world and has thus emerged as a hotbed of concern. “Pollution is rewriting that narrative… turning healthy individuals into patients. The fact that young people with no family history are developing RA should set alarm bells ringing," said Dr Neeraj Jain, Scientific Chairman and Vice Chairman, Department of Rheumatology at Sir Ganga Ram Hospital. “European cohorts similarly reported that people living in highly polluted cities had significantly higher morbidity related to autoimmune disorders. These findings mirror what doctors are now observing… with Delhi residents facing a double blow of respiratory distress and autoimmune flare-ups,” he said.
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