The year 2024 came with 39 polio cases in Pakistan and two fresh ones on October 20 itself in the Sindh province. A day earlier, four cases were also reported. As per the Regional Reference Laboratory for Polio Eradication in Islamabad, the newest victims are a girl and a boy.

Out of the 39 cases, 20 were from Balochistan, 12 from Sindh, 5 from Khyber Pakhtunkhwa and one each from Punjab and Islamabad. While Prime Minister's Focal Person for Polio Eradication Ayesha Raza Farooq acknowledged the rising cases of polio, he also noted that by June 2025, the cases will be eradicated.

As per the World Health Organisation (WHO), the only two countries where polio remains endemic are Pakistan and Afghanistan.

What Is Polio?

It is an illness caused by a virus that affects nerves in the spinal cord or brain stem. It can lead to a person being unable to move certain limbs, which can also lead to paralysis. Furthermore, it can also cause trouble breathing, and lead to death.

The polio virus is a naturally occurring virus that has been around since prehistoric times, as per the WHO. This disease can be found in humans and is spread through the faecal-oral route, which means it is transmitted when someone ingests food or water contaminated by human faeces.

Poliovirus is a small, single-stranded RNA virus that belongs to the Enterovirus subgroup of the Picornaviridae family and was first recognised as a distinct condition by English physician Michael Underwood in 1789. The virus was identified in 1909 by Austrian immunologist Karl Landsteiner.

About 5% of people with poliovirus get a mild version of the disease called abortive poliomyelitis. It has flu-like symptoms and can last for 2 to 3 days. The symptoms include:

• Fever
• Headache
• Muscle Aches
• Sore Throat
• Stomachache
• Loss of appetite
• Nausea
• Vomiting

A more severe form is the nonparalytic polio, affecting 1% of those infected which may have the symptoms such as:

• Neck pain or stiffness
• Aches or stiffness in arms or legs
• Severe headache

The most serious form is paralytic polio, while the symptoms start with those of nonparalytic polio and can progress to more severe signs including:

• Intense pain
• Extreme sensitivity to touch
• Tingling or pricking sensations
• Muscles spasms or twitching
• Muscle weakness progressing to a limp paralysis

Situation in Pakistan And Afghanistan

Pakistan and Afghanistan are the last two countries in the world where the wild poliovirus is still endemic as 100%, out of which 67.5% cases were from Pakistan and 35.5% were from Afghanistan.

India launched massive strikes on terror camps in Pakistan and PoK late night yesterday. The aerial operation came in response to the Pahalgam terror attacks that resulted in 26 people getting killed and several others getting injured last month. As tensions continue to rise in both countries, people in India have been asked to participate in mock drills to prepare for possible emergencies.

While people on both sides of the border prepare for a possible war, mental health experts have raised concerns about the psychological cost of such a situation. They opined that it could result in escalated stress, anxiety and fear. A recent study published in the International Journal of Mental Health Systems earlier this year aunderscored the escalating mental health crisis in Ukraine, exacerbated by the ongoing conflict. The study reveals that prior to the full-scale invasion, approximately 30% of Ukrainians had experienced mental health disorders, with depressive disorders surpassing the EU average. The conflict has severely strained the nation’s mental health infrastructure, underscoring the urgent need for comprehensive reforms and targeted interventions to address the rising rates of anxiety, PTSD, and depression among civilians and displaced populations.

How To Manage Anxiety In Such a Situation, As Per Expert

Dr Shilpi Saraswat, Clinical Psychologist at Sakra World Hospital, Bengaluru, recommends avoiding unnecessary exposure to news and staying in a supportive social circle when stuck in such situations. Here are a few steps you should follow:

1. Limit news exposure: Set boundaries on news consumption to avoid excessive exposure.

2. Stay informed, not overwhelmed: Focus on credible sources and updates rather than constant coverage.

3. Practice self-care: Engage in activities that promote relaxation and stress reduction, such as exercise, meditation, or hobbies.

4. Social support: Connect with loved ones, friends, or support groups to share feelings and concerns.

5. Grounding techniques: Use mindfulness exercises, deep breathing, or physical activity to stay present and focused.

Coping Strategies For Families And Children

If you are someone who resides with the elderly and children, Dr Saraswat recommends having an open discussion with them on the current situation. "Encourage honest discussions about feelings and concerns," he said. Moreover, you must provide reassurance and comfort to them. To avoid anxieties, it is also advised to maintain regular routines and activities to provide a sense of stability. You should also acknowledge and validate children's feelings, helping them process emotions. Moreover, monitor and limit children's exposure to news and media coverage.

Differentiating Normal Stress Responses from Serious Mental Health Concerns

1. Normal stress responses: Anxiety, worry, and fear are common reactions to stressful situations.

2. Signs of more serious concerns: Persistent symptoms, such as intrusive thoughts, nightmares, or avoidance behaviours, may indicate PTSD or other mental health concerns.

3. Panic disorders: Recurring panic attacks, persistent fear of having attacks, or avoidance behaviours may indicate a panic disorder.

4. Seek professional help: If symptoms persist or interfere with daily life, consult a mental health professional for guidance and support.

Heart disease is still the number one killer worldwide, and "bad" cholesterol – or LDL (low-density lipoprotein) – is at the heart of this health epidemic. Even after decades of depending on statins to manage high cholesterol, millions still have perilously high levels of LDL. But a revolutionary combination of drugs could finally bring hope to those who are fighting to keep their heart health in check, even with standard treatment.

A new cholesterol-lowering drug is a game-changer. A new two-drug combination—obicetrapib plus ezetimibe—has proven dramatic impacts on lowering LDL cholesterol in people who have high LDL levels even after they are on statins. In a new Phase 3 clinical trial from the Cleveland Clinic, this two-drug combination delivered a staggering 49% decrease in LDL cholesterol after only 12 weeks.

The results were presented at the European Atherosclerosis Society congress in Glasgow and simultaneously published in The Lancet, lending authority to what is potentially a large change in the treatment of cardiovascular disease. The trial enrolled 407 patients with a mean age of 68, all with LDL above the American Heart Association's suggested cutoff of 70 mg/dL for patients at high risk. Even while continuing their usual cholesterol-lowering medications, only those who received the new combo pill experienced such dramatic reductions in LDL.

Dr. Ashish Sarraju, the lead author and preventive cardiologist, stressed the need for increasing choices for patients. "In patients at higher risk, you want to lower LDL as soon as possible and maintain it as long as possible," he said. For those who have already had a heart attack or stroke—or are at high risk—this therapy may provide the aggressive lowering of cholesterol that statins alone cannot provide.

Why Statins Alone Are Not Enough Any More?

Statins have been the front-line therapy for high cholesterol for many years but have their weaknesses. They are intolerable to some patients, and in others, they fail to produce the LDL falls required to avoid repeat cardiovascular events. Even high-intensity statin therapy proves inadequate in those at highest risk.

Dr. Corey Bradley of Columbia University observes, "Many people have such a high LDL they will require multiple agents to control it." That's where the obicetrapib-ezetimibe combination steps in—providing a synergistic solution for patients who have reached a wall with conventional meds.

What Makes This Drug Different?

It’s worth noting that not all drugs in the same category have shown benefits in the past. CETP inhibitors, a class of drugs that includes obicetrapib, have previously failed to demonstrate protection against heart attacks or strokes in clinical trials. However, experts remain cautiously optimistic about this new formulation.

Dr. Robert Rosenson of Mount Sinai Health System said, "Some of the drugs in this class have not prevented strokes or heart attacks. But I am hopeful cautiously." NewAmsterdam Pharma, the Dutch firm behind obicetrapib, is now carrying out additional trials to see if this drug not only reduces LDL but also major cardiovascular events.

NewAmsterdam Pharma has revealed it will sit down with the U.S. Food and Drug Administration this year to talk about regulatory avenues for approval. Assuming everything goes according to plan, the new combination may soon be accessible to millions of patients in the U.S. and internationally.

Ways to Lower Your Cholesterol Naturally

Though new drugs such as this provide a hopeful answer for at-risk patients, they don't eliminate the necessity for ongoing lifestyle changes. The CDC says that only 20% of people can control their LDL levels with lifestyle changes alone. Nevertheless, every little bit helps—particularly when used in conjunction with medication.

Low cholesterol doesn't always mean taking medication—there are potent, natural lifestyle modifications that can do wonders to your lipid profile and heart health. Below are ways you can lower bad cholesterol (LDL) and increase good cholesterol (HDL) with realistic, long-term changes:

Follow a Heart-Healthy Diet

Emphasize a diet high in soluble fiber, healthy fat, and plant foods. Eat oats, legumes, apples and berries, vegetables, and whole grains. Replace saturated fat in red meat and whole milk dairy with heart-healthy fats like those of avocados, nuts, seeds, and olive oil. Eliminate trans fats altogether—they increase LDL and decrease HDL.

Get Moving with Regular Exercise

Physical activity tends to increase good cholesterol and decrease bad cholesterol. Be as active as possible throughout the week; aim for 150 minutes of brisk walking, cycling, or swimming per week. Even small activities like taking the stairs or taking the short walk after a meal can pay off in the long run.

Maintain a Healthy Weight

Losing a few pounds will improve cholesterol levels. Being overweight helps to raise LDL levels and lower HDL. Practice mindful eating, portioning, and consistent activity to induce a calorie deficit that allows for gradual, healthy weight loss.

Quit Smoking

Smoking injures the blood vessels, decreases good cholesterol, and places one at an increased risk for heart disease. After quitting in weeks, one starts to recover in terms of HDL cholesterol, and a year later, the risk for heart disease lessens significantly.

Limit Alcohol Intake

Even if moderate drinking contributes a little positive effect on the level of HDL, more drinking raises both total cholesterol and triglycerides. If you drink, consume it in moderate amounts—limited to one alcoholic beverage per day for women and two for men.

Manage Stress Effectively

Chronic stress can indirectly influence cholesterol by encouraging unhealthy habits such as overeating or smoking. Practice stress-reducing activities such as yoga, deep breathing, meditation, or simply taking a walk in nature to promote heart health.

Select Plant Sterols and Supplements Carefully

Some plant compounds such as sterols and stanols can inhibit the absorption of cholesterol. You can get these in fortified foods and natural supplements. Always consult a healthcare professional before taking any new supplement.

The release of this new combination therapy represents a possible paradigm shift in cholesterol treatment—especially among aging populations, genetically predisposed individuals, and those with underlying cardiovascular disease. If FDA-approved and integrated into clinical practice, this combination drug may have a profound impact on reducing the global incidence of heart disease.

These whole-body, evidence-based strategies provide a map to naturally enhance cholesterol and heart health—without resorting solely to prescription drugs.

Cancer is often seen as a disease that primarily affects older individuals. After all, the average age of diagnosis is 66, and the risk of developing cancer rises steadily with age. However, a disturbing trend is emerging: more young adults are being diagnosed with cancer before the age of 50. This article explores this shift, its potential causes, and the types of cancers that are rising in younger populations.

In the United States, cancer is diagnosed in fewer than 25 out of every 100,000 people under the age of 20, and it accounts for just 1 percent of all cancer diagnoses, according to the National Cancer Institute (NCI). By the time individuals reach the ages of 45 to 49, the incidence of cancer jumps to about 350 cases per 100,000 people. This rate almost triples to 1,000 cases per 100,000 in people 60 and above. Nevertheless, researchers now notice a concerning trend—a rise in the number of cancer cases being diagnosed in young adults, especially those below 50.

A new research by the NCI shows an in-depth analysis of early-onset cancers in the US. The research, which spanned over 2 million cases diagnosed between 2010 and 2019, revealed substantial increases in certain forms of cancer among younger individuals. Breast, colorectal, kidney, and uterine cancers were identified as the top drivers of this increase. Of the 33 cancers examined, 14 had increasing rates in at least one younger age group, with 63% of these early-onset cancers being in women.

The NCI's report compared cancer incidence in 2019 with what could have been anticipated from the rates in 2010. The results are worrisome:

Breast Cancer: The biggest proportion of the increase was seen in breast cancer, with approximately 4,800 extra cases in young adults compared to what could have been anticipated.

Colorectal Cancer: There were 2,000 more than anticipated cases of colorectal cancer.

Kidney Cancer: 1,800 more cases of kidney cancer were diagnosed.

Uterine Cancer: Uterine cancer diagnoses went up by 1,200 cases.

Interestingly, even as the diagnosis is on the increase, the mortality rates for the majority of cancers among young people have not actually increased. There were, however, sharp increases in the mortality rates for colorectal, uterine, and testicular cancers among the young population.

Why Is This Happening?

The causes of this rise in early-onset cancer are multifaceted and complex. Although more study is required, a number of theories have been put forward by specialists in the field:

Obesity: Obesity has been associated with a heightened risk of various cancers, including uterine and colorectal cancers, for many years. As obesity continues to increase, it could account for some of the rises in cancer diagnoses among young individuals.

Advances in Detection of Cancer: Enhanced screening techniques and shifts in guidelines for early detection may be contributing. These advances have resulted in increasing numbers of cancers being detected at an earlier stage, which may be contributing to the increase in diagnoses.

Delayed Childbearing: For women, delayed childbearing is linked with an increased risk of breast cancer. Pregnancy and lactation have been shown to decrease the risk of breast cancer, therefore delayed pregnancies might be adding to the increase in cases among younger women.

Environmental and Lifestyle Factors: Greater exposure to carcinogens, either through pollution, chemicals, or lifestyle choices, may also be affecting cancer rates among young people.

What Kinds of Cancer Are Increasing?

While the rate of cancer for some cancers in older individuals is decreasing, young people are experiencing more cases of certain cancers. The greatest increases have been seen in the following:

Breast Cancer

This cancer is among the most prevalent cancers of younger women, especially those under the age of 50. A concerning trend that has been seen is an increase in more aggressive subtypes of breast cancer, including triple-negative and HER2-positive breast cancers. These cancers are harder to treat and have poorer prognoses.

Colorectal Cancer

Previously viewed as a disease of predominantly older individuals, colorectal cancer is becoming more prevalent among young people. Early-onset colorectal cancer is specifically of concern because it is often diagnosed at later stages when it is more difficult to treat.

Uterine Cancer

This form of cancer is increasingly found in younger women. Similar to colorectal cancer, the increasing uterine cancer may be a result of the escalating obesity epidemic.

Kidney Cancer

Kidney cancer diagnoses have similarly increased in young adults. While the causes of this are unknown, it is believed that obesity and other lifestyle-related issues may be to blame.

Are Some Cancers Are Decreasing Too?

While there has been an increase in early-onset cancers, it must be added that cancer incidence is falling for various forms in younger age groups. The most significant falls have been observed in lung cancer and prostate cancer.

Lung Cancer: The decrease in lung cancer is, in large part, due to the substantial reduction in cigarette smoking prevalence during the last decades. This has resulted in a commensurate reduction in the incidence of young adults with lung cancer.

Prostate Cancer: The reduction in prostate cancer incidence can be attributed to revised screening recommendations that discourage the routine use of prostate-specific antigen (PSA) testing in young men. This has lowered the rate of unnecessary diagnoses and treatments.

How Are Early-Onset Cancers Different?

The most glaring distinction between early-onset cancers and those that are diagnosed later in life is age. Yet, the aggressiveness of some cancers, particularly breast cancer, is a major consideration. Younger patients tend to have more aggressive types of cancer, which tend to be treated with more aggressive and invasive therapies.

In breast cancer, for instance, younger women will tend to carry genetically caused cancers, like the ones related to BRCA mutation. But again, these genes only explain only 20% of early-onset breast cancer, which points to other genetic or environmental exposures as well.

Can Early-Onset Cancer Be Prevented?

Although it is not possible for anybody to avoid the risk of cancer entirely, some lifestyle choices will minimize the chance of cancer occurrence. According to experts, they include the following:

• Physical activity can lower the risk of developing many cancers, including breast and colon cancer.
• A balanced diet with plenty of fruits, vegetables, and whole grains can reduce the risk of cancer. Reducing processed foods and alcohol consumption is also helpful.
• Smoking is a major cause of cancer, especially lung cancer. Stopping smoking at any age can lower the risk substantially.
• If there is a family history of cancer, it is critical to bring this up with your physician. Genetic counseling and ongoing screening may help detect cancers at an earlier stage, when they are more treatable.
• Early awareness of cancer signs and symptoms is key. Regular check-ups and screenings, like mammograms and colonoscopies, can detect cancers before they become problematic, enhancing the potential for effective treatment.

Although the increase in early-onset cancers is distressing, it is also an urgent call for more research. Researchers need to work towards establishing the root cause of this surge, especially for cancers such as breast, colorectal, and uterine cancers. Through the discovery of the drivers behind these trends, we can then create better prevention methods and treatment options, improving the prognosis of younger cancer patients.

The growing number of cancers occurring before the age of 50 is an important public health issue that must be addressed now. Although certain cancers are decreasing, others are increasing, and it is imperative to keep monitoring and studying these trends to promote a healthier tomorrow for everyone.