Jonathan Van Ness, the star is best known for his charming on-screen presence on Netflix's 'Queer Eye', has shocked fans with a drastic new look. The 37-year-old recently went on social media to announce he has lost 66 pounds, posting before-and-after photos highlighting his impressive weight loss. Though his journey involved the use of GLP-1 medications, Van Ness also made considerable changes to his lifestyle in order to reach his outcomes.

Van Ness, who has always been open about his body image and mental health struggles, posted his weight loss progress through Instagram Stories. The comparison pictures showed an older picture of his with more of a fuller build next to his current, thinner version of himself. The overlay caption boasted, "Lost 66 pounds!" and was accompanied by the MyFitnessPal logo, insinuating that the use of dietary tracking helped in his makeover.

His honest disclosure immediately fueled discussions, not only on his remarkable weight loss, but also on the regimen he used to get there. One month ago, Van Ness had also quelled rumors, confessing in a TikTok video that he was taking an GLP-1 medication—one of the most buzzed-about weight-loss drugs in recent years.

Van Ness confirmed that he had been prescribed a GLP-1 drug after a consultation with his physician. GLP-1, or glucagon-like peptide-1, is a hormone that regulates blood glucose and hunger. Originally intended for the treatment of Type 2 diabetes, such drugs—such as brand names Ozempic, Wegovy, and Mounjaro—have become trendy among celebrities and the general public for their weight-reducing attributes.

"I've lost and gained weight many times quite publicly, but this time, I required a little bit of additional assistance," Van Ness described, pointing out that his most recent weight gain had been motivated by private personal struggles in the last couple of years. He acknowledged that binge-eating disorder was the central reason behind his weight changes, causing him to experience compulsive eating and guilt.

After attempting a pill form of the medication to no avail, Van Ness moved to an injectable GLP-1 in September 2023. The effect was near-instant. "For the first time ever in my life, I had control over what I ate," he explained, noting the medication has been "massively helpful."

Lifestyle Changes That Made the Difference

Although GLP-1 drugs were part of his change, Van Ness stressed that his weight loss was not only because of the medication. He consciously and sustainably changed his lifestyle so that he would take back control of his well-being.

"I want to mention GLP-1s have been a huge help, but I have also made huge other changes," he said in a social media post. These included:

Healthier Diet: Van Ness overhauled his diet, adopting healthier and more balanced meals.

Reducing Alcohol Consumption: Reducing alcohol consumption was an important factor in enhancing his physical as well as mental health.

Adopting Group Fitness: He emphasized that group Pilates had been the most important modification in his process, enhancing his overall mental and physical health.

"My mental state and overall mood is a different world since last year, and the most significant change was group fitness," he added.

Psychological Impact of Weight Loss and Body Image

Van Ness has been a long-time advocate for mental health awareness, frequently writing about the overlap between body image and emotional health. His recent weight gain, he conceded, had left him feeling "depressed and out of control." He credits medication, but also therapy, exercise, and self-care, with helping him find balance again.

His tale emphasizes a significant discussion regarding weight loss and the emotional price it extracts. Most people struggling with weight issues go through phases of bingeing, self-criticism, and anxiety. Van Ness' honesty regarding his experience motivates others to reach out and find various methods that suit them.

Are GLP-1 Medications a Growing Trend in Hollywood?

Van Ness is not the first public figure to speak about taking GLP-1 medications for weight loss. Over the past few years, a number of celebrities have admitted to taking the drugs.

Whoopi Goldberg has revealed that she lost considerable weight after taking Mounjaro, a GLP-1 drug taken for Type 2 diabetes.

Oprah Winfrey has talked about taking a GLP-1 agonist, although she has not revealed which exact drug.

Kelly Clarkson also revealed taking a weight-loss drug, though she claimed it was not Ozempic but did not provide more information.

The increasing discussion of these drugs has led to arguments about their availability, long-term health impacts, and ethics. Though they have been a miracle for those with weight-related health conditions, there is still fear of their overuse and social pressure to achieve specific body ideals.

With all the ongoing talk about GLP-1 meds, Van Ness' openness reminds us that weight loss isn't simply numbers on a scale but about being better, whole, and complete.

Vaccinated for human papillomavirus (HPV)? Now, take that Pap smear test. This is the most common advice women hear to prevent the risk of cervical cancer that annually causes around 6,60,000 new cases and around 350,000 deaths worldwide.

However, it's easier said than done for most of the fairer sex.

A Pap smear is typically a gynecological examination where a speculum is inserted to collect cells from the cervix.

Although the procedure is brief and generally safe, the discomfort discourages many from getting screened. Fear of pain, anxiety of the results, form the common psychological barriers worldwide, and is followed by shame, cultural attitudes, and concerns with male clinicians.

A study in Iran, published in the BMJ Open journal in January 2024, showed that psychological stress, cultural issues, and fear, along with limited information and health services, were the biggest hindrances to getting Pap tests.

Another research published in the BMC Women's Health in December 2022, focusing on Africa, Asia, and South America, reported that many women avoided or delayed Pap smears because they are afraid the procedure will hurt. Many also reported being embarrassed about the pelvic exam or fear of having a stranger see their private areas. Some also worried that the test could damage the uterus.

A Pap Smear test, however, is proven to be safe and is recommended for every woman above the age of 21 years.

“A Pap smear is a rapid, safe, and painless screening procedure that detects irregular cellular changes well before they become malignant. The ability to treat at this pre-cancerous stage of disease provides an excellent outcome,” Dr. Tirathram Kaushik, Senior Consultant GI, HPB, Gastrointestinal & Thoracic Oncology and Robotic Surgery, HCG Cancer Centre, Borivali, told HealthandMe.

A 2025 study, published in the Journal of Contemporary Clinical Practice, showed that pap smears are excellent at ruling out precancerous risks. It also remains a valuable screening tool where molecular testing is limited.

There are many myths about Pap smears that make people anxious or avoid screening. Let’s clear up the most common ones:

Pap Smears Are Painful

The Pap smear procedure, which takes only a few minutes, is often described as uncomfortable. While some feel like a quick pinch, others experience slight discomfort or spotting. Severe pain is not considered normal.

“From an oncology perspective, this myth results in a delay in diagnosis. Cervical cancer often occurs silently in its early stages, without any noticeable symptoms,” Kaushik said.

I Am Healthy, So I Don’t Need A Pap Smear

While individuals may feel completely well, they still have abnormal cells developing silently. As a result, regular Pap smear screening is important because it detects these changes early -- before they turn into cervical cancer.

“The HPV infection and subsequent changes that lead to cervical cancer happen slowly over many years. HPV infection is also very common, and one in two women is likely to get infected. Regular screening by a Pap smear will help to catch infection early before it can convert into cancer,” Dr. Deepak Jha, Chief - Breast Surgery & Sr. Consultant Surgical Oncology, Artemis Hospitals, told HealthandMe.

I Have Only One Partner, So I Don’t Need Screening

“HPV doesn’t need penetrative sex for infection. It can be transferred if there is any contact of bodily fluid. It’s always safe to test and be assured rather than repent later,” Dr. Jha said.

Testing Means Cervical Cancer

“Even if HPV is detected, it usually indicates a pre-cancerous stage that is highly treatable,” Dr. Parminder Kaur, Consultant Gynecologic Oncologist at CK Birla Hospital, Delhi, told HealthandMe.

Moreover, a Pap smear only screens for cervical cancer; it can’t detect other gynecological cancers such as cervical, ovarian, uterine (endometrial), vaginal, and vulvar cancers. So, screening and appropriate tests for those will be required, irrespective of the Pap smear.

I Am Old, So I Don’t Need A Pap Smear

I Got Vaccinated, So I Do Not Need A Pap Smear

Irrespective of vaccinated status, a woman should go for regular screening between the ages of 25 and 79. Also, if a woman already had HPV exposure before being vaccinated, she would not benefit, the experts said.

“Screening is not just a routine procedure - it is a preventive measure. In the treatment of cancer, early detection alters the disease course, whereas waiting for symptoms to develop means the disease is likely to be already advanced,” Dr. Kaushik said.

Dr Kaur called for more awareness and stated that open discussion are key to help more women take the important screening test.

When To Get Screened

The United States Preventive Services Task Force (USPSTF) and the American Cancer Society (ACS) recommend getting your first Pap test at age 21, followed by Pap testing every 3 years. Even if you are sexually active, you do not need a Pap test before age 21.

• Individuals must start getting Pap tests at age 21. If the result is normal, repeat the test after three years.
• For individuals aged between 30 and 65 years old, doctors are likely to recommend an HPV test along with a Pap test. If both are normal, repeat after five years.

In women older than 65, you don't need to be screened anymore if:

• You have had at least three Pap tests or two HPV tests in the past 10 years, and the test results were normal or negative, and
• You have not had a cervical precancer in the past, or
• You have had your cervix removed as part of a total hysterectomy for non-cancerous conditions, like fibroids.

Vaccinated for human papillomavirus (HPV)? Now, take that Pap smear test. This is the most common advice women hear to prevent the risk of cervical cancer that annually causes around 6,60,000 new cases and around 350,000 deaths worldwide.

However, it's easier said than done for most of the fairer sex.

A Pap smear is typically a gynecological examination where a speculum is inserted to collect cells from the cervix.

Although the procedure is brief and generally safe, the discomfort discourages many from getting screened. Fear of pain, anxiety of the results, form the common psychological barriers worldwide, and is followed by shame, cultural attitudes, and concerns with male clinicians.

A study in Iran, published in the BMJ Open journal in January 2024, showed that psychological stress, cultural issues, and fear, along with limited information and health services, were the biggest hindrances to getting Pap tests.

Another research published in the BMC Women's Health in December 2022, focusing on Africa, Asia, and South America, reported that many women avoided or delayed Pap smears because they are afraid the procedure will hurt. Many also reported being embarrassed about the pelvic exam or fear of having a stranger see their private areas. Some also worried that the test could damage the uterus.

A Pap Smear test, however, is proven to be safe and is recommended for every woman above the age of 21 years.

“A Pap smear is a rapid, safe, and painless screening procedure that detects irregular cellular changes well before they become malignant. The ability to treat at this pre-cancerous stage of disease provides an excellent outcome,” Dr. Tirathram Kaushik, Senior Consultant GI, HPB, Gastrointestinal & Thoracic Oncology and Robotic Surgery, HCG Cancer Centre, Borivali, told HealthandMe.

A 2025 study, published in the Journal of Contemporary Clinical Practice, showed that pap smears are excellent at ruling out precancerous risks. It also remains a valuable screening tool where molecular testing is limited.

There are many myths about Pap smears that make people anxious or avoid screening. Let’s clear up the most common ones:

Pap Smears Are Painful

The Pap smear procedure, which takes only a few minutes, is often described as uncomfortable. While some feel like a quick pinch, others experience slight discomfort or spotting. Severe pain is not considered normal.

“From an oncology perspective, this myth results in a delay in diagnosis. Cervical cancer often occurs silently in its early stages, without any noticeable symptoms,” Kaushik said.

I Am Healthy, So I don’t need A Pap Smear

While individuals may feel completely well, they still have abnormal cells developing silently. As a result, regular Pap smear screening is important because it detects these changes early -- before they turn into cervical cancer.

“The HPV infection and subsequent changes that lead to cervical cancer happen slowly over many years. HPV infection is also very common, and one in two women is likely to get infected. Regular screening by a Pap smear will help to catch infection early before it can convert into cancer,” Dr. Deepak Jha, Chief - Breast Surgery & Sr. Consultant Surgical Oncology, Artemis Hospitals, told HealthandMe.

I Have Only One Partner, So I don’t need Screening

“HPV doesn’t need penetrative sex for infection. It can be transferred if there is any contact of bodily fluid. It’s always safe to test and be assured rather than repent later,” Dr. Jha said.

Testing Means Cervical Cancer

“Even if HPV is detected, it usually indicates a pre-cancerous stage that is highly treatable,” Dr. Parminder Kaur, Consultant Gynecologic Oncologist at CK Birla Hospital, Delhi, told HealthandMe.

Moreover, a Pap smear only screens for cervical cancer; it can’t detect other gynecological cancers such as cervical, ovarian, uterine (endometrial), vaginal, and vulvar cancers. So, screening and appropriate tests for those will be required, irrespective of the Pap smear.

I Am old, So I don’t need A Pap Smear

I Got Vaccinated, So I Do Not Need A Pap Smear

Irrespective of vaccinated status, a woman should go for regular screening between the ages of 25 and 79. Also, if a woman already had HPV exposure before being vaccinated, she would not benefit, the experts said.

“Screening is not just a routine procedure - it is a preventive measure. In the treatment of cancer, early detection alters the disease course, whereas waiting for symptoms to develop means the disease is likely to be already advanced,” Dr. Kaushik said.

Dr Kaur called for more awareness and stated that open discussion are key to help more women take the important screening test.

When To Get Screened

The United States Preventive Services Task Force (USPSTF) and the American Cancer Society (ACS) recommend getting your first Pap test at age 21, followed by Pap testing every 3 years. Even if you are sexually active, you do not need a Pap test before age 21.

• Individuals must start getting Pap tests at age 21. If the result is normal, repeat the test after three years.
• For individuals aged between 30 and 65 years old, doctors are likely to recommend an HPV test along with a Pap test. If both are normal, repeat after five years.

In women older than 65, you don't need to be screened anymore if:

• You have had at least three Pap tests or two HPV tests in the past 10 years, and the test results were normal or negative, and
• You have not had a cervical precancer in the past, or
• You have had your cervix removed as part of a total hysterectomy for non-cancerous conditions, like fibroids.

Are you still experiencing brain fog, fatigue, and mood changes even after years of a mild COVID-19 infection? A new study showed that the SARS-CoV-2 virus, behind the COVID infection, can cause persistent brain inflammation and lung injury, according to a study.

Researchers from Tulane University, in Louisiana, US found that the brain inflammation lasts long even after the virus was no longer detectable.

Their study, published in Frontiers in Immunology, can answer why long COVID often includes neurological symptoms such as brain fog, fatigue, and mood changes.

"Long-term effects on the brain were unique to SARS-CoV-2. That distinction is critical to understanding long COVID," said lead author Dr. Xuebin Qin, professor of microbiology and immunology at the Tulane National Biomedical Research Center. Qin also mentioned "lasting lung injury" among COVID patients.

In a mouse model, the team found that immune cells in the lungs failed to fully stand down and also spiked the buildup of collagen -- a protein associated with scarring.

The changes stiffened lung tissue, making breathing feel more labored -- a possible answer to breathlessness faced by COVID survivors.

Further, the researchers also noted no repair to the injury, suggesting the virus may interfere with the lung's natural healing process.

On the other hand, in the brain, the mice with COVID showed signs of persistent brain inflammation weeks later. The team also reported tiny areas of bleeding.

Conducting a gene expression analysis, the team found ongoing inflammatory signaling and disruption of pathways involved in serotonin and dopamine regulation -- brain functions linked to mood, cognition, and energy levels.

What Is Long COVID?

Long COVID is a collection of symptoms that last three months or longer after your first COVID symptoms. They include fatigue, brain fog, headaches, breathlessness, altered sense of smell or taste, headaches, and more.

While many of the Long conditions remain to be fully recognized, some people have more than one symptom.

mRNA Vaccine Against COVID

As per recent data from the World Health Organization, more than 43,000 new cases have been reported from 61 countries, between January and February.

Vaccination that prevents SARS-CoV-2 infection is the most effective way to prevent long COVID.

Recently, the European Medicines Agency (EMA) recommended a marketing authorisation in the European Union (EU) for mCombriax -- a messenger RNA vaccine for protecting people aged 50 years and older against COVID-19 and seasonal influenza (flu).

Co-infection with the influenza virus and SARS-CoV-2 can result in more severe disease than would occur with either SARS-CoV-2 or influenza virus infection alone.

mCombriax works like other vaccines by preparing the body to defend itself against infection. It contains messenger RNA with instructions for making proteins found on SARS-CoV-2 and the following seasonal influenza viruses: influenza type A-H1N1, influenza type A-H3N2, and influenza type B of the Victoria lineage.