Scientists Develop 3D Heart Model Which Can Beat Cardiovascular Diseases

Scientists have created a three-dimensional "heart-on-a-chip" (HOC) model that beats on its own, uses calcium to initiate muscular activity and responds predictably to common drugs in hopes that it will help fight against cardiovascular diseases and heart failure. This engineered heart is the first to incorporate a dual-sensing platform that provides real-time tracking of activity throughout the heart tissue down to the cellular level, helping scientists measure cellular function, which is critical for preventing heart failure in patients with CVDs.First author Ali Mousavi, a biomedical engineer at the University of Montreal: "The ability to observe the tissue's response to different compounds in real time represents a major advantage for preclinical development and translational research."To create their heart-on-chip (HOC) models, researchers collected heart muscle and connective tissue cells from rats. They placed the cells in a gel rich in proteins and nutrients to help them grow, then put them onto tiny, flexible silicon chips.To measure how the tissue worked, they used two types of sensors. First, they attached the engineered heart tissue between two small elastic pillars. Each time the tissue beat, the pillars bent slightly, and this bending showed how strong the heartbeat was.Then they placed tiny, soft gel-based sensors inside the tissue. These very small droplets—about 50 micrometers wide—changed shape as the cells contracted. This allowed the researchers to measure mechanical stress at the level of individual cells.Talking about this development, senior author Houman Savoji, a mechanical and biomedical engineer at the University of Montreal said: "This breakthrough brings us even closer to true precision health by giving us the ability to identify the most effective medication for each person before treatment is even administered."The Rising Heart Attack CrisisHeart attacks occur when blood flow to the heart is severely reduced or blocked due to a buildup of plaque which is made of fat, cholesterol and other substances in the heart's arteries.During a heart attack, a lack of blood flow causes the cells and tissue in the heart muscle to die, leading to irreversible damage that can result in serious complications like arrhythmias, heart failure, cardiogenic shock, or cardiac arrest. It is one of the leading causes of death in the country. Four Indians experience a heart attack every minute, with one in four dying of the cause. Experts have also noticed a rising trend of nearly 50 percent of heart attack patients being under the age of 40, with half of all heart attacks in Indian men occurring under 50.Coronary Artery Disease: The Silent KillerCoronary artery disease (CAD) is one of the most common illnesses that can cause a heart attack in people. It develops over years and has no clear signs and symptoms apart from a heart attack.The illness begins due to a buildup of fats, cholesterol and other substances known as plaque in and on the artery walls.Over time, this can cause narrowing or blockage of the coronary arteries and block the supply of oxygen-rich blood to the heart which can lead to chest pain (angina), shortness of breath and ultimately, heart attacks.READ MORE: How This Chinese Medicine Can Improve Blood Flow In Angina PatientsTypically, those above the age of 45, having a biological family member with heart disease, lack of sleep, smoking, consuming saturated fats along with other autoimmune diseases such as lupus and rheumatoid arthritis, can increase the risk of developing CAD.Nearly one in 10 Indian adults suffer from CAD and about two million people die from the disease annually. Apart from this, about 18 to 20 million American adults aged 20 and older are also affected about the disease.How Much You Should Exercise To Prevent CAD?The American Health Association recommends performing at least 150 minutes per week of moderate-intensity aerobic activity, such as brisk walking, dancing and gardening or 75 minutes per week of vigorous aerobic activity, such as hiking, running, cycling or and playing tennis or a combination of both, preferably spread throughout the week to maintain heart health.Moreover, regular exercise can also reduce the risk of Type 2 diabetes, high blood pressure, dementia and Alzheimer’s as well as several types of cancer. It can also help improve sleep, cognition, including memory, attention and processing speed.Dr Hayes recommends opting for a cardiac evaluation such as an electrocardiogram, or EKG; a stress test; a cardiac MRI or CT scan to generate images of your heart if you notice changes in your ability to exercise or cannot perform consistent levels of exercise.

Scientists Develop 3D Heart Model Which Can Beat Cardiovascular Diseases

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