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Itisha Arya

Shingles Vaccine Linked To Slower Dementia Progression, Study Finds

shingles vaccine dementia

A <span><a href="https://www.healthandme.com/health/shingles">shingles</a></span> vaccination effort launched in Wales in 2013 has produced two findings that bring new optimism to <span><a href="https://www.healthandme.com/health/dementia">dementia</a></span> research. The program appears not only to lower the likelihood of mild cognitive impairment but also to slow the course of dementia in people who already have the condition. Shingles stems from the varicella zoster virus and causes a painful rash. 

Around one in three people in the United States will experience shingles during their lifetime, with the risk rising sharply with age. For this reason, adults aged fifty and older in the United States are advised to receive two doses of the <span><a href="https://www.healthandme.com/health/shingles">shingles</a> vaccine</span>.

The vaccine has long been known to prevent shingles with an effectiveness above ninety percent for older adults, but recent work suggests it may hold additional advantages.

Shingles, or herpes zoster, is caused by the varicella zoster virus, which is also responsible for chickenpox. It usually presents as a cluster of blistered skin on one side of the body, often forming a band across the torso. After a person recovers from chickenpox, the virus stays in the nerve cells and can reactivate years later, especially when the immune system weakens, according to Mayo Clinic.

Dementia refers to a collection of symptoms that include significant problems with memory, reasoning, and daily function. It results from damage to brain cells caused by several conditions, including Alzheimer’s disease and vascular dementia. Although dementia becomes more common with age, it is not considered a normal part of growing older, as outlined by the World Health Organization.

<h2><span rel="noindex">Shingles Vaccine Linked To <a href="https://www.healthandme.com/health/dementia">Dementia</a> Progression</span></h2>

Growing evidence indicates that receiving the shingles vaccine may lower the chances of developing dementia. A new study, published Tuesday in the journal Cell, builds on earlier research by proposing that the vaccine might also slow existing dementia, which could reduce the risk of death related to the disease.

“We see a change in the odds of dying from dementia among people who already have the condition,” said Dr. Pascal Geldsetzer, an assistant professor of medicine at Stanford University and senior author of the new study.

“That means the vaccine may not only prevent dementia, but it might also serve as a form of treatment because we notice improvements in people already living with the disease,” he said. “This was both surprising and encouraging.” The new study follows earlier work by Geldsetzer and his team showing that shingles vaccination may help delay or prevent dementia.

In that earlier analysis, researchers reviewed health records from older adults in Wales, where a shingles vaccine program for people in their seventies began on September 1, 2013. Under the rules of the program, individuals who were seventy-nine on that date could receive the vaccine for one year, while those aged eighty or older were not included.

That cutoff allowed researchers to compare outcomes between seventy-nine-year-olds who were offered the vaccine and eighty-year-olds who were not eligible but might have chosen to be vaccinated had they been allowed.

Challenges With The Shingles Vaccine And Reducing Dementia Progression

The next task will be to understand why the shingles vaccine might influence dementia risk or progression. The answer may lie in interactions involving the nervous system or immune response. Certain viruses that affect nerve tissue have been linked in animal studies to the harmful protein accumulation seen in Alzheimer’s disease.

Future research may examine larger and more diverse groups of people, and may also explore how the newer shingles vaccine compares with the older version used in Wales in 2013, which has since been replaced.

“At least directing part of our research efforts toward these pathways might bring important progress in both prevention and treatment,” said biomedical scientist Pascal Geldsetzer from Stanford University.

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A shingles vaccination effort launched in Wales in 2013 has produced two findings that bring new optimism to dementia research. The program appears not only to lower the likelihood of mild cognitive impairment but also to slow the course of dementia in people who already have the condition. Shingles stems from the varicella zoster virus and causes a painful rash. Around one in three people in the United States will experience shingles during their lifetime, with the risk rising sharply with age. For this reason, adults aged fifty and older in the United States are advised to receive two doses of the shingles vaccine.The vaccine has long been known to prevent shingles with an effectiveness above ninety percent for older adults, but recent work suggests it may hold additional advantages.What Is Shingles?Shingles, or herpes zoster, is caused by the varicella zoster virus, which is also responsible for chickenpox. It usually presents as a cluster of blistered skin on one side of the body, often forming a band across the torso. After a person recovers from chickenpox, the virus stays in the nerve cells and can reactivate years later, especially when the immune system weakens, according to Mayo Clinic.What Is Dementia?Dementia refers to a collection of symptoms that include significant problems with memory, reasoning, and daily function. It results from damage to brain cells caused by several conditions, including Alzheimer’s disease and vascular dementia. Although dementia becomes more common with age, it is not considered a normal part of growing older, as outlined by the World Health Organization.Shingles Vaccine Linked To Dementia ProgressionGrowing evidence indicates that receiving the shingles vaccine may lower the chances of developing dementia. A new study, published Tuesday in the journal Cell, builds on earlier research by proposing that the vaccine might also slow existing dementia, which could reduce the risk of death related to the disease.“We see a change in the odds of dying from dementia among people who already have the condition,” said Dr. Pascal Geldsetzer, an assistant professor of medicine at Stanford University and senior author of the new study.“That means the vaccine may not only prevent dementia, but it might also serve as a form of treatment because we notice improvements in people already living with the disease,” he said. “This was both surprising and encouraging.” The new study follows earlier work by Geldsetzer and his team showing that shingles vaccination may help delay or prevent dementia.In that earlier analysis, researchers reviewed health records from older adults in Wales, where a shingles vaccine program for people in their seventies began on September 1, 2013. Under the rules of the program, individuals who were seventy-nine on that date could receive the vaccine for one year, while those aged eighty or older were not included.That cutoff allowed researchers to compare outcomes between seventy-nine-year-olds who were offered the vaccine and eighty-year-olds who were not eligible but might have chosen to be vaccinated had they been allowed.Challenges With The Shingles Vaccine And Reducing Dementia ProgressionThe next task will be to understand why the shingles vaccine might influence dementia risk or progression. The answer may lie in interactions involving the nervous system or immune response. Certain viruses that affect nerve tissue have been linked in animal studies to the harmful protein accumulation seen in Alzheimer’s disease.Future research may examine larger and more diverse groups of people, and may also explore how the newer shingles vaccine compares with the older version used in Wales in 2013, which has since been replaced.“At least directing part of our research efforts toward these pathways might bring important progress in both prevention and treatment,” said biomedical scientist Pascal Geldsetzer from Stanford University.

shingles vaccine linked to slower dementia progression, study finds

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