Anyone who has been prescribed medication for depression knows the long list of possible side effects: fatigue, appetite changes, headaches, and more. But these physical reactions are not the same across all medications. Recent research shows that some antidepressants can cause quick changes in weight, heart rate, and blood pressure, while others are relatively mild. The purpose of this work was to rank antidepressants based on their known side effects, specifically those that appear within the first eight weeks of starting treatment.

What Are Antidepressants?

Antidepressants are prescription medications used to treat conditions like depression, anxiety, chronic pain, and more by boosting brain chemicals that regulate mood. Common types include SSRIs, SNRIs, and NDRIs. They often take several weeks to show full effect. Typical side effects can include dry mouth, weight changes, and dizziness. Interestingly, new research suggests that the side effect profile can vary depending on the specific antidepressant.

Types of Antidepressants

There are several categories of antidepressant medications, as per NHS:

• Selective serotonin reuptake inhibitors (SSRIs): Increase serotonin levels in the brain to improve mood.
• Serotonin-norepinephrine reuptake inhibitors (SNRIs): Raise both serotonin and norepinephrine, helping with mood, alertness, and stress.
• Tricyclic antidepressants: Affect serotonin and norepinephrine like SNRIs, but also influence other parts of the body and brain.
• Monoamine oxidase inhibitors (MAOIs): Boost brain chemical levels by blocking an enzyme that breaks them down.
• NMDA receptor antagonists: Work quickly to improve mood by targeting specific brain receptors, usually given in clinics if other medications fail.
• Atypical antidepressants: Don’t fit neatly into other groups, each affecting brain chemicals in unique ways.

Physical Side Effects Differ Across Antidepressants

Millions of adults in the U.S. rely on antidepressants for conditions such as depression and anxiety. Like all medications, these drugs can cause side effects, though the severity varies. Researchers from King’s College London and the University of Oxford examined just how differently side effects appear across 30 antidepressants, analyzing data from over 58,500 participants in more than 150 studies.

“Not all antidepressants are the same when it comes to their physical side effects,” explained Toby Pillinger, an academic clinical lecturer at King’s College London. The findings, published in The Lancet, are the first to link specific physical side effects to individual antidepressants, offering potentially important guidance for doctors prescribing these medications, which are taken by up to 17% of adults in Europe and North America.

Drugs reviewed included SSRIs like sertraline (Zoloft) and fluoxetine (Prozac), SNRIs like duloxetine (Cymbalta) and venlafaxine (Effexor), and NDRIs like bupropion (Wellbutrin).

What the Data Shows

The research looked at 30 commonly prescribed antidepressants across 151 studies involving over 58,500 patients. Not everyone develops side effects, but on average:

• Eight weeks of agomelatine use linked to a 2.4kg weight loss, whereas maprotiline led to nearly 2kg weight gain.
• Heart rate varied by 21 beats per minute between fluvoxamine, which slowed the heart, and nortriptyline, which sped it up.
• Blood pressure differed by 11 mmHg between nortriptyline and doxepin.

Antidepressants: Effects on Heart Rate and Blood Pressure

Some medications, like fluoxetine, were linked to increased systolic blood pressure, while others, like citalopram (Celexa), were not. Citalopram was associated with slight weight loss, decreased heart rate, and systolic blood pressure, with a minor rise in diastolic blood pressure. Venlafaxine raised heart rate, while paroxetine (Paxil) caused no heart rate changes.

“Clearly, no two antidepressants affect the body in the same way,” said Dr. Atheeshaan Arumuham from King’s College London.

Interestingly, commonly prescribed antidepressants in the U.S., such as fluoxetine, bupropion, and sertraline, were linked to weight loss over the short-term in these trials. For reference, about 1.4 million people were prescribed citalopram last year.

Antidepressants: Short-Term or Long-Term Side Effects?

A limitation of this research is that the studies analyzed were relatively short, with a median treatment duration much shorter than most real-world use. It also did not assess other common side effects, including sexual dysfunction, headaches, upset stomach, and, in rare cases, agitation or suicidal thoughts. Since the focus was on the first eight weeks, further research is needed to understand long-term effects.

Choosing the Right Antidepressant

As side effects differ across medications, there is no one-size-fits-all solution. Dr. Pillinger advises that selecting the right antidepressant should always be done in consultation with a qualified medical professional.

Our bodies may hit their peak strength, skin firmness, and ability to have children when we are young adults, but new studies have found that our brains actually perform their best much later in life.

As people get old, the perception that they are no longer capable of making decisions or that they stop remembering things becomes rampant. These assumptions can lead to age-based discrimination, such as favoring younger employees over older, experienced ones. However, how true is this assumption? Do we actually start experiencing cognitive decline as soon as we come close to midlife?

A study published in the journal Intelligence looked at data measuring abilities like reasoning, memory, processing speed, general knowledge, and emotional intelligence across different ages.

What Age Are We Best Mentally?

The findings challenge the idea that we’re mentally sharpest in our 20s. Instead, the research found that our overall psychological functioning peaks much later, typically between ages 55 and 60.

According to the lead study author, our mental ability doesn't really start to drop until around age 65, and the decline only gets noticeably faster after age 75.

The research also looked closely at five main personality traits: being outgoing, handling stress well, being careful and organized, being open to new things, and being agreeable.

How Does Our Personality Affect Our Brain Health?

The researchers discovered that many of these traits also reach their best levels later in life. For example, conscientiousness (being thorough and disciplined) peaks around age 65, and emotional stability (staying calm and balanced) is highest around age 75.

The study further found that our ability to make good moral judgments improves with age, and our skill at making rational decisions (resisting poor cognitive biases) may continue to improve even into our 70s and 80s. This helps explain why many top jobs in business and government are often held by people in their 50s and early 60s.

What Role Does Age Play In Real World?

This latest research focused on real, measurable psychological strengths that directly lead to better performance in the real world. Many of these strengths, like better judgment and decision-making, are vital for people in leadership positions.

However, despite these clear signs that older people are at their psychological peak, they still often face major challenges when looking for a new job or trying to stay in their current one.

Even though there is a law (the Age Discrimination in Employment Act of 1967) that protects people aged 40 and over from unfair treatment in hiring and firing, discrimination still happens in reality. An Ageism in the Workplace Survey found that a huge 90% of workers over age 40 have experienced ageism at work. Many employers wrongly believe that someone in their mid-50s is a poor long-term investment.

The hope is that these new findings will make it clear that companies need to adopt fair hiring and retention practices that include older workers. As the author noted, history is full of people who achieved their biggest successes well past the age society usually labels as the "peak."

Respiratory virus season is upon the United States as colder months arrive, bringing an expected rise in cases of COVID-19, influenza, and RSV. In its annual outlook, the Centers for Disease Control and Prevention (CDC) predicts that peak hospitalizations from these viruses during the 2025–26 season will be similar to last year. Public health experts speaking to ABC News have emphasised that vaccination remains the most effective way to protect against severe illness. Below, we answer common questions about the RSV vaccine for anyone seeking guidance.

What Is The RSV Vaccine?

Who Can Get An RSV Immunization?

According to the CDC, RSV vaccines are recommended for adults aged 75 and older, as well as those between 50 and 74 who have a higher risk of severe illness. Studies suggest that a single dose provides protection for at least two years in older adults. For infants, protection can be achieved either by vaccinating mothers during pregnancy or by giving babies an antibody shot after birth to help prevent severe RSV infection.

When Is The RSV Vaccine Available?

Eligible adults can receive the RSV vaccine at any time, though late summer and early fall are generally considered the best period, according to the CDC. For expectant mothers, the vaccine is usually available between September and January, while the antibody shot for infants is typically recommended from October through March.

How Much Does The RSV Vaccine Cost?

For those with insurance, the RSV vaccine may be fully covered. Without insurance, the shot can cost around $350, according to Dupont. “Patient assistance programs are available that can significantly reduce out-of-pocket costs,” Dupont added.

Does RSV Vaccine Have Any Side Effect?

Like all vaccines, the RSV shot can have side effects. Common ones include pain, redness, or swelling at the injection site, as well as fever, headache, fatigue, and muscle or joint aches. Serious side effects are rare but can occur. Fainting may also happen after the shot, and observation may be advised to prevent injury.

Common side effects

• Pain, redness, or swelling at the injection site
• Fever
• Fatigue
• Headache
• Muscle or joint pain
• Nausea or vomiting
• Diarrhea
• Swelling or tenderness under the arm
• Rare but serious risks
• Severe allergic reaction (anaphylaxis): Symptoms may include hives, facial or throat swelling, difficulty breathing, rapid heartbeat, or dizziness. This is a medical emergency; call emergency services immediately.
• Guillain-Barré Syndrome (GBS): A very rare condition where the immune system attacks the nerves. Seek medical attention if you experience sudden weakness, tingling in the hands or feet, or pain.
• Fainting: This can occur after vaccination, and you may be asked to stay for a short observation period to prevent injury.

Many people are choosing to become parents later in their lives. Whether it is due to financial reasons or due to difficulty conceiving, etc. However, many people bring up the ‘biological clock’ argument. While it is possible to have pregnancy later in life, there are some health implications, not just for the mother, but also for the child. Many people often place this responsibility on women. However, a new study shows that fathers who have children later in life may also risk passing down harmful mutations.

New research shows that as men get older, their sperm collects harmful mutations, which can raise the risk of health issues in their children.

Researchers in the UK studied sperm samples from 81 healthy men, ranging in age from 24 to 75. Using a highly accurate testing method, the team found that harmful changes, or mutations, build up in sperm over time. Simply put, the older a man is, the more his sperm’s genetic quality declines.

How Does Old Sperm Affect Offspring's Health?

The study identified over 40 genes that cause the sperm stem cells to mutate. This genetic process is known as "selfish sperm."

What's most alarming is that these harmful mutations don't just accumulate; they are actually favored during the creation of new sperm. This means that sperm cells carrying the mutations multiply and out-compete the healthy sperm, leading to a higher proportion of damaged cells. This process can lead to a two to three times higher risk of passing on disease-causing mutations. The study measured the percentage of sperm carrying disease-causing mutations and found a clear increase with age:

• Early 30s (26–42 years): About 2% of sperm carried disease-causing mutations.
• Middle-Aged and Older (43–74 years): This percentage rises significantly to between 3% and 5%.
• The overall rate of accumulation was calculated to be about 1.67 new mutations every year.
• The research specifically suggests that the genetic quality of a man's sperm starts to decline noticeably around age 43.

How Does Late Parenthood Affect Children?

These mutated genes are linked to developmental disorders and inherited syndromes that can increase the risk of certain cancers. The mutations that increase most sharply as the father ages are connected to severe neurodevelopmental disorders in children, including some conditions on the autism spectrum.

The study confirmed that specific rare genetic disorders, such as Apert, Noonan, and Costello syndromes, are rooted in this “selfish sperm” phenomenon.

These findings are particularly important today because older fatherhood is becoming much more common. The number of fathers over the age of 40 nearly doubled between 1972 and 2015.

This trend concerns the given related data: a recent analysis found that fathers over 40 had a 51% greater chance of having a child diagnosed with autism compared to fathers under 30.

While these results highlight an increased risk that older fathers should be aware of, the researchers stress that more study is needed. They also point out that while the number of mutated sperm increases with age, not all of them will lead to a successful pregnancy, as some may prevent fertilization or cause miscarriage.