When we talk about cancer, breast, lung, and colon usually dominate the conversation. But lurking quietly in the background is a lesser-known, often overlooked type: sarcomas. These rare cancers, which take root in connective tissues, don’t always get the attention they deserve. Yet, they deserve it and how.

Not Just One, But Many Types

Sarcomas are a group of cancers which arise from body tissues. It can be from bone, fat, muscle, tendons, nerves, blood and lymph vessels are the predominant ones.

Unlike most other cancers that generally strike older adults, sarcomas don’t discriminate by age. “These cancers can occur in relatively younger age groups,” Dr. Karthik K S, Consultant, Surgical Oncology at KMC Hospital, Mangalore, says. Sometimes, these are also triggered by certain genetic mutations, making them all the more complex.

The Trouble with Tumours

These tumours can quietly grow in any part of the body, which means the symptoms are often subtle and deceptive. Dr. Karthik says, “Presentations may be much simpler than the consequences. Unplanned treatment may lead to rather grievous consequences.”

Because of the wide-ranging locations where sarcomas can appear, they often call for specialists across disciplines. “The treatment of these types of cancers will need specialised doctors, often oncologist surgeons, medical and radiation oncologists,” he explains. In short, a generalist approach just won’t do.

Diagnosis: More Than Just a Scan

Before treatment even begins, the real detective work starts. “The patient will need a full evaluation,” says Dr. Karthik. That begins with imaging, but even this depends on where the sarcoma has taken hold. Once imaging has painted a picture, a biopsy is essential. “These diseases need a biopsy to prove the diagnosis and often subclassify the disease based on IHC (immunohistochemistry),” he says.

If there’s a suspicion of hereditary involvement, genetic studies may also be required. Only once everything is on the table—stage, type, and location—can doctors chalk out a treatment plan.

Surgery Takes the Lead

According to Dr. Karthik, “treatment includes surgery as a main modality of treatment.” But it’s rarely a one-man show. “Treatment may also include chemotherapy and radiotherapy,” he adds, making it a team effort from start to finish.

Kids Are Not Spared

Dr. Sachin Sekhar Biswal, Medical Oncology Consultant at Manipal Hospital, Bhubaneshwar, draws attention to another critical aspect: age is no protection. “Connective tissue is an important constituent of the human body. The cancer that arises from the connective tissue mostly constitutes sarcoma. It can be seen in all age groups, starting from infancy to geriatric populations.”

In fact, in children, sarcomas are surprisingly common. “Rhabdomyosarcoma is the most common type of cancer in the children,” Dr. Biswal states. “Apart from that, osteosarcoma and Ewing's sarcoma are also common types of sarcomas in children.”

Symptoms

Since sarcomas can develop anywhere in the body, the symptoms can be vague or misleading. Dr. Biswal points out, “It can present as a progressively increasing swelling or a lump, bone overgrowth with pain, swelling or limitation in the range of motion, or simply a vague lump based on its location.”

Which is why early detection is tough and treatment becomes even more time-sensitive.

Teamwork Makes the Treatment Work

Dr. Biswal explains that sarcoma treatment is not a one-specialist show. “Sarcoma treatment is always a multimodality effort involving medical and surgical oncologists, orthopaedic oncologists, radiation oncologists, interventional radiologists, onco-pathologists and the rehabilitation team.”

He shares that the most common treatment plan includes “surgical excision followed by radiation or chemotherapy”. When it comes to bone or limb sarcomas, gone are the days when amputation was the only solution. “Limb salvage therapy rather than amputation is the new way. It can be achieved by high-quality implants or autografts,” he adds.

Speed Is Everything

Time really is of the essence. Dr. Biswal stresses, “Though rare, the tendency to metastasise is high, such that diseases like Ewing’s sarcoma are considered systemic from the very time of diagnosis.” In other words, even at diagnosis, it’s already a whole-body concern.

But with timely diagnosis and swift treatment, outcomes can be significantly improved. “A timely diagnosis and a prompt treatment can save a life and avoid much morbidity,” Dr. Biswal reminds us.

Scrolling through social media, many women encounter stories of celebrities describing years of unexplained symptoms before receiving a diagnosis of polycystic ovary syndrome (PCOS). Model and actress Lori Harvey recently shared her experience with weight fluctuations, acne, facial hair growth, and painful irregular periods, highlighting a common struggle among women of reproductive age. Stories like hers resonate with women like Alexis King, who found validation in hearing someone else’s journey, as reported in Washington Post.

PCOS is a hormone disorder affecting roughly one in ten women worldwide, including about six million Americans. It is linked to both reproductive and metabolic dysfunction, increasing the risk of fertility problems as well as chronic conditions such as high blood pressure, diabetes, obesity, and cardiovascular disease. Despite its prevalence, PCOS remains underfunded and under-recognized, leaving many women to navigate the condition largely on their own.

A “Silent” Diagnosis

For many, PCOS is identified only after years of unexplained symptoms. Patients often encounter healthcare providers who focus on cosmetic solutions rather than addressing the underlying hormonal imbalance. Researchers note that PCOS is considered an “orphan disorder” in women’s health, receiving significantly less funding than conditions with comparable prevalence and severity. From 2016 to 2022, average annual funding for PCOS was around $32 million, compared with $262 million for rheumatoid arthritis and $66 million for tuberculosis, according to recent studies reported in Washington Post.

Experts stress the need for comprehensive management rather than relying on individual supplements, though some, such as inositol, have shown promise in improving metabolic and reproductive outcomes. There is no cure or FDA-approved treatment specifically for PCOS, though existing interventions can alleviate symptoms and reduce long-term health risks, according to Richard Legro, chair of obstetrics and gynecology at Penn State Health Milton S. Hershey Medical Center, as reported in Washington Post.

Challenges in Diagnosis

A full PCOS diagnosis requires meeting at least two of three criteria: irregular periods, elevated male hormones, or ovaries with fluid-filled sacs visible on ultrasound. Yet many patients never undergo complete hormone testing or imaging, leaving the disorder undiagnosed for years. Clinicians often lack training to treat PCOS effectively, as it spans multiple specialties, from reproductive endocrinology to general gynecology. Multidisciplinary clinics exist but are limited in number, forcing patients to seek care from providers unfamiliar with the full scope of the disorder, as reported in Washington Post.

Delayed diagnosis can have serious consequences. Women with PCOS face increased risks of infertility, pregnancy complications, and chronic conditions. Endometrial cancer risk is higher due to irregular shedding of the uterine lining, and Black women experience disproportionately higher rates of adverse outcomes due to later diagnosis and barriers to care.

Research and Emerging Treatments

In the absence of robust funding, clinicians have relied on medications such as metformin, which improves insulin sensitivity, to manage PCOS symptoms. Research is also exploring the use of weight-loss drugs, such as semaglutide, to regulate hormone levels, restore periods, and reduce metabolic risks. Early trials show promise, with participants reporting restored menstrual cycles, improved hormone balance, and weight loss, as reported in Washington Post.

Despite these advances, insurance coverage remains a challenge. Patients often must pay out of pocket for medications that are not yet FDA-approved specifically for PCOS. Researchers like Melanie Cree, a pediatric endocrinologist, are pushing for standardized testing and more clinical trials, but funding delays and reduced philanthropic support continue to slow progress.

As awareness grows, advocates and researchers aim to prioritize PCOS as a significant public health concern, emphasizing early detection, comprehensive treatment, and equitable access to care. For millions of women, improved understanding and treatment of PCOS could transform lives, reducing both immediate discomfort and long-term health risks, as reported in Washington Post.

For the first time, patients in England and Wales will be able to access a long-acting injection to prevent HIV through the NHS, bringing the policy in line with Scotland. The new jab, administered every two months, provides an alternative to daily oral pills, offering convenience and discretion for those who find tablets challenging to take.

Experts hope the introduction of cabotegravir (CAB-LA) injections will help the UK meet its goal of eliminating new HIV cases by 2030. Meanwhile, early results from another injection, lenacapavir, suggest that annual HIV prevention injections could become a possibility in the future.

A “Game-Changing” Option

Wes Streeting, the Secretary of State for Health and Social Care, described the new injection as “game-changing” and told the BBC: “For vulnerable people who are unable to take other methods of HIV prevention, this represents hope”.

HIV prevention therapy, known as PrEP (pre-exposure prophylaxis), is used by HIV-negative individuals to reduce the risk of infection. While daily oral PrEP has been effective for years, some people find it difficult to adhere to. Challenges include lack of privacy, homelessness, domestic violence, or the fear of others discovering their medication.

A long-acting injection that lasts for months addresses these issues, offering both practicality and discretion. Cabotegravir, produced by ViiV Healthcare, is intended to be used alongside safer sex practices, such as condom use. NHS England has secured a confidential discount from the manufacturer, whose list price is around £7,000 per patient per year, as reported by the BBC.

Who Will Be Eligible?

The injection will be offered to adults and adolescents at high risk of sexually acquired HIV who are eligible for PrEP but may struggle with daily tablets. Around 1,000 people are expected to be offered the injection initially, with others continuing or starting oral PrEP. Patients can access it through NHS-operated sexual health clinics “in the coming months,” according to the National Institute for Health and Care Excellence (NICE).

Dom Baldwin, who currently takes PrEP pills, told the BBC he is “over the moon” about the injections: “When you look at where we are now compared to the epidemic in the 80s… HIV is no longer a death sentence”.

Calls for Rapid and Equitable Rollout

Charities have emphasized the need for a fast rollout, as some patients face long waits for appointments. Richard Angell, of the Terrence Higgins Trust, said to the BBC that the therapy should be offered in more settings, not just sexual health clinics: “It’s highly effective and acceptable for patients, and a vital tool for tackling inequalities, with the potential to reach those who are not currently accessing other HIV prevention”.

Official figures show that PrEP access in England is increasing, but gaps remain. In 2024, 146,098 HIV-negative people attending sexual health services were at substantial risk of HIV, with about 76% starting or continuing PrEP, a 7.7% rise from 2023. However, uptake varies by group, with lower rates among black African heterosexual men and women compared to men who have sex with men.

Dr Michael Brady, NHS England’s National Advisor for LGBT+ Health, said to the BBC: “This long-acting injection is a significant addition to our HIV prevention strategies, giving us a powerful new option for people at risk of HIV who cannot have oral PrEP tablets”.

In a recent study published in The Lancet, by the Global Burden of Disease Study, 2023 reveals that non-communicable diseases (NCDs) like heart disease, stroke, and diabetes now account for nearly two-thirds of global deaths, surpassing infectious diseases, according to an analysis of over 33 years.

The study covered 375 diseases and injuries, including 88 risk factors and healthy life expectancy across 204 countries and territories. It included 660 subnational locations, from 1990 to 2023.

The report also highlighted the sharp rise in mental health disorders with anxiety disorders, which were increased by 63%. The report also noted an increase in depressive disorders by 26%.

Environmental Factors That Impact Health

Furthermore, it added that environmental risks such as extreme heats and air pollution also bears an impact on health. There have been deaths due to climate-sensitive exposures rising by 6% annually between 2013 and 2023.

In fact, recently, a health conference of the Indian Rheumatology Association revealed that pollution also triggers rheumatoid arthritis. Heat waves also pose serious health risks, from heat cramps and exhaustion to the life-threatening heatstroke, by overwhelming the body's ability to cool itself.

An Increase In Life Expectancy Rate

As per the study, the global life expectancy rates have rebounded post COVID-19 pandemic. It has now reached 76.3 for women and 71.5 years for men in 2023. Earlier, in the pandemic, the age for women went down to 74.7 years, while for men, it was at 69.3 years, in 2021. Since 1950, the global life expectancy has increased by roughly 20 years.

In 2023, the total deaths globally reached 60.1 million, which included 4.67 million deaths of children under five. The population growth and aging however has driven a 35.2 per cent increase in global deaths since 1950, under-five mortality has steadily declined in this period.

The report also highlighted the difference in the health outcomes. The global life expectancy has improved, however, the geographic inequities still persisted. The mean age at death rose from 46.4 years in 1990 to 62.9 years in 2023.

Who Lived Longer, Where?

High-income countries reported the longest lifespans, women lived up to 80.5 years on average, while men reached 74.4 years. In stark contrast, sub-Saharan Africa recorded the lowest life expectancy, with women living an average of 37.1 years and men 34.8 years.

The report highlights that nearly half of all global deaths and disabilities could be prevented by tackling key risk factors such as high blood sugar, obesity, and social determinants like sexual abuse and intimate partner violence.

India recorded 9.85 million deaths in 2023, ranking second after China’s 10.7 million. The average life expectancy in India stood at 73 years for women and 70.2 years for men.

Encouragingly, India has made notable strides in reducing child mortality. The under-five mortality rate has dropped to 32.1 deaths per 1,000 live births. However, due to the country’s large population, the total number of deaths among children under five remained high, at around 6,92,000.