As per the World Health Organization (WHO), 57 million people had dementia worldwide in 2021. the Alzheimer's Disease International (ADI) predicted that this number will almost double every 20 years and reach 78 million in 2030. However, there is hope. An Indian origin researcher in the US developed a probiotic cocktail that will help prevent dementia.

What Is Dementia?

As per Alzheimer's Association, dementia is a general term for loss of memory, language, problem-solving and other thinking abilities that are severe enough to interfere with daily life. Alzheimer's is the most common cause of dementia.

It is an umbrella term for loss of memory and other thinking abilities that are severe enough to interfere with daily life. There are various types of dementia, including Alzheimer's, Vascular, Lewy body, Frontotemporal, other includes Huntington's and mixed dementia.

What Is Anti-Dementia Probiotic Cocktail?

The cocktail is developed by Hariom Yadav from the University of South Florida. It is one of a kind of blend of probiotics that can positively impact the microbiome.

Hariom Yadav, director of the USF Health Center for Microbiome Research and associate professor of Neurosurgery and Brain Repair at the USF Health Morsani College of Medicine, is leading the charge. As senior author of two recent studies, his work centers on how gut health affects the brain and cognitive function.

The microbiome is the unseen community of microorganisms that live by the trillions in a person's gut. This probiotic cocktail works by positively influencing the microbiome—the vast, invisible community of trillions of microorganisms living in our gut.

When the Gut Goes Wrong

In a healthy person, these microorganisms coexist in balance. However, when harmful bacteria and viruses disrupt this harmony, it can trigger systemic issues throughout the body. Research now links such disruptions to long-term brain conditions, including dementia and Alzheimer’s disease. This is particularly alarming as dementia cases are expected to double, reaching nearly a million new diagnoses annually by 2060.

Probiotic Cocktail Shows Promise

In a study published in Scientific Reports in January, Yadav’s team tested the cocktail, which combines multiple strains of beneficial gut bacteria. Unlike current Alzheimer’s treatments that focus solely on brain biology, this cocktail offers a new direction—targeting the gut to protect the brain.

Testing the Cocktail on Mice

To evaluate its effects, mice were given the probiotic blend in their drinking water for 16 weeks. They then completed a "water maze" test, which challenged them to find a hidden underwater platform using visual cues. Mice that consumed the cocktail consistently outperformed those that didn’t.

Positive Results in Brain Health

The researchers observed that the probiotic mixture reduced the accumulation of harmful brain proteins linked to plaque formation. It also appeared to decrease brain inflammation and maintain the integrity of the blood-brain barrier, preventing dangerous microorganisms from leaking into the brain.

A Synergistic Approach to Gut Health

“We actually developed this cocktail a few years back,” said Yadav. “Normally, people look at single-strain probiotics. But we discovered that when used together as a consortia, they have more power to shift the microbiome from harmful to beneficial.”

Many people do not realise just how closely mental health and liver health are connected—especially when alcohol becomes a go-to coping strategy for stress, anxiety, or emotional overwhelm. What may seem like temporary relief can quietly evolve into a pattern that affects both the mind and the body in significant ways. Dhara Ghuntla, Psychologist affiliated with Sujay Hospital, 7 Hills Hospital, Criticare Hospital, in an interaction with Health and Me, spoke about the impact of stress, alcohol use and emotional eating on the liver.

In today’s fast-paced, high-pressure lifestyle, it is common for individuals to turn to alcohol to unwind or escape difficult emotions. In the short term, alcohol can create a sense of relaxation or numbness. However, over time, this reliance can shift into a habitual coping mechanism and eventually into dependence. While the psychological impact is often discussed, the physical consequences—particularly on the liver—are just as important.

The liver plays a critical role in detoxifying the body. Regular alcohol consumption places it under constant strain, impairing its ability to function effectively. Over time, this can lead to conditions such as fatty liver, inflammation, and even long-term liver damage. What makes this especially concerning is that early-stage liver issues often present with little to no obvious symptoms, allowing damage to progress unnoticed.

At the same time, liver health has a direct influence on mental well-being. When the liver is compromised, it can affect energy levels, mood regulation, and cognitive function. People may experience increased fatigue, irritability, anxiety, low mood, or emotional instability. This happens because the liver plays an indirect but essential role in brain health through metabolism and toxin clearance.

The Vicious Cycle

This creates a self-perpetuating loop. A person feeling stressed, low, or anxious may turn to alcohol for relief. While it may help temporarily, it simultaneously places stress on the liver. As liver function declines, mental health symptoms—such as fatigue, irritability, anxiety, or low mood—can worsen. This often leads the individual to consume more alcohol, reinforcing the cycle.

Adding another layer, many individuals who rely on alcohol are often dealing with underlying issues such as depression, anxiety, sleep disturbances, or chronic life stressors. Alcohol is frequently used as a form of self-medication. However, instead of addressing these root concerns, it masks them temporarily while deepening both psychological and physical harm. Over time, this pattern increases dependency and makes recovery more complex.

The Gut–Liver–Brain Connection

Liver health is also closely tied to gut function and brain health. When the liver is under stress, digestion can be affected, nutrient absorption may decline, and energy levels can drop. This interconnected system—the gut, liver, and brain—plays a key role in emotional regulation and overall well-being. Disruptions in one area can ripple across the others, influencing how a person thinks, feels, and functions daily.

Breaking the Pattern

Recognising this connection is the first step towards change. Instead of turning to alcohol, healthier coping strategies can help regulate stress and support both mental and physical health. Practices such as yoga, meditation, regular exercise, journalling, and maintaining a balanced diet can significantly improve resilience and emotional stability.

Prioritising mental well-being, addressing underlying psychological concerns, and protecting liver health are not separate goals—they are deeply interconnected. Seeking timely support, whether through therapy, lifestyle changes, or medical guidance, can help break the cycle.

Reducing or eliminating alcohol use is not just about avoiding physical harm; it is about creating space to heal the underlying causes of stress and emotional distress. Supporting the liver, nurturing the gut, and caring for mental health together can lead to more sustainable and meaningful well-being.

You pick up a jar on the kitchen shelf and shudder. You take a flight of stairs, and that old pain sinks into your hip. You get up in the morning, and your shoulder feels as though it has been wrung out. You attribute it to age, to a long day on your feet, to just how things are now. But what if your body is trying to tell you something very particular and you have been missing it?

Dr Apoorv Dua, Consultant, Orthopaedics, ISIC Multispeciality Hospital, in an interview with Health and Me, said that this may be a sign of bursitis—a condition that is much more widespread than most people realise, and much more treatable than most people are aware. The expert went on to answer common questions regarding extreme pain that comes with this condition.

What is bursitis?

Bursae are small, fluid-filled sacs located between your bones, muscles, and tendons. Imagine them as the natural cushioning system of the body—shock absorbers that ensure your joints move smoothly and painlessly. Under normal circumstances, you do not even think about them. However, when inflamed, due to repetitive motion, prolonged pressure, injury, or infection, they make their presence known in a very noticeable manner. This is bursitis. Although it most often appears in the shoulder, elbow, hip, and knee, it may occur in nearly any joint in the body.

Who gets bursitis—and why?

This is where the lifestyle connection cannot be overlooked. Bursitis does not discriminate, but it has definite patterns. The weekend warrior who runs ten kilometres on Saturday after sitting at a desk all week. The housewife who spends hours cleaning floors or squatting in the kitchen. The office worker who has been stooped over a computer. The gym enthusiast who does not warm up. The retired teacher who begins a walking routine too vigorously. All these individuals may be silently placing stress on their bursae, and in many cases, bursitis is the eventual outcome.

Age also plays a role—the bursae, like most of our connective tissue, grow weaker with age. Certain medical conditions such as rheumatoid arthritis, gout, and diabetes can increase the risk. However, in many instances, the cause is simply the way we move—or do not move—in our day-to-day lives.

What does bursitis feel like?

A key characteristic of bursitis is pain that is disproportionate to the activity causing it. Reaching overhead, sitting on a hard surface, pressing on your elbow, or walking downhill—these are not dramatic movements, yet with bursitis, they may trigger a sharp, deep, or burning pain that interrupts you mid-action. The affected joint is usually swollen and tender. The area may feel warm to the touch. Movement becomes guarded. Sleep, particularly in cases of shoulder bursitis, can be difficult, as lying on the affected side aggravates the pain.

The challenge with bursitis is that its symptoms can resemble other conditions—tendinitis, arthritis, a muscle strain, or even a ligament tear. Many individuals self-diagnose, self-treat with painkillers, and hope it will go away. Sometimes it does. However, chronic, untreated bursitis may persist for months and, in some cases, lead to complications.

Bursitis diagnosis

A thorough clinical examination is usually the first step. A skilled orthopaedic specialist can identify the affected bursa through specific physical assessments. Imaging, such as ultrasound or MRI, may be recommended depending on the case to confirm the diagnosis, rule out structural damage, or guide treatment.

If infection is suspected—indicated by increased redness, fever, and rapidly worsening pain—fluid may be aspirated from the bursa and tested. Septic bursitis is a serious condition that requires immediate medical attention and is treated differently from the more common non-infectious type.

Bursitis treatment

The encouraging fact about bursitis is that it responds well to treatment, particularly when detected early. Most cases are managed with a combination of rest, activity modification, ice application, and anti-inflammatory medication. Physiotherapy also plays an important role, helping to correct movement patterns, strengthen supporting muscles, and restore the full range of motion.

In more persistent cases, a corticosteroid injection into the bursa may provide rapid and significant relief by reducing inflammation at its source. Surgery is rare and is typically considered only in chronic, recurrent cases that do not respond to conservative treatment.

Prevention is better

In many instances, bursitis is linked to lifestyle—and that presents an opportunity for prevention. Even small changes can help: warming up before exercise, avoiding excessive strain on joints, maintaining a healthy weight to reduce pressure on hips and knees, and ensuring workstations are ergonomically designed.

Pain often becomes background noise—something we get used to, work around, and push through. However, bursitis reminds us that the body communicates with precision. That pain when you pick up a jar, that discomfort on the stairs—it is not simply ageing. It is a signal worth discussing with your doctor.

A nosebleed that will not stop or a small cut that continues to bleed far longer than expected—these are some of the most overlooked health problems. While these symptoms are often brushed aside as minor issues, they could be early indicators of an underlying bleeding disorder such as haemophilia. Dr Gaurav Kharya, Senior Consultant and Clinical Lead – Bone Marrow Transplant, Indraprastha Apollo Hospital, Delhi, answered FAQs regarding hemophilia—whether frequent nosebleeds in children are a cause for concern or not.

Understanding haemophilia

Haemophilia is a genetic condition that affects the blood’s ability to clot properly. In its absence, even minor injuries can lead to prolonged or excessive bleeding. Despite advances in treatment, many people remain undiagnosed, often until complications start appearing. This World Haemophilia Day, Dr Kharya highlights a critical gap: most people with haemophilia do not even know they have it.

A global diagnosis gap

The World Federation of Haemophilia estimates that over three-quarters of people with bleeding disorders worldwide remain undiagnosed, leaving hundreds of thousands without access to even basic care. To appreciate the scale of this gap, the expected number of patients with haemophilia globally is 1,125,000, of whom approximately 418,000 should have severe haemophilia. Reported figures fall dramatically short of both estimates.

India’s delayed diagnosis challenge

India’s diagnostic reality is particularly sobering. The median age at diagnosis for severe haemophilia in India stands at 60 months—five full years—compared to under 12 months in high-income countries. This delay is not just a matter of time but one that poses a risk of serious clinical consequences. Late diagnosis often means repeated, unmanaged bleeding episodes during early childhood, particularly into joints, before appropriate treatment begins.

Recognising the warning signs

Recognising the early warning signs can be critical in preventing long-term complications. Symptoms such as recurrent nosebleeds, heavy menstrual bleeding in females, and prolonged bleeding after minor injuries are often overlooked or dismissed. However, these are not just minor inconveniences but potential diagnostic indicators that require timely medical consultation rather than mere dismissal.

Treatment options for haemophilia

The treatments for haemophilia have never been more effective, but they work only for patients who have been diagnosed. In a condition where every missed bleed moves a joint closer to permanent damage, the most important clinical act is also the most basic one: recognition.