Health and Me

Ishita Srivastava

This Is When You Age the Most, Study Finds

Think you aged overnight or have you been seeing more signs of <span>aging</span> recently?

According to an August 2024 Nature <span>Ageing</span> study on molecular changes associated with ageing, humans age significantly twice in their life, once at an average age of 44 and the other at around age 60.

Geneticist <span>Michael Snyder</span> of Stanford University explained: "We're not just changing gradually over time; there are some really dramatic changes. It turns out the mid-40s is a time of dramatic change, as is the early 60s. And that's true no matter what class of molecules you look at."

The study found that about  81 percent of all the molecules they studied showed changes during one or both of these stages. Changes peaked in the mid-40s, and again in the early 60s, with slightly different profiles.

The mid-40s peak showed changes in molecules related to the metabolism of lipids, caffeine, and alcohol, as well as cardiovascular disease, and dysfunctions in <span>skin</span> and muscle.

The early 60s peak was associated with carbohydrate and caffeine metabolism, cardiovascular disease, skin and muscle, immune regulation, and kidney function.

However, the study authors noted that more granual research was needed to understand how the ageing process works at these peak ages. 

<h2>Which Gender Ages Faster?</h2>Researchers at the NYU School of Global Public Health have found that women who worry over their declining health may actually speed up the aging process due to the related psychological stress.

Mariana Rodrigues, a PhD student at NYU School of Global Public Health and the first author of the study, said: "Our research suggests that subjective experiences may be driving objective measures of aging. Aging-related anxiety is not merely a psychological concern, but may leave a mark on the body with real health consequences."

"We know from previous research that anxiety, depression, and mental health in general are associated with a number of physical health outcomes, but until now researchers haven’t focused on whether there is a correlation between worrying about aging and the process of aging itself.

“Women in midlife may also be multiple in roles, including caring for their aging parents. As they see older family members grow older and become sick, they may worry about whether the same thing will happen to them".

After analyzing data from 726 women, the researchers while worrying about declining health, had the strongest associations with biological aging, anxiety about declining attractiveness and fertility were not significantly associated with it.

They theorized that this may be because research shows that health-related concerns are more common and persist over time, while worries about beauty and reproductive health may fade with age.

“Aging is a universal experience,” said Rodrigues. “We need to start a discourse about how we as a society—through our norms, structural factors, and interpersonal relationships—address the challenges of aging.”

<h2>Warning Signs You May Be Aging Faster</h2><ul><li><strong>Constant fatigue and loss of energy: </strong>Everyday tasks feel harder, and the body tires more quickly than before.</li><li><strong>Skin and hair changes:</strong> Reduced collagen and keratin production leads to sagging, wrinkles, and thinning or loss of hair.</li><li><strong>Cognitive decline:</strong> Memory lapses, difficulty in planning, and problems with calculations may point to aging-related changes in the brain as grey matter begins to shrink.</li><li><strong>Chronic conditions: </strong>Lifestyle diseases like diabetes and hypertension are often tied to aging, linked to reduced insulin production and thicker, slower blood flow.</li></ul>

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Think you aged overnight or have you been seeing more signs of aging recently?According to an August 2024 Nature Ageing study on molecular changes associated with ageing, humans age significantly twice in their life, once at an average age of 44 and the other at around age 60.Geneticist Michael Snyder of Stanford University explained: "We're not just changing gradually over time; there are some really dramatic changes. It turns out the mid-40s is a time of dramatic change, as is the early 60s. And that's true no matter what class of molecules you look at."The study found that about  81 percent of all the molecules they studied showed changes during one or both of these stages. Changes peaked in the mid-40s, and again in the early 60s, with slightly different profiles.The mid-40s peak showed changes in molecules related to the metabolism of lipids, caffeine, and alcohol, as well as cardiovascular disease, and dysfunctions in skin and muscle.The early 60s peak was associated with carbohydrate and caffeine metabolism, cardiovascular disease, skin and muscle, immune regulation, and kidney function.However, the study authors noted that more granual research was needed to understand how the ageing process works at these peak ages. Which Gender Ages Faster?Researchers at the NYU School of Global Public Health have found that women who worry over their declining health may actually speed up the aging process due to the related psychological stress.Mariana Rodrigues, a PhD student at NYU School of Global Public Health and the first author of the study, said: "Our research suggests that subjective experiences may be driving objective measures of aging. Aging-related anxiety is not merely a psychological concern, but may leave a mark on the body with real health consequences.""We know from previous research that anxiety, depression, and mental health in general are associated with a number of physical health outcomes, but until now researchers haven’t focused on whether there is a correlation between worrying about aging and the process of aging itself.“Women in midlife may also be multiple in roles, including caring for their aging parents. As they see older family members grow older and become sick, they may worry about whether the same thing will happen to them".After analyzing data from 726 women, the researchers while worrying about declining health, had the strongest associations with biological aging, anxiety about declining attractiveness and fertility were not significantly associated with it.They theorized that this may be because research shows that health-related concerns are more common and persist over time, while worries about beauty and reproductive health may fade with age.“Aging is a universal experience,” said Rodrigues. “We need to start a discourse about how we as a society—through our norms, structural factors, and interpersonal relationships—address the challenges of aging.”Warning Signs You May Be Aging FasterConstant fatigue and loss of energy: Everyday tasks feel harder, and the body tires more quickly than before.Skin and hair changes: Reduced collagen and keratin production leads to sagging, wrinkles, and thinning or loss of hair.Cognitive decline: Memory lapses, difficulty in planning, and problems with calculations may point to aging-related changes in the brain as grey matter begins to shrink.Chronic conditions: Lifestyle diseases like diabetes and hypertension are often tied to aging, linked to reduced insulin production and thicker, slower blood flow.