After the long, emotionally and physically demanding journey of in-vitro fertilization (IVF), hearing the words “you’re pregnant” often feels like crossing the finish line. However, for many couples, particularly those navigating fertility challenges, pregnancy is only part of the journey—and miscarriage remains a deeply feared possibility.

Experts points out that although IVF brings a lot of couples closer to parenthood, it does not entirely prevent the risk of miscarriage. "About 15% of all pregnancies, whether they occur naturally or through assisted reproductive technology such as IVF or IUI, result in miscarriage," says Dr. Varsha Patil, a well-known fertility expert. The number may sound shocking, but with the knowledge of the causes, risk factors, and preventive measures, the couple is given the clarity and confidence to proceed.

What Is A Miscarriage?

A miscarriage in medical terminology is the spontaneous loss of pregnancy before 20 weeks of gestation. In Dr. Patil's opinion, miscarriages can be generally divided into two broad categories—early miscarriage, which is a pregnancy loss before 13 weeks, and late miscarriage, which takes place between 13 to 20 weeks. Although it's easy to think that when women become pregnant after IVF, they've exceeded the most dangerous period, the truth is usually different. IVF pregnancies, which are thoroughly monitored, are not completely safe from complications. Actually, some factors underlying the case—like maternal age, embryo quality, uterine anomalies, and hormonal imbalance—can still lead to miscarriage despite a successful embryo transfer.

What Causes Miscarriage After IVF?

Miscarriages after IVF are generally not an indication of treatment failure but usually result from natural biological and physiological problems. Chromosomal abnormalities are one of the most frequent reasons for miscarriage irrespective of how pregnancy is achieved. "An embryo with the incorrect number of chromosomes is unlikely to survive," says Dr. Patil, pointing to the biological problem that can sideline even the best-planned IVF pregnancy. In addition to this, maternal health is also crucial—chronic diseases like uncontrolled diabetes, thyroid disturbances, kidney illness, and autoimmune diseases can disrupt a normal pregnancy and predispose to loss. Lifestyle factors are also very important.

Cigarette smoking, alcohol use, illicit drug use, and even overuse of caffeine are all recognized risk factors for miscarriage. Dr. Patil reiterates that having IVF doesn't erase the need to make healthier lifestyle changes. Physical conditions like fibroids, polyps, a uterine septum, or an incompetent cervix can make it difficult to carry a pregnancy to term. Advanced age is another significant factor; women above 35 have a 25% or more chance of miscarriage, and for women aged above 40, this chance increases to more than 50%. In addition, serious anemia, malnutrition, and inadequate post-embryo transfer medical follow-up can adversely affect pregnancy and hence require holistic post-IVF care to ensure a successful process.

How Age Can Affect Chances Of Miscarriage After IVF?

Although age is a natural component of reproductive aging, it plays an extensive role in the success of IVF. Dr. Patil clarifies, "Between 20 and 35, the rate of miscarriage is 10–15%. But post 35, the rate increases significantly." This is partly because eggs from women who are older have a greater chance of chromosomal abnormalities.

For individuals who are thinking about IVF later in life, this information underscores the value of genetic screening and preconception counseling to get the healthiest embryos to transfer.

Role of Embryo Quality

Embryo quality is critical to the success of IVF—and to eliminating the risk of miscarriage. As Dr. Patil puts it, "A good quality embryo has a much lower risk of miscarriage than a poor quality one."

Chromosomal information clarifies the different rates of miscarriage associated with the quality of the embryo.

Research indicates that high-quality embryos suffer a miscarriage rate of about 13.3%, but low-quality embryos can suffer a much higher percentage, about 20%. This is where sophisticated reproductive procedures such as Preimplantation Genetic Testing for Aneuploidies (PGTA) are utilized. PGTA allows physicians to detect chromosomally normal (euploid) embryos prior to implantation, significantly enhancing the likelihood of a successful pregnancy while minimizing the risk of miscarriage. For couples who have gone through the devastation of miscarriage following IVF, the path ahead seems uncertain.

How long, then, should one wait before attempting another pregnancy? In Dr. Patil's opinion, a waiting time of 2 to 3 months is what is usually advised. This window of time accommodates both emotional recovery and physical healing," she explains. It also allows fertility doctors to assess any underlying complications, fine-tune medication regimens, and perform any further medical procedures that are required. Sparing this time not only gets the body ready for another cycle, but it also enables couples to rejoin the process with fresh hope and knowledge-based support.

Signs of Miscarriage Women Should Watch For

Pregnancies that occur through IVF are normally closely monitored, but it's still important for women to remain vigilant for complications. Dr. Patil enumerates the following signs that may be a sign of miscarriage:

• Spotting or brownish discharge
• Moderate to heavy vaginal bleeding
• Abdominal cramps or lower back pain
• Sudden loss of pregnancy symptoms (such as nausea or breast tenderness)
• Fluid or tissue passing from the vagina
• Lack of fetal heartbeat or growth on ultrasound

If any of these symptoms are noticed, immediate medical consultation is essential. "The sooner we take action, the greater opportunity we have to offer support or handle complications," she maintains.

A miscarriage, be it following natural conception or IVF, is not merely a medical occurrence—though an emotional one. Dr. Patil forbids couples to blame themselves. "It's a natural aspect of the reproductive cycle, frequently as a result of factors nobody has control over."

Support systems, counseling, and community groups may assist couples in dealing with sorrow in a positive way while remaining positive about the future. Significantly, a single miscarriage does not predict the next pregnancy to end similarly. With updated technologies, individualized fertility care, and psychological strength, numerous couples proceed to have healthy pregnancies following miscarriage.

Whereas IVF provides access to parenthood for millions worldwide, it's also important to note that it does not entirely eliminate the threat of miscarriage. Elements such as age, the quality of the embryo, maternal health, and lifestyle all remain crucial in determining the success.

What is still crucial, as Dr. Patil stresses, is educated optimism. "Couples must know about the risks but not be discouraged by them. With proper medical attention, emotional support, and healthy lifestyles, the journey to parenthood continues to hold hope."

Dr Varsha Patil is a Fertility specialist at GarbhaGudi IVF Centre, Bengaluru in India

Sleep hygiene is something we should all keep up with constantly. While you may think you can skimp on sleep, your body needs it to keep functioning properly. Not only does sleep help us make sure our body runs all its functions smoothly, but it also keeps a sleep debt. Losing an hour of sleep may not seem like much, but your body requires 4 hours more to make up for that lost hour of sleep. Understanding this, many people opt for afternoon naps that span a few hours to help them recover lost energy. However, these naps are also not all safe for your health, especially for older adults.

An afternoon nap might seem like a good idea for middle-aged and older adults, but these short rests could actually come with a significant cost. New research suggests that certain napping habits might increase the risk of an early death. These findings are expected to be presented at an upcoming meeting of the American Academy of Sleep Medicine (AASM).

Napping Patterns and Early Death

Researchers explained that people who slept longer during the day, had irregular napping schedules, or napped more around midday and early afternoon faced a greater risk. This was true even when other health and lifestyle factors were considered. These findings challenge the popular idea of the "power nap."

For the study, researchers looked at information from over 86,500 people taking part in the UK Biobank, a long-term health research project. The sleep habits of these individuals were tracked for a week using wrist devices, and then researchers compared these habits to death records. On average, the participants were 63 years old when their napping was monitored.

What Did The Research Find?

Over an 11-year follow-up period, nearly 5,200 people in the study passed away. The results showed a higher risk of dying sooner for:

• People who usually took longer naps during the day.
• Those whose napping times changed often.
• Individuals who napped between 11 a.m. and 3 p.m.

This last point goes against current AASM guidelines, which suggest that adults limit themselves to "power naps" of no more than 20 to 30 minutes in the early afternoon. Researchers noted that naps longer than half an hour can actually make you feel groggy, canceling out any potential benefits.

What Does Healthy Sleep Look Like For Different Ages

According to the Mayo Clinic, healthy sleeping patterns differ according to age. The recommendations give are,

Infants (4 to 12 months): Aim for 12 to 16 hours within a 24-hour day, including naps.

Toddlers (1 to 2 years): They need 11 to 14 hours in 24 hours, including naps.

Preschoolers (3 to 5 years): Target 10 to 13 hours within a 24-hour period, including naps.

School-aged Children (6 to 12 years): 9 to 12 hours every 24 hours is ideal.

Teenagers (13 to 18 years): 8 to 10 hours within a 24-hour period is recommended.

Adults: Most adults need 7 or more hours of sleep each night.

Other Factors Affecting Your Sleep Needs

Besides age, several other things can influence how much sleep you require,

Sleep Quality

It's vital not just how long you sleep, but how soundly. Frequent interruptions mean poor quality rest. Getting truly restful sleep is equally important as the total hours.

Previous Sleep Debt

If you haven't been getting enough sleep lately, your body needs extra rest. You'll have to make up for lost sleep to feel refreshed and function well.

Pregnancy

Hormonal shifts during pregnancy can make sleep difficult. Physical discomfort also contributes to poor sleep quality, leaving expectant mothers feeling less rested than usual.

Aging

While older adults need similar sleep amounts as younger adults, their sleep patterns change. They might sleep lighter, take longer to fall asleep, wake up more often, and have shorter sleep cycles at night.

Your daily cup of coffee might offer more than just a morning pick-me-up; it could actually influence how well you age. A new study, done by researchers in the Harvard T.H. Chan School of Public Health, involving nearly 50,000 women, investigated the long-term effects of drinking tea, coffee, and cola. The research found that coffee, specifically caffeinated coffee, can positively impact women's mental and physical health as they get older.

How Coffee Might Help Older Women

Researchers discovered that drinking coffee regularly could help women stay mentally sharp, physically strong, and generally well as they age. But, these good effects were only seen with coffee that had caffeine. People who drank decaf coffee didn't get the same benefits, and neither did tea drinkers. Even worse, the study found that women who drank soda had a "much lower chance of aging healthily."

Researchers said that while past studies linked coffee to certain health outcomes, her study is the first to look at how coffee affects many parts of aging over 30 years. She added that the findings suggest caffeinated coffee, unlike tea or decaf, might uniquely help people age in a way that keeps both their mental and physical abilities strong. These results were shared at a big meeting for nutrition experts.

What the Study Looked At

Researchers said that study was strong because it included many people and followed them for 30 years. They also looked at different ways people age well and collected lots of details about their eating and lifestyle habits every four years.

The researchers looked at information from nearly 47,513 women who were part of a long-term health study since 1984. They figured out how much caffeine these women consumed by asking about their intake of common caffeinated drinks like coffee, tea, soda, and decaf coffee.

They defined "healthy aging" as living to age 70 or older, not having 11 major long-term diseases, being able to move well, having good mental health, not having thinking problems, and not complaining about memory issues. After 30 years, the team estimated how the chance of healthy aging changed for every 80 mg of caffeine (about one small cup of coffee) that people drank daily.

They also looked at specific drinks. Their early analysis also considered other things that could affect healthy aging, such as body weight, smoking, drinking alcohol, physical activity, education level, and how much protein was in their diet. The data showed that by 2016, 3,706 of the women met all the requirements for healthy aging. In their middle age (45-60), these women typically drank about 315 mg of caffeine per day. This is roughly the amount in three small cups of coffee or one and a half large cups by today's standards. More than 80% of that caffeine came from regular coffee.

Regular Coffee vs. Other Drinks

For the women who aged healthily, each extra cup of regular coffee per day was linked to a 2% to 5% higher chance of doing well in later life. This benefit went up to about five small cups of coffee per day (or about 2.5 cups using today's sizes). The scientists found no clear link between drinking decaf coffee or tea and a higher chance of healthy aging. However, every extra small glass of soda was linked to a 20% to 26% lower chance of healthy aging. This shows that not all caffeine sources are good for you.

While AIDS-related deaths have dropped to their lowest since 2004, the world is still battling against HIV. Amid all this, a United Nations statement highlights the serious global health issue that it has become. Despite the years of progress and scientific breakthroughs, the disease still claims one life every minute, and continues to the global toll of the epidemic.

More than 30 million people across the world at this moment are receiving life saving antiretroviral treatment. As per the UN Under Secretary-General Amina Mohammed, this is a testament to the power of multilateral action. Speaking at the UN General Assembly’s review of the global AIDS response, she called it a “clear example of multilateral success.”

Impact of Funding Cuts

However behind these figures, is also a fragile system that Mohammed too stressed upon. "Global commitment is fading, funding is falling, and HIV services are being disrupted." This could undo years of hard work. The Health and Me has previously reported that the United States government also abrupted halted funding for a seminal mRNA-based HIV vaccine study, just days before its scheduled start in March 2025.

Health and Me also reported on the US' plan to freeze all foreign assistance, along with the UNAIDS, which could become a global threat for HIV cases. The UNAIDS takes up less than 1% of the overall US budget and since Trump's re-election, audits for cost-cutting and executive orders, especially in the healthcare sector has changed the shape of how aid worked before.

UNAIDS Executive Director Winnie Byanyima noted that HIV infections have in fact decreased in the recent years. In 2023, 1.3 million new cases were recorded, which is a 60% decline since the virus peaked in 1995. However, with this abrupt cut off in funding, it has created a situation of "panic, fear and confusion" in many of the African countries which are hit hardest by AIDS.

Urgent Need for Action

“We cannot let short-term cuts destroy long-term progress,” Mohammed urged. She called for the funding crisis to be treated with urgency and seriousness. In many low- and middle-income countries, healthcare budgets are being squeezed by the burden of debt servicing. In sub-Saharan Africa, half of the countries spend more on debt payments than on healthcare.

To counter this imbalance, Mohammed advocated for debt relief, global tax reform, and stronger international collaboration. She also emphasized the need for national governments to show stronger leadership and invest in sustainable HIV financing models.

Human Rights Are Health Rights

Beyond finances, Mohammed pointed to another major challenge: attacks on human rights. Marginalised groups—including LGBTQ+ individuals, sex workers, and people who use drugs—are often criminalised or face violence, hate speech, and stigma. Such punitive laws and attitudes only push people further away from testing, treatment, and prevention services.

“Protecting health means protecting human rights,” Mohammed stated, urging nations to remove discriminatory laws and support inclusive healthcare services. She also highlighted the role of community-led organizations, many of which are now facing defunding. These groups are often closest to at-risk populations and play a crucial role in delivering services, especially in hard-to-reach areas.

The Road Ahead

While the global community has made historic progress, the fight against AIDS is far from over. “The end of AIDS is not a mystery,” said Mohammed. “But success is not guaranteed.” She reiterated that with the right investments, policies, and leadership, eliminating AIDS by 2030 is still within reach—but only if the world “keeps up the fight.”