As worldwide use of GLP-1 drug such as Ozempic and Mounjaro increase, medical experts are ringing the alarm over a bizarre new cosmetic side effect- loose skin on the feet. Ozempic, generic name semaglutide, was originally created to treat type 2 diabetes. Now it's a name on every lip for its unbelievable impact on weight loss. By mimicking the hormone GLP-1, it reduces hunger, decelerates digestion, and regulates blood sugar. But with the touted advantages comes a new and less sexy concern: Ozempic feet.This is a slang term for visible signs of skin aging and sagging on the feet — a side effect now making its public debut thanks to social media gossip and sharp-eyed observers at celebrity makeovers. It's been added to a growing list of cosmetic issues like Ozempic face and Ozempic butt—terms used to describe the gaunt facial appearance and buttock deflation in some on these injectable medications.What Is 'Ozempic Feet'?'Ozempic feet' is a description of the creased, sloping skin and empty appearance of the feet — particularly at the top, where the skin is naturally thinner. This is due to a rapid and extreme reduction in fat reserves as patients lose weight. Unlike intentional body sculpting or fat reduction from exercise, weight loss with Ozempic is fast and even, subjecting areas that typically have small fat reserves, such as the feet.Experts explain that the sudden and severe loss of fat leaves skin looking deflated, aged, or disproportionate to the rest of your body. Your feet don't have much cushioning to begin with. After the fat loss, you're left with wrinkled skin and a higher likelihood of experiencing pain when walking.Essentially, the same drug that is helping drug users lose weight is giving them feet that look prematurely old without intending to.The celebrity side effect was the subject of viral rumination following reports of speculation between followers that TV personality Sharon Osbourne and chat show host Oprah Winfrey may have 'Ozempic feet.' Sharon, 72, posted a snap with her grandson in April 2025 that prompted fans to comment upon an inconsistency between ageless looking face and sharply creased ankles. The reaction varied from worry to wonder, "Your ankles are giving your age away," a follower suggested.Oprah Winfrey, 71, faced similar criticism when she showed up at the 55th NAACP Image Awards. Spectators commented on how loose her foot skin looked — a striking difference for someone who had seemingly shed almost 50 pounds on GLP-1 drugs.Neither Osbourne nor Winfrey has indicated whether they attribute these differences to their weight-loss regimens, but the internet chatter has pushed the topic into the mainstream.Is 'Ozempic Feet' a Cause for Concern?While the term is likely to be ringing somewhat flippant or superficial in tone, it opens up into a wider, more serious discussion of the long-term impact of rapid medical weight loss.Doctors note that any sudden change in weight — especially one achieved through drug methods — can affect soft tissue, elasticity of the skin, and distribution of fat. In a couple of cases, GLP-1 medication like Ozempic has been determined to cause treatment-induced neuropathy in patients with diabetes, producing symptoms of numbness, tingling, or burning sensations in the feet.Healthcare professionals suggest the users to take care of their foot health very carefully. "If you notice changes in your feeling, persistent pain, or swelling, seek medical attention," says Dr. Weintraub. "Your feet also develop symptoms of nutrient deficiency or rapid muscle and fat loss which can affect your balance and stance."Other Side Effects of Taking Weight Loss DrugsAs the fame of Ozempic shoots through the roof with nearly 1 in every 8 Americans having seemingly used GLP-1 medications by 2024, so has its psych effect.A study indicated that the patients taking semaglutide were 195% more likely to suffer from severe depression and over 100% more likely to be suicidal. Even though both the U.S. FDA and the European Medicines Agency (EMA) have stated that no conclusive link has been made between Ozempic and suicidal thoughts, the increased number of reports is raising alarms.These findings have prompted most health experts to emphasize the requirement for sustained assistance as well as frequent surveillance of individuals who take these drugs- physically as well as mentally.Add to the complexity is the "rebound" phenomenon. Northwestern University studies indicate that patients who had stopped GLP-1 therapy regained nearly two-thirds of the lost weight. The reversal also logged increases in blood pressure, cholesterol, and risk for cardiovascular disease thus, lifestyle alteration and upkeep a priority, even after the drug.Winfrey herself echoed those words in a recent interview, "These drugs are not a magic bullet. They're a tool, not a replacement for lifestyle change."'Ozempic feet' is a superficial aesthetic issue, but it reflects on a larger narrative: the evolving landscape of weight loss pharmaceuticals. As ever more people pursue drugs to manage weight and comorbid risk, the focus must remain with overall well-being far and above the reading on the scale.