After finally shedding those stubborn pounds with the help of a miracle drug—only to look in the mirror and hardly recognize your reflection. That’s the unexpected twist many users of Ozempic, the wildly popular weight-loss and diabetes medication, are now facing. From Hollywood red carpets to everyday clinics, this injectable GLP-1 drug has become the go-to for quick body transformations. But there's a catch—while your waistline may shrink, your facial features might too. Say hello to “Ozempic mouth,” a bizarre new side effect that's raising both brows and concern. As more patients report sagging skin, hollow cheeks, and deep mouth wrinkles, the question arises: Is the cost of weight loss more than just financial?

Originally designed as a treatment for type 2 diabetes, the drug's active ingredient, semaglutide, mimics the GLP-1 hormone to regulate blood sugar and suppress appetite. But as its off-label use for rapid weight loss explodes in popularity — especially among celebrities — so do the concerns about its unintended consequences.

The latest? A perplexing and increasingly common condition dubbed “Ozempic Mouth.”

Much like its predecessor “Ozempic Face”, which made headlines for causing gaunt, hollowed facial features, Ozempic Mouth refers to a very specific set of cosmetic changes — sagging skin around the mouth, deepened folds at the corners of the lips, increased vertical wrinkles, and drooping along the chin and lower face. The result is a prematurely aged look that’s difficult to reverse without cosmetic intervention.

What is ‘Ozempic Mouth’?

The popularity of GLP-1 drugs like Ozempic, Mounjaro, and Wegovy has surged across the US and globally. Recent 2024 data suggests that as many as 1 in 8 Americans have tried a GLP-1 agonist — a number expected to climb as these medications become more accessible and culturally normalized.

But as weight comes off quickly, it doesn’t always do so evenly — and therein lies the problem. Semaglutide doesn’t distinguish between fat deposits. It targets subcutaneous fat — the layer just beneath the skin that gives the face its youthful plumpness. While shedding belly and thigh fat may be welcome, losing fat in the delicate perioral region (around the mouth) leads to a sunken, drawn-out appearance.

The skin becomes thinner and more wrinkled, with what many are calling ‘lipstick lines’. Patients come in alarmed by how aged their face suddenly looks — particularly around the lips and chin.

Celebrities like Sharon Osbourne, Whoopi Goldberg, and Rebel Wilson — all of whom have openly discussed their Ozempic use — have been spotted with increasingly pronounced facial changes. Fans have noted visible differences: sharper jawlines, sagging cheeks, and tight-lipped smiles that hint at underlying volume loss.

This rapid facial transformation has made “Ozempic Mouth” a buzzword in dermatology offices across the globe, with patients urgently seeking remedies to counteract the unintended side effect of their newly slimmed-down physiques.

To combat the effects of Ozempic Mouth, many are turning to dermal fillers — injectable treatments that restore volume, reduce wrinkles, and add subtle plumpness to the skin. According to experts, filler procedures have tripled in the U.S. in the past decade, with 5.3 million performed in 2023 alone, up from 1.8 million in 2010.

Fillers can smooth the appearance of wrinkles and add fullness back to areas like the lips, nasolabial folds, and chin but these fixes don’t come cheap — with treatments ranging from $700 to $2,000 per syringe, depending on the provider and location.

Another alternative growing in popularity is Thermage, a non-invasive radiofrequency treatment that tightens the skin by stimulating collagen production. While not immediate, the results typically become visible in four to six months and can last up to two years.

Thermage works best when used as a preventative, ideally, people on Ozempic should start the treatment early in their weight-loss journey to minimize skin laxity.

Other Strange Ozempic Side Effects

“Ozempic Mouth” is just one of several strange new phenomena reported with GLP-1 medications. The broader term “Ozempic Face” describes the sunken appearance seen in the cheeks, under eyes, and temples — and now “Ozempic Feet” and “Ozempic Butt” are entering the lexicon.

Ozempic Feet refers to skin laxity and thinning skin on the tops of the feet, sometimes making bones more pronounced and shoes uncomfortable. Meanwhile, Ozempic Butt describes the sudden disappearance of fat from the buttocks, leaving some users self-conscious about their drastically altered silhouettes.

"I can feel every bone in my backside now,” one user confessed on a social forum, echoing a growing concern among rapid weight-loss patients.

GLP-1 drugs like Ozempic have revolutionized weight-loss treatment, giving hope to many struggling with obesity and related health conditions but as the aesthetic consequences of these medications become more visible, especially among public figures, experts are urging caution.

This is a medical therapy — not a beauty shortcut, warn experts. Rapid weight loss always has a physical cost. Understanding how it affects your body, especially your face, is key to setting realistic expectations.

As with any medical intervention, the decision to start a GLP-1 drug should be made in consultation with a licensed healthcare provider — with full knowledge of both the benefits and the very real, sometimes bizarre, side effects.

Heart failure has quietly emerged as one of India’s most serious and underestimated health challenges, driven by a rise in hypertension, diabetes, obesity, and delayed diagnosis of heart disease.

Due to a shortage of donor organs and a long waiting period before receiving the right treatment, end-stage heart failure patients in India faced a lot of difficulties a few years ago.

Today, advancements in heart transplant techniques are changing the situation from what was once an untreatable condition to a second chance at life.

Data from the National Organ and Tissue Transplant Organization (NOTTO) shows a significant year-on-year rise in heart transplants, with 253 transplants done in 2024, showcasing improved organ donation awareness, better coordination between hospitals, and stronger transplant networks.

What was once considered the only option is now emerging as a life-saving solution, offering patients not just a second chance but a return to a more meaningful and active life.

Why Are Heart Transplants Needed?

A heart transplant offers hope and gives a second life to patients whose hearts no longer support the body even after the best available medical aid.

Although it is never performed instantly, it becomes necessary whenever conditions of the heart result in end-stage heart failure, where the pumping function of the heart is compromised.

Also read: Harish Rana’s Family Donated His Heart Valves And Corneas After His Death From Passive Euthanasia

When medications and modern technologies cannot supply an adequate amount of blood and oxygen to the organs, patients experience extreme breathlessness, fluid buildup, fatigue, and repeated hospitalizations, making even simple activities like walking, eating, or lying flat exhausting.

As the flow of blood continues to deteriorate, failure is also expected in other vital organs such as the kidneys and liver. It is at this point that the transplantation of the donor heart is considered the only treatment option to ensure that the blood flow is normalized.

How Heart Transplantation Transforms Life?

Heart transplant is not just a surgical replacement of a failing organ, but a complete life restoration for patients with end-stage heart failure.

Its benefits include:

• Normalizes Heart Functioning: A healthy donor heart can immediately restore normal and effective blood flow. This will reduce weakness and fatigue that makes carrying out everyday tasks rather difficult.
• Enhances Survival Rates: Patients diagnosed with end-stage heart failure can only experience the best post-transplant survival outcomes when they undergo the transplant procedure as compared to other medical treatments.
• Enhances Quality of Life: The patients are able to attain independence once again as they are able to walk, sleep, travel, and socialize with their families and friends.
• Prevents Frequent Hospitalization: The successful transplant procedure prevents constant hospitalization, especially in cases with deteriorating heart failure, infections, and organ dysfunction.
• Protects Other Vital Organs: By restoring adequate blood flow, heart transplantation helps reverse damage to the kidneys, liver, and lungs caused by prolonged heart failure
• Permits Return to Normal Roles and Responsibilities: Patients regain their ability to work, take care of others, and carry out their daily responsibilities, which helps their emotional well-being.

Scottish Olympic legend Liz McColgan has warned athletes to wear sun protection during their training hours to protect their skin from “lasting consequences”.

Liz McColgan shared the health warning to athletes after undergoing surgery to remove lesions on her face.

The Olympic silver medalist from Dundee shared post-surgery photographs on the social media platform Instagram and lamented that, as a young runner, she never focused on wearing sun protection.

Avoiding sun cream because she felt it made her "sweat more" was her “ignorance”, said the 61-year-old former athlete.

“As a young athlete, I trained and raced in all weathers. Sun protection was never something I gave much thought to. In fact, I avoided it. I didn’t like the feeling of creams on my skin - I thought they made me sweat more, so I convinced myself I was better off without them. Looking back, that was ignorance,” Liz McColgan said.

“Recently, I had to undergo surgery to remove two lesions on my face. It was a stark reminder that the choices we make early on - especially the ones we dismiss as unimportant - can have lasting consequences,” she added.

Liz McColgan noted that athletes keep all their focus on "performance - mileage, sessions, recovery, nutrition”, but simple things like protecting their skin are often ignored.

“Yet it’s just as much a part of our overall health and wellbeing as any training session,” she said.

Sharing the health message to both young and old athletes, McColgan said, “Take sun protection seriously. Whether you’re training, racing, or even just spending time outdoors, protecting your skin matters.”

McColgan won a silver medal in the same event at the 1988 Olympic Games in Seoul. In 1991, she went on to win the 10,000m World Championships title in Tokyo.

Also read:5 Simple Do's And Don'ts For Healthy Skin

Why Sunscreen Is Essential

Using sunscreen protects the skin from harmful ultraviolet (UV) radiation, which causes

• skin cancer,
• premature aging,
• painful sunburns.

Should Sunscreen Be Used Indoors Too?

Sunscreen is meant to be part of a daily skincare routine. But most people reach for sunscreen when heading to the beach or stepping out for a long day in the sun.

According to dermatologists, sunlight can still reach you indoors.

Dr Khushboo Jha, Chief Dermatologist Consultant at Metro Hospital, explains that sunlight entering through windows can still affect the skin.

“While standard window glass blocks most UVB rays, which cause sunburn, UVA rays can still pass through. These rays penetrate deeper into the skin and are linked to long-term concerns such as premature aging, uneven pigmentation, and loss of skin elasticity,” she said.

These UVA rays are often overlooked because they do not cause immediate redness or burning like UVB rays. However, over time, they can lead to visible signs of skin aging and pigmentation.

Also read: Why Should You Must Apply Sunscreen Inside A Plane?

A Practical Approach To Daily Skincare

Dermatologists suggest viewing sunscreen as a preventive skincare habit rather than a rigid rule.

Dr Jha recommends incorporating sunscreen into your morning routine, particularly if your day includes stepping outdoors or spending time in naturally lit environments.

In simple terms, if daylight reaches your workspace or you plan to go outside later in the day, applying sunscreen in the morning is a small step that can help protect your skin over time.

Many men believe that as long as they feel healthy, active, and free from major illness, their fertility remains intact. While men do not have a sudden fertility cut-off like women, age still plays an important role when it comes to male fertility. Currently, a large number of men wish to start families later in life, often thinking their good health guarantees easy conception and fatherhood. They often neglect the age factor, even though it is linked to hormonal imbalance, stress, and genetic issues. A large number of men are unaware of their fertility health and continue to suffer. However, even in the absence of visible health problems, older men may face unexpected fertility challenges. Dr Madhukar J Shinde, Fertility Specialist at Nova IVF Fertility, PCMC, Pune, answered this for Health and Me.

Read more: The Overlooked Role of Men in IVF: Why Their Silent Strength Is Key to Fertility Success

Why do older men struggle with infertility?

Decline in sperm quality: Various studies have confirmed that as men age, sperm count, movement, and shape can slowly decline. Even if the numbers appear normal, DNA damage in sperm increases with age, which can reduce the chances of successful fertilisation.

1. Hormonal imbalance: It is important to note that testosterone levels naturally decrease over time. Lower testosterone can affect sperm production, sexual function, and overall reproductive performance, even when a man feels physically fit.
2. Some medical conditions tend to take a toll on fertility: Conditions such as diabetes, high blood pressure, and thyroid disorders become more common with age. These may be well-managed and symptom-free, but can still affect sperm health and fertility.
3. Stress and other lifestyle factors can impact fertility: Chronic stress, lack of sleep, smoking, alcohol consumption, or exposure to pollution can take a toll on sperm quality and lead to fertility issues that can be worrisome for men. Preservatives in a lot of frozen and junk food not only contribute to poor fertility health, but research suggests they may also affect DNA function. Therefore, men should stay vigilant.
4. Genetic issues: Advanced paternal age is associated with a higher risk of genetic mutations in sperm. This can further affect embryo development and increase the risk of miscarriage or certain developmental conditions.

Men must stay in touch with a fertility consultant who can design an appropriate treatment plan. The expert will evaluate them thoroughly and suggest lifestyle modifications such as a well-balanced diet, exercise, stress management through meditation, and medication for conditions such as diabetes, hypertension, and cholesterol. Awareness helps men take informed steps towards parenthood, even later in life. Certain pre-medications, including antioxidants advised by a fertility consultant, may significantly help in reducing DNA fragmentation, which contributes to poor sperm function. Therefore, men should prioritise their reproductive health, stay informed, and not suffer in silence.