Which COVID-19 Variants Are Going Around The World In 2025?

When the COVID-19 pandemic hit the world, many studies and experts predicted that COVID-19 is here to stay. While the extent to with it would affect an individual's health may have gone down, the virus, in fact, has continued to stay, and mutated. Almost like a viral fever, every year, there is a new variant and the virus seems to make head lines all over again.

This year, COVID-10 made a come back when Singapore and Hong Kong reported a spike in its cases. As per the Ministry of Health, the spike in the cases is attributed to the new variant, which is said to be on the loose - LF.7 and NB.1.8.1. These two are descendants of the JN.1 variant.

COVID-19 Variants In 2025

As per the World Health Organization, as of May 23, 2025, the following COVID-19 variants are currently circulating and are under monitoring:

KP.3 - This is a sub lineage of the JN.1, which comes from the Omicron variant. It evolved from the JN.1 and has a very similar structure too, with only two changes in spike as compared to JN.1. It also causes gastrointestinal symptoms like nausea, vomiting, etc. apart from the other common COVID-19 symptoms.

KP.3.1.1 - As per the Centers for Disease Control and Prevention (CDC), KP.3.1.1, of the Omicron family, is the predominant SARS-CoV-2 variant, which is an offshoot from within the KP.3 family.

LB.1 - It is said to be a spinoff of JN.1 with additional mutation, which sets it apart from the other strains.

XEC - As per the CDC and WHO, it is a highly transmissible coronavirus subvariant that comes from the SARS-CoV-2 Omicron strain. What makes it different is its hybrid result from a merger and rearrangement of two pre-existing COVID subvariants: Omicron sub-lineages KP.3.3, and KS.1.1.

LP.8.1 - This is also a variant of SARS-CoV-2, a descendant of the JN.1 lineage, with notable mutation in the spike protein. However, its ability to spread is not fully understood. Although, the resistance of LP.8.1 is similar to that of XEC and KP.3.1.1 across all serum groups tested. These results suggest that while LP.8.1 has lower pseudovirus infectivity than JN.1, its immune resistance is comparable to XEC and KP.3.1.1.

NB.1.8.1 - This is the new mutation causing a spike in cases in China and is part of the Omicron family. However, this means that the current vaccines and immunity from the recent infections should provide some protection against it. This is a highly contagious mutated variant, which has been detected in several US states and have prompted concerns among medical and health professionals.

As per Nebraska Medicine, this variant makes up for the 73% of cases in the US.

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Which Variant Is Active In India?

Like most of the active variants from the WHO list of variants under monitoring (VUM) comes from JN.1, the case of India is no different.

The current active variant in India is JN.1, which is a subvariant of the Omicron, which has evolved from the BA.2.86 variant, also known as Pirola. This was first identified in Luxembourg in 2023. Since then, it has spread to other parts of the world, including India.

It is more transmissible than the previous variants, the reason being, its specific mutations in its spike protein. These mutations help the variant to bind to humans easily.

As per the Indian SARS-CoV-2 Genomics Consortium (NSACOG) data, India has reported cases of LF.7 and NB.1.8.1 cases, both of which are descendants of JN.1.

The other common variants in India, apart from the JN.1, which comprises of the 53% of samples which have been tested as of now, are BA.2 with 26% cases, and other Omicron sub lineages at 20% of cases.