Cancer is a serious, life-long chronic disease and can hinder one's life expectancy. While there are many regions in one's body where cancer cells can develop, however lungs are a tempting place for cancer cells. This is where more than half of people with advanced cancer elsewhere in their bodies end up with lung tumors. As per the World Cancer Research Fund, there were 2,480,675 new cases of lung cancer in 2022. As per the World Health Organization, it is the most common cancer type world wide, with 1.8 million deaths annually, accounting for 19% of all cancer deaths.

However, now the researchers may know why lung is the region prone to development of cancer cells. This is because of the elevated levels of an amino acid called aspartate which appear to allow cancer cells to grow more easily inside the lungs. This was published in the journal Nature.

We found high levels of aspartate in the lungs of mice and patients with breast cancer compared to mice and patients without cancer, which suggests that aspartate may be important for lung metastasis,” lead researcher Ginevra Doglioni, a doctoral student with the Flemish Institute for Biotechnology’s Center for Cancer Biology in Belgium, said.

How was the study conducted?

New research has uncovered a potential driver behind the aggressiveness of certain lung cancers: aspartate, an amino acid the body uses to produce proteins. The findings could pave the way for better strategies to prevent lung tumors from growing or spreading, even in advanced cancer cases.

The researchers examined tumor cells from aggressive lung tumors and discovered that aspartate plays an important role in triggering the molecular pathways that underlie cancer aggressiveness. It appears to cause a chain reaction in gene activity, increasing cancer cells' ability to adapt to their surroundings and allowing for faster tumor development.

Aspartate is ordinarily present at extremely low levels in the bloodstream, but researchers discovered unusually high amounts in the lungs of mice with metastatic breast cancer. Similar patterns were seen in human lung tumor tissues, indicating a same mechanism.

Aspartate stimulates a surface protein on cancer cells, which drives the process. This activation sets off a cascade of gene signaling events, enhancing cancer cells' capacity to grow.

Understanding this mechanism provides an important insight into why the lungs are often a vulnerable site for tumor growth, particularly in cases where cancer has spread from other parts of the body.

The good news is that there are already drugs on the market that target similar mechanisms involved in this process. Researchers believe that with further studies, these existing treatments could potentially be adapted to specifically target lung cancer driven by aspartate.

This discovery could be especially beneficial in cases where cancer has metastasized, or spread, to the lungs. By targeting the processes that make the lungs more susceptible to cancer growth, doctors might be able to develop therapies that help keep the lungs cancer-free for longer.

The findings highlight the importance of ongoing cancer research and the potential to repurpose existing treatments for new uses. As the understanding of cancer biology continues to grow, these types of discoveries could lead to more effective and personalized approaches to treating and managing aggressive cancers.

Suicides are one of the leading causes of death around the world. While it is easy to say that the person who chose to take their lives did it of their own violation, Harvard psychologist Dr. Matthew Nock, explains the other side. “90% of people who try and kill themselves say, I didn't want to die per se. I wanted to escape from seemingly intolerable.” Speaking on the On Purpose podcast with Jay Shetty, Dr. Nock pointed out that the link between work pressure and suicidal thoughts varies by race and ethnicity.

The concerning rise in suicide cases tied to work pressure has fueled a social media conversation about toxic work culture. What was once considered a normal part of the professional grind is now being openly challenged, as people share personal stories of the anxiety, depression, and isolation caused by unhealthy work environments.

What Professions Are At High Risk Of Suicide?

According to Dr. Matthew Nock, certain careers are linked to a higher risk of suicide.

Police Officers

He noted that physicians and police officers are among those at high risk. He mentioned a spike in suicides among New York City police officers, who are predominantly white men, and shared that female police officers, in particular, face a higher risk, even when accounting for factors like age, race, and ethnicity.

According to a 2025 study published in the Police Practice and Research, on average, 21.4 out of every 100,000 officers died by suicide each year.

The study showed that the suicide rate was much higher for male officers (22.7 per 100,000) than for female officers (12.7 per 100,000).

Physicians

Dr. Nock explained that access to means is a significant factor in these high-risk professions, which helps explain why physicians, police officers, and military members have a much higher risk of suicide compared to others.

Another study published in 2024 The BMJ, showed that the number of suicides among doctors has been going down, female doctors are still at a much higher risk than other people.

When looking at all the data, male doctors were found to have a 5% higher risk of suicide compared to the general population.

In a more recent analysis of the last few years, the overall suicide rate for doctors has decreased, which is good news. But even with this improvement, female doctors still have a 24% higher risk than the general public.

Why We Need To Talk More About Suicide

Dr. Nock stresses the importance of openly discussing suicide, particularly in schools. He compared it to fire drills or earthquake preparedness, saying that since 15% of people will experience suicidal thoughts, it's crucial to equip everyone with a safety plan..Dr. Matthew Nock said, "We know that asking about suicide, talking about suicide, does not make people suicidal."

He noted that the people who act on suicidal thoughts often show different signs than those who just have the thoughts. While depression is a strong predictor of having suicidal thoughts, other factors like anxiety, aggressiveness, poor behavioral control, and drug or alcohol use are more closely linked to a person actually attempting suicide.

He believes that a small educational module on suicide in health class could help save lives by teaching people what to do if they or someone they know is struggling.

While we all know air pollution affects our health, did you know that it was actually driving cancer cases higher? This has led to a big rise in health problems worldwide. Past studies show that air pollution is linked to about seven million premature deaths each year and contributes to over 3% of all years of healthy life lost globally. This revelation was a big concern for public health, and to fix it, many measures were taken.

While some countries like the US showed promising results in bettering public health, a recent study in the International Journal of Public Health showed that this positive trend is not yet showed up in China.

How Is PM2 Pollution Affecting Our Health?

One of the most dangerous types of air pollution is called fine particulate matter, or PM2.5. These tiny particles come from car exhaust, factory smoke, and even from the smoke created by burning solid fuels inside homes. Because they are so incredibly small, they can stay suspended in the air for a long time and, when we breathe them in, they go deep into our lungs.

Once inside the body, PM2.5 can cause inflammation and even change our genes, which increases our risk for many illnesses, especially tracheal, bronchial, and lung (TBL) cancers. A new study looked at how much PM2.5 pollution has affected TBL cancer rates in China, Japan, South Korea, and the United States from 1990 to 2021.

Has Pollution-Related Health Risk Decreased Everywhere?

The study, which used data from the Global Burden of Disease (GBD) project, found some important trends:

Overall Cancer Rates Are Declining

The good news is that globally, the number of deaths and years of healthy life lost due to TBL cancer linked to PM2.5 pollution are going down. This positive trend was consistent in all the countries studied: China, Japan, South Korea, and the U.S.

China's Unique Challenge

Despite this global trend, China faced a much higher death rate from TBL cancer linked to PM2.5 compared to the other three countries. While their rates are decreasing, they still remain significantly higher than the worldwide average.

Household Pollution Hits Women Harder

The research also looked at pollution from burning solid fuels inside homes. The global death rate from TBL cancer linked to this type of pollution has remained stable, but it's actually increasing for women while it's decreasing for men. This highlights a specific danger for women in homes that rely on these fuels.

Will This Pollution Cancer Trend Keep Rising?

Looking ahead, researchers predict that the global death rate for TBL cancer caused by PM2.5 will actually increase over the next 29 years. However, the study notes that countries like China, South Korea, and the U.S. are expected to see a significant drop in their rates, while Japan's numbers are expected to stay about the same.

Overall, this study shows that while air pollution is a serious global health risk, the efforts to reduce PM2.5 exposure in many countries are making a real, positive difference.

Maintaining our gut health is not as easy as it seems. Even things like how you do your bowel movements could reveal how healthy your gut actually is. According to Dr. Saurabh Sethi, a board-certified gastroenterologist, many of us are making common mistakes on the toilet that can lead to real health problems. Here are three crucial habits to change to improve your gut health. Here are three mistakes' people make will they are in the washroom.

3 Bathroom Mistakes You Are Making

Stop Straining

Pushing or straining when you poop can cause serious issues like hemorrhoids, which are swollen veins in your rectum and anus, and anal fissures, which are small tears in the lining of your anus. In more severe cases, it can even lead to rectal prolapse, where part of the rectum slides out of the anus. Instead of forcing it, focus on taking deep breaths. This helps your abdominal muscles relax and allows your body to do its job naturally, reducing the risk of painful complications.

Put Down Your Phone

Scrolling on your phone while on the toilet can be a bad habit. Spending extra time on the toilet, even if you’re not straining, puts pressure on the delicate veins in your rectum. This can cause them to swell, significantly increasing your risk of hemorrhoids. To protect yourself, it’s best to keep your bathroom breaks short—ideally, under five minutes.

Don't Ignore the Urge

When you feel the need to poop, it's important not to hold it in, which makes it much more difficult to pass later, leading to and worsening constipation. When you feel the need to go, listen to your body. Holding it in causes your stool to get harder and drier, which makes constipation much worse and more painful later on. Train your gut to go when it says it's time.

Simple Ways To Improve Your Bowel Movements

Go at the Same Time Each Day

Try to create a routine. If you're often straining without success, try sitting on the toilet about 30-60 minutes after a meal, when your colon is naturally more active. A little stretching or a short walk beforehand can also help things get moving.

Use a Stool for Your Feet

The natural position for a bowel movement is squatting. You can mimic this position on a regular toilet by placing a small stool under your feet to raise your knees above your hips. This simple change helps your muscles relax and can make bowel movements easier and more complete.

Focus on Fiber and Fluids

Fiber is essential for creating soft stool that's easy to pass. Most adults should aim for 25 to 35 grams a day. Just remember to add it to your diet slowly. As you increase your fiber, be sure to drink more water and other non-caffeinated fluids, since caffeine can dehydrate you and make stool harder.

When to Seek Help

While these tips are a great starting point, sometimes you need more personalized help. You should talk to your doctor if you notice any of these signs:

• A recent, unexplained change in your bowel habits
• Blood in your stool
• Unexplained stomach pain
• A pelvic health physical therapist can also provide a full evaluation and create a personalized plan to improve your bowel health.