As per a new study published in the journal Nature, it has been revealed that some brain cells are more susceptible to aging and its affects as compared to others. This study is said to shed new light on why some people are at more risk for dementia, Alzheimer's disease and other such brain disorders as their age increase as compared to others.

“Aging is the most important risk factor for Alzheimer’s disease and many other devastating brain disorders. These results provide a highly detailed map for which brain cells may be most affected by aging,” Dr. Richard Hodes, director of the National Institute on Aging.

“This new map may fundamentally alter the way scientists think about how aging affects the brain and also provide a guide for developing new treatments for aging-related brain diseases,” Hodes added.

How Was The Study Conducted?

The study was conducted on mice and an advanced genetic analysis was used. With the help of that researchers compared individual cells in the brains of 2 month old "young" and 18 month old "senior" mice. The scientists then looked at the genetic activity of cell types located in 16 different regions constituting 35% of the total volume of mouse brain.

What Did The Study Find?

Researchers found that aging tends to decrease activity in genes associated with brain cells. For instance, aging reduced development of newborn neurons in at least 3 different parts of the brain. These parts include neurons associated with learning and memory.

Also, it was found that aging increased the activity of genes associated with immune and inflammatory functions.

Cells that were more sensitive to aging also appeared to surround the third ventricle, a major pipeline that enables spinal fluid to pass through a brain region called the hypothalamus. This region produces hormones that control body functions like maintaining a certain body temperature, heart rate, sleep, thirst, and hunger.

Some of these observations also matched with the previously done studies that linked aging with metabolism. Researchers explained that intermittent fasting and other calorie-restrictive diets have been shown to increase life span. This could be explained by the age sensitive neurons which were found in the hypothalamus producing hormones, which also control hunger and energy production.

“This study shows that examining the brain more globally can provide scientists with fresh insights on how the brain ages and how neurodegenerative diseases may disrupt normal aging activity,” John Ngai, director of the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies initiative, said in a news release.

What Is Alzheimer's or Dementia?

Whereas Dementia is an umbrella term to describe diseases that cause people to lose their cognitive functions. These diseases gradually progress decreasing the ability for someone to function in daily life and take care of themselves. There are some medications used to delay the onset of it and to manage it. People can reduce the chances of developing it by following a healthy diet and lifestyle.

Sometimes serious health issues fail to get recognized due to their simple symptoms. Many times, things as simple as a persistent cough, or a fever, can end up being a sign of a concerning health issue. Since we deal with these issues on a daily basis, people often do not get them checked out by a doctor; instead, they choose to stay home and recuperate.

However, having information about the same goes a long way. Experts explain these symptoms and issues to people on various platforms, like social media or governmental portals. One such warning was issued by the National Health Service, England (NHS) about a common warning sign, that many people experience after eating.

NHS says this feeling of ‘heartburn’ could actually be one of the "least-recognised" signs that someone might have cancer. What's concerning is that a large majority of people in Britain, around 79% according to their findings, would not even think that this particular symptom could be a signal of a deadly disease growing inside their body. This lack of awareness means that crucial early warning signs could be easily overlooked, potentially delaying diagnosis and treatment, which can have serious consequences for the outcome of the illness.

Heartburn Could Be A Serious Concern

A new survey that was carried out by NHS England revealed a worrying trend: many of the initial warning signs that could point towards cancer are being easily missed by the general public. One of the key examples they highlighted is heartburn and indigestion. These are feelings that a lot of people experience from time to time, often as a result of eating too much, eating their food too quickly, or consuming certain types of foods that don't agree with them.

However, the NHS experts are emphasizing that heartburn that persists for a period of three weeks or even longer could be an early indication of oesophageal cancer. This is a particularly dangerous form of cancer that sadly leads to the deaths of around 8,000 people in the United Kingdom every single year, making early detection absolutely vital for improving survival rates.

Recognizing Changed Signs

To get a better understanding of what the public knows about cancer symptoms, NHS England conducted a survey that involved a significant number of people, around 2,000 individuals in total. The results of this survey were quite revealing. They found that heartburn, specifically heartburn that lasts for three weeks or more, was the cancer symptom that people were least likely to recognize as a potential warning sign.

Eight out of every ten people who were surveyed, which translates to 79% of the participants, did not identify this persistent heartburn as something that could possibly indicate cancer. However, heartburn wasn't the only symptom that wasn't widely recognized. The survey also showed that more than half of the people didn't recognize blood in their urine (even if it happened just once), nearly half didn't recognize unexplained weight loss, and over four in ten people didn't recognize an unexplained lump anywhere on their body as a potential sign of cancer.

Signs You Should Not Ignore

NHS England advises contacting your doctor if you notice any of the following: lumps, changes in moles, blood in poo or pee, unusual bleeding, a cough lasting three weeks or more, mouth sores that don't heal, tummy trouble, unexplained tiredness, ongoing heartburn, unusual poo, unexplained pain, or bloating.

Other less common signs of oesophageal cancer include trouble swallowing, feeling sick, a persistent cough, a hoarse voice, loss of appetite or weight loss without trying, tiredness, throat or chest pain when swallowing, and black poo or coughing up blood.

When Todd Engel, based in Maryland, first noticed a change in his vision, he did not think it would change the rest of his life. However, within months, the 62-year-old went from working a full-time job and driving to becoming legally blind in both eyes. Now, Engel is suing Novo Nordisk, the manufacturer of Ozempic - the drug he believes took away his vision.

An Irreversible Loss

Engel was prescribed Ozempic in 2023 to help manage his type 2 diabetes. After four months later, he was diagnosed with nonarthritic anterior ischemic optic neuropathy (NAION). It is a rare condition where blood flow to the optic nerve is blocked and causes sudden and irreversible vision loss.

"He made a comment to me about how it’s painful to know he’s never going to see his wife smile again," said Engel’s attorney Jonathan Orent, who spoke to NBC News. "But he knows her voice so well, he can tell when she is smiling."

As per the American Academy of Ophthalmology, NAION affects about 10 in every 100,000 people over the age of 50. For Engel, the diagnosis meant that he no longer would work his job as a motor equipment operator. He also lost his ability to drive and the way he connects with his family.

What Does His Lawsuit Allege?

Filed in New Jersey’s Middlesex County Superior Court, the lawsuit accuses Novo Nordisk of negligence, alleging the pharmaceutical giant failed to properly warn users about the potential risk of NAION. Engel's legal team argues that the company was aware of the condition during early clinical trials but still chose not to include it in the warning label.

“Nothing was or is stopping Defendant from adding a warning regarding the risk of NAION,” the lawsuit states.

Had Engel known about a potential link between Ozempic and blindness, Orent said, he would have chosen a different medication. “There are a wide number of medications that can be used to treat diabetes — and treat it effectively,” Orent said to NBC News.

What Do Research Say About Ozempic And Blindness?

Ozempic, and its active ingredient semaglutide, is part of a class of drugs known as GLP-1 receptor agonists, initially designed to treat Type 2 diabetes but now widely used for weight loss. Recent studies have hinted at a possible link between semaglutide and NAION — though causation hasn’t been confirmed.

A 2024 study which analyzed six years of medical records from Boston patients found that people with diabetes who took semglutide were four times more likely to be diagnosed with NAION.

Even more striking, overweight or obese people without diabetes who took the drug were over seven times more likely to be diagnosed with NAION.

However, researchers noted this study wasn’t a randomized clinical trial and said more investigation is needed before drawing conclusions.

In February 2024, a separate paper published in JAMA Ophthalmology reported a more modest increase in the risk of NAION for people with diabetes on Ozempic. Like the earlier study, it also stressed the need for further research.

What Do The Manufacturers Say?

Novo Nordisk's spokeperson told the NBC News that current evaluations, including internal safety reviews and a study from the University of Southern Denmark found no causal relationship between NAION and Ozempic.

The company said that NAION is not listed as an adverse drug reaction. “This also relates to eye conditions, which are well-known comorbidities for people living with diabetes,” the spokesperson said.

Ever thought those weekend binges, skipped workouts, or stress-fueled all-nighters in your 20s wouldn't matter later? Think again. The truth is, those early habits don’t just fade—they follow you. And by your 30s, they often come knocking in the form of low energy, poor sleep, creeping weight, or even anxiety. But here’s the good news: small, healthy choices now can completely rewrite that story. Ready to see how your everyday habits are shaping your future health? Let’s dive in.

It turns out the consequences of your twenties don't just haunt your social media feed—they may be silently impacting your long-term health well before you reach middle age. A groundbreaking study published in the Annals of Medicine has revealed that bad habits such as smoking, excessive alcohol consumption, and physical inactivity begin taking a measurable toll on mental and physical health by the age of 36.

This research, led by Finnish scientists and conducted over the course of more than 30 years, offers one of the most comprehensive glimpses yet into how unhealthy lifestyle choices in early adulthood accelerate aging and disease risks, and perhaps more crucially, when exactly those effects begin to show.

Why 36 Is a Wake-Up Call for Health?

While much of previous research has focused on health deterioration starting in midlife, the new longitudinal study flips the script by starting earlier. Scientists from Finland followed over 300 individuals born in 1959 in the city of Jyväskylä from childhood into their early 60s. Health assessments were conducted at ages 27, 36, 42, 50, and 61, offering an unparalleled timeline of how unhealthy behaviors impact wellbeing over decades.

The researchers found that even by age 36—what many consider still "young adulthood"—participants who consistently smoked, drank heavily, and exercised infrequently already showed notable declines in both mental and physical health. This suggests that the damage doesn’t start in your 40s or 50s. It begins much earlier, and once set in motion, it compounds.

Measurable Impact of Risky Habits

The three behaviors monitored—smoking, heavy alcohol use (defined as over 875 units/year for women and 1,250 for men), and exercising less than once a week—were assessed alongside health outcomes like depressive symptoms, psychological well-being, self-rated health, and a metabolic risk score that measured blood pressure, waist size, cholesterol, blood sugar, and other markers.

Dr. Tiia Kekäläinen, lead author of the study and a health scientist at Laurea University in Finland, emphasized the urgency of early intervention. “Our findings highlight the importance of tackling risky health behaviours as early as possible to prevent damage from building up over the years,” she explained.

Unhealthy Habits Are Interconnected

One of the most compelling insights from the study is the recognition that the relationship between poor habits and poor health is likely two-way. A person under chronic stress may turn to drinking or smoking to cope, leading to more health issues, which in turn worsen stress and mental health—a vicious cycle.

This echoes similar findings from large-scale studies, such as the ongoing Nurses' Health Study and the Health Professionals Follow-up Study, conducted by the Harvard T.H. Chan School of Public Health. These studies emphasize the interconnected nature of diet, physical activity, and mental wellbeing across decades of life.

Not Just Physical, Mental Health Pays the Price Too

Interestingly, the study separated out which habits affected which aspects of health the most. Smoking was most closely tied to poor mental health outcomes, while lack of exercise impacted physical health most significantly. Heavy drinking, perhaps unsurprisingly, was associated with declines in both mental and physical wellbeing.

This finding is particularly relevant in a post-pandemic world where mental health concerns are on the rise among younger adults, and alcohol use among Americans has increased significantly, especially among women and young professionals.

Are Millennials and Gen Z At High Risk?

Though the data primarily pertains to individuals born in the late 1950s and early 1960s, researchers caution that its findings are still broadly applicable. However, younger generations may face different lifestyle risks—such as increased screen time, vaping, and dietary imbalances—that weren't as prevalent in earlier cohorts. Therefore, the health impact timeline could shift, but the underlying message remains: the earlier you adopt healthier behaviors, the better.

High-profile figures like Adele, Rupert Grint, and A$AP Rocky—all around the age of 36—have publicly grappled with smoking and drinking. Adele, who quit smoking at 23, cited concerns about her vocal cords. Rupert Grint revealed he gave up smoking when his daughter was born in 2020. These personal transformations reflect a growing awareness among public figures of the need to shift lifestyle habits before long-term damage becomes irreversible.

How to Build A Healthy Lifestyle?

Perhaps the most hopeful message from the study is that change is possible. Dr. Kekäläinen reiterates: “It is never too late to change to healthier habits. Adopting healthier habits in midlife also has benefits for older age.”

So, what are the takeaways for someone nearing or in their 30s?

• Begin exercising regularly—even once a week has a measurable benefit
• Reduce or quit smoking as soon as possible
• Practice moderation in alcohol consumption
• Seek mental health support when experiencing stress or depressive symptoms
• Maintain regular health check-ups to monitor metabolic indicators

Your 30s aren't just about career milestones or starting a family—they're a crucial checkpoint for your health journey. The choices you make today will echo through your 40s, 50s, and beyond.