Rabies is most often associated with dog-mediated transmission in humans, but the virus can infect a wide range of mammals. In 2026, unusual cases involving farm goats, beavers and Cape fur seals raised fresh questions about how rabies moves between species.Since July 2026, multiple US jurisdictions have reported human rabies exposures involving known rabies vectors or animals in which rabies is less commonly reported. The CDC issued a health advisory on September 10 “in response to recent reports of increases in human exposures to rabid or possibly rabid animals.”The concern is not limited to North America. At least 176 people had been bitten by rabid Cape fur seals along South Africa’s coastline by the end of 2025, while researchers have warned that the disease could spread to other marine mammal species.In North Carolina in 2026, a wild skunk entered a pen containing baby goats, some of which later tested positive for rabies. Of the 284 people evaluated by local health departments, post-exposure prophylaxis (PEP) was recommended for 213. In Maryland, a 13-year-old boy was attacked by a beaver while swimming at a state park and required surgery for his injuries.These cases raise a bigger question: Are unusual infections simply spillover from established rabies hosts, or can the virus establish sustained transmission in a new species? To understand this better, HealthandMe spoke to two experts.Also read: US CDC Warns Of Rising Human Rabies Exposure Risk: How To Stay SafeAre These New Rabies Hosts Or Spillover?Dr Anish T S, Professor at the School of Public Health, Kerala University of Health Sciences, told HealthandMe that rabies can infect mammals, but an infected animal is not necessarily a reservoir host.Genetic sequencing can help establish where an unusual infection came from and whether the virus is changing.“So one thing that we can do is genetic analysis. If we are able to pick up these animals infected by rabies, we find what kind of rabies virus it is and do maybe a sequencing of the genome of this virus.”“These kinds of analysis could be done still, but it is a question that whether this particular virus is changing its host or the virus is accumulating some kind of genetic mutations so that it can get maybe involved with some other animals. It can choose some other animals also as their host. It is actually a very pertinent question.”The Cape fur seal cases add another dimension to this question, with sustained rabies transmission reported within the marine mammal population.What Happens After Exposure?Dr NK Ganguly, former Director General of the Indian Council of Medical Research (ICMR), told HealthandMe that rabies in goats is rare, while beaver exposures need particular caution.“Beaver is one animal where we have to be very careful.”Dr Anish said rabies can also present as paralytic or “dumb” rabies, which may not show classic signs and could lead people to handle or treat an infected animal without recognizing the risk.Dr Ganguly stressed the need for prompt medical care after exposure.“The rabies incubation period is around 10 days. So if somebody has been exposed, they should be immediately vaccinated. And if the exposure is with a bite or something at the upper limbs, then they need to be given an antiserum as well as vaccinated.”“So depending on the exposure, you are given a vaccine which is available, and you are also given the cocktail of antibodies, the monoclonal antibodies, which act immediately.”Why Wildlife And Livestock Surveillance MattersRead More: Rabies Day Exclusive: ‘We Need To Target The Source’ For A Rabies-Free India By 2030, Says Veterinary EpidemiologistDr Ganguly said rabies can also circulate in wild and feral animals, including foxes, while cats and other species can also be infected.He said surveillance should extend beyond dogs to domestic animals that are in close contact with them and to wildlife where feasible.“Surveillance should include domestic animals also which are in close contact with the dogs.”“There should be surveillance. There should be sentinel surveillance. We should carry out, if it is affordable.”He also pointed to dog vaccination and sterilization, as well as bait vaccination for wildlife and stray animals.Could The Virus Be Changing?Dr Anish said unusual infections need investigation to determine whether they are isolated spillover events or linked to changes in the virus.“The real issue is if the virus is changing much because of mutations. Because rabies virus is not that much notorious for mutations. That is why most of our vaccines are working.”He said genetic studies could help answer whether existing vaccines and treatments would remain effective if significant mutations emerge.“So the genetic studies of the virus may give us the answers to these questions.” India’s Rabies Elimination ChallengeFor India, the experts said the priority remains breaking established dog-mediated transmission chains before focusing on less common pathways.“If you just look at the rabies situation in India, we are not even able to manage the pure dog-mediated rabies. That is, people are bitten by rabid dogs and people are getting infected, and we are not able to have maybe full coverage of vaccination, and all the other things are actually the biggest concern,” Dr Anish said.Dr Ganguly added that surveillance should include domestic animals also which are in close contact with the dogs. "But essentially, in the urban areas, the dog is the main animal, and we should—the Supreme Court has given now a lot of directions in this particular regard—that the dogs may be sterilized," the expert said. The pet dogs need to be vaccinated and other stray dogs should be taken to facilities where they need to be sterilized and they need to be vaccinated, the experts said.