Health and Me

Ishita Roy

Choline Deficiency Could Lead To Cognitive Decline

what is choline deficiency? how is it linked with cognitive decline?

<span>Choline</span> is often known as "brain food". It is a nutrient related to B vitamins that play an important role in body and brain functions. However, the concerning part is about 90% of people do not consume enough of it. 

It is essential for producing acetylcholine, which is a neurotransmitter that helps neurons or the nerve cells to build connections and communicate effectively. As people age, acetylcholine levels naturally decline. When these levels are lower than usual, it can cause conditions like Alzheimer's disease. Research also suggests that low levels of acetylcholine can impair memory, focus, and the ability to recall words. 

As per a 2021 study published in the journal <em>Behavioral Neurology</em>, individuals who consumed between 188 to 400 mg of choline on a daily basis had a lower risk of cognitive decline. They had at least 40% less risk of experiencing cognitive decline compared to those with lower intakes of choline. 

<h4>What Are The Different Kinds Of Choline? How They Benefit?</h4>

There are various forms of choline some benefit more than others. 

For instance phosphatidylcholine is a type of choline that is found in eggs and is linked with lower dementia risk. A 2019 study observed that every additional 50 mg per day of phosphatidylcholine intake was associated with a 10 percent decrease in the likelihood of developing dementia. Since a large egg contains around 169 mg of choline, most of which is phosphatidylcholine, incorporating eggs into the diet can be particularly effective. 

There are other emerging research in this field that suggests that increasing choline intake after Alzheimer's diagnosis could also slow the progression of the disease. It could also provide potential benefits even in the later stages of cognitive decline. 

<h4>Are There Other Health Benefits Of Choline?</h4>

Other than helping the brain stay sharp, choline can also help maintain healthy liver function. It can play an important role for fat and glucose metabolism and reduce the risk of metabolic diseases like fatty liver disease and Type 2 diabetes. 

It could also contribute to cardiovascular health by controlling inflammation, which is one of the leading reasons for heart diseases, including stroke. 

<h4>How Much Choline In Okay to Consume?</h4>

Although the body makes a small amount of choline naturally, it is not sufficient to meet daily needs. The recommended Daily Value (DV) for choline is 550 mg. This amount typically needs to be obtained through diet or supplements.

While it’s possible to get enough choline through food, certain groups, such as older adults or those following a plant-based diet, may find it challenging. In such cases, supplements may be considered. However, not all multivitamins provide sufficient choline, so selecting a specific choline supplement — ideally around 300 mg — could be necessary. Consulting with a healthcare provider before starting supplements is always advisable.

There are many common food that contains choline, some of them include: 

<ul><li>Egg, 1 large (169 mg)</li><li>Edamame, 1 cup (87 mg)</li><li>Turkey breast, 3.5 oz. (84 mg)</li><li>Chicken thighs, 3.5 oz. (75 mg)</li><li>Salmon, 3.5 oz. (79 mg)</li><li>Broccoli or Brussels sprouts, 1 cup (63 mg)</li><li>Red potato, 1 large (57 mg)</li><li>Kidney beans, ½ cup (45 mg)</li><li>2% milk, 1 cup (45 mg)</li><li>Cottage cheese, 1 cup (37 mg)</li><li>Plain low-fat yogurt, 1 cup (35 mg)</li></ul>

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choline deficiency linked to cognitive decline

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choline deficiency linked to dementia

choline deficiency linked to alzheimers

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Choline is often known as "brain food". It is a nutrient related to B vitamins that play an important role in body and brain functions. However, the concerning part is about 90% of people do not consume enough of it. It is essential for producing acetylcholine, which is a neurotransmitter that helps neurons or the nerve cells to build connections and communicate effectively. As people age, acetylcholine levels naturally decline. When these levels are lower than usual, it can cause conditions like Alzheimer's disease. Research also suggests that low levels of acetylcholine can impair memory, focus, and the ability to recall words. As per a 2021 study published in the journal Behavioral Neurology, individuals who consumed between 188 to 400 mg of choline on a daily basis had a lower risk of cognitive decline. They had at least 40% less risk of experiencing cognitive decline compared to those with lower intakes of choline. What Are The Different Kinds Of Choline? How They Benefit?There are various forms of choline some benefit more than others. For instance phosphatidylcholine is a type of choline that is found in eggs and is linked with lower dementia risk. A 2019 study observed that every additional 50 mg per day of phosphatidylcholine intake was associated with a 10 percent decrease in the likelihood of developing dementia. Since a large egg contains around 169 mg of choline, most of which is phosphatidylcholine, incorporating eggs into the diet can be particularly effective. There are other emerging research in this field that suggests that increasing choline intake after Alzheimer's diagnosis could also slow the progression of the disease. It could also provide potential benefits even in the later stages of cognitive decline. Are There Other Health Benefits Of Choline?Other than helping the brain stay sharp, choline can also help maintain healthy liver function. It can play an important role for fat and glucose metabolism and reduce the risk of metabolic diseases like fatty liver disease and Type 2 diabetes. It could also contribute to cardiovascular health by controlling inflammation, which is one of the leading reasons for heart diseases, including stroke. How Much Choline In Okay to Consume?Although the body makes a small amount of choline naturally, it is not sufficient to meet daily needs. The recommended Daily Value (DV) for choline is 550 mg. This amount typically needs to be obtained through diet or supplements.While it’s possible to get enough choline through food, certain groups, such as older adults or those following a plant-based diet, may find it challenging. In such cases, supplements may be considered. However, not all multivitamins provide sufficient choline, so selecting a specific choline supplement — ideally around 300 mg — could be necessary. Consulting with a healthcare provider before starting supplements is always advisable.What Foods Contain Choline?There are many common food that contains choline, some of them include: Egg, 1 large (169 mg)Edamame, 1 cup (87 mg)Turkey breast, 3.5 oz. (84 mg)Chicken thighs, 3.5 oz. (75 mg)Salmon, 3.5 oz. (79 mg)Broccoli or Brussels sprouts, 1 cup (63 mg)Red potato, 1 large (57 mg)Kidney beans, ½ cup (45 mg)2% milk, 1 cup (45 mg)Cottage cheese, 1 cup (37 mg)Plain low-fat yogurt, 1 cup (35 mg)

choline deficiency could lead to cognitive decline

Riya Baibhawi

Struggling To Maintain Fluid Balance—5 Fruits That Help Replenish Electrolytes

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<span>Electrolyte</span>s are minerals with an electrical charge, essential for various cellular functions like muscle contraction and maintaining fluid balance during exercise. Adequate electrolyte intake can help prevent dehydration and muscle cramps and support cognitive function and performance. These minerals—sodium, potassium, magnesium, and calcium—are lost through sweat and urine, making it important to replenish them throughout the day, especially after a run.

Among runners, low <span>sodium</span> levels are often a bigger concern than high levels. Sodium is the electrolyte most commonly lost in sweat, explains registered dietitian Kylee Van Horn. “It plays a key role in both muscle contraction, fluid balance, and the body’s ability to utilize glucose (sugars) in the small intestine,” she says. “It works alongside chloride and potassium to maintain fluid balance.”

Hyponatremia, or dangerously low sodium levels in the blood, typically results from too much fluid relative to sodium. This condition—exercise-associated hyponatremia (EAH)—can develop during or after strenuous physical activity and may lead to serious health issues.

Potassium works together with sodium and is vital for muscle contraction, blood pressure regulation, and preventing cramps. The recommended daily intake for potassium is around 4,700 milligrams.

“Magnesium and calcium support muscle contraction and energy production but are lost in smaller quantities through sweat,” Van Horn adds.

Though many people turn to electrolyte drinks, gels, or tablets, it’s easy to overlook that plenty of whole foods are rich in electrolytes. Moreover, many commercial sports drinks may contain only sodium and come with added sugars or other unwanted ingredients, while missing out on other vital electrolytes.

A study published in <span>Nutrients</span> suggests that hydrating foods can make up about 20% of our total water intake. Raw fruits and vegetables have the highest water content and often contain small amounts of electrolytes. These foods also provide carbohydrates, which are necessary for replenishing muscle glycogen after a workout. That’s all the more reason to aim for at least five servings of fruits and vegetables daily.

5 Fruits That Help Replenish Electrolytes

Adding a variety of fruits rich in electrolytes to your daily diet can enhance hydration, boost recovery, and support overall performance. Here are five seasonal options you can find at your local market:

Best known for their vitamin C content, strawberries also contain potassium. One cup provides about 5% of the daily recommended intake. Blend them into smoothies, add them to oatmeal, or enjoy them on their own. Strawberries may also ease GI distress thanks to their anti-inflammatory effects on the colon.

Tart cherries support muscle recovery and reduce inflammation. One cup offers 270–300 mg of potassium along with small amounts of calcium, magnesium, and sodium.

A favourite among runners, bananas offer 422 mg of potassium per medium fruit, plus magnesium. Pairing them with salted peanut butter can add sodium and improve post-run recovery.

Rich in vitamin C and antioxidants, a cup of diced mango provides nearly 7% of your daily potassium needs and some magnesium. Blend with calcium-rich yoghurt for an electrolyte-packed snack.

Composed of 92% water, watermelons are hydrating and contain potassium and antioxidants like vitamins A and C. Add a pinch of salt to boost both flavour and sodium intake.

Diet & Nutrition

sodium

nutrients

Electrolyte

Strawberries

Electrolytes are minerals with an electrical charge, essential for various cellular functions like muscle contraction and maintaining fluid balance during exercise. Adequate electrolyte intake can help prevent dehydration and muscle cramps and support cognitive function and performance. These minerals—sodium, potassium, magnesium, and calcium—are lost through sweat and urine, making it important to replenish them throughout the day, especially after a run.Among runners, low sodium levels are often a bigger concern than high levels. Sodium is the electrolyte most commonly lost in sweat, explains registered dietitian Kylee Van Horn. “It plays a key role in both muscle contraction, fluid balance, and the body’s ability to utilize glucose (sugars) in the small intestine,” she says. “It works alongside chloride and potassium to maintain fluid balance.”Hyponatremia, or dangerously low sodium levels in the blood, typically results from too much fluid relative to sodium. This condition—exercise-associated hyponatremia (EAH)—can develop during or after strenuous physical activity and may lead to serious health issues.Potassium works together with sodium and is vital for muscle contraction, blood pressure regulation, and preventing cramps. The recommended daily intake for potassium is around 4,700 milligrams.“Magnesium and calcium support muscle contraction and energy production but are lost in smaller quantities through sweat,” Van Horn adds.Though many people turn to electrolyte drinks, gels, or tablets, it’s easy to overlook that plenty of whole foods are rich in electrolytes. Moreover, many commercial sports drinks may contain only sodium and come with added sugars or other unwanted ingredients, while missing out on other vital electrolytes.A study published in Nutrients suggests that hydrating foods can make up about 20% of our total water intake. Raw fruits and vegetables have the highest water content and often contain small amounts of electrolytes. These foods also provide carbohydrates, which are necessary for replenishing muscle glycogen after a workout. That’s all the more reason to aim for at least five servings of fruits and vegetables daily.5 Fruits That Help Replenish ElectrolytesAdding a variety of fruits rich in electrolytes to your daily diet can enhance hydration, boost recovery, and support overall performance. Here are five seasonal options you can find at your local market:1. StrawberriesBest known for their vitamin C content, strawberries also contain potassium. One cup provides about 5% of the daily recommended intake. Blend them into smoothies, add them to oatmeal, or enjoy them on their own. Strawberries may also ease GI distress thanks to their anti-inflammatory effects on the colon.2. CherriesTart cherries support muscle recovery and reduce inflammation. One cup offers 270–300 mg of potassium along with small amounts of calcium, magnesium, and sodium.3. BananasA favourite among runners, bananas offer 422 mg of potassium per medium fruit, plus magnesium. Pairing them with salted peanut butter can add sodium and improve post-run recovery.4. MangoesRich in vitamin C and antioxidants, a cup of diced mango provides nearly 7% of your daily potassium needs and some magnesium. Blend with calcium-rich yoghurt for an electrolyte-packed snack.5. WatermelonsComposed of 92% water, watermelons are hydrating and contain potassium and antioxidants like vitamins A and C. Add a pinch of salt to boost both flavour and sodium intake.

struggling to maintain fluid balance—5 fruits that help replenish electrolytes

Tanya Dutt

Ozempic Without The Side Effects? Try This Drug-Free Method

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Semaglutide -based drugs like Ozempic and Wegovy have surged in popularity for their ability to suppress hunger and aid in quick <span>weight loss</span> but with the buzz, more and more people are still hesitant about medication use long-term—particularly with the gastrointestinal side effects and price tag that come with most of these injections. What if you could mimic some of the processes of these medications naturally without ever setting foot in a pharmacy?

Science today reveals that it's possible. Through the power of nutrition, timing, and meal form, you can boost your body's own levels of GLP-1 (glucagon-like peptide-1)—the hormone semaglutides are engineered to copy. No diet or habit can duplicate the pharmacological effect of Ozempic, but the correct lifestyle changes can have significant, long-term weight loss—without the risks.

<h2>What's Body's Natural "Fullness" Signal?</h2>

GLP-1 is a gut hormone that signals fullness, delays gastric emptying, and regulates insulin. How semaglutide drugs do this is by increasing levels of GLP-1 and preventing it from being broken down, prolonging that feeling of fullness from a matter of minutes to a few days. That's what triggers the dramatic reduction in appetite experienced with Ozempic.

But recent research shows that GLP-1 can even be boosted by natural methods—namely, with focused food selection, attentive consumption, and timing strategies.

<h2>What Are The Nutrients That Naturally Increase GLP-1?</h2>

At the center of any pharmaceutical-free weight reduction technique is food. But calories alone—certain nutrients direct the body's endocrine reactions, including GLP-1.

Fibre: Richly found in beans, vegetables, whole grains, nuts, and seeds, fibre is fermented within the gut by resident beneficial bacteria to release short-chain fatty acids that induce the release of GLP-1. Diets rich in fibre are always linked with weight loss—even when calories aren't limited.

Monounsaturated Fats: Olive oil, avocado, and nuts such as pistachios contain high levels of monounsaturated fats, which have been proven to raise GLP-1. Even a small trial comparing bread with olive oil to bread with butter showed higher levels of the hormone with the olive oil combination. Even combining carbs with any source of fat (such as cheese) increases GLP-1 over consuming carbs on their own.

Whole Foods Combinations: Placing avocado on a typical bagel breakfast or adding fibre-dense nuts as a snack can provide an GLP-1 kick. Foods that pair fibre and healthy fat—such as pistachios—are particularly potent.

<h2>Why Timing and Order of Meals Matter?</h2>

The tale doesn't end with ingredients—it continues to behavior. How, when, and in what order you eat is an important contributor to hormonal balance.

Meal Order: Beginning meals with protein or vegetables first, then eating carbs, results in more GLP-1 release. This easy adjustment—protein or greens first—is a key that can stabilize blood sugar and promote feelings of fullness.

Circadian Rhythms: GLP-1, as with all hormones, has a biological clock. Breakfast meals release much more GLP-1 than dinner meals. Eating a high-calorie breakfast results in greater satiety and improved metabolic effects compared to a calorie-dense dinner. Front-loading your calorie intake—eating "breakfast like a king"—isn't simply an old maxim; it's science.

Chewing and Rate of Eating: The chewing act might be more significant than you realize. In one study, eating chopped cabbage (one needed to chew it) resulted in higher GLP-1 levels than having the same vegetable as a purée. Further, eating a dessert, such as ice cream, at a slow rate over 30 minutes generated higher GLP-1 levels than rapid consumption in five. Eating more slowly can transmit stronger "full" messages to the brain.

<h2>How Natural GLP-1 Levels Compare to Medications?</h2>

It is worth noting the limitations of food intervention. Semaglutide drugs such as Ozempic raise GLP-1 levels to about 65 nanograms per millilitre of blood—more than a thousand times the 59 picograms induced by even the healthiest foods.

But weight loss is not the sole indicator of success. The Mediterranean diet that naturally increases GLP-1 through olive oil, nuts, vegetables, and lean meats has been proven to decrease the risk of heart disease by 30%. Semaglutide drugs, on the other hand, decrease cardiac risk by 20%. For overall health benefits, food trumps medicine.

<h2>Drug-Free Blueprint for Weight Loss</h2>

If you want a drug-free weight management that is in harmony with your body's natural rhythms and biochemistry, here are things worth considering incorporating into your lifestyle:

<ul><li>Eat breakfast as the biggest meal of the day.</li><li>Eat at least one high-fibre food per meal.</li><li>Emphasize healthy fats, particularly olive oil, avocado, and nuts.</li><li>Start meals with vegetables or proteins first, and then carbohydrates.</li><li>Munch slowly and thoroughly.</li><li>Space out meals to coincide with your body's circadian rhythm—eat sooner, not later.</li><li>Add in snacks such as pistachios or almonds, which pair fibre with healthy fat.</li></ul>

These practices won't provide magic in a single night, but they provide long-term weight control and metabolic wellness without side effects, addiction, or prescription renewals.

weight loss

ozempic alternatives

drug-free weight loss

natural glp-1 boosters

semaglutide without side effects

fiber for weight loss

mediterranean diet weight loss

healthy fat glp-1 stimulation

Semaglutide -based drugs like Ozempic and Wegovy have surged in popularity for their ability to suppress hunger and aid in quick weight loss but with the buzz, more and more people are still hesitant about medication use long-term—particularly with the gastrointestinal side effects and price tag that come with most of these injections. What if you could mimic some of the processes of these medications naturally without ever setting foot in a pharmacy?Science today reveals that it's possible. Through the power of nutrition, timing, and meal form, you can boost your body's own levels of GLP-1 (glucagon-like peptide-1)—the hormone semaglutides are engineered to copy. No diet or habit can duplicate the pharmacological effect of Ozempic, but the correct lifestyle changes can have significant, long-term weight loss—without the risks.What's Body's Natural "Fullness" Signal?GLP-1 is a gut hormone that signals fullness, delays gastric emptying, and regulates insulin. How semaglutide drugs do this is by increasing levels of GLP-1 and preventing it from being broken down, prolonging that feeling of fullness from a matter of minutes to a few days. That's what triggers the dramatic reduction in appetite experienced with Ozempic.But recent research shows that GLP-1 can even be boosted by natural methods—namely, with focused food selection, attentive consumption, and timing strategies.What Are The Nutrients That Naturally Increase GLP-1?At the center of any pharmaceutical-free weight reduction technique is food. But calories alone—certain nutrients direct the body's endocrine reactions, including GLP-1.Fibre: Richly found in beans, vegetables, whole grains, nuts, and seeds, fibre is fermented within the gut by resident beneficial bacteria to release short-chain fatty acids that induce the release of GLP-1. Diets rich in fibre are always linked with weight loss—even when calories aren't limited.Monounsaturated Fats: Olive oil, avocado, and nuts such as pistachios contain high levels of monounsaturated fats, which have been proven to raise GLP-1. Even a small trial comparing bread with olive oil to bread with butter showed higher levels of the hormone with the olive oil combination. Even combining carbs with any source of fat (such as cheese) increases GLP-1 over consuming carbs on their own.Whole Foods Combinations: Placing avocado on a typical bagel breakfast or adding fibre-dense nuts as a snack can provide an GLP-1 kick. Foods that pair fibre and healthy fat—such as pistachios—are particularly potent.Why Timing and Order of Meals Matter?The tale doesn't end with ingredients—it continues to behavior. How, when, and in what order you eat is an important contributor to hormonal balance.Meal Order: Beginning meals with protein or vegetables first, then eating carbs, results in more GLP-1 release. This easy adjustment—protein or greens first—is a key that can stabilize blood sugar and promote feelings of fullness.Circadian Rhythms: GLP-1, as with all hormones, has a biological clock. Breakfast meals release much more GLP-1 than dinner meals. Eating a high-calorie breakfast results in greater satiety and improved metabolic effects compared to a calorie-dense dinner. Front-loading your calorie intake—eating "breakfast like a king"—isn't simply an old maxim; it's science.Chewing and Rate of Eating: The chewing act might be more significant than you realize. In one study, eating chopped cabbage (one needed to chew it) resulted in higher GLP-1 levels than having the same vegetable as a purée. Further, eating a dessert, such as ice cream, at a slow rate over 30 minutes generated higher GLP-1 levels than rapid consumption in five. Eating more slowly can transmit stronger "full" messages to the brain.How Natural GLP-1 Levels Compare to Medications?It is worth noting the limitations of food intervention. Semaglutide drugs such as Ozempic raise GLP-1 levels to about 65 nanograms per millilitre of blood—more than a thousand times the 59 picograms induced by even the healthiest foods.But weight loss is not the sole indicator of success. The Mediterranean diet that naturally increases GLP-1 through olive oil, nuts, vegetables, and lean meats has been proven to decrease the risk of heart disease by 30%. Semaglutide drugs, on the other hand, decrease cardiac risk by 20%. For overall health benefits, food trumps medicine.Drug-Free Blueprint for Weight LossIf you want a drug-free weight management that is in harmony with your body's natural rhythms and biochemistry, here are things worth considering incorporating into your lifestyle:Eat breakfast as the biggest meal of the day.Eat at least one high-fibre food per meal.Emphasize healthy fats, particularly olive oil, avocado, and nuts.Start meals with vegetables or proteins first, and then carbohydrates.Munch slowly and thoroughly.Space out meals to coincide with your body's circadian rhythm—eat sooner, not later.Add in snacks such as pistachios or almonds, which pair fibre with healthy fat.These practices won't provide magic in a single night, but they provide long-term weight control and metabolic wellness without side effects, addiction, or prescription renewals.

ozempic without the side effects? try this drug-free method

High Cholesterol Linked To Longer Life Spans In This Blue Zone

Exercising May Not Be A Lifeline For Couch Potatoes Against Alzheimer’s Disease - You Need To Change THIS

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A recent study published in the journal <em>Nutrients</em> has challenged long-standing perceptions about cholesterol and longevity. Conducted among nonagenarians in Sardinia’s Blue Zone, the research suggests that moderate hypercholesterolemia (where LDL-C is equal to or more than 130 mg/dL) may be associated with longer lifespans. However, this potential protective effect was not observed in individuals with excessively <span>high cholesterol</span> levels, particularly among women.

For decades, medical guidelines have emphasised the need to lower cholesterol levels to reduce cardiovascular disease risk. However, emerging evidence indicates that the relationship between cholesterol and health outcomes may be more nuanced, particularly in older populations. The Sardinian study, led by a team of Italian researchers, examined whether higher cholesterol levels could act as a marker of resilience in aging populations.

Known as the 'cholesterol paradox,' the phenomenon describes findings that indicate higher cholesterol levels may correlate with lower mortality rates in elderly populations. Some experts believe this could result from reverse causality, where declining cholesterol levels are a consequence of poor health rather than a cause. In this study, the researchers controlled for this by excluding participants with severe illnesses or poor self-rated health, yet the association between higher LDL-C and longer survival remained.

The study focused on a cohort of 168 nonagenarians (81 men and 87 women) from Sardinia’s Blue Zone, a region renowned for its unusually high number of long-lived residents. Data collection began in 2018 and continued until December 2024, during which 20 participants remained alive. To ensure the accuracy of their findings, the study included only those whose four grandparents were born within the Blue Zone, thereby reducing genetic variability.

Researchers assessed lipid profiles using blood samples collected after an overnight fast. Serum cholesterol levels, including total cholesterol, LDL, HDL, and triglycerides, were measured according to established guidelines. Participants were then categorized based on LDL-C levels, with a threshold of 130 mg/dL separating those with moderate hypercholesterolemia from those with lower levels.

The findings indicated that those with LDL-C levels above 130 mg/dL had a significantly longer median survival of 3.82 years, compared to 2.79 years among those with lower LDL-C levels. Statistical analysis revealed that moderate hypercholesterolemia was associated with a 40% lower mortality risk, even after accounting for factors such as sex, smoking status, and comorbidities. Interestingly, however, total cholesterol levels above 250 mg/dL did not confer additional survival benefits and were linked to shorter lifespans in women.

The study also highlighted lifestyle factors that may influence the cholesterol paradox. Over 85% of male participants and 69% of female participants reported engaging in physical activity at least three times per week, suggesting that exercise may play a role in mitigating the risks associated with elevated cholesterol levels.

Moreover, dietary habits emerged as another potential factor. Participants with higher LDL-C levels reported greater cereal consumption, while those with lower non-HDL cholesterol levels consumed more olive oil. However, the study did not assess dietary intake over time, making it difficult to draw definitive conclusions about diet’s role in the observed associations.

While these findings suggest that moderate hypercholesterolemia may not be as detrimental for very old individuals as previously thought, the researchers emphasized that the study’s limitations warrant caution. The relatively small sample size, single-point cholesterol measurement, and focus on a genetically unique population mean that the results may not be generalizable to other groups.

Nevertheless, the study raises important questions about current cholesterol management guidelines for older adults. As life expectancy continues to rise, it may be necessary to adopt more individualized approaches to cardiovascular health, considering not just cholesterol levels but also genetic, dietary, and lifestyle factors.

High Cholesterol

Blue Zones

Longetivity

Weight Loss

A recent study published in the journal Nutrients has challenged long-standing perceptions about cholesterol and longevity. Conducted among nonagenarians in Sardinia’s Blue Zone, the research suggests that moderate hypercholesterolemia (where LDL-C is equal to or more than 130 mg/dL) may be associated with longer lifespans. However, this potential protective effect was not observed in individuals with excessively high cholesterol levels, particularly among women.For decades, medical guidelines have emphasised the need to lower cholesterol levels to reduce cardiovascular disease risk. However, emerging evidence indicates that the relationship between cholesterol and health outcomes may be more nuanced, particularly in older populations. The Sardinian study, led by a team of Italian researchers, examined whether higher cholesterol levels could act as a marker of resilience in aging populations.Known as the 'cholesterol paradox,' the phenomenon describes findings that indicate higher cholesterol levels may correlate with lower mortality rates in elderly populations. Some experts believe this could result from reverse causality, where declining cholesterol levels are a consequence of poor health rather than a cause. In this study, the researchers controlled for this by excluding participants with severe illnesses or poor self-rated health, yet the association between higher LDL-C and longer survival remained.The study focused on a cohort of 168 nonagenarians (81 men and 87 women) from Sardinia’s Blue Zone, a region renowned for its unusually high number of long-lived residents. Data collection began in 2018 and continued until December 2024, during which 20 participants remained alive. To ensure the accuracy of their findings, the study included only those whose four grandparents were born within the Blue Zone, thereby reducing genetic variability.Researchers assessed lipid profiles using blood samples collected after an overnight fast. Serum cholesterol levels, including total cholesterol, LDL, HDL, and triglycerides, were measured according to established guidelines. Participants were then categorized based on LDL-C levels, with a threshold of 130 mg/dL separating those with moderate hypercholesterolemia from those with lower levels.The findings indicated that those with LDL-C levels above 130 mg/dL had a significantly longer median survival of 3.82 years, compared to 2.79 years among those with lower LDL-C levels. Statistical analysis revealed that moderate hypercholesterolemia was associated with a 40% lower mortality risk, even after accounting for factors such as sex, smoking status, and comorbidities. Interestingly, however, total cholesterol levels above 250 mg/dL did not confer additional survival benefits and were linked to shorter lifespans in women.The study also highlighted lifestyle factors that may influence the cholesterol paradox. Over 85% of male participants and 69% of female participants reported engaging in physical activity at least three times per week, suggesting that exercise may play a role in mitigating the risks associated with elevated cholesterol levels.Moreover, dietary habits emerged as another potential factor. Participants with higher LDL-C levels reported greater cereal consumption, while those with lower non-HDL cholesterol levels consumed more olive oil. However, the study did not assess dietary intake over time, making it difficult to draw definitive conclusions about diet’s role in the observed associations.While these findings suggest that moderate hypercholesterolemia may not be as detrimental for very old individuals as previously thought, the researchers emphasized that the study’s limitations warrant caution. The relatively small sample size, single-point cholesterol measurement, and focus on a genetically unique population mean that the results may not be generalizable to other groups.Nevertheless, the study raises important questions about current cholesterol management guidelines for older adults. As life expectancy continues to rise, it may be necessary to adopt more individualized approaches to cardiovascular health, considering not just cholesterol levels but also genetic, dietary, and lifestyle factors.

high cholesterol linked to longer life spans in this blue zone

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