Health and Me

Ishita Roy

Just One Can Of Soda Is Enough To Damage Your Liver, Diet Soda Could Make It Worse, Suggests Study

Drinking just one can of soda, whether regular or diet, can significantly increase your risk of developing a deadly liver disease, suggested new research. The study is conducted by the First Affiliated Hospitals of Soochow University in Suzhou, China, and the findings were presented at the United European Gastroenterology Week (UEG Week), 2025. 

The study showed that people who consumed just 250 grams of soda daily, which is less than a standard 12-ounce can, had a higher likelihood of developing metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as the <span><a href="https://www.healthandme.com/health/non-alcoholic-fatty-liver">non-alcoholic fatty liver</a></span> disease (NAFLD). 

What was more alarming is that diet sodas appeared to be worse offenders, as the low or non-sugar sweetened beverages (LNSSBs) raised risk of MASLD up to 60%, while sugar-sweetened beverages (SSBs) increased it by 50%.

Also Read: <a href="https://www.healthandme.com/health-wellness/if-youre-alone-at-home-and-experience-a-heart-attack-heres-how-you-survive-according-to-doctor-article-152961451" data-type="tilCustomLink" target="_blank">If You're Alone At Home And Experience A Heart Attack, Here's How You Survive: According To Doctor</a> 

“These findings challenge the common perception that these drinks are harmless and highlight the need to reconsider their role in diet and liver health, especially as MASLD emerges as a global health concern,” said Lihe Liu, the study’s lead author and a graduate student in gastroenterology.

The study followed nearly 124,000 adults who did not have any liver disease as part of the UK Biobank, and tracked the participants' beverage habits over a 10-year period. The researchers used a 24-hour dietary questionnaire to assess how often and how much soda people drank. 

As a result, a clear link between soda intake, even in small amounts and liver fat buildup, MASLD was seen. The researchers also discovered that soda intake led to excess fat accumulation in the liver, causing inflammation, scarring, and eventually conditions such as cirrhosis or liver cancer. As per the Cleveland Clinic, this kind of chronic liver damage can shorten life expectancy. 

MASLD was once thought to affect only the people who consume a large quantity of sugar or alcoholic drinks, however, the new research now suggests that even less than one can of soda could increase the risk significantly. 

“Sugar-sweetened beverages can cause rapid spikes in blood glucose and insulin, promote weight gain, and increase uric acid levels, all of which contribute to liver fat accumulation,” explained Liu.

Also Read: <a href="https://www.healthandme.com/health-news/nobel-peace-prize-2025-explained-what-are-the-3-scientists-awarded-nobel-prize-in-medicine-for-article-152960150" data-type="tilCustomLink" target="_blank">Explained: What Are The 3 Scientists Awarded Nobel Prize In Medicine For?</a>

However, the surprising part is that diet soda could cause more harm. Why? They are often marketed as the healthier option, however, they are more harmful due to the addition of artificial sweetener. "They may affect liver health by altering the gut microbiome, disrupting the feeling of fullness, driving sweet cravings, and even stimulating insulin secretion,” Liu said.

Even though diet sodas contain fever calories, they could confuse body's metabolic processes, making it harder to regulate appetite and blood sugar, both of which can contribute to liver fat buildup. 

MASLD is the leading cause of liver cancer and liver failure worldwide. In the US alone, it has surged by 50% over the past three decades and affects about 38% of the population. 

The researchers suggested to replace soda with water. As per Liu, replacing sugary beverages with water could reduce the risk of MASLD by 12%, while replacing an artificially sweetened one lowered the risk by 15.2%.

“The safest approach is to limit both sugar-sweetened and artificially sweetened drinks,” Liu emphasized. “Water remains the best choice as it removes the metabolic burden and prevents fat accumulation in the liver, whilst hydrating the body.”

Health Conditions A-Z

health

one can of soda can cause liver disease

diet soda is bad for liver

soda can cause MASLD

nutrition

diet and nutrition

soda and liver disease

one can of soda can damage your liver

liver damage with soda

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Drinking just one can of soda, whether regular or diet, can significantly increase your risk of developing a deadly liver disease, suggested new research. The study is conducted by the First Affiliated Hospitals of Soochow University in Suzhou, China, and the findings were presented at the United European Gastroenterology Week (UEG Week), 2025. The study showed that people who consumed just 250 grams of soda daily, which is less than a standard 12-ounce can, had a higher likelihood of developing metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as the non-alcoholic fatty liver disease (NAFLD). What was more alarming is that diet sodas appeared to be worse offenders, as the low or non-sugar sweetened beverages (LNSSBs) raised risk of MASLD up to 60%, while sugar-sweetened beverages (SSBs) increased it by 50%.Also Read: If You're Alone At Home And Experience A Heart Attack, Here's How You Survive: According To Doctor “These findings challenge the common perception that these drinks are harmless and highlight the need to reconsider their role in diet and liver health, especially as MASLD emerges as a global health concern,” said Lihe Liu, the study’s lead author and a graduate student in gastroenterology.What Did The Study Find?The study followed nearly 124,000 adults who did not have any liver disease as part of the UK Biobank, and tracked the participants' beverage habits over a 10-year period. The researchers used a 24-hour dietary questionnaire to assess how often and how much soda people drank. As a result, a clear link between soda intake, even in small amounts and liver fat buildup, MASLD was seen. The researchers also discovered that soda intake led to excess fat accumulation in the liver, causing inflammation, scarring, and eventually conditions such as cirrhosis or liver cancer. As per the Cleveland Clinic, this kind of chronic liver damage can shorten life expectancy. MASLD was once thought to affect only the people who consume a large quantity of sugar or alcoholic drinks, however, the new research now suggests that even less than one can of soda could increase the risk significantly. Why Diet Soda Could Be Worse?“Sugar-sweetened beverages can cause rapid spikes in blood glucose and insulin, promote weight gain, and increase uric acid levels, all of which contribute to liver fat accumulation,” explained Liu.Also Read: Explained: What Are The 3 Scientists Awarded Nobel Prize In Medicine For?However, the surprising part is that diet soda could cause more harm. Why? They are often marketed as the healthier option, however, they are more harmful due to the addition of artificial sweetener. "They may affect liver health by altering the gut microbiome, disrupting the feeling of fullness, driving sweet cravings, and even stimulating insulin secretion,” Liu said.Even though diet sodas contain fever calories, they could confuse body's metabolic processes, making it harder to regulate appetite and blood sugar, both of which can contribute to liver fat buildup. What Is The Impact?MASLD is the leading cause of liver cancer and liver failure worldwide. In the US alone, it has surged by 50% over the past three decades and affects about 38% of the population. The researchers suggested to replace soda with water. As per Liu, replacing sugary beverages with water could reduce the risk of MASLD by 12%, while replacing an artificially sweetened one lowered the risk by 15.2%.“The safest approach is to limit both sugar-sweetened and artificially sweetened drinks,” Liu emphasized. “Water remains the best choice as it removes the metabolic burden and prevents fat accumulation in the liver, whilst hydrating the body.”