Health and Me

Itisha Arya

GLP-1 Drugs And Pregnancy: Are They Safe For Women Planning To Conceive?

glp1 drugs and pregnancy

In a study led by researchers at Mass General Brigham, pregnant individuals who stopped taking popular GLP-1 weight loss medications either before or early in their pregnancy were found to gain more weight and face higher risks of diabetes and hypertensive disorders during pregnancy. 

They were also more likely to deliver preterm compared with people who had never taken GLP-1 drugs. The study, published in JAMA, shows that women who had used these drugs may face increased risks of preterm birth, diabetes, and pregnancy-related high blood pressure conditions such as preeclampsia compared with those who had not taken them.

<h2>Is It Safe To Consume GLP-1 Drugs In Pregnancy?</h2>

GLP-1 medications include brands like <span>Ozempic</span>, <span>Zepbound</span>, Victoza, Trulicity, and <span>Wegovy</span>. They were originally developed to manage diabetes and control blood sugar but have become widely used for weight management and obesity treatment. These medicines may also help with conditions such as sleep apnea, improve heart and kidney health, and lower the risk of strokes.

Drugs like Ozempic and Wegovy belong to a class called glucagon-like peptide-1 (GLP-1) receptor agonists, which promote weight loss by mimicking a hormone that reduces appetite.

Many people regain weight after stopping these drugs, but pregnant women are generally advised against taking them. This has raised questions about how to safely help women wean off these medications around conception without increasing other health risks linked to obesity or diabetes.

<h2>Weight Loss Drugs Before Pregnancy Linked To Greater Weight Gain</h2>

The research team, led by Dr. Jacqueline Maya, looked at health records for nearly 1,800 pregnancies between 2016 and 2025, mostly among women with obesity. They found that women who stopped GLP-1 medications before or early in pregnancy gained an average of 7.2 pounds (3.27 kilograms) more than those who had never taken these drugs.

“The popularity of weight loss drugs has grown dramatically, but guidelines recommend stopping them before pregnancy because there isn’t enough safety data for unborn babies,” said Dr. Maya, a pediatric endocrinologist at Mass General Brigham for Children, as reported by Science Direct.

Women in the GLP-1 group also had a 32% higher risk of exceeding recommended pregnancy weight gain, a 30% higher risk of developing diabetes, a 29% higher risk of hypertensive disorders, and a 34% higher chance of preterm birth. Interestingly, there were no differences in C-section rates or babies’ birth weight and length.

Dr. Camille Powe, an endocrinologist and co-author of the study, noted that more research is needed to understand the benefits and risks of using GLP-1 drugs around pregnancy. “We need further studies to find ways to manage weight gain safely and reduce pregnancy risks when stopping GLP-1 medications,” Powe said, according to Science Direct.

<h2>Can You Take Ozempic Or Wegovy During Pregnancy?</h2>

Currently, there’s no safe role for GLP-1 use during pregnancy. No GLP-1 drugs are approved for expectant mothers.

Dr. Michael Snyder, MD, medical director of the Bariatric Surgery Center at Rose Medical Center and FuturHealth’s in-house obesity specialist, explains that human data on GLP-1s during pregnancy is very limited. Animal studies indicate potential risks including fetal growth restriction, pregnancy loss, and skeletal abnormalities at higher doses.

When someone takes a GLP-1 drug, their appetite changes, and it’s not yet clear how this could affect a pregnant person’s nutrition.

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In a study led by researchers at Mass General Brigham, pregnant individuals who stopped taking popular GLP-1 weight loss medications either before or early in their pregnancy were found to gain more weight and face higher risks of diabetes and hypertensive disorders during pregnancy. They were also more likely to deliver preterm compared with people who had never taken GLP-1 drugs. The study, published in JAMA, shows that women who had used these drugs may face increased risks of preterm birth, diabetes, and pregnancy-related high blood pressure conditions such as preeclampsia compared with those who had not taken them.Is It Safe To Consume GLP-1 Drugs In Pregnancy?GLP-1 medications include brands like Ozempic, Zepbound, Victoza, Trulicity, and Wegovy. They were originally developed to manage diabetes and control blood sugar but have become widely used for weight management and obesity treatment. These medicines may also help with conditions such as sleep apnea, improve heart and kidney health, and lower the risk of strokes.Drugs like Ozempic and Wegovy belong to a class called glucagon-like peptide-1 (GLP-1) receptor agonists, which promote weight loss by mimicking a hormone that reduces appetite.Many people regain weight after stopping these drugs, but pregnant women are generally advised against taking them. This has raised questions about how to safely help women wean off these medications around conception without increasing other health risks linked to obesity or diabetes.Weight Loss Drugs Before Pregnancy Linked To Greater Weight GainThe research team, led by Dr. Jacqueline Maya, looked at health records for nearly 1,800 pregnancies between 2016 and 2025, mostly among women with obesity. They found that women who stopped GLP-1 medications before or early in pregnancy gained an average of 7.2 pounds (3.27 kilograms) more than those who had never taken these drugs.“The popularity of weight loss drugs has grown dramatically, but guidelines recommend stopping them before pregnancy because there isn’t enough safety data for unborn babies,” said Dr. Maya, a pediatric endocrinologist at Mass General Brigham for Children, as reported by Science Direct.Women in the GLP-1 group also had a 32% higher risk of exceeding recommended pregnancy weight gain, a 30% higher risk of developing diabetes, a 29% higher risk of hypertensive disorders, and a 34% higher chance of preterm birth. Interestingly, there were no differences in C-section rates or babies’ birth weight and length.Dr. Camille Powe, an endocrinologist and co-author of the study, noted that more research is needed to understand the benefits and risks of using GLP-1 drugs around pregnancy. “We need further studies to find ways to manage weight gain safely and reduce pregnancy risks when stopping GLP-1 medications,” Powe said, according to Science Direct.Can You Take Ozempic Or Wegovy During Pregnancy?Currently, there’s no safe role for GLP-1 use during pregnancy. No GLP-1 drugs are approved for expectant mothers.Dr. Michael Snyder, MD, medical director of the Bariatric Surgery Center at Rose Medical Center and FuturHealth’s in-house obesity specialist, explains that human data on GLP-1s during pregnancy is very limited. Animal studies indicate potential risks including fetal growth restriction, pregnancy loss, and skeletal abnormalities at higher doses.When someone takes a GLP-1 drug, their appetite changes, and it’s not yet clear how this could affect a pregnant person’s nutrition.