Pregnancy an extraordinary process, and for some, it begins as a twin pregnancy that they may never even know. Research says that one in eight individuals enter the world as a twin, but in a lot of these instances, one of the babies does not make it to term. Research published in the journal Human Reproduction shows that early ultrasound research indicates vanishing twin syndrome in about 12% of pregnancies. This process, referred to as vanishing twin syndrome (VTS), is when one twin fails to develop and is digested by the remaining embryo and parent. Though the deceased twin does not leave any visible impression, recent studies indicate that their existence may be traced in the DNA of the remaining sibling.

A recent study by Jenny van Dongen at VU Amsterdam in the Netherlands has revealed distinct epigenetic modifications in the DNA of identical twins. Epigenetics is a process of chemical modifications that control gene expression without changing the sequence of the DNA itself, for example, DNA methylation, in which methyl groups bind to genes to turn them on or off. For instance, during early development of the embryo, epigenetic modifications cause cells to give rise to a variety of different tissues and organs. DNA methylation, whereby methyl groups become bound to genes to essentially activate or deactivate them, is the most researched of all epigenetic modifications.

During pregnancy at an early stage, many epigenetic changes occur when the embryo coordinates different cells into a variety of the body's diverse tissues and organs. Identical twins, which develop from a single fertilized egg that eventually divides, share a unique DNA methylation pattern that differentiates them from fraternal twins and non-twins as well. The scientists found that the pattern covers 834 genes, proposing a possible way to identify whether an individual was originally part of an identical twin pair.

How DNA Can Reveal a Vanishing Twin?

The research, published in Nature Communications, compared DNA methylation data from more than 6,000 people, including identical twins, fraternal twins, and non-twin relatives. The results indicated that the epigenetic markers remain present in adulthood, so a cheek swab test might one day be able to tell whether or not a person had a missing twin.

Based on this information, researchers created a computer program that can recognize people who were once part of an identical twin set. Although the study did not test specifically if the program could detect people who had a vanishing twin, data indicate that the test could be possible in the future.

Vanishing twin syndrome happens in about 12% of pregnancies, though less than 2% of twin pregnancies give birth to both twins. The cause of VTS is multifaceted and not yet fully understood, as shown in research published in the International Journal of Fertility and Sterility.

Chromosomal abnormalities or genetic mutations within the vanishing twin in a few instances stop it from properly developing. The genetic abnormalities have occurred at the time of conception and cannot be prevented or regulated. The other twin absorbs the tissue of the deceased twin, and the operation is usually non-harmful to the in-utero embryo.

Why Do Identical Twins Form in the First Place?

While it is known that a fertilized egg sometimes splits to create identical twins, the underlying reasons remain a mystery. Unlike fraternal twins, whose likelihood is influenced by genetics, identical twins appear to occur randomly. Identical twinning happens at a consistent rate worldwide, approximately three to four times per 1,000 births, suggesting that factors other than genetics may play a role.

Researchers believe that epigenetic changes may be at play. Because DNA methylation is important in early embryonic development, some epigenetic alterations may determine whether an embryo divides to create identical twins. But more research is required to establish whether these epigenetic signatures are a cause, consequence, or side effect of twinning.

In order to gain more insight into identical twinning and vanishing twin syndrome, researchers intend to perform functional studies in human cells and animal models. By studying the role of epigenetic changes in embryonic development, scientists hope to determine the exact mechanisms that result in the creation of identical twins.

Moreover, scientists can broaden their research to investigate a wider variety of epigenetic changes beyond the 834 genes that have been discovered to date. As DNA methylation is only one component of epigenetic control, studying other chemical alterations may yield more insights into early embryonic development.

Emotional and Clinical Impact of Vanishing Twin Syndrome

In parents with vanishing twin syndrome, the emotional implications may be strong. While VTS cannot be prevented or treated, clinical and emotional help is important in coping with grief and enduring pregnancy.

As defined by the Cleveland Clinic, VTS is typically diagnosed by ultrasound, when an earlier visible embryo cannot be seen. Parents tend to experience a blend of emotions, weighing the excitement of a progressing pregnancy against the loss of the missing twin. Knowledge of the biological reasons behind VTS can assist in giving closure and assistance to families plagued by this condition.

The US is facing a long-term decline in the birth rates. As per experts, this raises a concern in terms of what this means for country's future, especially with regard to health of its population, economy, and caregiving systems.

A Slight Rise in 2024

As per the new data released by the US Centers for Disease Control and Prevention (CDC), more than 3.6 million babies were born in 2024. This is just a 1% increase from the previous year, which had been the lowest record in births. While this uptick may seem encouraging, it is not enough to reverse the troubling trend.

The US fertility rate remains around 1.6 births per woman. This is significantly below the 2.1 births that is required to sustain the population growth without immigration.

As per the demographers, this continuous drop began during the Great Recession in 2007. It has continued steadily since.

Shift In Teen Births

One of the biggest shifts is the steep decline in teen births. In 1991, about 62 of every 1,000 teenage girl had a child. This number has now fell to just under 13 by 2024. This is a historic low that reflects a positive shift, better education, access to contraception, and changing attitudes about early parenthood.

Similar trend is seen among women in their 20s, as the rates their too have dropped. In 2007, about 106 of every 1,000 women aged 20 to 24 gave birth. By 2024, the number has dropped to around 57. For women aged 25 to 29, the rate fell from 118 in every 1,000 women in 2007, to 91 in 2024.

Though there has been a slight rise in births among women in their 30s, experts say that it is not enough to offset the overall decline.

Are Births Being Delayed?

“One of the big questions is all these births that haven’t occurred—are they just being delayed?” asked Ken Johnson, a demographer at the University of New Hampshire. “Or are a lot of these births going to be forgone entirely?”

The answer has significant public health implications. A shrinking younger population could lead to fewer caregivers for an aging society, higher burdens on healthcare systems, and a smaller workforce contributing to national health programs like Medicare.

Why Are Fewer Americans Having Kids?

As per experts, while people still want children, there is a lingering financial burden and social barriers too that get in a way. High student loans, debt, and the rising coast of child care, unstable housing, along with limited access to paid parental leave are all major concerns.

“People don’t have kids when they don’t feel good about their own futures,” said Karen Benjamin Guzzo, a family demographer at the University of North Carolina.

Can Policies Help?

Some political leaders are proposing measures to encourage parenthood. Former President Trump, for instance, has suggested “baby bonuses” and scholarships for married couples or parents. However, Johnson believes that without stronger, systemic support, the U.S. birth rate is unlikely to bounce back to replacement level.

Immigration may help slow the effects of falling birth rates. Many immigrants move to the U.S. with plans to start families, Johnson noted. “They bring the potential for babies in the future.”

Not so long ago, childhood was seen as a joyful chapter of life rich with play, discovery, and endless imagination but now, a dangerous shift is underway. More and more number of children and teens are fighting severe emotional struggles that were once considered rare in youth. From depression and anxiety to more serious, more intricate mood disorders, the emotional well-being of the next generation is in shambles.

A study appearing recently in JAMA Pediatrics put a spotlight on a frightening trend: a sharp and consistent rise in mood disorders in children and teenagers over the last six years. Over 1 in 10 kids—10.6%—suffered from anxiety in 2022, compared to 7.1% in 2016. Depression also increased, hitting 4.6% of children in 2022, up from 3.2% in 2016. These statistics are not abstract; they reflect an escalating emotional crisis among our children, one that requires immediate and thoughtful action from parents, medical professionals, educators, and policymakers.

These aren't one-time occurrences. They're indicators of a broader crisis that is occurring in schools, homes, and communities—one which was fueled by the pandemic but was well under way before that. As the stressors of childhood change and escalate, so does the psychological load on our children.

But whereas scraped knees or the flu are tangible and obvious, mood disorders can be intangible, misunderstood, or dismissed altogether. And if left unidentified or unaddressed, the impact can trail a child into adolescence and adulthood, impacting everything from grades to relationships, self-worth, and health outcomes.

Not Just a Post-Pandemic Phenomenon

Although the COVID-19 pandemic shed international light on mental health conditions, scientists explain that the increased prevalence of mood disorders among adolescents is not exclusively a pandemic phenomenon. "Our results highlight the urgent need to address youth mental health, which continued to decline even as we exited the pandemic," says Marie Heffernan, assistant professor of pediatrics at Northwestern University Feinberg School of Medicine.

The research, conducted on the National Survey of Children's Health, shows a bittersweet pattern: although a few physical medical issues such as asthma and migraine are reducing in numbers, mental and emotional ailments are increasing. This contrast serves to emphasize that children's emotional health must command just as much clinical attention as does their bodily well-being.

What Are Mood Disorders?

Mood disorders, or affective disorders, are mental illnesses that encompass major depression, bipolar disorder, and dysthymia. They are marked by disturbances in an individual's emotional state that exceed the normal ups and downs of childhood or adolescence. The emotional changes are persistent, intense, and hard to control, and they tend to interfere with a child's functioning at home, school, and in social relationships.

Some of the most frequently diagnosed mood disorders in children and adolescents are:

Major Depressive Disorder: Ongoing sadness or irritability for two weeks or more.

Persistent Depressive Disorder (Dysthymia): Ongoing low-grade depression for one year or more.

Bipolar Disorder: Intermittent periods of elevated and depressed mood.

Disruptive Mood Dysregulation Disorder (DMDD): Intense irritability and persistent outbursts of temper.

Substance-Induced Mood Disorder: Mood disturbances due to medication, drugs, or toxins.

Mood Disorders Caused by Medical Illnesses: Mood shifts brought on by chronic disease or injury.

How to Identify the Warning Signs

In contrast to adults, children and adolescents tend to convey emotional distress through physical complaints or behavioral problems instead of talking about sadness or anxiety. This can make it more difficult to identify mood disorders. The Children's Hospital of Philadelphia states that symptoms can be:

• Severe or persistent sadness, irritability, or anger
• Substantial changes in sleep, appetite, or energy
• Withdrawal from friends or family, or withdrawal from social events
• No interest or pleasure in activities that they used to enjoy
• Difficulty with schoolwork without an identifiable cause
• Excessive physical complaints such as headaches or stomachaches

More often than not, these symptoms are confused with "phases" or attributed to stress or personality traits. That diagnostic delay can result in escalating symptoms or the emergence of comorbid conditions such as substance abuse or conduct disorders.

Why Are Today's Kids More Vulnerable Emotionally?

Experts cite several overlapping reasons for the explosion of mood disorders in young people:

Heightened Academic and Social Stress: Children today are under enormous pressure to succeed—academically, athletically, and socially—with little time left for emotional regulation.

Social Media and Online Exposure: Ongoing exposure to filtered realities, cyberbullying, and online validation cycles can exacerbate feelings of inadequacy and anxiety.

Family Life and Stress: Domestic instability, economic struggles, or family conflict can have a significant effect on a child's emotional resilience.

Deficiencies in Mental Health Infrastructure in Schools: Most schools do not have adequate psychological support staff or school programs emphasizing emotional well-being.

Stigma and Lack of Awareness: Mental health, in most communities, is still stigmatized, and its underreporting and underdiagnosis follow accordingly.

Managing Mood Disorders with Early Intervention

Mood disorders in children can be treated—if caught early. Treatments include:

• Cognitive Behavioral Therapy (CBT) to assist in coping with detrimental thought patterns in children
• Medication, as needed and very closely monitored
• Family Therapy to treat systemic stressors
• School-Based Support Services, including counseling and emotional wellness programs

Experts have said that continued concern and resources are justified at a national level to explain and treat the array of possible reasons for increasing anxiety and depression.

What Can Parents and Schools Do?

The awareness is the beginning, parents need to notice not only the changes in behaviour, but also emotional and physical signals that indicate distress. Schools, in return, require improved mental health education for teachers and more accessible support systems for pupils.

Promoting open dialogue about mental health, safe emotional release, and decreasing stigma can help children get through their feelings. As has been proven through research, numerous children benefit immensely from early, long-term intervention—and go on to live strong, healthy lives.

The emotional well-being of our children is not a specialty concern—it's a global public health imperative. With anxiety and depression levels steadily increasing, the time to take action is now. Being able to provide children with the proper resources, attention, and support systems can influence not only their emotional well-being in the short term but their capacity to thrive in the future.

The Talk. If you are an adult, a parent, or in your early adulthood, you must have heard about "The Talk". This conversation, as important as it is to have, could also be anxiety inducing.

What Exactly Is "The Talk"?

The question that may loom over parents is when is it the right age to have "The Talk"? But, before we get to that, let us discuss what "The Talk" is?

By "The Talk", people mean to drop the bomb, or address the elephant in the room. This conversation involves talking to your kids about puberty that will bring about many changes in their bodies, their minds, how they fell, and much more.

"The Talk" is not just one conversation that can happen only once in your life. It is an on-going discourse. However, having "the Talk" at least once, sets the foundation for kids and tells them that they can reach out to their parents whenever they wish to.

As per the CS Mott Children's Hospital National Poll on Children's Health, about 41% of parents reported that they approached talking with their child about puberty only when prompted by child. Only 36% of parents think it is best to have this conversation before the age of 10. So, what is the right age?

If experts are to be believed, it is best to bring this conversation up before your child brings it to you.

However, it is an anxiety-inducing process. But why is this important to talk?

“It’s easy to assume a child is too young for conversations about puberty, but many parents are surprised to find their tween already showing signs,” said Sarah Clark, Mott Poll Co-Director.

Early discussions, she explains, allow parents to present the information in an age-appropriate way, easing confusion and anxiety. If parents don’t begin the conversation, kids may seek answers from classmates, social media, or television.

Different Approaches, Different Comfort Levels

The poll revealed a wide range of parental approaches:

Proactive Parents: About half said they start conversations before questions arise.

Reactive Approach: Two in five wait until their child brings it up.

Avoidance: Around 5% avoid the topic altogether.

Many parents feel uneasy: one in five worry about embarrassment, and one in six fear saying the wrong thing. Some children resist as well—25% of parents with 10- to 12-year-olds say their child doesn’t want to talk about puberty, and a third of parents with 7- to 9-year-olds feel their child is too young to understand.

Parental History Shapes Comfort

Parents' past experiences with “The Talk” also play a role. Fewer than one in three received adequate information from their own parents. More than a third never had the conversation at all.

“Whether they realize it or not, parents may bring their own childhood experiences into how they handle this now,” Clark noted.

Navigating Topics of Sex and Reproduction

Another common challenge: knowing whether to include discussions about sex and reproduction, and if so, how much to share. Clark advises starting with the basics—physical and emotional changes—then layering in more detail over time.

Confidence in spotting puberty varies. About half of parents say they can recognize signs of puberty, and 60% of parents with 10- to 12-year-olds say they’ve already seen them. Among parents of younger children (ages 7–9), 17% have noticed early signs, while nearly a third remain unsure what to look for.