A new Nature Human Behaviour (2026) study suggests that single-session psychological exercises lasting less than 10 minutes can lead to measurable decreases in depression symptoms even one month later.

Depression is one of the most common mental health disorders in the world. Every year, hundreds of millions of people suffer from depression, and many are unable to get therapy because of cost, stigma and the dearth of mental-health professionals.

Symptoms include excessive sadness, depression often includes fatigue, changes in appetite, sleep disturbances, difficulty concentrating and feelings of hopelessness. Treatment requires professional guidance for diagnosis and management.

A 10-Minute Intervention With Lasting Effects

All the brief interventions took less than 10 minutes to complete and were designed to teach practical coping skills that are commonly used in psychotherapy. Some exercises helped participants to reframe negative thoughts, while others focused on motivation, goal-setting or making sense of things by helping others. Participants completed surveys measuring their well-being immediately after the session and again one month later.

The results were striking: while many exercises boosted motivation and hope immediately, two interventions - Interactive Cognitive Reappraisal and Finding Focus - showed measurable reductions in depression symptoms even after a month. On average, participants experienced about a four percent greater reduction in depression scores compared with the control group.

Although the improvement may appear small, researchers note that brief, scalable interventions could reach millions of people who currently lack access to mental-health care as they can be completed in a few minutes and delivered online, these exercises may allow people to take initial steps toward better mental health, especially those waiting for professional help or unwilling to ask for help.

The scientists also stressed that these activities are not intended to substitute for therapy, but should be seen as readily available tools to help with emotional health.

Exercise and Mental Health: A Growing Body of Evidence

Previous research also shows that a quick burst of activity can make you feel better from other research too. A British Journal of Health Psychology 2024 study found that just 10 minutes of daily mindfulness practice significantly improved well-being and reduced symptoms of depression and anxiety among more than 1,200 participants from 91 countries.

Similarly, the US National Institutes of Health (2019) reviews suggest that the physical activity itself may help improve mood and depressive symptoms, strengthening the relationship between movement and mental health.

Collectively, these findings suggest that even small doses of mental or physical activity may lead to psychological benefits.

A Small Step That Can Make a Difference

Depression can make people feel trapped and out of control. The good news of the new research is that it suggests that big changes aren’t always necessary to move forward.

Sometimes, doing a small task, like spending 10 minutes learning a new coping skill or doing a quick mental exercise, is enough to change the way you think and gradually improve mood.

As researchers investigate these brief interventions, one thing is becoming clear: when it comes to mental health, few minutes matter more than we think.

Cortisol is one of the body's most powerful hormones, which is essential for survival, yet capable of quietly undermining health when chronically elevated. The line between beneficial training stress and harmful overload is thinner than most athletes realize, and the body's early warning signals are easy to dismiss.

Understanding how cortisol responds to exercise and when that response tips from adaptive to destructive is foundational to training smarter, recovering better, and protecting long-term health.

Why Cortisol Matters

Cortisol is a vital, life-sustaining hormone essential for survival and adaptation. During physical exertion, it ensures the immediate mobilization of energy by triggering the breakdown of stored carbohydrates and fats (gluconeogenesis and lipolysis) to fuel working muscles. Additionally, it maintains vascular integrity and acts as a powerful anti-inflammatory agent, safely modulating the immune system to protect the body against extreme inflammation caused by exercise-induced tissue damage.

When Exercise Becomes Stress

Exercise is naturally an acute stressor, but it transitions into a harmful chronic stress when training loads exceed the body's ability to recover. High-intensity, prolonged aerobic exercise or extreme high-volume resistance training, combined with inadequate rest, sleep disruption, and external stressors, keeps the hypothalamic-pituitary-adrenal (HPA) axis constantly activated. When the natural 24-hour cycle of cortisol is disrupted and if the body does not get a long enough period of low cortisol exposure, exercise transitions from a positive adaptation (eustress) into destructive physiological strain.

Beyond Stress: How Excess Cortisol Reshapes the Body

The physical remodeling that chronic cortisol causes is profound and operates at the molecular level. Protein degradation occurs through activation of the ubiquitin–proteasome system. Cortisol further suppresses anabolic pathways by inhibiting mTOR signaling and reducing insulin-like growth factor 1 activity, leading to a sustained decrease in protein synthesis.

Visceral fat cells, the deep abdominal fat surrounding internal organs, have more cortisol receptors than fat cells elsewhere in the body. When cortisol levels remain elevated, these receptors essentially attract and store more fat in the midsection.

While Ozempic or Wegovy offer weight loss benefits, a significant caveat is the risk of regaining the kilos. This is not only a waste of money and effort but may also affect overall health.

About 70 per cent of people who stop these drugs eventually regain much of the weight they lost, often within 18 months.

Now, US researchers have developed a new minimally invasive procedure that resets the gut, and in early trials, has shown potential to help people maintain weight loss after stopping these popular drugs, which contain semaglutide — a GLP-1 receptor agonist — as the main ingredient.

Presenting the research at the Digestive Disease Week (DDW) 2026, the team noted that the procedure works by renewing the lining of the upper small intestine. It potentially “resets” metabolism and helps preserve the benefits of weight loss.

The technique is called duodenal mucosal resurfacing. In a clinical trial, people who underwent the procedure regained far less weight compared to others after discontinuing the medication.

"Finding a treatment that allows patients to stop these medications without weight regain or loss of metabolic benefit is a huge unmet need," said lead author Shelby Sullivan, director of the Endoscopic Bariatric and Metabolic Program at Dartmouth Health Weight Center and professor of medicine.

"These findings indicate that this minimally invasive procedure may provide lasting weight-loss maintenance."

How The Procedure Works

Duodenal mucosal resurfacing is an investigational endoscopic treatment that uses controlled heat to remove damaged tissue from the inner lining of the duodenum, the first section of the small intestine just below the stomach.

This process, which ablates the unhealthy mucosal layer, encourages the growth of new, healthier tissue.

The treatment targets the small intestine, where many of the hormones affected by GLP-1 drugs are produced. Over time, diets high in fat and sugar can alter the lining of the duodenum, changing how the body processes food and regulates hormones. These changes can contribute to insulin resistance and metabolic disease.

By restoring a healthier mucosal layer, the procedure aims to reset the body's response to food, helping to stabilize metabolism at a lower body weight after stopping medications like Ozempic.

How Was The Study Conducted?

The findings are based on an early group of participants with six months of follow-up data. Among 45 people in this cohort, 29 received the resurfacing treatment while 16 underwent a sham procedure.

All participants had previously lost at least 15 per cent of their body weight using tirzepatide before stopping the drug. On average, patients lost about 40 pounds while on GLP-1 therapy. Six months after discontinuing the medication, those in the control group regained significantly more weight. Participants who received the sham procedure regained about 40 per cent more weight than those who underwent the actual treatment.

In addition, patients who had more extensive resurfacing regained only about 7 pounds and kept more than 80 per cent of their weight loss.

By comparison, the control group regained roughly twice as much. The gap between the two groups continued to widen from one to six months after the procedure, suggesting the benefits may persist and even strengthen over time.

"What's particularly encouraging is that the benefit appears to increase over time rather than fade, and that it behaves like a drug in terms of dose response," Dr. Sullivan said. "That gives us confidence that we're targeting the right biology."

No serious complications were reported from either the device or the procedure. Recovery is relatively quick, with most patients returning to normal activities within about a day.

At a time when most people follow a sedentary lifestyle, exercise is nothing short of medicine. However, for someone who is lazy, workouts can take a good deal of effort — but what if we told you that there are some simple exercises that will not take much of your time and can be done easily while lying flat on your back? According to experts, without having to lift a finger, you can get in shape.

Best workouts to do in bed

Researchers at Teikyo University in Tokyo, Japan, found that people can improve their agility, balance, and flexibility by engaging in a simple exercise programme that involves three exercises. These exercises engage the leg muscles and core in an easy and safe position. Writing in the journal PLOS One, the study authors compared the routine to Pilates, and experts said that it can help prevent falls and support early rehabilitation.

Adults are recommended to do two and a half hours of exercise each week, but about a third of people do not meet this target. In this study, 39 healthy men and women in their 20s, with optimal flexibility, balance, speed, and strength, were involved. They were all tested before and after a two-week regimen of lying down and working out. The exercises they were asked to perform were:

1. Tense the abs for five seconds while pressing them with the fingers—repeat three times
2. Lifting the hips off the ground to form a bridge pose, keeping the feet flat on the ground—hold for five seconds and repeat 10 times
3. Bending one leg at the knee and holding the ankle at 90 degrees, clenching and unclenching the toes; ensure that the heel slides along the floor towards and away from the body—repeat three times with each leg

Fifteen days later, participants showed significant improvement in standing balance, flexibility, and agility. However, they did not show improvement in raw muscle strength, jumping ability, or grip strength tests. Scientists said that these improvements were likely due to better muscle control rather than increased muscle mass. They also noted that no prior research has shown an exercise programme that is short and performed in a supine position to be effective in this way. However, this routine, which showed improvements in flexibility, agility, balance, and stability, shows promise. It could also be helpful for rehabilitation in older adults.

What is exercise snacking?

Exercise snacking refers to an approach created for people who struggle to find time for long gym sessions. Instead of spending hours at the gym, people can perform small bursts of exercise throughout the day. These sessions are an effective way to stay active without needing to block out time specifically for fitness. They can be spread across the day, with mini workouts lasting five to 10 minutes and repeated multiple times. The benefits are significant when practised consistently, especially for those with desk jobs or those suffering from diabetes, hypertension, high cholesterol, or even depression.