Health and Me

Ishita Roy

Can Aspirin Stop Colorectal Cancer From Returning?

A daily low dose of <span>aspirin</span> could significantly reduce the risk of <span>colorectal <a href="https://www.healthandme.com/health/cancer">cancer</a></span> returning in certain patients, according to a clinical trial published in the <em>New England Journal of Medicine</em>. 

The study, conducted by researchers at the Karolinska Institute and Karolinska University Hospital in Sweden, involved 626 participants with stages 1 to 3 colon or rectal <span><a href="https://www.healthandme.com/health/cancer">cancer</a></span> whose tumors carried specific genetic mutations.

Colorectal cancer affects about 2 million people worldwide every year, and between 30 to 40% of them experience a recurrence. Identifying low-cost, widely available treatments that can prevent relapse is critical in improving survival rates and easing the burden on healthcare systems.

This trial is particularly significant because while earlier observational studies suggested aspirin might benefit cancers with mutations in the PIK3 signaling pathway, this is the first time the theory has been tested in a randomized clinical trial.

Participants were randomly assigned to either receive low-dose aspirin daily or a placebo. Over a follow-up period of three years, those in the aspirin group were up to 55 percent less likely to see their cancer return.

<strong>Aspirin group: </strong>7.7% recurrence rate within three years

<strong>Placebo group: </strong>14.1 to 16.8% recurrence rate, depending on mutation type

“Aspirin is a drug that is readily available globally and extremely inexpensive compared to many modern cancer drugs, which is very positive,” said lead researcher and surgeon Anna Martling from the Karolinska Institute.

<h2>How Aspirin May Work Against Cancer</h2>

Researchers believe aspirin helps prevent cancer recurrence in multiple ways:

<ul><li>Reducing inflammation, which plays a role in tumor growth</li><li>Restricting tumor cell proliferation</li><li>Limiting platelet function, which cancer cells often exploit to spread and protect themselves</li><li>Potentially disrupting the PIK3 pathway, slowing tumor development</li></ul>

While the exact molecular mechanisms remain unclear, the study provides strong biological evidence that aspirin could be effective in genetically defined subgroups of colorectal cancer patients.

One major advantage highlighted by the researchers is that colorectal cancers are already screened for genetic mutations. In this study, more than one-third of cases involved the relevant PIK3 mutations. That means many patients could easily be identified as candidates for aspirin therapy without requiring additional costly tests.

“Aspirin is being tested here in a completely new context as a precision medicine treatment,” Martling noted. “This is a clear example of how we can use genetic information to personalize treatment and at the same time save both resources and suffering.”

Low-dose aspirin has long been recognized for lowering the chances of repeat heart attacks and strokes. However, it is not without risks. Previous studies have linked aspirin use to an increased likelihood of internal bleeding and other complications.

The researchers stress that while the results are encouraging, more work is needed to confirm long-term benefits, identify which patients are most likely to benefit, and balance the risks against the potential advantages.

With millions of new colorectal cancer cases each year and a significant portion facing recurrence, this research opens the door to a simple, cost-effective approach to treatment. If confirmed in larger studies, aspirin could become a powerful tool in the fight against one of the world’s most common cancers.

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14-year-old Instagram Influencer Diagnosed With Acute Myeloid Leukemia Passes Away

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A daily low dose of aspirin could significantly reduce the risk of colorectal cancer returning in certain patients, according to a clinical trial published in the New England Journal of Medicine. The study, conducted by researchers at the Karolinska Institute and Karolinska University Hospital in Sweden, involved 626 participants with stages 1 to 3 colon or rectal cancer whose tumors carried specific genetic mutations.Why This Study MattersColorectal cancer affects about 2 million people worldwide every year, and between 30 to 40% of them experience a recurrence. Identifying low-cost, widely available treatments that can prevent relapse is critical in improving survival rates and easing the burden on healthcare systems.This trial is particularly significant because while earlier observational studies suggested aspirin might benefit cancers with mutations in the PIK3 signaling pathway, this is the first time the theory has been tested in a randomized clinical trial.The Trial ResultsParticipants were randomly assigned to either receive low-dose aspirin daily or a placebo. Over a follow-up period of three years, those in the aspirin group were up to 55 percent less likely to see their cancer return.Aspirin group: 7.7% recurrence rate within three yearsPlacebo group: 14.1 to 16.8% recurrence rate, depending on mutation type“Aspirin is a drug that is readily available globally and extremely inexpensive compared to many modern cancer drugs, which is very positive,” said lead researcher and surgeon Anna Martling from the Karolinska Institute.How Aspirin May Work Against CancerResearchers believe aspirin helps prevent cancer recurrence in multiple ways:Reducing inflammation, which plays a role in tumor growthRestricting tumor cell proliferationLimiting platelet function, which cancer cells often exploit to spread and protect themselvesPotentially disrupting the PIK3 pathway, slowing tumor developmentWhile the exact molecular mechanisms remain unclear, the study provides strong biological evidence that aspirin could be effective in genetically defined subgroups of colorectal cancer patients.Precision Medicine PotentialOne major advantage highlighted by the researchers is that colorectal cancers are already screened for genetic mutations. In this study, more than one-third of cases involved the relevant PIK3 mutations. That means many patients could easily be identified as candidates for aspirin therapy without requiring additional costly tests.“Aspirin is being tested here in a completely new context as a precision medicine treatment,” Martling noted. “This is a clear example of how we can use genetic information to personalize treatment and at the same time save both resources and suffering.”Benefits and RisksLow-dose aspirin has long been recognized for lowering the chances of repeat heart attacks and strokes. However, it is not without risks. Previous studies have linked aspirin use to an increased likelihood of internal bleeding and other complications.The researchers stress that while the results are encouraging, more work is needed to confirm long-term benefits, identify which patients are most likely to benefit, and balance the risks against the potential advantages.With millions of new colorectal cancer cases each year and a significant portion facing recurrence, this research opens the door to a simple, cost-effective approach to treatment. If confirmed in larger studies, aspirin could become a powerful tool in the fight against one of the world’s most common cancers.

aspirin this common pain medicine can stop you colorectal cancer from returning

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Her family announced her passing away; Credits: Instagram

<span>Zuza Beine</span>, a 14-year-old Instagram influencer from Wisconsin who openly documented her battle with <span>acute myeloid leukemia</span> (AML), has died, her family announced Tuesday.

Diagnosed with AML at the age of 3, Zuza spent much of her childhood undergoing treatment. Despite the challenges, she connected with 1.8 million followers on her Instagram account, @zuzas_way_to_healing, where she shared both the struggles and small joys of living with <span>cancer</span>.

<h3>Her family confirmed her passing in a heartfelt statement on Instagram:</h3>

<em>"It is with broken hearts that we share that <span rel="noindex">Zuza died</span> yesterday morning. She lived 11 of her 14 years with a relentless cancer, yet lived more fully and gratefully than most. Her being changed us forever, and her dying will too."</em>

Over the years, Zuza became known for her candid videos, including her popular “Get Ready With Me” posts, where she openly discussed treatment, pain management, and daily routines. Just days before her death, she told followers about the intense pain she was experiencing. “I’m constantly on pain medicine because my body hurts so, so, so bad,” she said in a video posted last Thursday.

One day later, she shared another update: “I can barely walk right now I’m in so much pain.” Yet, her final video on Sunday, just hours before her passing, reflected gratitude for life’s smallest moments, a recurring theme in her posts.

Her family described Zuza as both brave and honest, saying her openness inspired many to find beauty even in hardship. “More than anything, she wanted to be a normal, healthy kid. But what made her life so beautiful was how she faced the hardest circumstances and still lived fully,” they wrote.

<h2>What Is Acute <span rel="noindex">Myeloid</span> Leukemia (AML)?</h2>

According to the National Institute of Health, US, AML is a rapidly progressing myeloid neoplasm characterized by the clonal expansion of primitive hematopoietic stem cells, known as blasts, in the bone marrow. 

In other words, as the American Cancer Society describes, it is a type of cancer that starts in the blood-forming cells of the bone marrow. The Cancer Research UK explains that it starts from young white blood cells called granulocytes or monocytes in the bone borrow.

It is a rare cancer and happens when certain genes or chromosomes mutate. 

<strong>Myeloid leukemia:</strong> Involves cells that would normally produce neutrophils, a type of white blood cell.

<strong>Acute monocytic leukemia (AML-M5): </strong>Affects cells that develop into monocytes, another white blood cell.

<strong>Acute megakaryocytic leukemia (AMLK): </strong>Involves cells that should produce platelets or red blood cells.

Acute promyelocytic leukemia (APL): Affects immature white blood cells called promyelocytes, preventing them from developing normally.

AML affects about 4 in every 100,000 adults each year. Roughly 1,160 children are diagnosed annually in the U.S.

<h2>Symptoms of Acute Myeloid Leukemia</h2>

In its early stages, AML can feel like a lingering cold or flu. Because it is aggressive, symptoms usually progress quickly and may include:

<ul><li>Fatigue, weakness, or dizziness</li><li>Fever and night sweats</li><li>Easy bruising or bleeding (such as nosebleeds or bleeding gums)</li><li>Frequent or persistent infections</li><li>Loss of appetite and unexplained weight loss</li><li>Shortness of breath</li><li>Pale or cold skin</li><li>Headaches or swollen lymph nodes</li><li>Bone, back, or abdominal pain</li><li>Tiny red spots on the skin (petechiae)</li><li>Wounds or sores that don’t heal</li></ul>

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Zuza Beine, a 14-year-old Instagram influencer from Wisconsin who openly documented her battle with acute myeloid leukemia (AML), has died, her family announced Tuesday.Diagnosed with AML at the age of 3, Zuza spent much of her childhood undergoing treatment. Despite the challenges, she connected with 1.8 million followers on her Instagram account, @zuzas_way_to_healing, where she shared both the struggles and small joys of living with cancer.Her family confirmed her passing in a heartfelt statement on Instagram:"It is with broken hearts that we share that Zuza died yesterday morning. She lived 11 of her 14 years with a relentless cancer, yet lived more fully and gratefully than most. Her being changed us forever, and her dying will too."        Over the years, Zuza became known for her candid videos, including her popular “Get Ready With Me” posts, where she openly discussed treatment, pain management, and daily routines. Just days before her death, she told followers about the intense pain she was experiencing. “I’m constantly on pain medicine because my body hurts so, so, so bad,” she said in a video posted last Thursday.One day later, she shared another update: “I can barely walk right now I’m in so much pain.” Yet, her final video on Sunday, just hours before her passing, reflected gratitude for life’s smallest moments, a recurring theme in her posts.Her family described Zuza as both brave and honest, saying her openness inspired many to find beauty even in hardship. “More than anything, she wanted to be a normal, healthy kid. But what made her life so beautiful was how she faced the hardest circumstances and still lived fully,” they wrote.What Is Acute Myeloid Leukemia (AML)?According to the National Institute of Health, US, AML is a rapidly progressing myeloid neoplasm characterized by the clonal expansion of primitive hematopoietic stem cells, known as blasts, in the bone marrow. In other words, as the American Cancer Society describes, it is a type of cancer that starts in the blood-forming cells of the bone marrow. The Cancer Research UK explains that it starts from young white blood cells called granulocytes or monocytes in the bone borrow.It is a rare cancer and happens when certain genes or chromosomes mutate. Types of AMLMyeloid leukemia: Involves cells that would normally produce neutrophils, a type of white blood cell.Acute monocytic leukemia (AML-M5): Affects cells that develop into monocytes, another white blood cell.Acute megakaryocytic leukemia (AMLK): Involves cells that should produce platelets or red blood cells.Acute promyelocytic leukemia (APL): Affects immature white blood cells called promyelocytes, preventing them from developing normally.AML affects about 4 in every 100,000 adults each year. Roughly 1,160 children are diagnosed annually in the U.S.Symptoms of Acute Myeloid LeukemiaIn its early stages, AML can feel like a lingering cold or flu. Because it is aggressive, symptoms usually progress quickly and may include:Fatigue, weakness, or dizzinessFever and night sweatsEasy bruising or bleeding (such as nosebleeds or bleeding gums)Frequent or persistent infectionsLoss of appetite and unexplained weight lossShortness of breathPale or cold skinHeadaches or swollen lymph nodesBone, back, or abdominal painTiny red spots on the skin (petechiae)Wounds or sores that don’t heal

14-year-old instagram influencer diagnosed with acute myeloid leukemia passes away

Aarushi Bhadury

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Nutrition

Common Sugary Drinks Can Increase The Risk Of Colorectal Cancer: Study Reveals A Direct Link To Advancement Of The Cancer

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GPs in England are being urged to adopt a “Jess’s Rule”, an initiative that urges doctors to rethink their treatment if, even after three patient appointments, the patient is still experiencing the same undiagnosed symptoms. This new initiative, called Jess's Rule, is being rolled out across the NHS to help prevent avoidable deaths by catching serious illnesses earlier, especially in young people. The rule is not a law, but a strong directive designed to make a more thorough diagnostic process standard practice nationwide.

While this new rule may help many people, it is a direct result of the tragic story of <span>Jessica Brady</span>. At just 27, she passed away from advanced stage 4 cancer in 2020. Before her diagnosis, she had more than twenty appointments with her GP practice over five months, all while her symptoms were getting progressively worse. Despite her persistence, her condition was repeatedly misdiagnosed or dismissed. 

Ultimately, her family had to seek private care, and only then was she diagnosed with a type of cancer so advanced that no treatment was possible. She died just three weeks after her diagnosis. Jessica's story highlights the critical need for a system that ensures a patient's concerns are taken seriously, especially when initial treatments or diagnoses aren't working. 

<h2>Who Is At Risk For Less Cancer Diagnoses? </h2>

A big aspect of Jess's Rule is its focus on reducing health inequalities. Studies have shown that younger patients and those from minority backgrounds often face delays in getting a proper diagnosis. One of the reasons given was that their symptoms might not fit the typical patterns seen in older or white patients, which then leads to their concerns being dismissed. 

According to Gov.UK, a report found that half of all 16 to 24-year-olds with cancer needed three or more appointments to get a diagnosis. Jess's Rule is made to combat this problem by focusing on the fact that a patient's age or background should not be a reason to overlook a potential serious illness. 

The NHS hopes that this rule, which is urged to be followed across the nation, will help ensure everyone receives the same high standard of care. This initiative is a tribute to Jessica's legacy and her family's tireless efforts to prevent other families from enduring similar grief. 

Jess's Rule isn't a strict law, but it's a guide for medical professionals. When a patient's symptoms don't improve after three appointments, the rule suggests that the GP should take further action. This step might include moving from phone consultations to a face-to-face appointment, conducting a more in-depth physical examination, or ordering additional tests. 

It also encourages doctors to review the patient's records carefully, consult with a colleague for a second opinion, or refer the patient to a specialist. The aim is to formalize what many good doctors already do: if something isn't right, don't give up. 

According to Health and Social Care Secretary Wes Streeting, Jessica's death was a "preventable and unnecessary tragedy," and Jess's Rule will ensure that every patient receives "thorough, compassionate, and safe care." The initiative is a collaborative effort between the Royal College of General Practitioners (RCGP) and NHS England.

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GPs in England are being urged to adopt a “Jess’s Rule”, an initiative that urges doctors to rethink their treatment if, even after three patient appointments, the patient is still experiencing the same undiagnosed symptoms. This new initiative, called Jess's Rule, is being rolled out across the NHS to help prevent avoidable deaths by catching serious illnesses earlier, especially in young people. The rule is not a law, but a strong directive designed to make a more thorough diagnostic process standard practice nationwide.Who Is Jess from Jess’s Rule? While this new rule may help many people, it is a direct result of the tragic story of Jessica Brady. At just 27, she passed away from advanced stage 4 cancer in 2020. Before her diagnosis, she had more than twenty appointments with her GP practice over five months, all while her symptoms were getting progressively worse. Despite her persistence, her condition was repeatedly misdiagnosed or dismissed. Ultimately, her family had to seek private care, and only then was she diagnosed with a type of cancer so advanced that no treatment was possible. She died just three weeks after her diagnosis. Jessica's story highlights the critical need for a system that ensures a patient's concerns are taken seriously, especially when initial treatments or diagnoses aren't working. Who Is At Risk For Less Cancer Diagnoses? A big aspect of Jess's Rule is its focus on reducing health inequalities. Studies have shown that younger patients and those from minority backgrounds often face delays in getting a proper diagnosis. One of the reasons given was that their symptoms might not fit the typical patterns seen in older or white patients, which then leads to their concerns being dismissed. According to Gov.UK, a report found that half of all 16 to 24-year-olds with cancer needed three or more appointments to get a diagnosis. Jess's Rule is made to combat this problem by focusing on the fact that a patient's age or background should not be a reason to overlook a potential serious illness. The NHS hopes that this rule, which is urged to be followed across the nation, will help ensure everyone receives the same high standard of care. This initiative is a tribute to Jessica's legacy and her family's tireless efforts to prevent other families from enduring similar grief. How Does Jess’s Rule Work? Jess's Rule isn't a strict law, but it's a guide for medical professionals. When a patient's symptoms don't improve after three appointments, the rule suggests that the GP should take further action. This step might include moving from phone consultations to a face-to-face appointment, conducting a more in-depth physical examination, or ordering additional tests. It also encourages doctors to review the patient's records carefully, consult with a colleague for a second opinion, or refer the patient to a specialist. The aim is to formalize what many good doctors already do: if something isn't right, don't give up. According to Health and Social Care Secretary Wes Streeting, Jessica's death was a "preventable and unnecessary tragedy," and Jess's Rule will ensure that every patient receives "thorough, compassionate, and safe care." The initiative is a collaborative effort between the Royal College of General Practitioners (RCGP) and NHS England.

What Is Jess's Rule? How A Missed Cancer Diagnosis Led To A New Rule For General Practitioners

what is jess's rule? how a missed cancer diagnosis led to a new rule for general practitioners

What Is Leucovorin? The Drug Trump Suggests As A Treatment For Autism?

What Is Leucovorin - The Drug Trump Suggests As A Treatment For Autism?

Tylenol And Autism: Trump Announces Link Between The Two, Science Does Not Back Him

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US President Donald Trump held a<a href="https://www.healthandme.com/health-news/tylenol-and-autism-trump-announces-link-between-the-two-science-does-not-back-him-article-152876441" data-type="tilCustomLink" target="_blank"> press conference to announce the connection between the use of Tylenol</a>, a popular pain and fever relief medicine during pregnancy and <span>autism</span>. Trump in the press conference also suggested <span>Leucovorin</span>, as a potential treatment for autism symptom.

<strong>Read: </strong><a href="https://www.healthandme.com/health-news/tylenol-and-autism-trump-announces-link-between-the-two-science-does-not-back-him-article-152876441" data-type="tilCustomLink">Tylenol And Autism: Trump Announces Link Between The Two, Science Does Not Back Him</a> 

<h2><span rel="noindex">What Is Leucovorin</span>?</h2>

It is known as <span>folinic acid</span>, a form of folate, also an essential B vitamin or B9, which has been approved by the US Food and Drug Administration (<span>FDA</span>) for counteracting the toxic effects of certain cancer drugs. It can counteract methotrexate that blocks body's use of folate. 

The drug is also used to enhance the effects of chemotherapy drugs and to treat specific types of anemia. 

<h2>How Is Leucovorin Administered? Who Makes Leucovorin?</h2>

The drug can be administered orally or intravenously. While it is manufactured by dozens of companies, notes US FDA, on Monday itself, FDA published a notice to the Federal Register ahead of Trump's press conference to approve a version of Leucovorin manufactured by GlaxoSmithKline or GSK. 

GSK had previously withdrawn from FDA's consideration when it stopped making the drug. However, as per the FDA notice, "The FDA is working with GSK, the innovator of Wellcovorin (leucovorin calcium), on a process to include the essential scientific information needed for the safe and effective use of these drug products for adults and pediatric patients with CFD (cerebral folate deficiency)."

<h2>Is Leucovorin Effective For Autism?</h2>

As per the FDA notice, leucovorin calcium, branded as Wellcovorin by GSK is sent for approval for patients with cerebral folate deficiency, which is a neurological condition that affects folate, an essential vitamin for brain health, transport into the brain.

The FDA notice mentions that individuals with CFD have been "observed to have developmental delays with autistic features". 

FDA Commissioner Marty Makary, MF, MPH said that in over two decades, the US has "witnessed a tragic four-fold increase in autism". He further noted: "Children are suffering and deserve access to potential treatments that have shown promise. We are using gold standard science and common sense to deliver for the American people.” 

George Tidmarsh, MD, PhD, Director of the FDA's Center for Drug Evaluation and Research said that FDA is collaborating with GSK to broaden the existing Wellcovorin label and is committed to "finding and treating the root causes of autism".

<strong>Read: </strong><a href="https://www.healthandme.com/health-news/trumps-claim-on-linking-tylenol-and-autism-is-unscientific-according-to-doctors-article-152876959" data-type="tilCustomLink">Trump's Claim On Linking Tylenol And Autism Is Unscientific, According To Doctors</a> 

<h2>Why Leucovorin Is Considered To Treat Autism?</h2>

Doctors have been using leucovorin off-label for autism, repurposing the drug beyond its original approval, reported <em>Reuters</em>. 

Research from <strong>SUNY Downstate Medical Center</strong> and others suggests that as many as three-quarters of children with autism may have genetic variations or autoimmune issues that interfere with folate processing in the brain.

Smaller studies have linked these problems to more severe autism symptoms and found that leucovorin treatment may help improve speech, social interaction, and irritability. Still, the Autism Science Foundation cautions that the research is in its early stages, and more evidence is needed before firm conclusions can be drawn.

<strong>Read: </strong><a href="https://www.healthandme.com/health-news/trump-suggests-changes-in-childhood-vaccines-says-it-is-based-on-what-he-feels-article-152876627" data-type="tilCustomLink">Trump Suggests Changes In Childhood Vaccines, Says It Is Based On What He Feels</a>

A <strong>2016 study </strong>published in <em>Molecular Psychiatry</em>, which was a randomized controlled trial suggested that this specialized form of folate can improve communication and language skills in some children with Autism Spectrum Disorder (ASD). 

A<strong> June 2020 study</strong> published in the<em> Seminars in Pediatric Neurology </em>suggests folate (vitamin B9) plays a vital role in brain development and function, helping with DNA synthesis, methylation, and neurotransmitter production. Some children with autism struggle with folate metabolism, particularly in transporting folate into the brain, a condition known as cerebral folate deficiency.

Another<strong> 2020 study</strong> published in October in <em>Seminars in Pediatric Neurology </em>suggests that in many cases, the immune system produces antibodies that target the folate receptor alpha (FRα) on brain cells. These folate receptor autoantibodies (FRAA) block folate entry into the brain, resulting in low brain folate levels even when blood levels are normal. While only about 5–10% of the general population carries these antibodies, research suggests that 50–70% of children with autism may have them. This disruption is thought to significantly affect speech and cognitive development.

However, Dr. David Mandell, a professor of psychiatry and autism expert at the University of Pennsylvania, told <em>Reuters </em>that leucovorin might well be a possible treatment for some children with autism, "but the evidence we have supporting it... is really, really weak."

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autism

leucovorin autism

US President Donald Trump held a press conference to announce the connection between the use of Tylenol, a popular pain and fever relief medicine during pregnancy and autism. Trump in the press conference also suggested Leucovorin, as a potential treatment for autism symptom.Read: Tylenol And Autism: Trump Announces Link Between The Two, Science Does Not Back Him What Is Leucovorin?It is known as folinic acid, a form of folate, also an essential B vitamin or B9, which has been approved by the US Food and Drug Administration (FDA) for counteracting the toxic effects of certain cancer drugs. It can counteract methotrexate that blocks body's use of folate. The drug is also used to enhance the effects of chemotherapy drugs and to treat specific types of anemia. How Is Leucovorin Administered? Who Makes Leucovorin?The drug can be administered orally or intravenously. While it is manufactured by dozens of companies, notes US FDA, on Monday itself, FDA published a notice to the Federal Register ahead of Trump's press conference to approve a version of Leucovorin manufactured by GlaxoSmithKline or GSK. GSK had previously withdrawn from FDA's consideration when it stopped making the drug. However, as per the FDA notice, "The FDA is working with GSK, the innovator of Wellcovorin (leucovorin calcium), on a process to include the essential scientific information needed for the safe and effective use of these drug products for adults and pediatric patients with CFD (cerebral folate deficiency)."Is Leucovorin Effective For Autism?As per the FDA notice, leucovorin calcium, branded as Wellcovorin by GSK is sent for approval for patients with cerebral folate deficiency, which is a neurological condition that affects folate, an essential vitamin for brain health, transport into the brain.The FDA notice mentions that individuals with CFD have been "observed to have developmental delays with autistic features". FDA Commissioner Marty Makary, MF, MPH said that in over two decades, the US has "witnessed a tragic four-fold increase in autism". He further noted: "Children are suffering and deserve access to potential treatments that have shown promise. We are using gold standard science and common sense to deliver for the American people.” George Tidmarsh, MD, PhD, Director of the FDA's Center for Drug Evaluation and Research said that FDA is collaborating with GSK to broaden the existing Wellcovorin label and is committed to "finding and treating the root causes of autism".Read: Trump's Claim On Linking Tylenol And Autism Is Unscientific, According To Doctors Why Leucovorin Is Considered To Treat Autism?Doctors have been using leucovorin off-label for autism, repurposing the drug beyond its original approval, reported Reuters. Research from SUNY Downstate Medical Center and others suggests that as many as three-quarters of children with autism may have genetic variations or autoimmune issues that interfere with folate processing in the brain.Smaller studies have linked these problems to more severe autism symptoms and found that leucovorin treatment may help improve speech, social interaction, and irritability. Still, the Autism Science Foundation cautions that the research is in its early stages, and more evidence is needed before firm conclusions can be drawn.Read: Trump Suggests Changes In Childhood Vaccines, Says It Is Based On What He FeelsA 2016 study published in Molecular Psychiatry, which was a randomized controlled trial suggested that this specialized form of folate can improve communication and language skills in some children with Autism Spectrum Disorder (ASD). A June 2020 study published in the Seminars in Pediatric Neurology suggests folate (vitamin B9) plays a vital role in brain development and function, helping with DNA synthesis, methylation, and neurotransmitter production. Some children with autism struggle with folate metabolism, particularly in transporting folate into the brain, a condition known as cerebral folate deficiency.Another 2020 study published in October in Seminars in Pediatric Neurology suggests that in many cases, the immune system produces antibodies that target the folate receptor alpha (FRα) on brain cells. These folate receptor autoantibodies (FRAA) block folate entry into the brain, resulting in low brain folate levels even when blood levels are normal. While only about 5–10% of the general population carries these antibodies, research suggests that 50–70% of children with autism may have them. This disruption is thought to significantly affect speech and cognitive development.However, Dr. David Mandell, a professor of psychiatry and autism expert at the University of Pennsylvania, told Reuters that leucovorin might well be a possible treatment for some children with autism, "but the evidence we have supporting it... is really, really weak."

what is leucovorin - the drug trump suggests as a treatment for autism?

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