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Itisha Arya

Doctors Warn: Omeprazole Could Trigger Dangerous Reactions With Diazepam And More — See Full List

omeprazole dangerous reaction

Those taking <span>omeprazole</span> have been warned that certain other substances entering their system could undermine the effectiveness of the medication. Widely prescribed across the UK, this proton pump inhibitor (PPI) helps treat conditions such as heartburn, stomach ulcers, and gastro-oesophageal reflux disease (GERD). It works by lowering stomach acid levels and is available in multiple forms, including capsules, tablets, and liquids. Health guidance usually recommends that over-the-counter use should not exceed two weeks due to the risk of side effects.

However, depending on the severity of a person’s condition, a GP may advise continuing omeprazole for a longer period through prescription. <span>NHS</span> guidance highlights that if someone is taking multiple medications, certain drugs may interfere with omeprazole’s action.

Omeprazole, sold under brand names such as Prilosec and Losec, is a commonly used medication that lowers the amount of acid the stomach produces. It belongs to a class of drugs called proton pump inhibitors (PPIs) and is used to treat conditions caused by excessive stomach acid, including heartburn, gastroesophageal reflux disease (GERD), and stomach ulcers, as per NHS.

<h2>Other Medicines That May Affect Omeprazole</h2>

The NHS UK website states: "There are some medicines, remedies and supplements that may not mix well with omeprazole."

Drug interactions can influence how well omeprazole works. Conversely, omeprazole itself may cause other medications to lose their effectiveness or behave differently than intended.

<h2>Medicines You Should Not Mix With Omeprazole</h2>

The NHS warns that people on omeprazole should be cautious with certain drugs, including:

<ul><li>Lansoprazole</li><li>Famotidine</li><li>Diazepam</li><li>Warfarin</li><li>Clopidogrel</li><li>Digoxin</li><li>Phenytoin</li><li>St John’s Wort</li><li>Atazanavir</li><li>Nelfinavir</li></ul>It’s also important to limit alcohol consumption while taking omeprazole, as alcohol can increase stomach acid and worsen the very symptoms the medication is intended to relieve.

<h2>Consult Your Doctor or Pharmacist</h2>

This list does not cover every medicine that may interact with omeprazole. If you are taking omeprazole, the NHS recommends checking with your doctor or pharmacist before taking any other medications, vitamins, supplements, or herbal remedies.

The leaflet included with your omeprazole pack provides further details about possible interactions. If you are unsure about the safety of combining omeprazole with other substances, it is best to seek advice from a pharmacist or doctor.

<h2>Why Long-Term Use of PPIs Can Be Risky</h2>

Dr Punam Krishan from BBC Morning Live cautioned that while proton pump inhibitors (PPIs) are generally safe when used as directed, they are not meant for indefinite use. “These medications shouldn’t be taken unnecessarily or for extended periods without a doctor’s oversight,” she said.

Prolonged use may slightly increase the risk of low magnesium or vitamin B12 levels and can make gut infections, particularly Clostridioides difficile (C. diff), more likely.

C. diff is a bacterium normally present in the gut, but it can multiply excessively when the gut balance is disrupted, sometimes leading to persistent diarrhoea. “That’s a warning sign,” Dr Krishan noted. “If you experience diarrhoea or notice changes in your bowel habits, consult your doctor right away. Regular check-ups are essential for anyone taking PPIs long-term.”

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Those taking omeprazole have been warned that certain other substances entering their system could undermine the effectiveness of the medication. Widely prescribed across the UK, this proton pump inhibitor (PPI) helps treat conditions such as heartburn, stomach ulcers, and gastro-oesophageal reflux disease (GERD). It works by lowering stomach acid levels and is available in multiple forms, including capsules, tablets, and liquids. Health guidance usually recommends that over-the-counter use should not exceed two weeks due to the risk of side effects.However, depending on the severity of a person’s condition, a GP may advise continuing omeprazole for a longer period through prescription. NHS guidance highlights that if someone is taking multiple medications, certain drugs may interfere with omeprazole’s action.What Is Omeprazole?Omeprazole, sold under brand names such as Prilosec and Losec, is a commonly used medication that lowers the amount of acid the stomach produces. It belongs to a class of drugs called proton pump inhibitors (PPIs) and is used to treat conditions caused by excessive stomach acid, including heartburn, gastroesophageal reflux disease (GERD), and stomach ulcers, as per NHS.Other Medicines That May Affect OmeprazoleThe NHS UK website states: "There are some medicines, remedies and supplements that may not mix well with omeprazole."Drug interactions can influence how well omeprazole works. Conversely, omeprazole itself may cause other medications to lose their effectiveness or behave differently than intended.Medicines You Should Not Mix With OmeprazoleThe NHS warns that people on omeprazole should be cautious with certain drugs, including:LansoprazoleFamotidineDiazepamWarfarinClopidogrelDigoxinPhenytoinSt John’s WortAtazanavirNelfinavirIt’s also important to limit alcohol consumption while taking omeprazole, as alcohol can increase stomach acid and worsen the very symptoms the medication is intended to relieve.Consult Your Doctor or PharmacistThis list does not cover every medicine that may interact with omeprazole. If you are taking omeprazole, the NHS recommends checking with your doctor or pharmacist before taking any other medications, vitamins, supplements, or herbal remedies.The leaflet included with your omeprazole pack provides further details about possible interactions. If you are unsure about the safety of combining omeprazole with other substances, it is best to seek advice from a pharmacist or doctor.Why Long-Term Use of PPIs Can Be RiskyDr Punam Krishan from BBC Morning Live cautioned that while proton pump inhibitors (PPIs) are generally safe when used as directed, they are not meant for indefinite use. “These medications shouldn’t be taken unnecessarily or for extended periods without a doctor’s oversight,” she said.Prolonged use may slightly increase the risk of low magnesium or vitamin B12 levels and can make gut infections, particularly Clostridioides difficile (C. diff), more likely.C. diff is a bacterium normally present in the gut, but it can multiply excessively when the gut balance is disrupted, sometimes leading to persistent diarrhoea. “That’s a warning sign,” Dr Krishan noted. “If you experience diarrhoea or notice changes in your bowel habits, consult your doctor right away. Regular check-ups are essential for anyone taking PPIs long-term.”