Dr. Mathew Samuel Kalarickal, a pioneer of interventional cardiology, has passed away on April 18, 2025, in Chennai, at the age of 77, marking an end to an era in coronary angioplasty and stenting technology. Popularly known as the 'Father of Angioplasty in India,' Dr. Kalarickal transformed heart care, changing the lives of thousands of patients and redefining the face of contemporary interventional cardiology.

Born on January 6, 1948, in Kerala, Dr. Kalarickal's journey to becoming one of the world's most renowned cardiologists was set early in life. After completing his medical studies at Kottayam Medical College, he went on to pursue specialization in cardiology from Chennai but his stint in the United States of America, under the guidance of Dr. Andreas Gruentzig—the man universally accepted as the 'Father of Coronary Angioplasty'—would establish the foundation for his groundbreaking career.

Dr. Kalarickal's return to India in 1985 proved to be turning point. Coronary angioplasty was a new, unexplored area in India at that time, and one that fell behind progress in the U.S. and Europe. Sensing this lacuna, Dr. Kalarickal chose to introduce this revolutionary procedure to India, with a vision of making lifesaving heart procedures reach more people.

First Angioplasty in India

In 1986, Dr. Kalarickal performed the very first angioplasty in India, a process which would subsequently alter the direction of heart treatment in the country. Angioplasty at that time was not a widely known procedure in India, and coronary artery disease was on the rise. During the first year, he had only treated 18 patients. But by 1987, that figure had risen to 150, an unmistakable indicator of both the increasing demand for this life-saving operation and the confidence that patients had in Dr. Kalarickal's skills.

His success in India did not remain confined to its borders, Dr. Kalarickal played a key role in setting up angioplasty centers in various nations in the Asia-Pacific region, such as Pakistan, Bangladesh, Sri Lanka, the United Arab Emirates, Indonesia, Thailand, and Malaysia. His relentless efforts to educate and train physicians in these nations helped ensure that this new technique spread like wildfire, eventually saving countless lives and making heart procedures more available worldwide.

Role of Dr. Kalarickal in Expanding Angioplasty Globally

Dr. Kalarickal's role was not just to bring angioplasty to India and the rest of the region. As an innovator, he was a pioneer in bringing new innovations to the world of angioplasty and stenting. One of his greatest feats was becoming the first Indian cardiologist to introduce and practice the application of drug-eluting bio-absorbable stents, which improved the efficacy of angioplasty by a large margin and minimized the threat of re-blockage in coronary arteries.

Having done more than 10,000 angioplasties, Dr. Kalarickal's expertise and commitment to improving heart health were second to none. He also contributed significantly to academia, establishing the National Angioplasty Registry of India, through which data on angioplasty operations could be gathered and analyzed to streamline and enhance practice nationwide. His contributions had an effect on the medical fraternity and made him a mentor to numerous budding cardiologists in India and overseas.

Dr. Kalarickal's success was not limited to the operating room. His leadership positions in major medical societies demonstrate his reputation as a world leader in interventional cardiology. He was president of the Asian-Pacific Society of Interventional Cardiology from 1995 to 1997 and then went on to chair the Asian-Pacific Society of Cardiology section of Interventional Cardiology between 1995 and 1999. His presidency in these societies promoted the use of angioplasty and stenting procedures around the world and consolidated the group of cardiologists in Asia.

His work was duly appreciated in many awards and honors. Dr. Kalarickal received the esteemed Padma Shri award in 2000, one of the highest civilian awards in India, for his outstanding work in cardiology. He was also awarded the Dr. B.C. Roy Award in 1996 for his notable contributions to medicine, the Doctor of Science Award by Dr. M.G.R. University in 2003, and a Lifetime Achievement Award in 2008.

While Dr. Kalarickal was well-known for his medical knowledge, he was as much admired for being a mentor. Dr. Sai Satish, who is a senior interventional cardiologist in Chennai, was trained by Dr. Kalarickal and collaborated with him for more than two decades. Talking about his experiences during his mentor's time, Dr. Satish stated, "There will never be another Dr. Mathew Samuel Kalarickal in my life.". He taught me in ways that few people ever managed, and I will miss him every time I enter a cath lab." This is a sentiment shared by many other cardiologists who were fortunate enough to learn from him. His dedication to educating and empowering the future generation of heart doctors has left an invaluable legacy on the specialty of cardiology.

Dr. Kalarickal's contributions have saved thousands of lives, and his legacy will never be lost in the profession of interventional cardiology. His vision, commitment, and pioneering attitude have revolutionized heart disease treatment in India and across the globe. With the advent of angioplasty, he revolutionized the procedure that used to be an extremely invasive and dangerous one and turned it into a routine, life-saving one.

How Angioplasty Saves Your Heart?

Angioplasty is a minimally invasive procedure to open up narrowed or blocked coronary arteries due to a buildup of fatty plaques. Plaque buildup in the arteries over time can limit blood supply to the heart, resulting in angina (chest pain) or even heart attacks. Angioplasty is done to relieve these blockages, restore normal blood flow, and prevent heart-related complications. But in what way precisely does angioplasty save the heart?

While undergoing angioplasty, a catheter is inserted into the clogged artery with a balloon at the end. The catheter is advanced through the bloodstream with great caution until it enters the area where the blockage is. Having reached its destination, the balloon is inflated, pushing the plaque against the artery walls, effectively opening up the artery and reinstating blood circulation to the heart. In most instances, a tiny mesh tube known as a stent is also inserted to keep the artery open and prevent it from closing again.

Angioplasty can be carried out in patients with different types of coronary artery disease, such as patients who have experienced heart attacks, those with chronic angina, and those at high risk for cardiac events due to plaque deposition. Angioplasty is commonly carried out on patients who are not ideal candidates for standard open-heart surgery.

Instant Relief and Long-term Advantages

Perhaps the greatest benefit of angioplasty is the relief that it brings promptly to the patient. Post-procedure, patients can notice dramatically decreased symptoms of chest pain, shortness of breath, and tiredness, all typical with clogged arteries. The normalization of blood flow tends to keep the heart from working as hard and lowers the risk of heart attacks.

In the long run, angioplasty ensures that the heart is not subjected to further harm by providing it with a sufficient supply of oxygenated blood. This is particularly vital in individuals suffering from coronary artery disease because continuous blood flow is crucial to maintaining heart muscle health. Angioplasty can greatly eliminate the risk of heart failure, heart attack, or stroke by opening up clogged arteries. Also, the procedure has been demonstrated to enhance quality of life in general, since patients are frequently able to resume normal activities following the procedure without the restrictions created by chest pain and other symptoms.

One moment, Dr Cornelius Sullivan was focused on a patient during surgery, and the next moment, he woke up in ambulance, headed to the emergency room.

According to the American Society of Anesthesiologists (ASA), Dr Sullivan had struck his head on a monitor that had been moved behind him in a surgery center. This serious accident had resulted in a two-night hospital stay and kept him away from work for weeks. However, this is not the first time he had suffered a work-related injury. This is, in fact, the third time this has happened, noted ASA.

"Boom Strikes"

These injuries are often called "boom strikes". These occur when anesthesiologists accidentally bump into operating room (OR) equipment that is mounted on fixed or moveable arms. These could be monitors, lights, or screens.

While any OR staff member could be hurt this way, anesthesiologists are particularly more vulnerable to such injuries. Their work requires them to operate in tight, also, often crowded spaces. It also requires them to move quickly during emergencies, which further increases the risk of collision with equipment.

Why The Problem Is Growing?

As per ASA, the risk of boom strikes have been on the rise. This is also because of an increase in sophisticated equipment being added to operating rooms and surgeries are also now performed in much smaller spaces.

As per a survey conducted by the organization, it was found that more than half of anesthesiologists reported experiencing at least one work-related injury, including head injuries. These numbers have highlighted the growing concern over physical safety in an already demanding and high-pressure environment.

Can New Guidelines Improve Safety?

In response to these alarming findings, the ASA has issued a new Statement on Anesthesiologist Head Injuries in Anesthetizing Locations.

The statement formally recognizes boom strikes as a serious occupational hazard and even a potential medical emergency — especially dangerous during outpatient procedures or in cases where no backup anesthesiologist is immediately available to take over patient care.

Dr. Mary Ann Vann, chair of ASA's Ad Hoc Committee on the Physical Demands of Anesthesiologists, also experienced a work-related head injury. Drawing from personal experience, Dr. Vann helped develop the new safety recommendations, aimed at preventing such incidents.

What Have Been The Key Recommendations?

The ASA outlined several measures to reduce the risk of head injuries among anesthesiologists, including:

Holding Regular Safety Meetings: OR teams should meet frequently to discuss safety concerns and review past incidents.

Creating Safety Teams: Special teams should be tasked with reviewing and tracking reports of boom strikes to identify patterns and solutions.

Involving Anesthesia Staff in Room Planning: Clinical anesthesia personnel should have a voice when designing or rearranging procedure rooms to ensure equipment placement considers movement and space needs.

Tracking Head Injuries: Systematic documentation of head injuries can help health systems better understand causes and outcomes, leading to more informed prevention strategies.

The ASA emphasized that head injuries in the OR are not just minor accidents but events that can have serious consequences for patient safety and anesthesiologists’ health.

By implementing the new guidelines and raising awareness, the ASA hopes to make operating rooms safer environments for all medical professionals — and ensure that anesthesiologists can continue their vital work without unnecessary risk.

As the United States battles its worst measles outbreak in decades, a disturbing controversy is brewing. Public health is being complicated not just by the virus's spread but also by the promotion of suspicious medical practices at the top levels of leadership. Robert F. Kennedy Jr., long-time critic of mandatory vaccinations and current Health Secretary, has openly endorsed a Texas physician who saw patients with children while actually infected with measles an action warned by health officials to potentially have devastating effects on public health.

The Centers for Disease Control and Prevention (CDC) reported measles infections skyrocketed to 884 cases of confirmed infection in 29 states during 2025, with areas of concentration being Texas, New York, California, and other regions. Texas alone represents 646 cases, making it the center of the outbreak. Scarily, at least six states, Indiana and Ohio included, have shown outbreaks, a definition used when there are three or more linked cases. The increase has already killed at least three people, two of whom are young children.

The measles resurgence is a grim reminder of just how easily highly infectious measles can re-establish itself among populations, particularly if vaccination is below par. Deemed eradicated in the United States as far back as 2000, measles teeters on the cusp of endemically reintroducing itself today—a failure at public health for which increasing numbers of professionals presume vaccine hesitation lies at its center.

In recent interviews, Kennedy has doubled down on his views that natural immunity is superior to vaccine-induced protection. On Fox News, he wistfully remembered a day when "everybody got measles" and acquired lifelong immunity. It is true that measles infection normally provides lasting immunity, but the disease also poses serious risks, such as encephalitis, blindness, and death—risks that have been greatly diminished by vaccines.

Kennedy has posited that the Measles, Mumps, and Rubella (MMR) vaccine is capable of producing adverse reactions and should always be a question of individual choice and not one of public health mandate. Nonetheless, public health officials emphasize that the risks entailed by the vaccine are phenomenally low relative to the threat posed by the disease itself.

Controversy mounted when a video appeared depicting Dr. Ben Edwards, a Texas doctor, seeing patients while obviously infected with measles. Filmed in a pop-up clinic established by anti-vaccine activists, the video depicts Edwards affirming he came down with symptoms--including a rash and low-grade fever--a day before the footage was taken.

Even though he knew he was contagious, Edwards kept seeing patients without proper protective equipment, such as an N95 mask. Experts say this action probably infected countless people particularly children and their families with a potentially deadly virus.

Rather than condemning Edwards' actions, Kennedy greeted him days later and publicly endorsed him on social media as an "extraordinary healer." Together with another doctor, Edwards was praised for advocating alternative care such as vitamins and cod liver oil—none of which are shown to prevent or cure measles.

Risk of Misinformation

Top health experts have been quick to denounce both Edwards' behavior and Kennedy's support. Measles is one of the most infectious diseases known to science, with the virus able to remain in the air for up to two hours after an infected individual has vacated the room. People are infectious for a number of days before and after the rash has erupted.

Dr. Saad Omer, Director of the Yale Institute for Global Health, has declared the move "an egregious violation of basic public health principles," warning that endorsement by officials could encourage others to disregard safety measures and fuel outbreaks even further.

Worryingly, Dr. Edwards himself disclosed in the video that he'd been given numerous doses of MMR vaccine and yet had got measles, insisting that vaccine-acquired immunity "wears off." Health officials explain that whereas immunity would inevitably wane fractionally over years, two shots of MMR vaccine are approximately 97% effective in avertting measles.

Why Measles May Become Endemic?

The stakes are high. Recent research from Stanford University shows that even slight declines in vaccination rates could make measles endemic in the United States within two decades. A 10-percentage-point drop could lead to millions of cases over 25 years, reversing decades of public health progress.

The COVID-19 pandemic interrupted childhood immunizations worldwide, but vaccine hesitancy had already been increasing prior to 2020, driven by misinformation campaigns and politicized rhetoric. In a time when skepticism of health authorities is on the rise, the implications of such distrust could be disastrous.

Public health experts are calling for action now to slow the current epidemic and avoid future ones. Getting more people vaccinated—even by 5%—would dramatically decrease the number of future cases of measles, keep vulnerable groups such as infants and immunocompromised patients safe, and save lives.

Measles Prevention

Parents should feel free to discuss vaccine safety and effectiveness openly with pediatricians. Policymakers need to re-emphasize school-entry vaccine mandates and continue working to push back against lethal disinformation.

The MMR shot is still the gold standard of protection. The CDC recommends that children should get two doses and that travelers should make sure to get vaccinated a minimum of two weeks prior to traveling internationally. As this current outbreak proves, complacency is not an option.

As measles cases increase and public trust in vaccines erodes, America is at a crossroads. Leaders can be the voice of reason and protect communities—or fan confusion that gives preventable illnesses an opportunity to flourish. RFK Jr.'s recent actions and endorsements speak to the urgent need for evidence-based, clear leadership on public health. The most vulnerable depend on it.

Tuberculosis (TB) is a deadly global health crisis despite being a curable disease. In 2023 alone, TB killed about 1.25 million people globally — more than any other infectious pathogen. While the ability of months- or years-long courses of antibiotics to kill Mycobacterium tuberculosis, the bacteria that cause the disease, treatment success is not certain for all. In fact, in approximately 12% of patients, TB recurs even after treatment.

The major roadblock is that clinicians today lack a specific test to see if TB bacteria were completely removed from the body by treatment. Failing to have accurate monitoring mechanisms, doctors have to implement the same six-month treatment regimen in all patients and accept that some will be over-treated and some will be failures. However, all that may soon change, thanks of a breakthrough RNA-based TB detection test that Dr. Kayvan Zainabadi, assistant professor of molecular microbiology at Weill Cornell Medicine, and his India-based team are developing.

Modern TB treatment protocols are dependent on clinical experience and sputum-based diagnostic procedures that identify bacterial DNA. However, these procedures are fraught with limitations. Despite the successful treatment, residual bacterial DNA can continue to be present in the patient's system, resulting in false positives and making it difficult to clearly perceive the status of the disease.

This diagnostic imprecision compels physicians to remain with a "one-size-fits-all" six-month treatment regimen, even when evidence indicates that most patients might be cured earlier. Long-term exposure to highly effective antibiotics not only risks patients developing side effects but also places a heavy burden on healthcare systems, particularly in low-resource settings where TB is most prevalent.

Dr. Zainabadi’s research introduces a groundbreaking concept: using ribosomal RNA (rRNA) as a rapid, sensitive, and accurate marker of TB infection. Unlike DNA, RNA is inherently less stable and degrades quickly after bacterial death, minimizing the risk of false positives.

The innovation is aimed at the detection of the 16S rRNA of Mycobacterium tuberculosis, which is a part essential to bacterial protein synthesis. Its prevalence in the cell makes it a prime target for detection even in small or difficult-to-access samples.

Significantly, this RNA-based method might overcome the sputum reliance that is sometimes tricky to obtain from high-risk populations such as children or HIV-infected individuals. Rather, less intrusive sample forms might be utilized, providing a more patient-centered, convenient, and scalable platform.

How Does It Work?

The RNA test operates by extracting 16S rRNA from patient samples and amplifying it using highly sensitive molecular methods. Since rRNA degrades quickly after bacterial cells die, detecting it gives real-time feedback regarding the presence of active TB infection — something DNA-based tests cannot consistently provide.

In practice, a sample would be taken from the patient (possibly from gastric fluid, blood, or other more readily accessible fluids) and run through the RNA detection system. If live bacteria are present, the 16S rRNA signature would show up in the test results, providing clinicians with an instant readout of disease activity.

The rapidity and precision of this methodology may significantly reduce diagnostic turnaround times from weeks or months to mere minutes or hours. This results in quicker clinical decisions, more targeted interventions, and substantial reductions in patient anxiety and healthcare expenditures.

Is It More Helpful Than Other Diagnostic Tests?

In comparison to conventional sputum microscopy and DNA-based molecular diagnostics, the RNA-based test has a number of revolutionary benefits.

First, its ability to target active infection — not just bacterial residue — prevents patients from being subjected to unnecessary or excessive treatment. This specificity is especially important in combating multidrug-resistant TB, where inappropriately using antibiotics exacerbates resistance problems.

Secondly, the fact that it can accept non-sputum samples makes it much more convenient. It is not possible for several children and immunocompromised individuals to produce sufficient sputum, and clinicians are left with the option of using invasive and less effective gastric lavage methods. An RNA-based test would equalize access to proper TB diagnosis among these high-risk populations.

Third, in the field of TB drug discovery, this test might be a game-changer. Rather than waiting two years to determine if a drug is effective, researchers would be able to monitor bacterial clearance in real-time, moving clinical trials forward more quickly and lowering costs.

Lastly, at a macro health systems level, a quick, precise, and less intrusive diagnostic device would be a game-changer for TB-endemic countries where resources are tightly constrained and the disease burden is highest.

The stakes are as high as they could possibly be. TB has continued to be a recalcitrant worldwide killer, too often fueled by diagnostic ambiguity and treatment inefficacy. An RNA-based diagnostic test such as the one Dr. Zainabadi and his colleagues are creating is not only an incremental step but a potential paradigm shift in how we combat the disease.

As the study continues, the expectation is that this new technology will not only revolutionize individual patient treatment but also redefine the public health sector in the global fight against tuberculosis.