India is seeing a new surge in COVID-19 cases, with active cases reaching over 3,395 as of May 31 — nearly three times the number in a little over two weeks. Kerala, Maharashtra, and Delhi have turned into the biggest hotspots, even though health authorities continue to insist that severity is low. The increase, while not alarming in terms of hospitalizations, has seen India's health authorities keeping a closer watch with the identification of new Omicron subvariants and local clusters of cases.

With a sharp spike in active cases India is back on the global health radar. Though the numbers are still low compared to earlier waves, the rising trend in a number of states, along with the identification of new Omicron subvariants, is worth examining.

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India has witnessed an increase in active COVID-19 cases threefold in the last two weeks, from 1,010 on May 19 to 3,395 on May 31, with official government data. The rise is specifically prominent in Kerala, Maharashtra, and Delhi — regions that have typically been early warning signs of wider transmission trends within the country.

Kerala, which currently holds the highest number of active cases at 1,336, has seen a surge from just 430 cases reported on May 26. Maharashtra follows closely with 467 active cases, more than doubling from its 209 count just days ago. Delhi’s trajectory is also concerning, with a leap from 105 to 375 cases in the same period.

Although these figures are still small compared to the peak of the pandemic, the week-on-week surge suggests a possible first wave of transmission that is being watched closely by experts.

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Covid Cases: The Current Clinical Scenario

As much as there has been an increase in case numbers, the severity of infection is still low, highlight the Indian health officials and experts. Majority of the patients are recovering under home isolation and only a few need hospitalization.

Official sources and the Indian Council of Medical Research (ICMR) indicated that there is "no cause for concern" in terms of public health emergency. ICMR Director General Dr. Rajiv Bahl provided assurances to the public, saying, "As of now, the severity is generally low. There's nothing to worry about. We should be vigilant and always be prepared."

This indicates that even as the rate of transmission could be increasing, the healthcare system is not getting strained, and the virus remains following a clinically milder pattern than in earlier waves.

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Where Covid Cases Are Rising?

India's new COVID-19 scenario is extremely regionalized, with southern and western states witnessing initial hints of flare-ups prior to infections starting to rise in northern India.

Here's a closer examination of major states:

Kerala: From 430 cases on May 26 to 1,336 on May 31. Six fatalities have been reported.

Maharashtra: Cases went from 209 to 467; seven deaths have been reported.

Delhi: Triplication of cases, from 105 to 375, with three deaths.

Karnataka: From 47 to 234 active cases in under a week.

Tamil Nadu, Gujarat, Uttar Pradesh, West Bengal, Rajasthan, Madhya Pradesh, and Punjab have all experienced moderate increases.

These figures do not only reflect an increase in transmission but a geographical spread that crosses urban and semi-urban hubs, increasing the stakes for surveillance and containment.

Four COVID deaths in India in the past 24 hours — one in each of Delhi, Kerala, Karnataka, and Uttar Pradesh. Although deaths are still in single digits, the number of deaths in this new spike includes:

• Kerala (6 deaths since May 26)
• Maharashtra (7 deaths)
• Karnataka and Delhi (3 deaths each)
• Other states like Tamil Nadu, Gujarat, Rajasthan, Madhya Pradesh, and Punjab (1 death each)

With the present low rates of hospitalization and minimal clinical severity, these deaths are being assessed in the context of co-morbidities and age-related susceptibility.

Is Multi-Variant Spread Behind the Covid Surge In India?

Epidemiologists are particularly interested in understanding whether new variants may be fueling this latest uptick. According to the Indian SARS-CoV-2 Genomics Consortium (INSACOG), two new Omicron subvariants have been detected in India:

NB.1.8.1: Detected in Tamil Nadu in April

LF.7: Four cases detected in Gujarat in May

Globally, these variants have contributed to a rise in infections in Southeast Asian countries like Singapore, Hong Kong, and parts of China.

Still, the World Health Organization (WHO) now categorizes both NB.1.8.1 and LF.7 as "variants under monitoring" rather than "variants of concern" or "variants of interest." The WHO's current position is that:

"Based on the evidence available, the added public health risk from NB.1.8.1 is assessed as low at a global level."

The most common circulating strain in India is JN.1, with 53% of the sequenced cases, followed by BA.2 with 26%, while the rest of the 20% consists of other Omicron sublineages.

Covid-19: Surveillance and Public Health Strategy

India's response to the ongoing surge is being organized through the Integrated Disease Surveillance Programme (IDSP). The government is focusing on genomic sequencing, local containment strategies, and respiratory hygiene awareness.

Public health messaging remains on high alert but against panic. No restrictions on travel, lockdowns, or new public orders have been implemented thus far.

Dr. Bahl once again reinforced, "People do not need to take any immediate action. They should follow normal precautions. So, there is nothing special to do right now."

That means maintaining current best practices like handwashing, mask-wearing in close indoor environments, and self-isolation when symptomatic.

Covid-19: Should the World Be Concerned Now?

For the global community, India's recent development is a reminder of the unpredictable nature of the pandemic. Although the world has largely left behind COVID-19 as an emergency, localized outbreaks in densely populated areas like India can ripple outward — particularly if emerging variants start to demonstrate greater transmissibility or immune escape.

The positive news still is that vaccines continue to provide strong protection against severe illness, and India's national immunization program has maintained high coverage in adult groups. However, ongoing genomic surveillance and real-time data transparency will remain crucial to avert larger outbreaks.

India's COVID-19 surge, while of limited magnitude and clinical severity, is a multifaceted convergence of regional patterns of transmission, emerging variant sequences, and preparedness in public health. With cases being largely mild and mortality rates low, the nation's health care system is still in hand but not resting on its laurels.

In the meantime, there is no cause for global alarm. Nevertheless, India's experience should prompt health systems everywhere to remain on high alert, keep genomic surveillance going, and inform the public in a transparent manner. The virus is evolving, but so is our combined ability to deal with it.

Keltie Knight, Canadian-born American television presenter and a podcast host, now 43, a couple of years ago had blurry vision. She writes for Telegraph UK that she could not read the teleprompter on set. "I started to panic," she says.

She used to be a professional ballet before her career on television took off. She writes this made her so busy that her health started to deteriorate more and more. "I was so tired that I could have easily slept for 22 hours a day. The walk from my room to the bathroom became so exhausting that sometimes I wouldn’t have the energy to go. My hair started falling out, and I sometimes had rashes and hives all over my body for no reason," she writes.

She usually brushed off the most of it as stress-related, but one day her symptoms became unexplainable.

Keltie Knight Health Update: The Symptom That Triggered Her

She says that three years ago, things got "really bad". She could not see from one of her eyes, and her gum bled "profusely". She was depressed and started to blame herself for having a big career that destroyed her health.

"I told only my husband, Chris, how I was really feeling. I never took a sick day and never complained to anyone at work that I was feeling unwell. Chris was extremely supportive, but I wasn’t myself and I knew it was hard on him. I would come home after a long day of masking and be on another planet. I certainly wasn’t a present wife and constantly worried that I was never going to get better," she says

Keltie Knight Health Update: Doctors Gaslit Her For Years

She said that during that period she visited 15 different doctors. She had also gotten multiple iron blood infusions and tests for every possible disease. "Most of them just told me to eat more vegetables and get some rest."

After a lot of trial and error, she finally found a specialist who carried out an in-depth blood test, which is how she got a diagnosis. She was diagnosed with microcytic anaemia.

Keltie Knight Has Microcytic Anaemia: What It Means

It is a condition where a person's red blood cells are smaller than usual because they do not have enough hemoglobin, which is a protein present in the red blood cell. It helps the red blood cells carry oxygen throughout the body. Low hemoglobin also causes your red blood cells to be paler than normal or "hypochromic".

Keltie Knight Health Update: What Happened After The Diagnosis?

She was also told that her ferritin levels were "incredibly low". It was 8, while 15 is the standard.

"My doctor had a conversation with my gynaecologist and they decided that, due to my deficiency, the best thing they could do was to stop my period completely, because I was losing too much blood," writes Knight.

"We talked through a few options and decided on an ablation, which is effectively burning the lining of the uterus," she writes about her treatment options. However, when she went in for an MRI, her uterus was "heart-shaped", which meant an ablation could not work because the thermal balloon would not be able to reach all parts of it.

Keltie Knight Health Update: Treatment Options

Hysterectomy was the only solution she was left with. This meant that her uterus and her cervix would be removed. Which also meant that she would not only not get her period, but would never be able to have children.

"I had already decided that motherhood wasn’t the right path for me, but it was still a hard decision to make. On the one hand, I was desperate to get better, so I was willing for them to take my uterus and cervix out; on the other, getting a hysterectomy was so final," she writes. Throughout all, she notes, her husband Chris was very supportive.

While the surgery was successful, returning to work was a little bumpy. Returning to work after a month and standing up for long periods was difficult. She says she wore a corset under her clothes "to keep everything tight and upright" in a hope that things would eventually improve, and they did.

Eight months later, she does not have the rashes anymore, her hair is shiny and gorgeous, as she writes, and she was not tired all the time. "I finally felt like myself again."

Nipah virus outbreak in India has triggered screenings across Asian airports. However, the health authorities of the Kolkata hospital where two nurses were admitted confirmed that one of the two nurses has been discharged from hospital. While this may be a good sign, there is still need to be cautious of the virus.

Nipah Virus Outbreak In India: How Does It Work?

Experts and doctors are still telling people to be cautious of what they eat, as the fatality rates are from 40 per cent to as high as 75 per cent. It is a zoonotic infections that infects vital organs like brain and lungs. However, the virus is also able to manipulate body's immune system.

Nipah Virus In India: How Does It Affect Immune System?

Nipah virus is lethal because it can outpace, suppress and misdirect immune responses. Speaking to NDTV, Dr Dip Narayan Mukherjee, Consultant, Microbiology and Infectious Diseases at CK Birla Hospitals said, Nipah virus leaves the body unable to clear the infection in time. "Understanding this immune disruption is critical to explaining why Nipah causes severe encephalitis, multi-organ failure and high mortality, and why early detection and containment remain the most effective tools against it."

This immune disruption begins early in the infection. The body’s first line of defense against viruses is the innate immune system, which relies heavily on interferons. These signalling proteins alert neighboring cells to the threat and trigger antiviral mechanisms that slow viral replication.

“One of the earliest ways Nipah evades immunity is by interfering with the innate immune response,” Dr Mukherjee says. “The virus suppresses interferon activity, allowing it to multiply rapidly before the immune system can respond adequately.”

Research published by the World Health Organization and other virology institutes shows that specific Nipah virus proteins block interferon signalling pathways. This gives the virus a crucial head start, enabling widespread infection before the immune system is fully activated.

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Nipah Virus Outbreak In India: Inflammation And Low Immunity

As the infection progresses, Nipah targets the cells lining blood vessels, a feature that sets it apart from many other respiratory viruses. Damage to these vessels allows the virus to spread to multiple organs, including the brain, while also triggering widespread inflammation.

Instead of a controlled antiviral response, the body releases large amounts of inflammatory molecules. This excessive inflammation leads to tissue injury, swelling and organ dysfunction, contributing to respiratory failure, neurological symptoms and circulatory collapse in severe cases.

Another hallmark of Nipah infection is immune exhaustion. Although the virus does not directly infect most immune cells, the intense inflammatory environment causes them to become overactivated and eventually dysfunctional. Once these defense cells lose their ability to control viral replication, the infection accelerates, and supportive care becomes less effective in later stages.

When Nipah crosses into the brain, immune control becomes even more limited. The brain’s immune responses are naturally restrained to prevent damage, allowing the virus to persist. At the same time, inflammation causes swelling, seizures and encephalitis. Neurological complications remain the leading cause of death in Nipah outbreaks.

Nipah Virus Outbreak In India: Why Antibodies Against The Infection Arrive Late

The adaptive immune response, which includes antibody production and virus-specific T-cells, also struggles to keep pace with the rapid spread of Nipah. By the time neutralizing antibodies are produced, significant organ damage may have already occurred, particularly in the brain. This delayed response explains why severe encephalitis is common even in people without underlying health conditions.

Using artificial intelligence (AI) in breast cancer screening can reduce the number of cancers diagnosed in late stages by 12 percent, according to a major new study from Sweden.

The study found that fewer women in the AI group were diagnosed with breast cancer in the years after screening. There were 1.55 cancers per 1,000 women in the AI-supported group, compared with 1.76 per 1,000 in the standard screening group.

According to lead author Dr Kristina Lang of Lund University in Sweden, this indicates better early identification of clinically relevant cancers. She said of the results: “Our findings show that AI-supported screening improves the early detection of breast cancers that are more likely to become aggressive or advanced.

“This results in fewer serious cancers being diagnosed in the interval between screenings.”

She added that wider adoption of AI-supported mammography could ease workforce pressures on radiologists while improving early detection, including of aggressive cancer subtypes.

What Did The Study Find?

The study, published in The Lancet, involved around 100,000 women who took part in routine mammography screening between April 2021 and December 2022, making it the first large randomised trial to assess how AI performs in real-world breast cancer screening.

Women were randomly divided into two groups. One group received standard screening, where mammograms were read by two radiologists and the other group had AI-supported screening, where an AI system assessed the scans first.

Low-risk cases were read by one radiologist, while higher-risk cases were checked by two, with the AI also flagging suspicious areas.

The results showed that 81 percent of cancers in the AI-supported group were detected during screening, compared with 74 percent in the standard screening group—a nine percent increase. Importantly, false-positive rates remained similar, at 1.5 percent in the AI group and 1.4 percent in the control group.

Despite positive results, Dr Lang cautioned that introducing AI into healthcare must be done carefully, using validated tools and continuous monitoring to understand how performance may vary across regions and over time.

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Breast Cancer: A Rising Crisis

About 1.9 lakh Indian women are diagnosed with breast cancer annually, meaning that a new case is diagnosed every four minutes. On average, a woman in India dies of breast cancer every eight minutes, highlighting how urgently the country needs stronger awareness, early diagnosis and sustained care.

One factor that sets India apart is the age at which women are affected. Almost half of all breast cancer patients in the country are younger than 45. This is a much higher proportion than seen in many Western nations, where the disease is usually detected later in life.

Moreover, sedentary habits, excessive consumption of processed foods as well as alcohol and smoking promotes obesity and hormonal changes which pave the way for breast cancer development.