It is no surprise that when anyone looks for innovation and technology, the first name that comes to their mind is of Japan. In yet another breakthrough, Japan may be too close to invent lab. Last year, it was declared that Japan will begin its clinical study of artificial red blood cells that can be stored for transfusion in times of emergency. This was released by Nara Medical University.

It is now in the process of developing artificial blood cells and aims to put these artificial cells into practical use by 2030. This would be world's first.

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Lab-Grown Blood: Why Is This Happening?

Japan is battling a shrinking population, where the older population dominates the younger ones. In 2024, Japan had a record of high 36.25 million people aged 65 or older, representing 29.3% of the total population. This indicates a significantly larger proportion of elderly citizens as compared to the young population.

This has led to a shortage of blood supply, as older people cannot donate blood. As per the Red Cross Society, donors up to 65 years of age can donate blood. While there is no upper age limit, you must be in good health to meet other eligibility criteria.

A 1987 study published in JAMA titled Blood Donation by the Elderly: Clinical and Policy Considerations, notes that it is far more feasible for individuals within the age bracket of 66 to donate blood. Another comparative study from 2019, published in Biomedical Excellence for Safer Transfusion Collaborative (BEST) Investigators noted that while there is no exclusion for older donors, the limit is solely based on their safety.

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Another reason why this clinical study is being conducted is because white blood cells obtained form already donated blood can only be stored for less than a month at low temperatures. However, the artificial cells can be stored for two years at room temperature. As the artificial cells are also made from any blood type, they can be used without confirming a patients' blood type and could be administered even during transportation by ambulance, confirmed the researchers.

The university also said that if no side effects are confirmed with 400ml of administration, the trial will shift to examine the treatment's efficacy and safety.

Who Is Leading This Study?

A team led by Professor Hiromi Sakai of the Nara Medical University is leading this study. The approach involves extracting hemoglobin, which is the oxygen carrying molecule in the red blood cells from expired donor blood, and then encasing it in a protective shell to create stable, virus-free artificial red blood cells.

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How Artificial Blood is Different From Donated Blood?

The main difference lies in the absence of blood type, which further eliminates the need for compatibility testing. This is what makes it invaluable in the case of emergency.

Professor Teruyuki Komatsu of Chuo University is also leading the artificial oxygen carrier study. This uses albumin-encased hemoglobin to stabilize blood pressure and treat conditions like hemorrhage and stroke. For now, animal studies have shown promising results.

How Is Artificial Blood Made?

The process usually starts with stem cells. This is where special cells are that can in fact develop into different types of cell in your body. This includes red blood cells, platelets, or even skin cells.

Scientists use a specific type of cell called the haematopoietic stem cells, which can produce all types of blood cells, including the WBC, RBC, and platelets. They are then placed in a lab setting to turn these stem cells into blood cells.

Cedric Ghevaert, who is the professor of transfusion medicine at the University of Cambridge, explained that scientists are then able to "gene edit" the stem cells to boost blood production and remove blood group markers, as reported in Aljazeera.

Have Others Tried To Make Artificial Blood?

The United States military has invested $46m in developing ErythroMer, a synthetic blood substitute designed to be universally compatible and stable without refrigeration. The product is still under research.

In 2022, a clinical trial in the UK also marked a breakthrough where laboratory-grown red blood cells were transfused into human volunteers to assess their safety standards and longevity, as reports Aljazeera.

In 2013, the U.S. Defense Advanced Research Projects Agency (DARPA) estimated that producing a single unit of lab-grown blood cost over $90,000. Thanks to improvements in production techniques, that cost has now dropped to under $5,000 per unit. In contrast, hospitals in the U.S. paid an average of just $215 per unit for donated red blood cells in 2019.

Legendary pop singer Connie Francis, whose voice defined an era with heartbreak ballads and upbeat rock-n-roll hits, has died at the age of 87. Her publicist and longtime friend, Ron Roberts, confirmed the news on Facebook on Thursday, writing:

“It is with a heavy heart and extreme sadness that I inform you of the passing of my dear friend Connie Francis last night. I know that Connie would approve that her fans are among the first to learn of this sad news.”

Though the cause of her death has not yet been made public, Francis had been hospitalized just two weeks earlier for what she described as “extreme pain” due to a pelvic fracture. The beloved singer had kept fans updated about her health condition through heartfelt posts on social media.

Health Struggles in Her Final Days

On July 2, Francis shared that she had been hospitalized in Florida, undergoing tests to identify the cause of her pain. Her updates were filled with optimism, despite having been moved to the intensive care unit and missing a scheduled appearance on Cousin Brucie’s Independence Day radio show.

By July 3 and 4, Francis posted that she was “feeling much better,” and expressed gratitude for her supporters. However, she remained under medical observation, and in a post the following week, she revealed that doctors were still trying to get to the root of her condition.

This wasn’t her first health battle.

In May, Francis had shared that she had suffered a hip injury that left her temporarily wheelchair-bound. Her openness about her condition made her all the more endearing to longtime fans who had followed her through the highs and lows of both her professional and personal life.

A Trailblazing Career That Crossed Borders and Genres

Born Concetta Rosa Maria Franconero in 1937, Connie Francis rose to fame in the late 1950s with her breakthrough hit “Who’s Sorry Now,” a song that she famously performed on television after nearly being dropped by her label. The track became a massive hit, charting internationally and setting the stage for a string of chart-topping singles.

She followed with hits like “Stupid Cupid,” “Lipstick on Your Collar,” “Don’t Break the Heart That Loves You,” and the carefree anthem “Vacation.” Her clear, emotional voice resonated with millions and helped her bridge musical genres—from rock ’n’ roll and country to standards and international ballads.

Francis sang in more than a dozen languages, including Italian, Yiddish, and Swedish, and found global success at a time when international stardom was rare for American artists. Her versatility and emotional range made her one of the best-selling female pop stars of her generation.

A Social Media Resurgence in Recent Years

In the digital age, Connie Francis found renewed fame among younger audiences thanks to social media platforms like TikTok and Instagram Reels. Her 1965 song “Pretty Little Baby” became a viral favorite, introducing her music to a new generation and reminding the world of her timeless appeal.

Four people in Florida have died from Vibrio vulnificus, a dangerous bacterium often dubbed the "flesh-eating" bacteria, as the state reports a total of 11 infections this summer. The deaths occurred across Hillsborough, Bay, Broward, and St. Johns counties, according to the Florida Department of Health’s latest update released on July 11.

Cases have also been identified in Duval, Escambia, Lee, Manatee, Santa Rosa, and Walton counties. While the numbers might seem small, health officials say the consequences can be devastating if the infection is not caught early.

What Is Vibrio Vulnificus?

Vibrio vulnificus is a naturally occurring bacterium found in warm saltwater or brackish water, which is a mix of salt and freshwater. It thrives particularly well during the hotter months, which is why infections spike from May through October. According to the Centers for Disease Control and Prevention (CDC), the bacteria is halophilic, meaning it needs salt to survive.

While rare, the infection can cause necrotizing fasciitis. It is a condition where flesh-eating bacteria could destroy the tissue under the skin, and can lead to death in just a few days if left untreated.

How People Get Infected?

According to Dr. Norman Beatty, an infectious disease specialist and associate professor at the University of Florida, as reported by WUSF, West Central Florida's NPR station broadcasting news, there are two main ways people typically contract Vibrio vulnificus.

“We can consume it through contaminated shellfish, specifically oysters,” Beatty said. If ingested, the bacteria can cause symptoms like nausea, vomiting, diarrhea, and abdominal cramps.

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But the more dangerous and more common route, he explains, is through open wounds. “If someone with a cut or scrape enters brackish or saltwater contaminated with Vibrio vulnificus, the bacteria can enter the body through the skin and cause serious infection,” he warned.

Symptoms to Watch For

Symptoms often appear quickly; sometimes within hours of exposure. Early signs include redness, pain, and swelling around the wound. As the infection progresses, it can cause skin ulcers, blisters, and even tissue death. Systemic symptoms like fever, chills, and low blood pressure may also follow.

“A delay in treatment can lead to serious complications, including amputations or even death,” Dr. Beatty cautioned.

Who’s Most at Risk?

People with weakened immune systems, liver disease, or chronic health conditions are at greater risk of developing severe infections. But Dr. Beatty emphasized that even healthy individuals aren’t immune.

“I’ve seen otherwise healthy people who got a small cut while fishing or kayaking and ended up battling this infection,” he said.

How to Stay Safe?

With summer in full swing and more people spending time in and around water, doctors urge caution. If you have an open wound, avoid wading or swimming in warm seawater or brackish water. If exposure happens accidentally, clean the wound immediately with soap and bottled water. Covering healing wounds with waterproof bandages can also reduce the risk of infection.

If symptoms develop after being in such water or consuming raw seafood, particularly oysters, seek medical attention immediately and inform the doctor of your recent exposure.

A Persistent Health Threat

WUSF reports that in 2024 alone, Florida reported 82 Vibrio vulnificus cases and 19 deaths. Some of those were tied to flooding from Hurricane Helene, which caused contaminated water to spread inland. In past years, spikes in infections have been linked to major storms and hurricanes, including Hurricane Ian in 2022.

The CDC estimates around 80,000 Vibrio-related illnesses occur in the U.S. each year, with about 100 deaths, many of them preventable with timely care.

As Dr. Beatty puts it, “This is not a bacteria to take lightly. With increased awareness and a bit of caution, we can lower the risk and save lives.”

Donald Trump, announced the White House, is suffering from a chronic vein condition, known as venous insufficiency. The news was announced on Thursday, after days of speculation regarding photographs that showed bruising on the US president's hand.

Trump also experienced swelling in his legs and underwent a "comprehensive exam" while he took an aspirin. As per the White House Press Secretary Karoline Leavitt said that Trump's bruised hand was consistent with "tissue damage from frequent handshaking", and taking aspirin was "part of a standard cardio-vascular prevention regimen".

For Trump and his supporters this news comes as a blow, not just because of his health concerns, but also because he, 79, has often boasted about his good health, so far to say, "the healthiest president that's ever lived".

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What Is Chronic Venous Insufficiency?

As per John Hopkins Medicine, chronic venous insufficiency occurs when your leg veins don’t allow blood to flow back up to your heart. Normally, the valves in your veins make sure that blood flows toward your heart. But when these valves don’t work well, blood can also flow backwards. This can cause blood to collect (pool) in your legs.

Symptoms, especially if not treated well, could lead to:

• Pain
• Swelling
• Cramps
• Skin Changes
• Varicose Veins
• Legs Ulcers

What Causes This Condition?

This condition could happen if you are overweight, pregnant, or have a family history of the problem. It can also happen if you had damage to your leg due to an injury, surgery, or any previous blood clot.

Other causes are:

High blood pressure in the leg veins over time, due to sitting or standing for long periods

• Lack of exercise
• Smoking
• A blood clot in a deep vein, often in the calf or thigh (deep vein thrombosis)
• Swelling and inflammation of a vein close to the skin, often in the legs (phlebitis)

John Hopkins Medicine notes the following as symptoms of the condition:

• Swelling in your legs or ankles
• Tight feeling in your calves or itchy, painful legs
• Pain when walking that stops when you rest
• Brown-colored skin, often near the ankles
• Varicose veins
• Leg ulcers that are sometimes hard to treat
• Having an uncomfortable feeling in your legs and an urge to move your legs (restless legs syndrome)
• Painful leg cramps or muscle spasms (charley horse)

What Do The Officials Say?

As per Dr Meryl Logan, assistant professor of vascular surgery at the University of Texas at Austin, veins and valves in this condition "propel the blood up and out of the leg" and back toward the heart, as is also reported by the BBC.

"So what chronic venous insufficiency is, is when those veins and valves don't work and blood goes backwards down the legs," she said.

White House physician Sean Barbabella has confirmed in a statement to reporters that Donald Trump’s condition is “benign and common,” particularly among people over the age of 70.

Further tests showed no evidence of heart failure, kidney issues, or any other systemic illness, Barbabella noted, echoing details shared earlier by spokesperson Steven Cheung and Trump advisor Brian Leavitt.

The doctor added that, overall, Trump is in “excellent health.”

Speculation began after photographers spotted what looked like swelling in Trump’s legs during the FIFA Club World Cup final in New Jersey on July 13. A few days later, photos from his meeting with Bahraini Prime Minister Salman bin Hamad bin Isa Al Khalifa at the White House showed noticeable bruising on his hands.