Health and Me

Rachel V Thomas

Missouri Reports 2 Cases Of Deadly Clade I Mpox, US Tally Rises To 3 In 2026

Two adults living in Missouri have been diagnosed with the more severe Clade I <a href="https://www.healthandme.com/health/mpox">Mpox</a>, taking the total number of cases in the US to three this year.

As per the US CDC, since November 2024, there have been 12 reported cases of clade I Mpox in the country. With the two cases in Missouri, the total tally rises to 14.

The Missouri Department of Health and Senior Services (DHSS), in a statement, said that both individuals had recent international travel to countries where Mpox is more prevalent. 

Further investigation revealed that the two cases are unrelated to one another and are not believed to be connected to any locally acquired Mpox cases. 

“While risk to the general public remains low, Mpox is still active,” said Dr. George Turabelidze, state epidemiologist. 

“We recommend those who are at risk for Mpox infection to get vaccinated and ensure they complete the 2-dose series,” Turabelidze added. 

Earlier this week, <a href="https://www.healthandme.com/health-news/mpox-outbreak-first-case-of-severe-strain-reported-in-new-york-city-article-153842627" data-type="tilCustomLink">New York City</a> reported the first case of Mpox Clade I in the US.

Last week, health authorities in Argentina announced the country's first locally acquired case of mpox clade Ib, raising concerns about the potential for community transmission in South America. 

According to the CDC, more than 53,000 clade I monkeypox cases, including more than 200 deaths, have been reported in several countries in Central and Eastern Africa since January 1, 2024.

Between March 2025 and March 2026, 30 countries have reported 37,170 confirmed cases of the deadly strain, including 165 deaths.

The majority of the cases are reported from the Democratic Republic of the Congo, Sierra Leone, and Uganda.

The CDC maintains that the risk of clade I Mpox to the general public in the US remains low, while for men who have sex with men, it is low to moderate.

What is Mpox? Why is Clade 1 more deadly?

Mpox is a disease caused by two different genetic types of the mpox virus, called Clade I and Clade II. 

The Missouri health department said that Clade I is more likely to cause severe illness and death, especially in people who have a weak immune system.

The latest records also show that Clade I has a mortality rate of 1-10 percent compared to Clade II’s 1-4 percent. 

Both types of the virus spread primarily through direct physical contact with a symptomatic person with Mpox or through contact with used items contaminated with the Mpox virus. It is not spread through the air. 

But, statistics have shown that Clade 1 infects children more than adults. 

People with Mpox are considered infectious until all their lesions have crusted over, the scabs have fallen off and a new layer of skin has formed underneath, and all the lesions on the eyes and in the body (in the mouth, throat, eyes, vagina and anus) have healed too. 

Other symptoms of mpox which may develop prior to a rash can include 

The CDC urges rapid response measures, such as contact tracing and vaccination, to effectively stop disease spread. 

Vaccination reduces the risk of getting mpox and can reduce symptoms if infected.

Health Conditions A-Z

health

Missouri

Mpox

Missouri Mpox

Clade I Mpox

Missouri health department

monkey pox

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Two adults living in Missouri have been diagnosed with the more severe Clade I Mpox, taking the total number of cases in the US to three this year. As per the US CDC, since November 2024, there have been 12 reported cases of clade I Mpox in the country. With the two cases in Missouri, the total tally rises to 14. The Missouri Department of Health and Senior Services (DHSS), in a statement, said that both individuals had recent international travel to countries where Mpox is more prevalent. Further investigation revealed that the two cases are unrelated to one another and are not believed to be connected to any locally acquired Mpox cases. “While risk to the general public remains low, Mpox is still active,” said Dr. George Turabelidze, state epidemiologist. “We recommend those who are at risk for Mpox infection to get vaccinated and ensure they complete the 2-dose series,” Turabelidze added. Earlier this week, New York City reported the first case of Mpox Clade I in the US. Last week, health authorities in Argentina announced the country's first locally acquired case of mpox clade Ib, raising concerns about the potential for community transmission in South America. Clade 1 OutbreaksAccording to the CDC, more than 53,000 clade I monkeypox cases, including more than 200 deaths, have been reported in several countries in Central and Eastern Africa since January 1, 2024. Between March 2025 and March 2026, 30 countries have reported 37,170 confirmed cases of the deadly strain, including 165 deaths.The majority of the cases are reported from the Democratic Republic of the Congo, Sierra Leone, and Uganda.The CDC maintains that the risk of clade I Mpox to the general public in the US remains low, while for men who have sex with men, it is low to moderate.What is Mpox? Why is Clade 1 more deadly? Mpox is a disease caused by two different genetic types of the mpox virus, called Clade I and Clade II. The Missouri health department said that Clade I is more likely to cause severe illness and death, especially in people who have a weak immune system. The latest records also show that Clade I has a mortality rate of 1-10 percent compared to Clade II’s 1-4 percent.  Both types of the virus spread primarily through direct physical contact with a symptomatic person with Mpox or through contact with used items contaminated with the Mpox virus. It is not spread through the air. But, statistics have shown that Clade 1 infects children more than adults. People with Mpox are considered infectious until all their lesions have crusted over, the scabs have fallen off and a new layer of skin has formed underneath, and all the lesions on the eyes and in the body (in the mouth, throat, eyes, vagina and anus) have healed too. Other symptoms of mpox which may develop prior to a rash can include fever, chills, headache, exhaustion, muscle aches, sore throat, swollen lymph nodes. The CDC urges rapid response measures, such as contact tracing and vaccination, to effectively stop disease spread. Vaccination reduces the risk of getting mpox and can reduce symptoms if infected.