Two adults living in Missouri have been diagnosed with the more severe Clade I Mpox, taking the total number of cases in the US to three this year.

As per the US CDC, since November 2024, there have been 12 reported cases of clade I Mpox in the country. With the two cases in Missouri, the total tally rises to 14.

The Missouri Department of Health and Senior Services (DHSS), in a statement, said that both individuals had recent international travel to countries where Mpox is more prevalent.

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Further investigation revealed that the two cases are unrelated to one another and are not believed to be connected to any locally acquired Mpox cases.

“While risk to the general public remains low, Mpox is still active,” said Dr. George Turabelidze, state epidemiologist.

“We recommend those who are at risk for Mpox infection to get vaccinated and ensure they complete the 2-dose series,” Turabelidze added.

Earlier this week, New York City reported the first case of Mpox Clade I in the US.

Last week, health authorities in Argentina announced the country's first locally acquired case of mpox clade Ib, raising concerns about the potential for community transmission in South America.

Clade 1 Outbreaks

According to the CDC, more than 53,000 clade I monkeypox cases, including more than 200 deaths, have been reported in several countries in Central and Eastern Africa since January 1, 2024.

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Between March 2025 and March 2026, 30 countries have reported 37,170 confirmed cases of the deadly strain, including 165 deaths.

The majority of the cases are reported from the Democratic Republic of the Congo, Sierra Leone, and Uganda.

The CDC maintains that the risk of clade I Mpox to the general public in the US remains low, while for men who have sex with men, it is low to moderate.

What is Mpox? Why is Clade 1 more deadly?

Mpox is a disease caused by two different genetic types of the mpox virus, called Clade I and Clade II.

The Missouri health department said that Clade I is more likely to cause severe illness and death, especially in people who have a weak immune system.

The latest records also show that Clade I has a mortality rate of 1-10 percent compared to Clade II’s 1-4 percent.

Both types of the virus spread primarily through direct physical contact with a symptomatic person with Mpox or through contact with used items contaminated with the Mpox virus. It is not spread through the air.

But, statistics have shown that Clade 1 infects children more than adults.

People with Mpox are considered infectious until all their lesions have crusted over, the scabs have fallen off and a new layer of skin has formed underneath, and all the lesions on the eyes and in the body (in the mouth, throat, eyes, vagina and anus) have healed too.

Other symptoms of mpox which may develop prior to a rash can include

fever,

chills,

headache,

exhaustion,

muscle aches,

sore throat,

swollen lymph nodes.

The CDC urges rapid response measures, such as contact tracing and vaccination, to effectively stop disease spread.

Vaccination reduces the risk of getting mpox and can reduce symptoms if infected.

India's neighbor in the east, Bangladesh, is facing the worst of a crisis in the form of a massive measles outbreak. As per media reports, measles in Bangladesh has taken 545 lives. Facing this growing challenge, the authorities are in complete disarray.

The nation has been struggling with the disease almost from the beginning of the year, but as of now, the situation has worsened and appears as one of the worst outbreaks of measles since the inception of the country in 1971.

According to the local media, the country has a total of 458 suspected deaths and 87 confirmed deaths linked to measles since mid-March of this year. On the other hand, Bangladesh has seen 64,940 suspected measles cases and 8,719 confirmed infections in the same period.

The Directorate General of Health Services (DGHS) of Bangladesh has said that since the 15th of March, the number of admitted patients with measles was 51,585. This information was directly released by the Health Emergency Operations Center and Control Room, which is under the authority of DGHS.

Why The Measles Cases Are On The Rise In Bangladesh?

The United Nations Children’s Fund (UNICEF) said that gaps in immunization worsened during and after the 2024 student-led uprising that toppled the government, leaving large numbers of children unprotected. UNICEF emphasized the need to boost vaccination programmes and provide more funding for health facilities in the future.

Why The Situation Can Go South From Here?

Bakrid or Eid al-Adha is an occasion that is widely celebrated in Bangladesh. This Eid usually sees massive gatherings and festivities. As measles is a highly contagious disease, the chances of spreading the disease during the festivities are very likely. The public health experts and doctors are warning against attending mass gatherings. Other than that, usual long-distance travel and family visits during Eid holidays could spread the disease at an exorbitant pace.

What Is Measles?

Measles is a highly contagious virus that spreads through direct contact or through the air when an infected person coughs or sneezes. It is a vaccine-preventable disease that can cause devastating complications, including blindness, pneumonia, encephalitis, and long-term immune dysfunction.

Symptoms usually appear in 7 to 14 days after exposure and may include:

• high fever,
• cough,
• runny nose,
• red eyes,
• rashes across the body.

How To Stay Safe From Measles?

• Maintaining good hygiene, such as frequent handwashing and covering the mouth while coughing or sneezing, helps reduce transmission.

• Avoiding close contact with infected individuals and ensuring proper nutrition to boost immunity are also important.

• Public awareness and community health programs play a crucial role in prevention.

European countries like France, the United Kingdom, Spain, and Germany are experiencing early heatwaves and record-breaking conditions.

The sweltering heat conditions have affected scores of people, reportedly resulting in the deaths of about seven people in France. The unusually high temperatures early in May are being triggered by a phenomenon called a “heat dome”.

“A classic, highly anomalous and powerful Heat Dome has parked over Western and Central Europe,” said Severe Weather Europe in a statement.

The forecaster also warned that temperatures are soaring by 12-16°C above “long-term climatological norms” with an extraordinary thermodynamic plume sending “a massive core of extreme warmth over Spain, Portugal, Ireland, the UK, France, and Germany”.

As a result, southern and southwestern regions, including Portugal, Spain, and France, will experience daytime temperature highs of 38°C. The majority of France is under a moderate to high temperature warning, while Germany and the UK are witnessing maximum temperatures exceeding 30°C, the Euronews reported.

“Air mass will be even hotter in the coming days for many countries, as the Heat Dome aloft intensifies further,” the weather forecaster said.

“Because this pattern restricts vertical mixing and cloud cover, maximum and minimum temperatures alike will challenge historical monthly records across hundreds of stations in Western Europe,” it added.

What Is A Heat Dome?

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Also known as a ‘heat bubble’, the term heat dome is a weather phenomenon in which a strong high-pressure system traps hot air over a region for weeks.

The system forms over a large area in the atmosphere, and causes extremely hot and dry weather conditions. It traps hot air and prevents it from flowing to rise and cool. This air then becomes compressed and heats up, leading to a dome-shaped area of hot air that can persist for several days or even weeks.

How A Heat Dome Forms

• A strong high-pressure system develops in the upper atmosphere
• Air sinks toward the ground and becomes compressed
• Compression increases temperatures
• The hot air expands and becomes trapped like a lid over the region
• Winds struggle to push the system away, allowing heat to build up

Effects Of A Heat Dome

Heat domes can lead to:

• Record-breaking temperatures
• Prolonged heatwaves
• Increased risk of dehydration and heatstroke
• Drought conditions
• Wildfires
• Stress on power grids and water supplies

Studies have proven that the incidence of heat domes is increasing in prevalence due to climate change.

How Heatwave Differs From Heat Dome

According to the Met Office, a heatwave is an “extended period of hot weather relative to the expected conditions of the area at that time of year, which may be accompanied by high humidity”.

On the other hand, a heat dome is a specific, stagnant, high-pressure atmospheric system that parks itself over a region. It traps hot air near the ground like a “lid on a pot”, and can typically last anywhere up to several weeks compared to a heatwave that sustains itself for just days or weeks.

Heatwaves In Europe

Climate change is increasingly driving heat conditions across the globe. According to the EU’s Copernicus Climate Change Service, 2025 was the third-hottest year on record, both globally and in Europe. The past three years – 2024, 2023, and 2025, in that order – were the hottest ever recorded globally.

Last year, temperatures exceeded 40°C in dozens of nations, pushing countries into drought, igniting wildfires, and killing thousands.

When it comes to weight loss, many try their own ways to drop the extra kilos. While portion control is advised, there are many who turn to starvation just to drop the extra kilos. In 2016, Japanese scientist Yoshinori Ohsumi won the Nobel Prize for his findings on autophagy. These findings facilitated a better understanding of conditions like dementia and Parkinson's disease. Autophagy refers to natural regeneration, which occurs at a cellular level. It reduces the chances of contracting diseases while also increasing lifespan.

Since then, drugmakers have been working towards coming up with a drug that can stimulate the process; wellness and diet experts have been willing to find a way to naturally induce the process by restricting carbs, fasting, and engaging in high-intensity exercise.

What do scientists have to say?

Experiments were also conducted on mice, and it was found that the ones who were put on genetic tools, fasting, or drugs had a tendency to live longer and remain in better overall shape. However, it is still unclear how the same effect can be replicated in humans. In mice, for instance, the effects of fasting on the brain are evident within 24 hours. In other body parts, such as the liver, the effects occur more quickly. Despite knowing that fasting is good for health, experts are unsure about the ideal duration of fasting for maximum health benefits. Researchers say that fasting does not induce autophagy, but it does have other health benefits.

What is autophagy?

Autophagy is derived from "self" and "phagein," which means "to eat." The process involves cells degrading and recycling their components. It provides fuel for energy and building blocks for cell renewal. Post-infection, it can destroy viruses and bacteria. Cells use the process to get rid of damaged organelles and proteins, and it helps counteract the adverse effects of ageing.

Autophagy was discovered in the 1960s, but its importance was recognised after Yoshinori Ohsumi's research. Researchers said that what they discovered protected against diseases like Huntington's, Parkinson's, and some forms of dementia. It also seemed beneficial in the context of infection control, along with protecting against excessive inflammation. New lifestyle books now suggest that the process can be switched on by making changes to diet and lifestyle or by observing a fast.

The impact on muscle mass

A book titled Glow 15 by Naomi Whittel shares a 15-day programme including 16-hour fasts three times a week. It shares a plan that reduces protein intake on some days, involves eating carbs later, and combines all this with high-intensity exercise. In the basic tests themselves, volunteers at Jacksonville University in Florida experienced several health benefits. Some of the participants lost about 3.5 kilos in 15 days. Others saw improvements in lean muscle mass, blood pressure, and a reduction in fine lines. Researchers said that none of these changes could cause harm to health.

Is fasting safe for all?

Researchers note that fasting too much is not a good idea for anyone. Before making drastic or major changes to lifestyle or diet, it is advised to check with a doctor first. Experts look at autophagy with optimism, and studies show that proteins together form clumps in the nerve cells of Alzheimer's and Parkinson's patients.