Nisha Pandey

New Vitamin B12 Therapy That Crosses Blood-Brain Barrier Shows Promise In Fighting Deadly Brain Cancer: Study

New Vitamin B12 Therapy Shows Promise Against Aggressive Brain Cancer, Says Study

A recent study has found that a modified form of vitamin B12 therapy may prove to be a new and promising way to treat glioblastoma, one of the most aggressive forms of brain cancer.

With limited treatment options, patients are usually treated with surgery, radiation therapy, and chemotherapy. Usually, the chance of survival is not bright after diagnosis.

<h2>New Vitamin B-12 Compound Shows Promise In Glioblastoma Treatment</h2>

Published in the journal Oncoscience, the research study is based on nitrosylcobalamin (NO-Cbl), a vitamin B12-based compound that contains and slowly releases nitric oxide.

The main purpose of the study was to find out whether the <a href="https://www.healthandme.com/health-wellness/starving-cancer-or-weakening-the-patient-understanding-the-truth-about-sugar-and-cancer-article-154764686" data-type="tilCustomLink">vitamin B-12</a> compound could cross the blood-brain barrier, a protective layer that prevents many medicines from reaching the brain and directly targeting glioblastoma tumors.

The blood-brain barrier is one of the biggest challenges in treating glioblastoma, as it protects the brain from harmful substances, blocking many cancer drugs from reaching tumor tissue.

Also read: <a href="https://www.healthandme.com/health-news/cholera-outbreak-in-sudan-117-dead-838-suspected-cases-says-who-article-154805677" data-type="tilCustomLink">Ebola Outbreak Spreads To Fourth Province In DR Congo As Cases Rise To 1,274</a>

The researchers examined how NO-Cbl affected different types of cancer cells, particularly how it moved through the body of rats with glioblastoma. The results showed that NO-Cbl had an anti-cancer effect on several types of tumors.

Most importantly, the compound was able to cross the blood-brain barrier and accumulate inside <a href="https://www.healthandme.com/health-news/could-chemotherapy-soon-be-optional-astrazeneca-and-gilead-drugs-show-promise-for-breast-cancer-patients-article-154757598" data-type="tilCustomLink">glioblastoma</a> tumors in animal studies.

Researchers also found that the compound remained active in tumor tissue for at least 24 hours, delivering nitric oxide directly to cancer cells without affecting normal tissues.

They also tested NO-Cbl in combination with two existing glioblastoma treatments: temozolomide, the standard chemotherapy drug for the disease, and TRAIL, an experimental cancer therapy.

In laboratory-grown glioblastoma cells, the combinations alleviated cancer cell growth much more effectively than any of the treatments used on their own.

Also read: <a href="https://www.healthandme.com/health-news/cholera-outbreak-in-sudan-117-dead-838-suspected-cases-says-who-article-154805677" data-type="tilCustomLink">Cholera Outbreak In Sudan: 117 Dead, 838 Suspected Cases, Says WHO</a>

A glioblastoma is a fast-growing glioma, a type of tumor that stems from glial cells, which protect nerve cells in the brain and spinal cord.

Glioblastoma can occur at any age but is more commonly found in older adults. The average age at diagnosis is 64.

Public figures among those afflicted include former President Joe Biden's son, Beau Biden, who succumbed to this cancer in 2015. John McCain also passed away in 2018 due to glioblastoma.

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According to the MD Anderson Cancer Center, around 12,000 glioblastoma cases are diagnosed in the United States every year. All glioblastomas are grade IV <a href="https://www.healthandme.com/health-wellness/how-car-t-cell-therapy-is-transforming-blood-cancer-treatment-article-154748853" data-type="tilCustomLink">brain tumors</a>, meaning they contain the most abnormal looking cells and are the most aggressive.

About 13,000 Americans are diagnosed with glioblastoma each year, accounting for almost half of all cancerous brain tumors, according to the Cleveland Clinic. More than 10,000 people in the U.S. will succumb to the disease every year, the National Brain Tumor Society reports.

In the light of limited treatment options for glioblastoma, this study is a ray of hope as it shows promise in slowing down the growth of cancer cells by overcoming challenges like treatment resistance.

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A recent study has found that a modified form of vitamin B12 therapy may prove to be a new and promising way to treat glioblastoma, one of the most aggressive forms of brain cancer. With limited treatment options, patients are usually treated with surgery, radiation therapy, and chemotherapy. Usually, the chance of survival is not bright after diagnosis.New Vitamin B-12 Compound Shows Promise In Glioblastoma Treatment Published in the journal Oncoscience, the research study is based on nitrosylcobalamin (NO-Cbl), a vitamin B12-based compound that contains and slowly releases nitric oxide. The main purpose of the study was to find out whether the vitamin B-12 compound could cross the blood-brain barrier, a protective layer that prevents many medicines from reaching the brain and directly targeting glioblastoma tumors. The blood-brain barrier is one of the biggest challenges in treating glioblastoma, as it protects the brain from harmful substances, blocking many cancer drugs from reaching tumor tissue. Also read: Ebola Outbreak Spreads To Fourth Province In DR Congo As Cases Rise To 1,274 About The Study The researchers examined how NO-Cbl affected different types of cancer cells, particularly how it moved through the body of rats with glioblastoma. The results showed that NO-Cbl had an anti-cancer effect on several types of tumors. Most importantly, the compound was able to cross the blood-brain barrier and accumulate inside glioblastoma tumors in animal studies. Researchers also found that the compound remained active in tumor tissue for at least 24 hours, delivering nitric oxide directly to cancer cells without affecting normal tissues.They also tested NO-Cbl in combination with two existing glioblastoma treatments: temozolomide, the standard chemotherapy drug for the disease, and TRAIL, an experimental cancer therapy. In laboratory-grown glioblastoma cells, the combinations alleviated cancer cell growth much more effectively than any of the treatments used on their own. Also read: Cholera Outbreak In Sudan: 117 Dead, 838 Suspected Cases, Says WHO About Glioblastoma A glioblastoma is a fast-growing glioma, a type of tumor that stems from glial cells, which protect nerve cells in the brain and spinal cord.Glioblastoma can occur at any age but is more commonly found in older adults. The average age at diagnosis is 64.Public figures among those afflicted include former President Joe Biden's son, Beau Biden, who succumbed to this cancer in 2015. John McCain also passed away in 2018 due to glioblastoma.                          According to the MD Anderson Cancer Center, around 12,000 glioblastoma cases are diagnosed in the United States every year. All glioblastomas are grade IV brain tumors, meaning they contain the most abnormal looking cells and are the most aggressive. About 13,000 Americans are diagnosed with glioblastoma each year, accounting for almost half of all cancerous brain tumors, according to the Cleveland Clinic. More than 10,000 people in the U.S. will succumb to the disease every year, the National Brain Tumor Society reports. In the light of limited treatment options for glioblastoma, this study is a ray of hope as it shows promise in slowing down the growth of cancer cells by overcoming challenges like treatment resistance.

new vitamin b12 therapy shows promise against aggressive brain cancer, says study

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New Vitamin B12 Therapy That Crosses Blood-Brain Barrier Shows Promise In Fighting Deadly Brain Cancer: Study

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