Breakthrough for endometriosis sufferers as first-of-its-kind pill to be available on NHS in England. This marks a significant advancement in the treatment of a condition that impacts an estimated 1.5 million women in the UK. The new drug, relugolix-estradiol-norethisterone (relugolix combination therapy or Ryeqo), offers a more comfortable and less stressful option compared to current treatments. But it will be accessible to only those patients who have already tried every alternative.

Endometriosis is a long-term condition in which tissue that's like the womb lining grows somewhere else in the body, often in the pelvis, bladder, and bowel. This ectopic tissue, like normal endometrial tissue, thickens, breaks down, and bleeds during each menstrual cycle, but without a means of exit from the body. This activity causes intense inflammation, scarring, and the development of adhesions that can lead to intense pain and fertility issues.

The condition is also legendary for its late diagnosis, with the majority of women taking nine years on average to receive an official diagnosis. Symptoms tend to be wrongly diagnosed as other conditions such as fibroids, pelvic inflammatory disease, or irritable bowel syndrome (IBS), so early detection is not always easy.

Symptoms of endometriosis are likely to include:

• Severe period pain that interferes with daily life
• Heavy menstrual bleeding
• Painful urination or bowel movements
• Lower abdominal pain in a chronic form
• Painful sex
• Fatigue and breathlessness
• Mood swings, anxiety, and depression
• Trouble conceiving

How the New Pill Works?

In contrast to existing injectable therapies that necessitate regular clinic visits, the newly approved pill provides a more convenient option for treating endometriosis at home. Relugolix combination therapy functions by inhibiting certain hormones that drive endometriosis growth while also offering required hormone replacement to offset side effects.

Conventional injectable medications have the potential to aggravate symptoms initially before they bring relief, and thus complicate the treatment process for patients. Ryeqo works faster and reduces the use of multiple drugs, which streamlines the treatment process. Patients no longer need to visit hospitals and clinics repeatedly as they can take a pill daily. Physical as well as psychological stress is also minimized.

Who Can Benefit from the New Treatment?

Although promising, the new pill will only be offered to women who have already attempted and failed other medical or surgical interventions for endometriosis. It is predicted that about 1,000 women per year will receive this treatment on the NHS.

Aside from addressing endometriosis, Ryeqo has also been approved by NICE for treating moderate to severe symptoms of uterine fibroids, another condition that affects numerous women.

Helen Knight, NICE director of medicines evaluation, underlined the significance of this approval, saying, "This new treatment represents a potential step-change in the management of endometriosis, returning control to patients while maintaining value for the taxpayer."

The release of this pill is a welcome relief, as women with endometriosis often have limited treatment options available to them. Today, managing the condition typically consists of pain killers, hormonal therapies, and, in extreme cases, operations like laparoscopies or hysterectomies.

NHS national clinical director for women's health Dr. Sue Mann emphasized the pill's benefits, saying, "This first-of-a-kind treatment for endometriosis – a condition which can be hugely debilitating – will give women more control over their own health by potentially enabling them to receive the treatment they require in the privacy of their own homes, without the necessity of going to regular appointments."

Cost and Availability of the Pill

The treatment is priced at £72 for a 28-day supply (VAT excluded). Although the cost appears high, the long-term advantages of minimizing hospital consultations and enhancing patients' quality of life make it an economical intervention in the wider healthcare context.

The pill will be accessible via standard NHS commissioning, thereby allowing those who qualify to use it without incurring extra financial costs.

What This Means for Women's Health?

The approval of Ryeqo is a welcome step in the right direction, but it also points to the continuing issues in endometriosis treatment. There are still many women who experience long delays in diagnosis and treatment, and there is an urgent need for more research, awareness, and funding for improved solutions.

Although this new pill will not cure endometriosis, it is a step in the right direction for making the disease more manageable and enhancing the quality of life for thousands of women. As medicine develops further, the desire would be for treatments to be more inclusive and accessible, eventually leading to improved outcomes for those suffering from endometriosis.

For women suffering from endometriosis, the approval of this new daily pill is a ray of hope. Reducing the necessity for the need of invasive procedures and numerous doctor visits, it enables patients to get in control of their well-being in a more convenient manner. Nevertheless, ongoing advocacy and studies have to be present to ensure that all women who suffer from the same condition get the care and treatment they need.

Amber cold health alerts have been announced for parts of northern England after forecasts warned that falling temperatures could lead to more deaths, particularly among older and vulnerable people. The UK Health Security Agency has issued two amber-level alerts for north-east and north-west England, which will be in effect from 8pm on Sunday until midday on Monday 5 January.

UK Under Amber Cold Health Alert: Elderly And Vulnerable People At Highest Risk

The agency said the expected cold spell is likely to increase pressure on healthcare services, with more vulnerable people needing medical attention. Officials warned this could lead to a rise in deaths, especially among those aged 65 and above and people with existing conditions such as heart disease, respiratory illnesses, and other long-term health problems.

UK Under Amber Cold Health Alert: UKHSA Gives Alert

UK Under Amber Cold Health Alert: Concerns Over Indoor Temperatures

The agency warned that indoor temperatures in buildings such as hospitals, care homes, and clinics are expected to drop. Maintaining the recommended indoor temperature of 18C may be difficult, increasing health risks for patients and residents. While all other regions in England will be under a lower-level yellow alert, officials said there is still potential for added pressure on health services. Staffing shortages linked to travel disruption were also flagged, along with possible impacts on essential services such as transport and energy.

How Does Cold Weather Affect People In The UK

Cold weather in the UK can worsen existing health problems and create new risks, particularly during prolonged spells of low temperatures. It places extra strain on the heart and lungs, increases the likelihood of infections, and can make daily life harder for people who struggle to keep warm. Those living in poorly insulated homes or facing high heating costs are often hit the hardest.

The Met Office said much of England will remain cloudy overnight, with patches of frost and fog likely to develop. These conditions could lead to difficult and potentially hazardous travel on Monday morning.

Sub-zero Temperatures Forecast In Parts Of The UK

Overnight temperatures are expected to fall to around minus 1C in Penrith and hover close to freezing in parts of the Lake District where the amber alert is in place. In northern areas of Scotland, temperatures are forecast to drop further, reaching between minus 6C and minus 7C, as per Sky News.

A brisk northerly breeze is also expected along the north-east coast of England, making conditions feel colder and more uncomfortable. Dr Agostinho Sousa, head of extreme events and health protection at UKHSA, as per Sky News, urged people to look out for friends, family, and neighbours as the cold weather sets in.

“The temperatures we are expecting can have a serious impact on health,” he said. “They increase the risk of heart attacks, strokes, and chest infections, particularly among people over 65 and those with existing health conditions.”

Nearly 200 residents of Piprauli village in Uttar Pradesh’s Budaun district received anti-rabies injections as a precaution after learning that the raita, a curd-based dish served at a funeral, had been prepared using milk from a buffalo that later died following a dog bite.

Rabies Scare In Uttar Pradesh: Nearly 200 Villagers Get Vaccinated

Almost 200 people from Piprauli village in Uttar Pradesh’s Budaun district were given rabies vaccines as a safety measure days after consuming raita made from the milk of a buffalo that had been bitten by a dog. Villagers said the funeral ceremony took place on December 23, where raita was served to attendees. It later came to light that the buffalo whose milk was used had been attacked by a dog a few days before the event, as per NDTV.

The buffalo died on December 26, which led to panic in the village amid fears of possible infection. Soon after, villagers visited the Ujhani Community Health Centre, where they were administered rabies vaccinations.

Rabies Scare In UP: CMO Dr Rameshwar Mishra Clarifies Risk Of Transmission

Chief Medical Officer Dr Rameshwar Mishra said on Sunday that authorities were informed about a buffalo in the village that had been bitten by a suspected rabid dog and later died after showing symptoms associated with rabies.

There were reports that villagers had consumed what was believed to be “infected” raita. As a precaution, everyone who may have been exposed was advised to get vaccinated.

“Prevention is better than cure. Anyone who had even the slightest doubt was given the anti-rabies shot. Usually, there is no risk after milk has been boiled, but vaccination was done to eliminate any possible danger,” Dr Mishra said, as per NDTV. The health department confirmed that no cases of illness have been reported in the village so far and that the situation remains stable.

The CMO added that all those who came for vaccination were given the injection without delay at the Ujhani Community Health Centre. To ensure smooth access, primary and community health centres remained open on both Saturday and Sunday.

What Is Rabies Pre-Exposure Prophylaxis Vaccine?

Rabies pre-exposure prophylaxis, also known as PrEP, involves a series of injections taken before any potential exposure to the rabies virus, as per Cleveland Clinic. It is mainly advised for people at higher risk, including veterinarians, animal handlers, laboratory staff, and travellers visiting areas where rabies is common. While PrEP does not eliminate the need for treatment after a bite, it simplifies post-exposure care. Those who have received PrEP require fewer follow-up doses and do not need rabies immunoglobulin, which can be difficult to obtain during emergencies and can save valuable time.

How Can Rabies Pre Exposure Prophylaxis Vaccine Protect You?

According to Dr Deepa Aggarwal, MD, DNB, an allergy specialist with over 20 years of experience from LHMC and AIIMS Delhi, who shared insights on her Instagram account, the rabies pre-exposure prophylaxis vaccine helps prepare the immune system in advance.

It allows the body to build antibodies before any exposure occurs. If a vaccinated person is bitten later, they only need two booster shots and no immunoglobulin. This faster immune response reduces the chance of the virus reaching the brain, which is especially important for people at higher risk or in situations where medical care may be delayed.

Today, Delhi again woke up to a thick layer of smog, and the adjoining cities like Noida, Ghaziabad, Gurugram, and Faridabad too woke up to zero-visibility fog on Monday. The air quality too dipped down to 'severe' category, with AQI registered at 400 plus on the index. While on Sunday, the AQI did show some improvement, as the city registered 'very poor' AQI, however, by the end of the day, the capital city was trapped under fog and pollution.

Delhi Struggling With Pollution And Cold Wave

The Indian Meteorological Department (IMD) has also issued an orange alert for Delhi on 29 December, Monday. The maximum temperature is expected to be around 22 degree Celsius, while the minimum will be at 7 degree Celsius. Mornings would encounter heavily dense fog, while there is an expectation of marginal relief on December 30. Most of North India is also said to be worst hit, including states like Uttar Pradesh, where thick fog is predicted till December 31, Punjab and Haryana is expected to face cold wave through December 30, and Himachal and Uttarakhand could see rain and snowfall from December 30 onwards.

As per IMD, cold wave is a condition of air temperature which becomes fatal to human body when exposed. This happens during the winter seasons and the cold wave impact gets aggravated due to wind speed. Cold Wave is considered when minimum temperature of a station drops to 10 degree Celsius or less for plains and 0 degree Celsius for Hilly regions.

Read: Delhi Sees Some Relief From Toxic Air; GRAP IV Removed, 'Will Bring Down Pollution In 5 Years,' Says Nitin Gadkari

How Can Cold Waves Impact Your Health?

IMD says that cold wave could cause mild to severe hypothermia. The common symptoms include shivering, dizziness, drowsiness, irritability, confusion, slowed, slurred speech, and altered vision. This happens when body experiences a lowered core temperature below 34.4 degree Celsius.

Frostbite is another health hazard that can happen due to cold waves. It is freezing of body tissue, accompanied with hypothermia. When ice crystal form between the cells of the skin and grow by extracting fluid from the cells, the circulation is obstructed, causing additional damage to the tissue affected. It commonly affects hands, feet, ears, nose and cheeks. The common symptoms are redness in skin, or skin turning grey. Some may also experience tingling sensations, fingers turning numb yellowish, waxy, or grey color.

Chilblains could be caused due to exposure to cold, wet, and humid conditions. Repeated prolonged exposure of bare skin could lead to this development in just few hours. It could impact your ears, nose, cheeks, fingers, and toes. Common symptoms include skin turning pale and colorless, prickly sensations, red, swollen, hot, and itchy skin and blisters.

Dehydration could also happen due to lack of fluid intakes, which is common during extreme cold. This could lead to headaches, dizziness, dry mouth, stomach cramps, and increased heartbeat. IMD notes carbon monoxide poisoning or CMP, snow blindness, and trench foot are also common during cold seasons, and provides ways to prevent these from happening.

What Do These Alerts Mean?

Delhi is currently under Orange Alert for cold wave. What do these different alerts mean?

Green Alert: This means no action will be taken, as this is a normal day during winter season

Yellow Alert: This means 'be updated' and refers to cold wave alert where the conditions in isolated areas may persist for two days

Orange Alert: This means 'be prepared' and refers to severe cold wave conditions that could persist for two days. This could also mean that though the condition is not severe, but the conditions could persist for four days or more

Red Alert: This means 'take action' and refers to severe cold wave conditions that persists for more than two days, or total number of cold wave days exceeding six days