Shingles, a painful viral infection due to the reactivation of the varicella-zoster virus (VZV), is primarily known for its blistering rash and nerve pain. New research indicates, however, that shingles vaccine can be significant in preventing dementia. This recent finding paves the way to new avenues to understand the association between viral illness and brain wellness, which might change preventive treatment against cognitive degeneration in aging individuals.

Once a person has had chickenpox, he or she carries the varicella-zoster virus for life. The virus lies dormant within nerve cells and may reappear years later as shingles, commonly because of compromised immunity with age, stress, or illness.

Shingles appears as a painful rash, typically on one side of the body, and may persist for weeks. Aside from the rash, the infection may cause severe complications like postherpetic neuralgia (PHN), a long-term nerve pain syndrome that lasts for months or even years. In rare instances, shingles may infect the eye, causing blindness.

The Centers for Disease Control and Prevention (CDC) estimates that approximately 1 in every 3 Americans will develop shingles at some time during their lifetime. Vaccines have been recommended to avoid the condition, but recent studies indicate they might also have an added bonus—prevention from dementia.

Shocking Link Between Shingles and Dementia

Dementia, such as Alzheimer's disease, is a rapidly increasing worldwide health issue, with millions of older adults at risk. Although the causes of dementia are still unknown, researchers have long suspected that some viruses, specifically those in the herpes family (which includes VZV), may play a role in cognitive decline.

A study recently published in Nature determined that getting the shingles shot lowered the risk of developing dementia dramatically. Scientists followed more than 280,000 elderly people in Wales who got the original shingles vaccine, Zostavax, and identified a 20% decrease in dementia incidence over the next seven years.

Lead author Dr. Pascal Geldsetzer of Stanford University said the results were "very robust" and added that women appeared to gain more benefit from the vaccine than men. Since women are at greater risk for dementia, these results could have important implications for future prevention efforts.

Can Shingles Cause Cognitive Decline?

Although no one knows the exact mechanisms, several theories discuss how the shingles virus might enhance the risk of dementia:

Inflammation and Brain Damage: The varicella-zoster virus has the ability to cause inflammation in the body, including the brain. Chronic inflammation is recognized to speed up cognitive decline and may play a role in neurodegenerative diseases such as Alzheimer's.

Vascular Effects: The virus has the ability to infect blood vessels in the brain, leading to clots or constricting blood flow. Decreased cerebral circulation is a well-documented risk factor for dementia and stroke.

Amyloid Protein Formation: A study by the University of Colorado Anschutz Medical Campus indicates that shingles can encourage the formation of amyloid plaques, a characteristic of Alzheimer's disease. These adhesive proteins clump together in the brain, interfering with normal function and speeding up cognitive decline.

Can Shingles Vaccination Protect Against Dementia?

The research suggests that shingles vaccination can lower the risk of dementia by inhibiting reactivation of the virus and triggering inflammation in the brain. It is unclear, however, whether the same protective mechanism works for the newer, more effective Shingrix vaccine, which supplanted Zostavax in 2020.

In contrast to Zostavax, which had a live but attenuated form of the virus, Shingrix is a genetically modified vaccine that consists of certain viral proteins to stimulate an immune response. Shingrix has been 97% effective in preventing shingles in clinical trials, versus 51% for Zostavax. Whether it can help prevent dementia, however, is an open question scientists are eager to investigate.

Who Should Receive the Shingles Vaccine?

The CDC advises Shingrix for people aged 50 and above, as well as younger adults with compromised immune systems. The vaccine is given in two doses, spaced a few months apart, and is very effective in preventing shingles and its complications.

With these advantages, however, vaccine acceptance continues to be low, with less than 40% of eligible Americans having gotten their shots. The most frequent side effects are mild flu-like symptoms and pain at the site of injection, but experts point out that the advantages far outweigh the risks.

Tips for Reducing Dementia Risk

Although shingles vaccination holds great potential for dementia prevention, it is not the only answer. Experts suggest an integrated approach to brain health that involves:

Living an Active Lifestyle: Physical exercise on a regular basis enhances circulation to the brain and averts cognitive loss.

Healthy Nutrition: A diet modelled on Mediterranean cuisine, featuring high intakes of fruits, vegetables, whole grains, and healthy fats, is supportive of brain function.

Social and Mental Stimulation: Mental activity with reading, puzzles, or social engagement may build cognitive reserve.

Control of Chronic Illnesses: Control of high blood pressure, diabetes, and cholesterol lowers the risk of dementia.

The association of shingles with dementia risk demonstrates the complex ways infectious illnesses affect overall well-being. Finding that shingles vaccination can decrease risk of dementia adds yet another persuasive argument to convince older people to be vaccinated. Although more study is necessary to validate the results, the study holds out hope that a straightforward vaccine has a key part to play in maintaining cognitive capacity and enhancing the quality of life among aging groups.

As scientists continue to investigate the link between viral infections and brain health, one thing is certain: guarding yourself against shingles might have advantages that reach far beyond the skin. With the increasing global burden of dementia, interventions such as vaccination could become a key part of the arsenal in the battle against cognitive decline.

US childhood vaccination rates have taken a disturbing decline, exacerbated by the disruption caused by the COVID-19 pandemic. It is not simply a statistic—but a warning sign of future health threats. The effects are already being seen, with measles rebounding and potentially the return of other diseases once brought under control, such as rubella and polio. A recent Stanford Medicine study, published in the Journal of the American Medical Association, paints a dire picture: a 10% decline in vaccination rates could result in millions of measles cases over the next 25 years.

The rising danger of preventable illness, and the reason why vaccination is key to protecting public health. From the emergence of vaccine hesitancy to the surging spread of measles.

The drop in childhood vaccinations in the U.S. has been a rising concern among health professionals. Although the disruptions brought about by the COVID-19 pandemic were a major factor, the trend of declining immunization rates is not new. For years, growing vaccine hesitancy, driven by misinformation, political controversy, and skepticism about health systems, has fueled a change in public perception, particularly among parents. Consequently, fewer kids are getting the necessary vaccines and diseases that previously were under control are now being a threat again.

The research done by a group of researchers from Stanford, together with other universities' experts, shows the risk of measles becoming endemic again in the U.S. It might occur in as little as two decades if the vaccination rate is sustained at current levels. Nevertheless, a 10 percent decline in the rate of vaccinations could make things even worse, and millions of individuals could become susceptible to infection, hospitalizations, and death.

Measles is the most infectious disease on Earth, with the potential to spread quickly through populations. Prior to the introduction of the measles vaccine in 1963, the illness was rampant throughout the U.S., affecting millions of individuals annually. Indeed, before the vaccine, an estimated 3 million to 4 million individuals were infected with the disease every year, with 400 to 500 deaths, 48,000 hospitalizations, and 1,000 instances of brain swelling (encephalitis).

As per the CDC, measles remains a lethal disease, primarily for children. It spreads via respiratory droplets when an infected person coughs or sneezes and symptoms may range from fever, cough, runny nose, and a characteristic red, blotchy rash. As the disease is vaccine-preventable with the MMR (measles, mumps, rubella) vaccine, unvaccinated individuals are at the greatest risk of being infected and infecting others.

The recent study by Stanford researchers utilized large-scale epidemiological modeling to simulate how infectious diseases like measles would spread across the United States based on different levels of childhood vaccination coverage. The results are concerning. Even at current vaccination rates, the study suggests that measles could re-emerge as an endemic disease in the U.S. within the next two decades. A mere 10 percentage point reduction in vaccination coverage would accelerate this process significantly, potentially resulting in millions of measles cases in the next 25 years.

Dr. Nathan Lo, a Stanford physician and the study's senior author, underscored the seriousness of the situation. "Our nation is at a tipping point for measles to become a routine household disease again," he said. "The declining routine childhood vaccinations, coupled with increasing vaccine hesitancy, may send us to a place we were working to avoid for decades."

Vaccine Hesitancy and Its Contribution to the Measles Outbreak

The problem of vaccine hesitancy has been a major contributor to the fall in immunization rates. The disinformation regarding the safety and effectiveness of vaccines has instilled fear and confusion, particularly among parents. A KFF survey published in 2025 found that more than half of adults were unsure about whether to believe assertions about the risks of the measles vaccine—assertions that have been magnified by anti-vaccine personalities, such as Robert F. Kennedy Jr.

This widespread misinformation has caused many to doubt the necessity of vaccines for diseases no longer perceived as a threat, like measles. But as recent outbreaks have shown, measles is hardly eradicated and still poses a lethal threat, especially to vulnerable groups like infants, immunocompromised individuals, and the unvaccinated.

Recent measles outbreaks in the U.S. are stark reminders of the risks of low vaccination levels. In 2025 alone, the nation has already seen some 800 cases of measles, the most in a single year since 2019. The largest outbreak took place in West Texas, which had over 620 cases, 64 hospitalizations, and two deaths. These outbreaks are a wake-up call that the U.S. is not immune to outbreaks of this extremely contagious disease.

According to Mathew Kiang, a study co-author, "The impact of waning vaccinations won't be sudden, but the aggregate effect could be devastating. If we do not take action now, we can expect millions of measles cases in the coming years."

What Can Be Done to Prevent a Measles Crisis?

Although the situation is grim, there is hope. Specialists such as Dr. Lo and Kiang propose that even slight increases in vaccination rates could make a significant difference in preventing the spread of measles and other preventable illnesses. A 5 percent boost in vaccination coverage could avert a sharp spike in cases, safeguard vulnerable populations, and ultimately save lives.

Health professionals remind parents to discuss with pediatricians the value of vaccinations and have faith in healthcare professionals' recommendations. Public health officials and policymakers also need to act to address vaccine misinformation and make sure vaccination mandates for school entry are intact.

This study's findings highlight the crucial role that vaccination plays in protecting public health. By potentially preventing millions of cases and countless fatalities, high vaccination coverage needs to be sustained. With the U.S. still struggling to deal with the consequences of declining vaccine coverage, it is vital that both the public and policymakers take proactive measures to ensure that such diseases as measles do not experience a resurgence.

The decision to vaccinate is such a simple choice, but the difference it makes can be gargantuan. It is incumbent on all of us—parents, medical practitioners, and members of society—to take our turn in safeguarding the next generation against the ruining effects of vaccine-preventable diseases. As Dr. Lo highlighted, "Increasing vaccination levels by just 5% can make a world of difference in keeping these diseases at bay."

Every year on 25 April, World Malaria Day is observed to raise awareness about one of the deadliest yet preventable diseases. As per the World Health Organization (WHO), there were 263 million malaria cases and 5,97,000 malaria deaths across 83 countries in 2023. The WHO African Region carries a disproportionately high share of the global malaria burden. As per the numbers, this Region was home to 94% of the malaria cases, accounting for 246 million and 95% of malaria deaths. Children under 5 accounted for about 75% of all malaria deaths in the Region.

Ahead of World Malaria Day, WHO also called for renewed efforts at all levels - from global policy to community action to accelerate progress towards eliminating malaria.

World Malaria Day 2025 Theme

This year, WHO has joined the RBM Partnership to End Malaria and other partners in promoting: "Malaria Ends With US: Reinvest, Reimagine, Reignite". This is a grassroot campaign that aims to re-energize efforts at all levels, from global policy to community action, to accelerate progress towards malaria elimination.

World Malaria Day History

World Malaria Day was first celebrated internationally in 2008, building upon the earlier "Africa Malaria Day", which had been observed b African countries since 2001. The date, April 25, was established by WHO in 2007 during the World Health Assembly. In 2007, it was the 60th session of the World Health Assembly where the proposal to rename Africa Malaria Day to World Malaria Day was made to acknowledge the global presence of malaria.

World Malaria Day Significance

The day has a strong significance in healthcare as it brings attention to the disease that still continues to take so many lives, especially in low-income and tropical regions. It also serves as an important reminder to continue spreading awareness about the disease as well as promoting its prevention, treatment and continuous international cooperation to fight against it.

What Is Malaria?

The WHO describes malaria as a life-threatening disease spread to humans by some types of mosquitoes, mostly found in tropical countries. However, they are preventable and curable.

WHO notes: "Malaria is spread to people through the bites of some infected anopheles mosquitoes. Blood transfusion and contaminated needles may also transmit malaria. The first symptoms may be mild, similar to many febrile illnesses, and difficult to recognize as malaria. Left untreated, P. falciparum malaria can progress to severe illness and death within 24 hours.

There are 5 Plasmodium parasite species that cause malaria in humans, and 2 of these species – P. falciparum and P. vivax – pose the greatest threat. P. falciparum is the deadliest malaria parasite and the most prevalent on the African continent. P. vivax is the dominant malaria parasite in most countries outside of sub-Saharan Africa. The other malaria species which can infect humans are P. malariae, P. ovale and P. knowlesi."

What Are The Symptoms?

The early symptoms are fever, headache and chills, which can usually start within 10 to 15 days of getting bitten by an infected mosquito.

Some types of malaria can cause severe illness and death. Infants, children under 5 years, pregnant women, travellers and people with HIV or AIDS are at higher risk. Severe symptoms include:

• extreme tiredness and fatigue
• impaired consciousness
• multiple convulsions
• difficulty breathing
• dark or bloody urine
• jaundice (yellowing of the eyes and skin)
• abnormal bleeding

A new AI-powered blood test that can detect 12 types of cancer is to be tested on NHS patients. Using this test, experts would now be able to detect cancerous cells in people much before the symptoms appear. The trial, conducted on 8,000 patients, will analyse blood samples for tiny fragments of genetic material released by tumours.

The test called miONCO-Dx, was created using data from 20,000 patients. Initial tests have produced promising results, having shown that it can detect 12 of the most lethal and common cancers, including bowel cancer, at an early stage, with over 99% accuracy. With no other trial currently working in the same way, this is a world-leader and will support in placing Britain at the forefront of revolutionising healthcare. Notably, the UK government has awarded £2.4m to run the trial of the genetic test, which was developed by the University of Southampton and the biotech startup Xgenera.

How Does It Work?

The test was created by Xgenera, in collaboration with the University of Southampton. As little as 10 drops of blood are all that's needed to detect up to 12 common cancers. The test works by measuring the microRNA in a blood sample and using AI to identify if cancer is present and, if so, where it is located in the body.

What Cancers Will It Detect?

Lung, gastric, prostate, oesophageal, liver, bladder, ovarian, bowel, pancreatic and breast cancers–as well as bone and soft tissue sarcoma and a type of brain tumour. The Department of Health said the test was now ready for the "validation and verification" stage.

Professor Sir Stephen Powis, NHS England's national medical director, said: "This blood test has the potential to help us detect bowel cancer earlier and reduce the need for invasive tests, and the next step in this trial will now be vital in gathering further evidence on its effectiveness and how it could work in practice."

How Is A Blood Test Conducted?

A blood test is a simple medical procedure used to check various health conditions. Here's how it is typically conducted:

1. Preparation: Depending on the test, you may be asked to fast for 8–12 hours. The healthcare provider will explain any specific instructions.

2. Collection: You’ll usually be seated or lying down. A healthcare professional will tie a tourniquet around your upper arm to make the veins more visible. The inside of your elbow is the most common site for drawing blood.

3. Cleaning: The area is cleaned with an antiseptic to reduce the risk of infection.

4. Drawing Blood: A sterile needle is inserted into the vein, and blood is collected into one or more vials or tubes.

5. Post-collection: Once enough blood is collected, the needle is removed, and a cotton ball or bandage is applied to stop any bleeding.

6. Processing: The blood samples are then sent to a lab for analysis.