Tennis great Monica Seles, in an interview with Associated News, recently shared that she was diagnosed with myasthenia gravis (MG) three years ago. This is the first time she's spoken publicly about the disease, which is a rare condition that causes muscles to become weak.

Seles, who won nine major tennis titles, first noticed something was wrong while hitting tennis balls. She said she started seeing two balls instead of one and felt a sudden weakness in her arms and legs. She also mentioned that simple things like blowing out her hair became very difficult.

Seles said it was hard for her to accept the diagnosis at first. She decided to speak out to help others, hoping her story will bring more attention to myasthenia gravis. Before she got her diagnosis, she had never heard of the condition.

What Is Myasthenia Gravis?

Medscape explains that myasthenia gravis is a chronic neuromuscular disease. This means it's a long-term illness that affects the way your nerves and muscles work together. It causes weakness in the muscles that you can control, such as those in your arms, legs, and face. While it can affect people of any age, it is most common in:

• Young women under 40
• Older men over 60

Symptoms of Myasthenia Gravis

The most common symptoms of MG are:

• Visual problems which includes drooping eyelids and seeing double.
• Your muscles might feel weak and tired very quickly, and this can change from day to day or even hour to hour.
• Your facial muscles can become weak, which may make a smile look more like a snarl.
• Difficulty speaking or swallowing, you might also have trouble pronouncing words or swallowing food.
• Weakness in the neck or limbs like your arms, legs, or neck may feel weak

The symptoms of MG can sometimes look like other conditions, so it's always important to see a doctor for a proper diagnosis. People with MG may experience periods when their symptoms get worse (flare-ups) and periods when they get better (remission), but the condition is rarely cured completely.

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How is Myasthenia Gravis Diagnosed?

To figure out if you have MG, your doctor will ask about your symptoms and medical history. One key way they test for it is by giving you a specific medicine. If your muscle weakness quickly gets a lot better after taking the medicine, it's a strong sign that you have MG.

Doctors might also use other tests. They can do blood tests to look for certain antibodies that are common in people with MG. They might also use nerve and muscle tests to see how your nerves are sending signals to your muscles and to measure your muscle's electrical activity.

Treatment and Management of Myasthenia Gravis

While there's no cure for MG, the symptoms can be controlled. The main goal of treatment is to make your muscles stronger and prevent problems with breathing and swallowing. Most people with MG can live normal or close-to-normal lives with the right care.

Treatment often includes medicine, such as drugs that control the immune system or help your muscles work better. Sometimes, a doctor may suggest surgery to remove the thymus gland, which can help reduce symptoms for many people. Other treatments, like plasmapheresis, can be used to remove the bad antibodies from your blood.

Can You Prevent Myasthenia Gravis?

To help prevent a myasthenia crisis, you should always take your medicines exactly as prescribed. It can also help to take your medicine 30 to 45 minutes before meals to prevent food from getting into your lungs.

Try to avoid getting sick by staying away from people with colds or the flu, and make sure you get proper nutrition, rest, and manage your stress. It is also very important to always tell your doctors about your MG diagnosis and the medicines you are taking before they prescribe you anything new. Some medicines can interfere with your condition or your treatment.

The most serious complication of MG is a myasthenia crisis. This is when you have extreme muscle weakness, especially in the muscles you need to breathe. This is a medical emergency and may require help from a breathing machine.

Seles, who is 51, said she has learned to live with a "new normal." She sees this challenge as just another "reset" in her life, similar to when she moved to the U.S. as a young teenager or when she was recovering from a stabbing. Her message is one of strength and a reminder to always adjust, just like a tennis player on the court.

A new study from scientists in Miami has raised a big red flag saying that heavy alcohol consumption does not just damage your liver; it could also be quietly harming your pancreas and paving the way to one of the most lethal cancers in the world. While nobody talks much about this organ, it keeps your show running. Sitting behind the stomach, the pancreas organ produces the digestive enzymes that help you break down food, as well as the hormones that regulate your blood sugar.

The fresh study, published in Cellular and Molecular Gastroenterology and Hepatology, sheds new light on how alcohol-induced inflammation accelerates the development of the deadly disease.

The Miami researchers discovered that alcohol, in high quantities, can damage the very pancreatic cells that make those enzymes. This injury sparks inflammation that can smoulder away until it creates precancerous lesions. Left unchecked, these can evolve into pancreatic cancer, a disease with a grim reputation.

A gene that could save the day

Not everyone who enjoys a tipple is destined for cancer. For the disease to develop, researchers found that a mutation in a gene called Ras, which controls cell growth, must also be present. But when alcohol was paired with a pro-inflammatory molecule in experiments, the effects mimicked alcohol-induced pancreatitis, complete with inflammation, lesions, and cancer.

The breakthrough? By disabling a gene called CREB, the scientists stopped both precancerous and cancerous lesions from forming. In other words, CREB seems to hold the keys to either the safe or self-destruct modes for your pancreas.

Why this matters more now

Pancreatic cancer kills over 9,000 people in the UK and more than 52,000 in the US every year. The five-year survival rate? About 10 to 12 per cent, among the lowest of any cancer. To make matters worse, cases are rising among younger people, though deaths have not yet spiked.

What makes this cancer so deadly is its silence. Symptoms rarely appear until it has already spread, and by then, treatment options are limited.

The stealthy symptoms you should not ignore

• Belly pain that radiates to your back
• Unexplained weight loss and loss of appetite
• Jaundice (yellowing of the skin and eyes)
• Pale or floating stools, dark urine, and itching
• New or worsening diabetes
• Fatigue or weakness

By the time these appear, the disease is often in an advanced stage, which is why prevention is key.

Defining ‘heavy drinking’

The study defined heavy alcohol use as eight or more drinks per week for women and 15 or more for men. Over months and years, that adds up to a consistent assault on your pancreas.

Complications that make life harder

Pancreatic cancer isn’t just fatal; it can also cause a series of painful, exhausting complications:

• Weight loss as the body struggles to absorb nutrients
• Blocked bile ducts leading to jaundice
• Abdominal pain from tumors pressing on nerves
• Bowel obstructions
• Painful swelling in the limbs due to blood clots

Reportedly, managing these often requires procedures like stent placements or even nerve-block injections, adding more physical and emotional strain to an already heavy burden.

How to reduce the risk

• Cut back on alcohol: You do not need to go teetotal overnight, but trimming down your weekly intake could protect your pancreas.
• Quit smoking: Tobacco and alcohol together are really bad.
• Maintain a healthy weight: Extra body fat increases inflammation and strains your pancreas.
• Eat for your pancreas: Load your plate with vegetables, fruit, and whole grains, and keep processed foods to a minimum.
• Stay active: Exercise helps manage weight and lowers inflammation.

The UKHSA has noted that a new strain of COVID-19 virus, called Stratus, with two variants, XFG and XFG.3, has accounted for a high proportion cases in England, reports the Independent. Among these two variants, XFG.3 has accounted for 30% of cases in the country.

However, experts have suggested to not panic on the arrival of this new strain. Dr Alex Allen, consultant epidemiologist of UKHSA said, "It is normal for viruses to mutate and change over time," as reported by the Independent. However, the UKHSA has also confirmed that it continues to monitor all strains of COVID in the UK. For now, experts are not concerned over the spread.

What Is Stratus XFG and XFG.3?

As per the World Health Organization (WHO), XFG is a "variant under monitoring" and that any health risk posed by this variant remain low at the global level.

As of now, globally, XFG has the highest relative growth when compared to the other variants that are currently active and circulating, including "Nimbus" NB.1.8.1.

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The WHO also confirmed that current data does not indicate that this variant leads to more severe illness or deaths than the other currently active variants in circulation.

Unique Symptoms Of Stratus COVID Strain

While the strain is said to be not a cause of concern, the symptoms may be unique from what we traditionally know COVID symptoms to be.

The WHO however, time and again has said that there is no increase in severity. It said, "While there are reported increases in cases and hospitalisations in some of the [South-east Asia Region] countries, which has the highest proportion of XFG, there are no reports to suggest that the associated disease severity is higher as compared to other circulating variants."

Dr Allen also seconded the opinion and said, "Based on the available information so far, there is no evidence to suggest that the XFG and XFG.3 variants cause more severe disease than previous variants, or that the vaccines in current use will be less effective against them.”

The unique symptoms of Stratus COVID strain includes:

• Sore throat or hoarseness, as experts have also claimed that Stratus can give patients a "hoarse voice".
• Headaches that can last several days
• Nasal congestion and mild fever
• Fatigue that lingers beyond acute phase

Other than these unique symptoms, the common COVID symptoms like change in smell or taste, shortness of breath and chest discomfort remain, however, it may be uncommon in vaccinated individuals.

Are There Any Risks Around The New Stratus Strain?

XFG is growing rapidly compared to co-circulating variants globally. However, XFG exhibits only marginal additional immune evasion over [other varient] LP.8.1. While there are reported increases in cases and hospitalizations in some of the [South-east Asia Region] countries, which has the highest proportion of XFG, there are no reports to suggest that the associated disease severity is higher as compared to other circulating variants. The available evidence on XFG does not suggest additional public health risks relative to the other currently circulating Omicron descendant lineages," said WHO.

Do We Need New Vaccines For The New Strain?

The WHO said that as per the current available data, the currently approved COVID-19 vaccines are expected to remain effective against symptomatic and severe diseases, including caused by the new strain.

However, Dr Kaywaan Khan, Harley Street GP and founder of Hannah London Clinic told Cosmopolitan UK that due to certain mutations in the spike protein in Stratus strain, it could evade antibodies "developed from prior infections or vaccinations".

While WHO noted that the risk of vaccine evasion is low, it also noted that more studies must be added to assess the risk of antibody escape.

Every year, on August 13, World Organ Donation Day is observed, globally, to spread awareness about the importance of organ donation and to make people aware about the misconceptions that surround organ donation.

World Organ Donation Day 2025 Theme And Significance

This year's theme for World Organ Donation Day is 'Answering the Call'. This theme highlights the important function played by the professionals in the organ donation community. What it means is to encourage more to strengthen their dedication to save as many lives as possible through organ donation and transplantation.

The Pace Hospital notes that as of 2021, globally, 1,44,302 organ transplantations had occurred, of which, 26.44% were of deceased organ donation. India performed a total of 12,259 transplantation, contributing to 8% in global transplantations. In India, the most transplants that took place were for kidneys at 74.27%, liver at 23.33%, heart at 1.23%, lung at 1.08%, pancreas at 0.15%, and small intestine at 0.03%.

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The overall number of deceased donors transplantation in India was 4.5%. While the deceased donors transplantation in India was reported 759 for kidney, 279 for liver and 99 for heart, the Indian Ministry of Health's estimated that it needs 175,000 kidneys, 50,000 livers, hearts, and lungs and 2,500 pancreas to meet the demand.

The Indian Ministry of Road and Transport and Highway's 2021 report notes that more than 1.5 lakh were reported as accident-related mortalities, however, only 552 deceased brain deaths organ transplantations took place in 2021. This is why it is more so important to raise awareness about organ donation to help those in requirement and reducing the number of patients on the waiting list.

History Of Organ Donation

It was in 1954, when the first successful organ transplant was performed. It was a kidney transplant by Dr Joseph Murray and his team at Peter Bent Brigham Hospital in Boston, Massachusetts.

The donor was Ronald Lee Herrick, who donated his organ to his twin brother Richard Herrick. Later in 1990, the doctor was honored with Nobel Prize in Physiology and Medicine for bringing advances in organ transplantation.

Th United Network for Organ Sharing (UNOS) highlights the timeline of the first donations and transplants performed of different organs.

• 1996: First simultaneous kidney and pancreas transplant performed.
• 1967: First successful liver transplant performed.
• 1968: The Southeast Organ Procurement Foundation implemented the first computer-based organ matching system, which was dubbed as UNOS. It successfully performed the first isolated pancreas transplant and heart transplant.
• 1981: First successful heart-lung transplant performed.
• 1983: First successful single-lung transplant performed. Cyclosporine, the first of a number of drugs that effectively treat organ rejection by suppressing the human immune system, introduced.
• 1984: National Organ Transplant Act (NOTA) was passed.
• 1986: First successful double-lung transplant performed.
• 1987: First successful intestinal transplant performed.
• 1988: First split-liver transplant performed.
• 1989: First successful living donor liver transplant performed.
• 1990: First successful living donor lung transplant performed.
• 1992: UNOS helped found Donate Life America to build public support for organ donation.
• 1998: First successful adult-to-adult living donor liver transplant performed.

How Organ Donation Can Change A Life?

In March 2024, a dedicated Delhi-based teacher, Meena Mehta was declared brain dead and her organs were donated to many, including her hands, shared her nephew Jawed Mehta. A 45-year-old Delhi-based painter had lost both his hands in a 2020 train accident, who received hand transplant. The hands were of Meena Mehta. After a 12-hour long surgery, the painter was able to paint again. Meena Mehta also donated her kidney, liver, and corneas, which has changed lives of three more people.