US tech billionaire and anti-ageing advocate Byran Johnson has revealed a major miscalculation involving a drug he once believed was a cornerstone of his protocol: Rapamycin. He said that the immunosuppressant, originally developed for organ transplant patients and now touted in anti-ageing circles, was something he had been experimenting with for five years. However, instead of reversing his age, it resulted in some serious.Inspired by a 2009 study that showed rapamycin could extend the lifespan of mice by up to 14%, along with a 2023 human trial where 65% of participants reported feeling healthier while on the drug, Johnson began carefully fine-tuning his dosage in hopes of maximizing benefits while minimizing risks. But instead of enhanced vitality, the tech entrepreneur began noticing a series of unsettling side effects like: 1. Mouth Ulcers2. Delayed Wound Healing3. Elevated Cholesterol4. Spike In Blood Sugar 5. Rise in Resting Heart RateWhat Does Science Say?Recently, a study conducted on the same by Yale University researchers supported Johnson's view, stating that the drug might accelerate biological ageing. Researchers identified 16 adverse effects on epigenetic markers (biological indicators tied to ageing), raising serious concerns about Rapamycin's long-term use as a longevity enhancer.While Johnson concluded that he has stopped taking rapamycin, he underscored that this isn't a defeat but rather a strategic pivot. "This is not the end-this is a reset," he said. "It's important to share both wins and failures. That's how progress is made."What Is Rapamycin?Rapamycin is an immunosuppressant (medication that reduces the body's immune response) commonly used for organ transplant patients to prevent organ rejection. It is also called sirolimus and has been previously shown to extend the life span in multiple models. According to Essential Interventional Cardiology, it is a natural macrocyclic lactone that binds to specific cytosolic proteins called FK506 binding protein, which blocks G1 to S cell cycle progression by inhibiting the activation of a protein known as mTOR (mammalian target of rapamycin). Johnson Is Building New ReligionThis comes as the 47-year-old announced that he is building a new religion that is aimed at saving human life. In a series of X posts, Johnson introduced his new ideology, "Don't Die", which he believes is the key to human survival and aligns artificial intelligence (AI) with humanity's best interests. "Don't Die is the next great framework. It's how we transition into the era of AI and solving death," he wrote in one of his posts. The tech millionaire also announced the launch of his new app and urged people to be a part of it to become those who can be "admired and respected" by the 25th century. "Dear humanity, I am building a religion. Wait a second, I know what you're going to say. Hold that knee-jerk reaction and let me explain. First, here's what's going to happen: + Don't Die becomes history's fastest-growing ideology. + It saves the human race. + And it ushers in an existence more spectacular than we can imagine. It is inevitable. The only question is: will you be an early or late adopter?" he wrote.