Two decades ago, veterinary epidemiologist Stephanie Venn-Watson made a remarkable discovery while studying the well-being of bottlenose dolphins trained by the US Navy. She found that the healthiest dolphins had elevated levels of a specific saturated fatty acid—C15:0. When these dolphins consumed fish rich in C15:0, their insulin, glucose, and cholesterol levels improved.

Now, C15:0, also known as pentadecanoic acid, is gaining recognition in longevity research. Studies suggest that this molecule may help lower the risk of fatty liver disease, Type 2 diabetes, and heart disease—and potentially even reverse these chronic conditions. Additionally, C15:0 is being explored for its ability to improve sleep, boost energy levels, and support joint health, drawing comparisons to well-known anti-aging drugs like rapamycin and metformin.

Venn-Watson, along with her husband Eric, a Navy physician, harnessed the potential of C15:0 by launching the supplement Fatty15 under the Seraphina Therapeutics brand in 2021. She further details her journey from marine mammal research to longevity science in her book, The Longevity Nutrient, arguing that C15:0 could be a key factor in extending human healthspan.

How Does C15:0 Work?

Like omega-3 fatty acids, C15:0 is considered an essential nutrient that the body cannot produce in sufficient amounts, requiring dietary intake or supplementation. However, research suggests that C15:0 may offer broader health benefits than omega-3.

This fatty acid activates AMPK, an enzyme essential for maintaining cellular energy balance. AMPK activity declines with age, leading to chronic inflammation and metabolic disturbances. Additionally, C15:0 inhibits mTOR, a protein linked to aging and cellular dysfunction. By targeting so-called “zombie cells” that have stopped dividing but continue to release harmful signals, C15:0 may help mitigate age-related diseases.

C15:0 also influences receptors responsible for regulating immunity, metabolism, mood, sleep, and appetite, potentially offering widespread health benefits.

Where Can You Get C15:0?

C15:0 is primarily found in whole-fat dairy products such as milk, butter, sour cream, and certain cheeses. According to Venn-Watson, one tablespoon of butter provides approximately 75 milligrams of C15:0. Other sources include high-oleic sunflower oil, meat, seafood, and seeds.

For those looking to supplement their intake, a daily dosage of 100 to 200 mg is recommended. Fatty15, Venn-Watson’s supplement, contains 100 mg of pure C15:0 per capsule. To make C15:0 more accessible, her team is developing it as a food fortifier.

How Long Does It Take to See Results?

Venn-Watson notes that about half of fatty15 users report experiencing benefits within two weeks, while 72% observe noticeable effects within 16 weeks. Some customers have reported improved sleep, enhanced hair and nail growth, and overall better well-being.

While dietary supplements like fatty15 do not require the rigorous testing of prescription medications, Venn-Watson emphasizes that extensive safety studies and controlled clinical trials have shown no adverse effects.

Is C15:0 More Effective Than Other Longevity Compounds?

Comparisons with other longevity molecules have placed C15:0 in an impressive position. Rapamycin, originally used to prevent organ rejection in transplant patients, is widely studied for its anti-aging properties. Similarly, metformin, a diabetes medication, has been investigated for its potential lifespan-extending effects. According to Venn-Watson, recent research suggests that fatty15 slightly outperformed rapamycin in cellular repair benefits while significantly surpassing metformin in effectiveness.

As research into C15:0 continues, its potential role in longevity and disease prevention could make it a game-changer in health and wellness.

Air pollution levels in Delhi rises after the festive celebrations in October, and due to the cold weather, the polluted air looms around us. While all of us are aware of the respiratory illnesses caused by air pollution, a new study has now shown that it could also trigger rheumatoid arthritis.

At the 40th annual conference of the Indian Rheumatology Association (IRACON 2025), which was held at the Yashobhoomi in Dwarka, with leading rheumatologists present there, revealed that there is plenty evidence that shows how toxic air and PM2.5 pollution could fuel a surge in cases of rheumatoid arthritis across Delhi-NCR.

What is rheumatoid arthritis?

It is a chronic autoimmune disease that causes pain, swelling, stiffness, and warmth in the joints and affects mostly small joints of hands and feet in a symmetrical pattern. It occurs when the immune system attacks the body's own tissue, particularly the lining of the joints and leads to inflammation or even damage to cartilage and bones.

What Are The Experts Saying?

The experts have pointed out that autoimmune diseases like rheumatoid arthritis was traditionally linked to genetics and immune system dysfunction. However, now it is increasingly being associated with environmental factors too. One of the biggest trigger is air pollution. As per the current estimates, the condition affects 1% of India's adult, and pollution adds fuel to the fire. The experts suggested with pollution being on the rise, the cases are expected to increase too.

"When pollution levels are high, the patients who do well otherwise, their condition also worsen… We are observing a rise in RA cases in patients living in polluted areas with no family history or genetic predisposition to autoimmune disease,” said Dr Uma Kumar, Head of Rheumatology at AIIMS Delhi. She also pointed out that most of these patients are between the age 20 to 50. “This is a public health emergency we can no longer ignore,” she said.

Dr Pulin Gupta, who is a professor and rheumatologist at the Dr Ram Manohar Lohia Hospital said, “What we are witnessing is not just a increase in cases of RA but these cases are also more severe… Reduced green spaces in urban areas are worsening the problem, depriving residents of protective environmental buffers.”

He also said that studies have now shown a strong association between exposure to PM2.5, nitrogen oxides, and ozone with increased risk of rheumatoid arthritis cases. "Living near busy roads, which means constant traffic-related pollution, has also been linked to higher RA risk,” he said.

What Is The Study Experts Are Basing Their Opinions At?

Dr Gupta pointed out the study that was the base of this claim of the relationship between pollution and rheumatoid arthritis. The 'landmark study' is published in the European Medical Journal, 2025, which has provided strong genetic evidence that connect air pollution to autoimmune diseases, including rheumatoid arthritis.

The study has used two-sample Mendelian randomisation approach and identified significant causal links between common pollutants and immune system dysfunction. It has also highlighted environmental damage as a crucial driver in the rise of these diseases.

Dr Gupta pointed out that Delhi is one of the top 10 most polluted cities in the world and has thus emerged as a hotbed of concern.

“Pollution is rewriting that narrative… turning healthy individuals into patients. The fact that young people with no family history are developing RA should set alarm bells ringing," said Dr Neeraj Jain, Scientific Chairman and Vice Chairman, Department of Rheumatology at Sir Ganga Ram Hospital.

“European cohorts similarly reported that people living in highly polluted cities had significantly higher morbidity related to autoimmune disorders. These findings mirror what doctors are now observing… with Delhi residents facing a double blow of respiratory distress and autoimmune flare-ups,” he said.

Joe Biden, the former president of United States in May announced that he had been diagnosed with prostate cancer and that it has spread to his bones. As per the recent reports, Biden is not undergoing a new phase of treatment for an aggressive form of cancer, confirmed a spokesperson.

The spokesperson of the former president said, "As part of a treatment plan for prostate cancer, President Biden is currently undergoing radiation therapy and hormone treatment."

As per the reports, the radiation treatment is expected to last for five weeks, and it will thus mark a new point in his care. He has already been taking a pill form of hormone medication for his condition.

It was last month only when Biden, 82, started a skin cancer treatment, known as Mohs surgery. What worried people was the large bandage on his forehead, which had been visible in public appearance.

The procedure, however, went well, the physician wrote: "all cancerous tissue was successfully removed" and that "no further treatment is required."

What Happened To President Joe Biden?

The former U.S. president revealed in May that he had been diagnosed with an aggressive form of prostate cancer that had already spread to his bones. His office stated that he was exploring multiple treatment options to manage the illness effectively and maintain his quality of life.

Following his diagnosis, he shared a heartfelt message on X, thanking people for their love and support, and acknowledging that cancer is a disease that touches every family in some way.

Medical experts noted at the time that because the cancer had metastasized, it was likely developing for several years before being detected. Prostate cancer can grow slowly in many cases, but when it reaches advanced stages, it often spreads to nearby tissues or bones, making treatment more complex.

Is Prostate Cancer Common In Men?

Men of his age group are typically not screened regularly for prostate cancer. According to the American Cancer Society, prostate screening is generally recommended every two years for men in their 50s and 60s, depending on risk factors and family history. It remains unclear whether he had undergone prostate cancer screening during his last medical examination while in office.

Now approaching his 83rd birthday, the former president is said to be “doing well” under ongoing medical supervision. His health updates have been closely watched, given his age and public profile.

In 2023, during a routine physical exam, doctors removed a skin lesion from his chest that was later confirmed to be cancerous.

He left the White House in January, just months after suspending his re-election campaign the previous year. In a significant political move, he endorsed Vice President Kamala Harris as his successor, citing his confidence in her leadership.

The final months of his presidency and campaign were marked by debates over his age and fitness for office, criticisms that he and his family consistently dismissed. Despite these challenges, his recent updates suggest a focus on health, family, and recovery, as he continues to receive widespread support from the public.

Each year on October 12 the world observes Arthritis Day to bring attention to the medication condition and ways to find out to prevent and to treat it as there is no cure. However, apart from the traditional treatments like medication, physical therapy, lifestyle changes, and surgery to manage symptoms, there have ben new treatments in the recent times too. Before jumping into what those treatments are, let us first understand what is arthritis?

It is a medical term for joint pain, inflammation, and stiffness, with over 100 different types. It also includes osteoarthritis and rheumatoid arthritis.

Osteoarthritis: It is a progressive, degenerative joint disease where the protective cartilage cushioning the ends of the bones breaks down. It then causes pain, stiffness, swelling and reduced mobility and affects the hands, knees, hips and spine.

Rheumatoid Arthritis: It is a chronic autoimmune disease that causes pain, swelling, stiffness, and warmth in the joints and affects mostly small joints of hands and feet in a symmetrical pattern. It occurs when the immune system attacks the body's own tissue, particularly the lining of the joints and leads to inflammation or even damage to cartilage and bones.

What Are The New Treatment On Arthritis?

As per the multiple new studies present at the American Society of Radiation Oncology (ASTRO), 2025, researchers from Korea, the US, and Germany reported that mild doses of radiation can significantly reduce pain and also improve mobility in patients with osteoarthritis.

Radiation Therapy For Arthritis

In South Korea, a randomized clinical trial was conducted with 114 volunteers, who had knee arthritis, and were treated with 3 Gy of radiation, which had spread over six sessions. Researchers also noticed that 70% of participants experienced meaningful improvement in pain, function and overall functioning. This was way higher than the 42% improvement seen in the placebo group.

Low-dose radiation is already common in the Europe. However, strong randomized data was limited till now. Dr Byong Hyuck Kim of the Seoul National University, who led the study also emphasized that here, the radiation doses are 10 to 20 times lower than cancer therapy levels and targets only the joints far from the vital organs.

Artificial Cartilage Helps Arthritis

Researchers from the University of Cambridge designed an artificial cartilage that could help with arthritis treatment. This 'cartilage' can sense tiny changes in the body, including arthritis flare-up and release drugs exactly when and where they are needed.

The 'cartilage' is squishy in nature and can be loaded with anti-inflammatory drugs that are released in response to small changes in pH in the body. During arthritis flare-up, joint becomes inflamed and more acidic. The 'cartilage' becomes softer as the change in pH is noticed, especially when the acidity increases and it triggers the release of drug molecules that can be encapsulated within its structure.

The entire study is published in the Journal of American Chemical Society.