The liver is one of the largest and hardest-working organs in the human body. It plays a crucial role in keeping you healthy by filtering toxins from the blood, aiding digestion, storing energy, and performing hundreds of other vital tasks. When this powerhouse organ becomes damaged or starts to underperform, your body often gives off warning signs, and some of the earliest clues can show up on your skin.

Liver disease is a progressive condition that, if left untreated, can lead to serious complications such as cirrhosis or liver failure. The good news is that catching it early makes a big difference. According to experts, there are visible skin changes you can notice yourself that might hint at underlying liver trouble.

Here are four skin-related signs that could point to liver disease and why they happen, as per Dr Saurabh Sethi, MD, MPH, board-certified gastroenterologist, hepatologist, and interventional endoscopist trained at AIIMS, Harvard and Stanford.

Yellowing of the Skin and Eyes (Jaundice)

This is perhaps the most well-known sign of liver issues. Jaundice occurs when bilirubin, a yellowish pigment produced during the breakdown of red blood cells, builds up in the body. Normally, the liver processes bilirubin and flushes it out. But when the liver is damaged or inflamed, this process is disrupted, leading to yellowing of the skin and the whites of the eyes. If you or someone you know notices this change, it’s a strong signal to get checked.

Spider Angiomas (Spider-like Blood Vessels)

These are small, web-like clusters of dilated blood vessels that often appear on the face, neck, upper chest, or arms. They get their name because they resemble tiny red spiders just under the surface of the skin. In liver disease, they tend to appear due to increased estrogen levels in the body, which the liver normally helps regulate. Their presence could be more than just a cosmetic concern—it may be a sign of liver dysfunction.

Palmar Erythema (Red Palms)

Palmar erythema refers to redness and sometimes swelling of the palms, particularly around the base of the thumb and little finger. This condition is also linked to elevated estrogen levels in the bloodstream and increased blood flow, both of which may result from impaired liver function. It can be a subtle symptom that’s easy to miss, but it’s worth noting if it persists without another explanation.

Unexplained Itching, Especially at Night

If you're experiencing persistent itching that doesn’t seem to have a clear cause, and particularly if it gets worse at night, it could be linked to liver disease. This type of itching often stems from the buildup of bile salts under the skin, which happens when the liver struggles to eliminate waste properly. Unlike typical skin conditions, liver-related itching usually doesn't come with a rash, which makes it even trickier to identify.

Understanding Liver Disease and Its Stages

Chronic liver disease doesn’t develop overnight. According to the Cleveland Clinic, it typically progresses through four key stages: hepatitis (inflammation), fibrosis (mild scarring), cirrhosis (advanced scarring), and eventually liver failure if left untreated.

Globally, liver disease is responsible for around 2 million deaths each year, roughly 4 percent of all deaths. In the U.S., it affects about 4.5 million adults, with men being diagnosed almost twice as often as women.

Why Early Detection Matters

Many symptoms of liver disease can be subtle or easily mistaken for other conditions. That’s why it’s so important to pay attention to changes in your body, especially your skin. If you notice any of these signs, consider speaking to a healthcare provider. Early detection and proper management can help prevent the disease from progressing and protect your long-term health.

The World Health Organization estimates that 10 percent (190 million) of reproductive-age women worldwide suffer from endometriosis.

The chronic and complex menstrual disease that affects many women is characterized by severe pain during menstruation, heavy menstrual bleeding, chronic pelvic pain (pain that does not go away when the menstrual cycle ends), infertility, and abdominal bloating and nausea.

The incurable condition poses a significant challenge to women as it affects their personal and professional lives, relationships, and fertility, among others, due to persistent pain and fatigue.

The diagnosis also gets delayed, as endometriosis is often confused with PCOS, or Polycystic Ovary Syndrome, due to some overlapping symptoms like irregular menstrual periods. The symptoms may continue to persist or recur after treatment is initiated.

In a powerful statement resonating with millions worldwide, Indian American author and television host Padma Lakshmi has shared her experience with the condition.

Opening about her personal battle with endometriosis, the 55-year-old, Co-founder of Endometriosis Foundation of America, said that the condition made her understand how strong she is and called for greater awareness and self-advocacy among women.

"Endometriosis has taught me that I should always listen to my body. Pain is your body's way of telling you something is wrong,” said Lakshmi, in a media post on social media platform Instagram.

"Through my struggles with endometriosis, I've learned that, actually, I have a very high threshold for pain, that I may be stronger than I know, but that I shouldn't always need to be,” PopSugar quoted her as saying.

Lakshmi noted that it is now her life's mission "to advocate for my own health, and also to advocate for all women with endometriosis."

What Is Endometriosis?

Endometriosis happens when tissue similar to the lining of the uterus grows outside the uterus. These tissues commonly develop on the ovaries, fallopian tubes, or the pelvic lining.

Endometriosis affects many women and can impact their daily lives, including their ability to work comfortably. Many women continue their professional responsibilities despite experiencing severe discomfort, fatigue, and pain.

Raising awareness about the condition and encouraging supportive workplaces can help women manage both their health and career more effectively.

Since it is a progressive disorder, timely intervention remains key to managing it. In many cases, women live with symptoms for several years before receiving the correct diagnosis, which can delay treatment and affect their quality of life.

Treating Endometriosis

Treatment is particularly based on the severity of symptoms. Women will be advised lifestyle modifications such as regular exercise, stress management, and an anti-inflammatory diet. Non-steroidal anti-inflammatory drugs may help reduce discomfort.

Hormonal therapies may also be used to control symptoms. Some women will be advised to undergo laparoscopy to remove endometriotic cysts.

Minimally invasive surgery can help remove lesions and restore pelvic anatomy, which may also improve fertility in some cases. In advanced cases, surgery can be recommended to women.

In a shocking incident, a woman contracted the herpes virus after using shared lipstick samples at a cosmetic store, raising concerns about makeup hygiene.

The incident highlights the risks involved in trying products that come into direct contact with the skin and are shared with a lot of people.

Also Read: World Autism Awareness Day 2026: Can Cell Therapy Be The Future Of Autism Treatment?

What Is Herpes?

The herpes simplex virus (HSV) is very common, and the infection is lifelong. But the symptoms can come and go over different periods of life. Many people never get any symptoms linked to their infection.

The common virus, carried by up to 50 to 80 percent of adults, can cause painful blisters or ulcers. It primarily spreads by skin-to-skin contact. It is treatable but not curable.

There are two types of herpes simplex virus: HSV-1 and HSV-2.

HSV- 1 is the most common and usually spreads by oral contact. It causes infections in or around the mouth (such as oral herpes or cold sores), as well as genital herpes.

Common oral herpes symptoms include

• blisters (cold sores)
• open sores (ulcers) in or around the mouth or lips.

HSV-2 generally spreads by sexual contact and causes genital herpes.

Its symptoms include painful

• bumps,
• blisters,
• open sores (ulcers) around the genitals or anus.

How Makeup Testers Can Spread Infection

Experts warned that makeup testers can become a breeding ground for germs. The repeated use of the open samples can spur their growth and can then spread by “double-dipping” — reusing an applicator after touching the skin. This can transfer viruses and bacteria between users.

“You can absolutely get a herpes infection from a makeup tester," Dr. Whitney Bowe, a dermatologist in New York City, told TODAY. "The more ‘double dipping’ that occurs, the higher the chance of spreading viruses or bacteria at a makeup counter.”

A 2010 study by researchers from Rowan University in New Jersey found that cosmetic samples harbored strep, E.coli, and staph.

For two years, the team examined makeup testers at makeup counters, specialty stores, and drug stores. They found that Saturday is the busiest day of the week, and 100 percent of the samples carried some sort of germ.

How To Stay Safe?

To reduce the risk of infection, experts recommend:

• Much like the toothbrush, personal cosmetics and cosmetic brushes must not be shared.
• Wash and dry your brushes regularly to avoid bacterial growth.
• Avoid applying testers directly to your lips or skin
• Use disposable applicators
• Test products on your hand rather than your face
• Avoid using testers if you have cuts, chapped lips, or active infections.

April 2 is celebrated worldwide as “Autism Awareness Day” and April as Autism month to create awareness and promote inclusivity and acceptance in society for individuals with autism.

So what exactly is Autism, and why do we need to create a culture of awareness and acceptance?

As per DSM V (Diagnostic and Statistical Manual of Mental Disorders) criteria, in simple terms, there is poor eye contact, impaired social communication skills, repetitive patterns (certain movements or fixation on certain toys, objects), difficulties with sensory processing - extreme sensitivity to sensory inputs (dislike loud noises, sensitive to touch), etc.

As a child, these individuals may not respond to name-calling, have poor eye contact/lack gestures like pointing, etc., lack imagination in play, and may not be able to relate and respond to the emotions of others. They have set routines and dislike changes to their routines. All this can cause significant disruption to their day-to-day functioning.

This year’s theme of -Autism and Humanity- Every Life has Value” reiterates the need for inclusion of autism, ensuring equitable representation of these individuals. Ensuring that society not only recognizes them but also treats them with equal respect and dignity.

Educational Support and Inclusive Workplace

Sarva Shiksha Abhiyan (SSA) was one of the Government's flagship programs, along with Action for Autism, to disseminate information in schools regarding inclusive education for autism. Education is a key foundation to ensure children with autism get suitable opportunities as adults. Special educators, with additional support in schools, can go a long way in ensuring their potential is maximized.

Many IT giants like Microsoft, Google, and SAP encourage tapping the potential of individuals with autism and their exceptional skills. In our country, organizations and NGOs, including Action for Autism, offer training for future employment opportunities.

There is a spectrum of Autistic Spectrum Disorders (ASD) known as Asperger’s syndrome, and these individuals have normal to above average intelligence and can have some exceptional skills, and the world includes some living examples of these with a higher IQ, some of whom are the most successful and famous personalities. Even on the other end of the spectrum, autistic individuals have exceptional skills, some of which include great attention to detail, creativity, problem-solving, and lateral out-of-the-box thinking.

Options for flexible working hours (part-time), understanding their need for routines, and explaining them beforehand regarding important changes to schedules can help them adapt better to an otherwise challenging workplace.

The Need For Sensitization

Understanding individuals with autism may need little extra support, being a little flexible with time deadlines, giving simple instructions, especially written/visual ones, and allowing them time to overcome their communication barriers can go a long way in ensuring they feel heard and valued like anyone else in the workplace.

Sensitization of all major organization employees to foster a culture of acceptance and awareness, and an accessible work environment, is the need of the hour. Autistic individuals do well in a variety of job profiles, including IT, technology, finance, art and creativity, and administration.

Environmental modifications like background noise cancellation with headphones help those with sensory processing issues. At the end of the day, none of us is perfect, it's recognizing our special skills and strengthening them.

Possibilities are endless if we wish to encourage and make these individuals heard. So, let’s carry the Autism Awareness Day beyond a mere day of awareness and light it up blue. Let’s value and acknowledge them being different, but also empower them to act on their special skills to earn them a dignified place in society and the workplace.