Happiness is influenced by a complex interplay of various chemicals in our brain, particularly four key neurotransmitters, D.O.S.E or Dopamine, Oxytocin, Serotonin, and Endorphins. These chemicals, often referred to as "happiness chemicals," are responsible for creating feelings of joy, motivation, connection, and calm.

However, when there's a deficiency in any of these, it can significantly affect our mood, energy, and overall well-being. Let’s dive into what these four neurotransmitters are, how their deficiency impacts us, and how we can boost their levels naturally.

Dopamine: The Motivation and Reward Chemical

Dopamine is often called the "motivation molecule." It plays a major role in enabling motivation, learning, and the pleasure-reward system in the brain. When we accomplish something — whether it’s finishing a project, completing a workout, or achieving a goal — dopamine gives us that sense of satisfaction and determination to continue.

Deficiency Effects:

When dopamine levels are low, it can lead to procrastination, low self-esteem, lack of focus, and general fatigue. A person might feel anxious, hopeless, or experience mood swings because the brain isn’t getting the reward signals it needs.

Boosting Dopamine:

You can increase dopamine levels by setting and achieving small goals, exercising regularly, eating foods rich in L-Tyrosine (such as almonds, avocados, and eggs), and practicing mindfulness or meditation. Engaging in creative activities like writing or drawing also helps boost dopamine levels.

Oxytocin: The Bonding Chemical

Oxytocin is often referred to as the "love hormone" or "cuddle hormone" because it plays a major role in social bonding and trust. It’s released when we hug, touch, or engage in other forms of physical affection. Oxytocin fosters feelings of connection and emotional intimacy, making it essential for relationships, family bonding, and even team cooperation.

Deficiency Effects:

A lack of oxytocin can lead to feelings of loneliness, stress, anxiety, and difficulties in forming or maintaining relationships. Low oxytocin levels are associated with feelings of isolation and disconnection from others.

Boosting Oxytocin:

You can raise your oxytocin levels through physical touch, socialising, spending quality time with loved ones, and even engaging in activities like massage or listening to soothing music. Acts of kindness, such as helping others or volunteering, also help release oxytocin.

Serotonin: The Mood Stabiliser

Serotonin is responsible for feelings of well-being and contentment. It helps regulate mood, sleep, digestion, and even social behavior. People who have balanced serotonin levels often feel calm, confident, and emotionally stable. Serotonin is crucial in helping people feel valued and significant among their peers.

Deficiency Effects:

Low serotonin levels are linked to depression, low self-esteem, irritability, and mood swings. Individuals may feel overly sensitive to criticism, experience panic attacks, or struggle with social phobias when serotonin is deficient.

Boosting Serotonin:

You can boost serotonin by getting regular exercise, exposing yourself to sunlight, engaging in cold showers or massages, and practicing mindfulness. Simple activities like walking in nature, meditating, or doing yoga are also effective serotonin enhancers.

Endorphins: The Pain Reliever

Endorphins are the body’s natural painkillers. Released in response to stress, pain, or intense physical activity, they help alleviate discomfort and promote a sense of euphoria. Endorphins are what make you feel good after a workout or a hearty laugh, often referred to as the "runner's high."

Deficiency Effects:

Without enough endorphins, people may experience anxiety, depression, chronic pain, and insomnia. A deficiency in endorphins can make daily life feel overwhelming and physically draining.

Boosting Endorphins:

To boost endorphins, engage in laughter, exercise, and stretching activities. Eating spicy foods or dark chocolate can also stimulate endorphin production. Regular massage therapy and meditation are other ways to naturally elevate endorphin levels.

Falling asleep to the gentle hum of white noise might seem like a good idea, but a brain doctor warns it could actually cause problems later on, especially if you make one big mistake. This expert, Dr. Baibing Chen (known as Dr. Bing online), suggests that trying to sleep better with loud white noise could raise your risk of getting dementia in the future. He personally avoids three things before bed, and making white noise too loud is one of them.

Hidden Danger of Loud White Noise

Dr. Bing explains that many people use white noise machines to block out annoying sounds like traffic, a partner's snoring, or even a dog licking its paw in the middle of the night. But he warns that if the machine is too loud, it can slowly damage your hearing. He highlights that losing your hearing is one of the biggest risk factors for dementia when you get older. While there's no strong proof that white noise itself directly causes dementia, some studies do suggest that being exposed to a lot of noise over time, including very loud white noise, might be linked to a higher chance of developing dementia.

What Exactly Is White Noise and Does It Help You Sleep?

The Sleep Foundation describes white noise as a type of "broadband noise" that includes all sounds our ears can hear. Think of the static hiss from an untuned radio or the gentle hum of a fan – these are common examples of white noise. Studies on whether white noise actually helps you sleep have shown mixed results.

Some research found that white noise helped newborn babies fall asleep faster, and also helped adults living in noisy parts of New York City drift off more quickly and get better sleep. However, in some cases, white noise actually made it harder for people to fall asleep. This suggests that whether it helps or not really depends on each person and their specific situation.

How to Use White Noise Safely

You can buy special white noise machines from stores, or you can use cheaper options like smartphone apps, which you can find in app stores. If you enjoy nature sounds, pink noise might be a better choice for you, as it includes calming sounds like rain, waterfalls, and flowing rivers. The Sleep Foundation says that some therapists often use pink noise to help treat hearing problems or ringing in the ears (like tinnitus). Here are some safety tips for listening to white noise.

Keep the volume low

Dr. Bing advises setting your white noise machine to a maximum of 50 decibels. This is similar to the quiet hum of a refrigerator.

Maintain a safe distance

Place the machine at least 30 centimeters (about a foot) away from your bed, especially for children.

Address hearing loss

Untreated hearing problems can lead to loneliness and a decline in thinking abilities, both of which increase dementia risk.

Get your hearing checked

The Alzheimer's Society recommends regular hearing tests, especially if you're between 40 and 65, as hearing loss can be an early sign of dementia or increase your risk.

Consider hearing aids

There's evidence that using hearing aids might help slow down thinking problems related to dementia.

A PubMed search for “ivermectin” and “cancer” yields hundreds of preclinical studies, many conducted on cell cultures or mice. In the sector of alternative cancer treatments, few drugs have generated as much buzz—and controversy—as ivermectin. Once lauded for its ability to treat parasitic infections and awarded a Nobel Prize for its contribution to global health, ivermectin has more recently been at the center of misleading narratives, first as an alleged cure for COVID-19 and now as a so-called “cancer breakthrough.”

Social media, podcasts, and even some patient communities are abuzz with stories of miraculous recoveries and scientific “breakthroughs.” But what’s driving this surge of interest, and does the science live up to the hype?

For decades, ivermectin was best known as a safe and effective treatment for parasitic diseases like river blindness and scabies. Its impact was so significant that it earned its discoverers the Nobel Prize in 2015. But after being widely discredited as a COVID-19 treatment, ivermectin found new life in online cancer forums and alternative health circles, where it’s now promoted as a cheap, accessible alternative to mainstream cancer therapies.

The renewed interest in ivermectin as a potential cancer therapy has largely been driven by non-scientific sources. On platforms like X (formerly Twitter), Substack, and YouTube, influential figures promote ivermectin as a natural, low-cost cure "suppressed by big pharma."

One viral moment came during a widely viewed episode of The Joe Rogan Experience, in which actor Mel Gibson recounted how three friends with stage IV cancer reportedly became cancer-free after taking ivermectin and fenbendazole. That snippet, viewed by nearly 20 million people, has fueled speculation—despite the anecdotal nature of the claims.

Further fanning the flames, public figures like Robert F. Kennedy Jr. have accused health authorities of deliberately suppressing ivermectin to favor profit-driven cancer treatments—a claim lacking credible evidence but resonating with those distrustful of traditional medicine.

What Is Ivermectin Approved For?

Ivermectin is a U.S. FDA-approved antiparasitic drug, used for treating river blindness (onchocerciasis), strongyloidiasis, lice, and scabies in humans. It’s also commonly used in veterinary medicine to treat parasitic infections in animals.

Its development and application in tropical medicine were so impactful that the researchers behind ivermectin received the Nobel Prize in 2015. However, its uses have always remained confined to parasitic infections—not viral illnesses like COVID-19, and certainly not cancer.

How Ivermectin Might Work Against Cancer?

Ivermectin’s anticancer effects appear to be unrelated to its anti-parasitic action. Instead, the drug disrupts cancer cell signaling, impairs mitochondrial function, induces autophagy (a process that can kill cancer cells), and inhibits cancer stem cells. It also weakens the mechanisms that allow tumors to resist chemotherapy and evade the immune system.

In the Brazilian rat study, nano-encapsulated ivermectin not only shrank tumors but also improved the health of surrounding brain tissue and reduced abnormal blood vessel growth—suggesting multiple avenues of attack against cancer.

What the Science Says About Ivermectin and Cancer?

A search of scientific literature reveals hundreds of studies linking ivermectin to cancer research. Some of these suggest that ivermectin may interfere with cancer cell metabolism, inhibit tumor growth, or boost immune response in lab-controlled environments. But—and this is critical—lab results do not equal human results.

Dr. Peter P. Lee, chair of the Department of Immuno-Oncology at the Beckman Research Institute of City of Hope, has studied ivermectin's immune-stimulating effects in mice. While findings hinted at some tumor-modulating potential, they fell far short of demonstrating therapeutic value in humans.

At the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, early results from a phase 1/2 trial combining ivermectin with immunotherapy in metastatic triple-negative breast cancer patients showed no significant benefit. Of the eight patients evaluated, six experienced disease progression, one had a partial response, and one achieved stable disease.

Risks of Using Ivermectin as a Cancer Therapy

Promoting ivermectin for cancer without evidence carries several dangers:

Neurological toxicity: High doses can lead to seizures, confusion, blurred vision, or even coma.

Drug interactions: Ivermectin can interfere with common cancer medications, such as blood thinners or immunotherapy agents.

Treatment delays: Perhaps most concerning is the risk that patients may delay or forgo evidence-based cancer treatments in favor of unproven, alternative drugs. Such delays can allow the cancer to progress unchecked.

False hope and financial exploitation: Some patients may spend time, money, and emotional energy pursuing unproven remedies, only to face worsening outcomes.

Why the Sudden Surge in Popularity?

Several factors have converged to make ivermectin a hot topic in cancer circles. Social media amplification has played a major role, with influencers and alternative health advocates promoting ivermectin as a cheap, “natural” alternative to mainstream cancer treatments. These promotions often rely on cherry-picked studies or anecdotal stories of success, rather than clinical evidence. Distrust in conventional oncology also fuels interest—many patients, disillusioned by the side effects, financial burden, or perceived limitations of standard therapies, are increasingly drawn to off-label or experimental alternatives like ivermectin.

Preclinical breakthroughs, such as the much-publicized Brazilian nano-ivermectin study in animals, add to the intrigue by generating hopeful headlines, despite lacking human trial data. Finally, political and cultural overtones stemming from ivermectin’s controversial use during the COVID-19 pandemic have transformed the drug into a rallying point for individuals skeptical of established medical authorities, further complicating the public narrative around its potential role in cancer treatment.

Where Does This Leave Patients and Doctors?

While the science around ivermectin and cancer is evolving, the consensus among oncologists and researchers is clear: There is no solid evidence that ivermectin can cure or significantly treat cancer in humans. The most promising findings are still limited to laboratory and animal studies, and ongoing clinical trials have yet to show meaningful benefit in people.

That said, the safety profile in small studies is reassuring, and the innovative use of nanotechnology to deliver ivermectin to brain tumors is a genuine scientific advance—one that warrants further research but not premature celebration.

Curiosity Is Good—But Let's Stick to the Science

The buzz around ivermectin as a cancer cure is based more on anecdotes and viral claims than on real science. While early lab data may inspire future studies, there is currently no evidence that ivermectin can treat or cure cancer in humans. Ivermectin’s journey from Nobel-winning anti-parasitic to cancer “miracle drug” is a testament to both the power of scientific curiosity and the dangers of viral misinformation.

Patients facing cancer deserve hope—but not false hope. Turning away from proven therapies in favor of unproven ones could have devastating consequences.

Sex is typically all about pleasure, intimacy, and—yes—a healthy dose of natural feel-good hormones but for some, sex can also have an added, decidedly uncomfortable surprise: an allergic reaction to semen. Though it sounds unusual and even bizarre to many, semen allergy, or medically termed seminal plasma hypersensitivity (SPH), is a legitimate and underdiagnosed condition—and notably, it doesn't only occur in women, men can also experience it.

SPH is a type I hypersensitivity reaction—much like the way some individuals react to peanuts, pollen, or dander from a cat. First described in the late 1960s, SPH is not caused by the sperm cells themselves, but by proteins of the seminal plasma, the fluid that coats sperm. One main perpetrator seems to be prostate-specific antigen (PSA), a protein found in common semen.

What is Semen Allergy?

A semen allergy is a reaction by the immune system to proteins within seminal plasma, the liquid that transports sperm, rather than sperm cells. It was first described in the 1960s and is now considered a type 1 hypersensitivity, which includes such allergies as peanuts, pollen, and animal dander.

The reaction may lead to burning, itching, redness, or swelling wherever semen touches the skin or mucous membranes. In more severe reactions, it may initiate systemic symptoms like hives, wheezing, dizziness, or even life-threatening anaphylaxis.

Is Semen Allergy Really That Common?

SPH was previously thought to be very rare, with fewer than 100 cases reported around the globe in the late 1990s. More recent findings contradict this. A late 1990s study discovered that almost 12% of women with postcoital symptoms could be diagnosed with probable SPH. Figures now estimate that as many as 40,000 American women may be suffering from the condition. The experts warn that their estimates are probably on the low side, however, because so many individuals are unwilling to complain about sex-related symptoms or misdiagnosed with yeast infections or other problems.

Men, in fact, can be allergic to their own semen—a condition referred to as post-orgasmic illness syndrome (POIS). POIS is a rare condition that results in flu-like symptoms like fatigue, brain fog, and muscle pain just after ejaculation.

Women with the condition can experience symptoms within minutes after exposure to semen—usually during or after unprotected anal or vaginal sex. They can experience anything from irritation (burning, redness, vulvar or vaginal lining swelling) to systemic allergic reactions like hives, facial swelling, wheezing, diarrhea or even anaphylaxis. Although there have been no reported deaths from semen allergy the physical and emotional cost it can exact is immense.

What Triggers a Semen Allergy?

At the core of the disorder lies the immune system confusing proteins contained in seminal fluid as dangerous invaders. This may activate the release of histamines and other inflammatory chemicals that trigger itching, pain or worse.

One can be allergic to the semen of one partner but not the other because of individual protein combinations and possible residues of drugs, foods, or allergens such as Brazil nuts in semen. There can be cross-reactivity in extremely rare instances when a person with a dog allergy, for instance, can be allergic to semen because the canine and human PSA proteins have similarities. Other aspects that can affect:

Genetic susceptibility: Individuals with a history of allergy or atopic disease in the family are potentially predisposed to SPH.

Cross-reactivity: Certain proteins within semen bear resemblance to allergens on pet dander or even food proteins, causing an unanticipated reaction. A woman with a hypersensitivity to dogs, for instance, can produce an allergic reaction to semen because proteins in semen share structural features.

Medications and diet: Residuals of drugs or food allergens may be found in semen, resulting in reactions in reactive partners.

Hormonal changes: Menstrual cycle fluctuations or pregnancy can affect immune system reactions and symptom intensity.

If you regularly have burning, itching, or swelling in the genitalia following unprotected intercourse—and the symptoms resolve when a condom is worn—you might be facing SPH. Systemic signs such as hives, wheezing, or lightheadedness within minutes of ejaculation are stronger predictors.

Keep in mind that a number of other conditions are similar in symptoms—yeast infection, UTI, or latex allergy among them. That's why expert diagnosis is necessary. Allergy testing on your partner's semen (or using PSA-specific antibodies) can shed some light.

Wait, Men Can Be Allergic to Their Own Semen?

Yes, it is possible. In a very rare condition known as Post-Orgasmic Illness Syndrome (POIS), men develop flu-like symptoms—muscle pain, tiredness, mental confusion—just after ejaculation. Although the reason is not clear, POIS is believed to be an allergic or autoimmune response to one's own semen.

In others, men experience rashes or irritation of the skin on the shaft or foreskin of the penis—particularly if semen comes into contact with the skin during sex or masturbation. In some instances, skin-prick testing using the man's own semen can diagnose this condition.

Impact on Fertility and Relationships

SPH does not cause infertility, but it can complicate conception. Since avoiding semen is the most effective way to prevent symptoms, couples trying to conceive face unique challenges. Treatments include:

• Antihistamines taken before sex to reduce or prevent symptoms.
• Desensitization therapy, where diluted seminal plasma is introduced gradually to build tolerance.
• IVF with washed sperm, which removes the allergenic proteins, allowing for conception without triggering a reaction.
• A lot of women with SPH have successfully gotten pregnant, naturally or with medical interventions

Can You Prevent or Treat Semen Allergy?

The most simple and effective way to avoid symptoms is to employ the use of condoms, which can suitably avoid contact with semen and nullify allergic reactions altogether. Nonetheless, when condoms are unavailable or in cases of severe symptoms, antihistamines, EpiPens, and desensitization procedures might come into play.

It's important to see a board-certified allergist, preferably with experience in treating unusual sexual allergies. In a few instances, referrals to academic medical centers are necessary because of the esoteric nature of this condition.

Why People Don't Know About Semen Allery?

Even in 2025, sexual health still carries a significant stigma. Many people, especially women, feel uncomfortable discussing pain or irritation following sex. This silence can lead to misdiagnosis, with symptoms often attributed to yeast infections, bacterial vaginosis, or STIs.

In Bernstein's 1997 research, almost half of the symptomatic women had never been tested for SPH. Consequently, many of them wasted decades suffering in silence, receiving ineffectual treatment and even relational strain.

In spite of its prevalence, semen allergy continues to be underdiagnosed and subject to misconceptions. Stigma, shame, and lack of familiarity among medical providers translate into many individuals suffering silently. Research indicates that almost half of women with post-coital symptoms have never been examined for SPH.

A stinging, burning feeling after sex is never normal—and not something you need to be ashamed of. If you think that you might be allergic to semen, don't stay silent. Speak with your doctor, push for proper testing, and discuss your options.