The former Big Bang Theory star, Mayim Bialik, has opened up about her user experience of using the popular GLP-1 medication, which led to weeks of debilitating side effects after a single low-dose injection. Mayim said she needed IV fluids at home after experiencing 'explosive' gastrointestinal symptoms. In an essay that she penned for The Free Press titled "My GLP-1 Nightmare," the 50-year-old actress admitted that she had grappled with body image issues since she was a teenager. However, she emphasized that weight loss was not her primary reason for taking GLP-1 medication. "I went on a weight-loss drug because a doctor told me it might help ease symptoms I’ve struggled with for basically my entire adult life," Mayim said. Mayim revealed that she had been diagnosed with the autoimmune disorder, Graves’ disease, at age 23. The American actress wrote that in the last 25 years, the disorder has led to unexplained symptoms including "full-body rashes and welts, severe histamine reactions to foods and smells, palpitations, hourly wake-ups for an entire year, crying jags alternating with crippling depression." The former "Jeopardy" host recalled that from connective tissue disease to mast cell activation syndrome (MCAS) to Sjögren’s syndrome, and dysautonomia, she got a series of diagnoses, yet "no single specialist could quite explain". Severe Side Effects After A Single GLP-1 Injection Thus, on the advice of three different doctors, who suggested GLP-1 because "the drugs have shown promise in reducing the systemic inflammation that drives autoimmune conditions," Mayim decided to take the medication a few months ago, Fox News reported. While she hoped that GLP-1 could be the "magic cure," the experience quickly took an unexpected turn. "I took one shot of the lowest dose of a synthetic GLP-1, and to say I had an adverse reaction would be somewhat of an understatement," she said. "Explosive, uncontrollable diarrhea. Sulfur burps were so violent that they left me afraid to open my mouth in public. Sneezing attacks every time I tried to eat or drink—which apparently has a name, snatiation." "Cramping. Bloating. Full-body aching, as though I had the flu," she continued. "And an inability to keep down even small sips of water without sprinting to the bathroom with yet more explosive diarrhea. More than three times, I didn’t make it." Mayim recalled that she struggled to hold down food or water, and the ordeal left her so dehydrated that she needed IV fluids. Mayim wrote that she ultimately decided to discontinue taking the GLP-1 and gave her "remaining hundreds of dollars of shots" to a friend. View this post on Instagram A post shared by mayim bialik (@missmayim)]]>Why Weight Loss Drugs May Not Work For AllAlso read: Not Everyone Taking Ozempic, Other GLP-1 Drugs Will Lose Weight, Experts SayGLP-1 receptor agonist drugs such as Ozempic and Wegovy have shown significant benefits for people with diabetes and obesity. While these GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Reasons include:1. Genetic and Hormonal Variability2. Underlying Medical Conditions3. Unrealistic ExpectationsA recent study suggests that genetic resistance may also be at play. In other words, some people are biologically less responsive to these medications, making these drugs less effective.