Anyone who has been prescribed medication for depression knows the long list of possible side effects: fatigue, appetite changes, headaches, and more. But these physical reactions are not the same across all medications. Recent research shows that some antidepressants can cause quick changes in weight, heart rate, and blood pressure, while others are relatively mild. The purpose of this work was to rank antidepressants based on their known side effects, specifically those that appear within the first eight weeks of starting treatment.

What Are Antidepressants?

Antidepressants are prescription medications used to treat conditions like depression, anxiety, chronic pain, and more by boosting brain chemicals that regulate mood. Common types include SSRIs, SNRIs, and NDRIs. They often take several weeks to show full effect. Typical side effects can include dry mouth, weight changes, and dizziness. Interestingly, new research suggests that the side effect profile can vary depending on the specific antidepressant.

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Types of Antidepressants

There are several categories of antidepressant medications, as per NHS:

• Selective serotonin reuptake inhibitors (SSRIs): Increase serotonin levels in the brain to improve mood.
• Serotonin-norepinephrine reuptake inhibitors (SNRIs): Raise both serotonin and norepinephrine, helping with mood, alertness, and stress.
• Tricyclic antidepressants: Affect serotonin and norepinephrine like SNRIs, but also influence other parts of the body and brain.
• Monoamine oxidase inhibitors (MAOIs): Boost brain chemical levels by blocking an enzyme that breaks them down.
• NMDA receptor antagonists: Work quickly to improve mood by targeting specific brain receptors, usually given in clinics if other medications fail.
• Atypical antidepressants: Don’t fit neatly into other groups, each affecting brain chemicals in unique ways.

Physical Side Effects Differ Across Antidepressants

Millions of adults in the U.S. rely on antidepressants for conditions such as depression and anxiety. Like all medications, these drugs can cause side effects, though the severity varies. Researchers from King’s College London and the University of Oxford examined just how differently side effects appear across 30 antidepressants, analyzing data from over 58,500 participants in more than 150 studies.

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“Not all antidepressants are the same when it comes to their physical side effects,” explained Toby Pillinger, an academic clinical lecturer at King’s College London. The findings, published in The Lancet, are the first to link specific physical side effects to individual antidepressants, offering potentially important guidance for doctors prescribing these medications, which are taken by up to 17% of adults in Europe and North America.

Drugs reviewed included SSRIs like sertraline (Zoloft) and fluoxetine (Prozac), SNRIs like duloxetine (Cymbalta) and venlafaxine (Effexor), and NDRIs like bupropion (Wellbutrin).

What the Data Shows

The research looked at 30 commonly prescribed antidepressants across 151 studies involving over 58,500 patients. Not everyone develops side effects, but on average:

• Eight weeks of agomelatine use linked to a 2.4kg weight loss, whereas maprotiline led to nearly 2kg weight gain.
• Heart rate varied by 21 beats per minute between fluvoxamine, which slowed the heart, and nortriptyline, which sped it up.
• Blood pressure differed by 11 mmHg between nortriptyline and doxepin.

Antidepressants: Effects on Heart Rate and Blood Pressure

Some medications, like fluoxetine, were linked to increased systolic blood pressure, while others, like citalopram (Celexa), were not. Citalopram was associated with slight weight loss, decreased heart rate, and systolic blood pressure, with a minor rise in diastolic blood pressure. Venlafaxine raised heart rate, while paroxetine (Paxil) caused no heart rate changes.

“Clearly, no two antidepressants affect the body in the same way,” said Dr. Atheeshaan Arumuham from King’s College London.

Interestingly, commonly prescribed antidepressants in the U.S., such as fluoxetine, bupropion, and sertraline, were linked to weight loss over the short-term in these trials. For reference, about 1.4 million people were prescribed citalopram last year.

Antidepressants: Short-Term or Long-Term Side Effects?

A limitation of this research is that the studies analyzed were relatively short, with a median treatment duration much shorter than most real-world use. It also did not assess other common side effects, including sexual dysfunction, headaches, upset stomach, and, in rare cases, agitation or suicidal thoughts. Since the focus was on the first eight weeks, further research is needed to understand long-term effects.

Choosing the Right Antidepressant

As side effects differ across medications, there is no one-size-fits-all solution. Dr. Pillinger advises that selecting the right antidepressant should always be done in consultation with a qualified medical professional.

Bob Harris, the renowned BBC Radio 2 host, has informed his listeners of being hospitalized again for prostate cancer treatment.

Posting on social media platform Instagram, Harris said he is receiving treatment for an issue that has developed over the past few weeks.

“As many of you know, I suffer from prostate cancer, and every now and again I experience setbacks that need attention. Now is one of these moments,” he wrote, along with a picture of himself lying in a hospital bed while smiling for the camera.

Harris noted that he’s taking short break away from his programs. However, he confirmed that this week’s Country Show is scheduled as planned, and his Sounds of the 70’s episode on 12th April will feature an 80th birthday celebration special he recorded before attending the C2C Festival with Zoe Ball.

Noting that he can’t state the day of his return as the host, he said: “I know that I will come back… and come back stronger”.

“I hate missing programs and I am keen to get back into the studio as soon as I can”.

Calling himself “blessed” for the support he received from friends and family and listeners of his show, Harris said that during his absence, Darius Rucker will guest on Country, while Shaun Keaveny will cover Sounds of the 70’s for a few weeks.

"I am so blessed to have the love of my family and the support of my friends who have rallied round me at what has proved to be an unexpectedly testing time,” Harris said.

Prostate Cancer: The UK’s Most Common Male Cancer

Prostate cancer remains the most common cancer among men in the UK, with around 55,000 cases diagnosed every year. Despite this, there is currently no national screening program because of concerns over the accuracy of PSA tests.

In November 2025, former UK Prime Minister David Cameron revealed his prostate cancer diagnosis and also called for a targeted screening.

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In an interview with Times, he said, "You always hope for the best. You have a high PSA score - that is probably nothing. You have an MRI scan with a few black marks on it. You think, ‘Ah, that’s probably OK.’ But when the biopsy comes back, and it says you have got prostate cancer. You always dread hearing those words. And then literally as they’re coming out of the doctor’s mouth you’re thinking, ‘Oh, no, he’s going to say it. He’s going to say it. Oh God, he said it.’"

The former PM, said that he had a prostate-specific antigen (PSA) test for the screening that looks for proteins associated with the form of the disease. His result was high, and a biopsy after that revealed his cancer.

In October 2024, six-time Olympic gold medallist Chris Hoy revealed he had been diagnosed with terminal stage 4 cancer. His prostate cancer had spread to his shoulder, pelvis, hips, ribs and spine.

A woman’s health check-up is not about being paranoid. It's about refusing to treat your body as an afterthought.

You may not be able to control every diagnosis you ever get. But you can control how late you meet it. That's what preventive care is all about. Early detection through these screenings helps manage hormonal changes, cancer risks, and metabolic health.

From routine blood tests to specialized screenings, Dr. Supriya Bali, Director, Internal Medicine, Max Super Speciality Hospital, Saket, spoke to HealthandMe on specific tests crucial for women, right from their 20s

In Your 20s: Laying A Strong Foundation

Your 20s are all about establishing healthy habits that will carry you through life. Even if you feel great, this is a crucial time to get in the habit of seeing your doctor regularly.

Recommended screening includes:

• Blood pressure check – Every 1-2 years if normal; more often if elevated
• Pap smear – Start at age 21 (or by age 25 if you’ve never been sexually active); every three years if results are normal
• Chlamydia and gonorrhea screening – Annually for sexually active women under 25
• HPV vaccine – If not already completed by 26
• Skin check – Monitor moles and sun damage, especially if you tan easily
• Mental health screening – Don’t ignore stress, anxiety, or depression

In Your 30s: Reproductive And Preventive Health In Focus

As the body begins to undergo subtle changes in the 30s, regular screenings, hormonal health checks, and lifestyle adjustments are increasingly important.

Recommended screenings in 30s include:

• Pap + HPV co-test – Every 5 years starting at 30 (or Pap every 3 years)
• STI screening – Based on risk factors and symptoms
• Blood pressure and cholesterol check – Especially if you have a family history
• Blood sugar test – Especially if you’re planning a pregnancy or have had gestational diabetes
• Breast exam – Regular self-monitoring and breast ultrasound if you suspect a lump.
• Mental health and sleep – Ongoing check-ins with your doctor
• Fertility discussions – If you're planning or delaying pregnancy

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In Your 40s: Monitoring Long-Term Risk Factors

This is a time when early signs of chronic conditions may start to show up, especially if there’s a family history of heart disease, diabetes, or cancer.

You should get these screenings at certain times:

• Mammography screening: Begin at 40 years of age (earlier if you have a family history of breast cancer).
• Pap smear & HPV test: Pap and HPV every 5 years or Pap alone every 3 years.
• Cholesterol & Blood Pressure Testing: Every 1-2 years.
• Blood glucose test (diabetes screening): especially if you're overweight or at risk for diabetes.
• Thyroid function testing is optional—especially if you feel tired, cold, or have been losing weight or have changes in your bowel habits.
• Weight discussions regarding healthy nutrition and active lifestyle—assist with maintaining a healthy weight.
• Perimenopause begins in your 40's; if you experience mood swings or changes in sleep, hot flashes, or irregular cycles, please speak with your doctor.

Also read: What Your Mammogram Says About Your Heart?

In Your 50’s: Maintain Strength, Stay Ahead of Aging

Maintaining your strength, the ability to prevent illness/disease from affecting you, and remaining proactive against the challenges that arise due to aging will be your focus at this stage.

Every individual will have their own unique series of recommended screenings; however, everyone will benefit from some type of recommended screening.

Some commonly recommended screenings include:

• Mammogram screening program; every 1-2 years.
• Colorectal cancer screening, beginning at age 45 through age 75.
• Bone density scan-if at high risk.
• Hearing/Vision checks annually or as required (on an as-needed basis).
• Blood pressure, cholesterol, and diabetes screening every year.
• Lung cancer screening among those with a history of smoking.
• Vaccines--including shingles, pneumonia, flu, and COVID-19 booster.
• Cognitive screening - to discover memory concerns, changes in mental sharpness, or cognitive function.

Vapes were marketed as a safer option than cigarettes, but research now shows they carry serious health risks -- from lung damage to meningitis to cancer.

Vaping has been a serious concern in the United States, with New York Attorney General Letitia James in 2025 filing a lawsuit against e-cigarette manufacturers and distributors.

The lawsuit accused the companies of fueling a youth vaping crisis, alleging that these companies that manufacture vapes, especially with flavors, have misled consumers about the safety of their products while deliberately targeting young people through deceptive marketing.

Now, a new study, published in JAMA Network Open, has for the first time assessed trends in young children's nicotine exposures across all types of products.

Shockingly, electronic cigarette-related incidents increased 243 percent over the past eight years in young children, especially among those under five years of age, said researchers from the Rutgers New Jersey Medical School.

In contrast, tobacco exposures from conventional products such as cigarettes decreased by 43 percent.

Unlike cigarettes, these devices are often ready to use, brightly colored, require little effort to activate, and appear more like toys than a harmful product.

"This significant spike in children breathing in these substances tells us the risk has changed: It's no longer just about a toddler swallowing something they found on the floor," said lead author Perry Rosen, who conducted the research at the New Jersey Poison Control Center.

"Many recent cases involve children actively using e-cigarette devices after gaining access to them," Rosen added.

Key Findings

The findings were based on an analysis of more than 92,000 reported nicotine exposures in children ages 5 and younger between 2016 and 2023.

The researchers noted that vaping risks often involved children who inhaled the vapors directly from the devices. They also found that children exposed to e-cigarettes were more likely to require a visit to a health care facility compared with those exposed to cigarettes.

According to researchers, young children naturally mimic the behaviors they see around them. So, parents and caregivers must keep vaping devices away from the reach of young children.

Previous research has shown that even moderate ongoing nicotine exposure can lead to lasting health effects on developing lungs, including increased risk of bronchitis and worsening asthma.

"When children see caregivers or older family members vaping, they may copy that behavior—bringing the device to their mouth and inhaling—without any understanding they are exposing themselves to a harmful substance," said Diane Calello, executive and medical director of the New Jersey Poison Control Center.

Vaping: A Concern

Vaping has become a more common form of tobacco use among American middle and high school students.

As per the US Centers for Disease Control and Prevention (CDC), nearly 1.6 million students used e-cigarettes in 2024, with 87.6 percent of them opting for a flavored product.

It is the flavor that makes it even more addictive, and people want to keep smoking it, resulting in it being emptied and refilled way more quickly.

This means those who smoke flavored cigarettes consume more tobacco than those who smoke unflavored ones.