A widely used test for detecting ovarian cancer may not work as effectively for Black and Native American women, found the new study from the University of Pennsylvania. The research was published in JAMA Network Open. It found that these patients are 23% less likely to show elevated levels of CA-125, which is a protein that is used as a key biomarker in ovarian cancer screening.

One of the most common ways to screen for ovarian cancer is by measuring CA-125 levels in the blood. It is also recommended by the American Cancer Society. However, the new study also suggests that current testing may not be equally reliable for all racial groups.

How Did The Study Get To This Conclusion?

The study analyzed medical records of over 200,000 ovarian cancer patients from 2004 to 2020. The data was used from the US National Cancer Database. The researchers found that because Black and Native American women are less likely to have elevated CA-125 levels. They could also face delays in diagnosis, which could lead to further worse health outcomes.

Has There Been A Historical Bias In Cancer Research?

The authors of this study also noted that the original research linked CA-125 to ovarian cancer may only have been conducted on White patients. However, because the race of the participants was not recorded, there is uncertainty about whether CA-125 is an equally effective biomarker across different populations.

Dr. Alistair Forrest, a genome biology expert at the Harry Perkins Institute of Medical Research in Australia, said the study underscores the importance of recognizing biological differences between populations. He added that a test effective in one group may not be as useful in another.

Have There Been Cases Of Racial Disparities In Healthcare Before?

Women are often told to "put up" with the pain. Members of Westminster's Women and Equalities Committee in their report noted that women with gynaecological or reproductive issues are not provided the support they need. Women with conditions such as heavy periods, endometriosis and adenomyosis are dismissed for asking for help. Chairwoman of the committee Sarah Owen also said that women were being "fobbed off" and told that this would not have happened "if it was a man."

In terms of race, the one who is credited as the father of modern gynaecology, James Marion Sims experiments on Black women without anesthesia. He had no background in gynaecology and yet no one stopped him when he would examine and treat Black women. To have a better look at the woman's injury, he would position her on all fours, leaned forward and used his fingers to help him see inside. This is what led to the discovery of the modern speculum, a bent handle of a pewter spoon.

Racial Disparities in Ovarian Cancer Outcomes

This research builds on existing studies that have identified racial disparities in ovarian cancer detection and survival rates. According to findings from the 2023 Ovarian Cancer Evidence Review Conference:

• Ovarian cancer is most common in Native American and White women.
• Black omen are 18% more likely to die from ovarian cancer compared to White women.
• There is no significant difference in mortality between Hispanic, Asian, Pacific Islander, and White patients.
• Black women are more likely to be diagnosed at an advanced stage, which reduces survival chances.

Malaria is a life-threatening disease that is spread to humans by a specific type of mosquito. It is preventable and curable, but only if detected on time. People who are at high risk include travellers, pregnant women and those with HIV/AIDS. On Friday, while marking World Malaria Day, the World Health Organisation (WHO) asserted that half of the total global population is at risk of this vector borne disease. So now, the question arises: how does it spread?

Malaria is a vector-borne disease. It is spread through female anopheles mosquitoes. These mosquitoes carry single-cell P. Falciparum, which is a pathogen behind this disease. There are five types of Plasmodium parasite, with P. Falciparum (which is found in the African region) and P. Vivax ( common outside the sub-Saharan region) being the most popular. Left untreated, P. Falciparum malaria can progress to severe illness and death within 24 hours.

Malaria Can Be Spread Through Blood Transfusion

But there is empirical evidence that it can also be transmitted through blood transfusion and contaminated needles. Transfusion-transmitted malaria (TTM) occurs when an uninfected person receives blood from a donor who is infected with malaria parasites. While malaria transmission through transfusion is rare, especially in non-endemic areas, it remains a significant concern in certain regions.

According to a systematic review of studies conducted by National Library of Medicine, Plasmodium parasites were shown to survive in whole blood and plasma when stored at 4°C for up to 18 days, and detectable parasites can present even up to 28 days when frozen, although with diminished infectivity.

How To Identify Malaria?

The early symptoms of Malaria are fever, headache and chills, which can usually start within 10 to 15 days of getting bitten by an infected mosquito. Some types of malaria can cause severe illness and death. Infants, children under 5 years, pregnant women, travellers and people with HIV or AIDS are at higher risk. Severe symptoms include:

• extreme tiredness and fatigue
• impaired consciousness
• multiple convulsions
• difficulty breathing
• dark or bloody urine
• jaundice (yellowing of the eyes and skin)
• abnormal bleeding

People with severe symptoms should get emergency care right away. Getting treatment early for mild malaria can stop the infection from becoming severe. Malaria infection during pregnancy can also cause premature delivery or delivery of a baby with low birth weight.

Disproportionate Share Of Global Malaria Burden

The WHO African Region continues to carry a disproportionately high share of the global malaria burden. In 2023, the region was home to about 94% of all malaria cases and 95% of deaths. Children under 5 years of age accounted for about 76% of all malaria deaths in this region. Over half of these deaths occurred in four countries: Nigeria (30.9%), the Democratic Republic of the Congo (11.3%), Niger (5.9%) and United Republic of Tanzania (4.3%).

If you're trying to conceive or even think you might be pregnant, the wait and anticipation for a pregnancy test can be nerve-wracking—hope, worry, excitement, or fear all in one little plastic stick but before you rip open that foil package, there's something important you may be forgetting: the expiration date.

Yes, pregnancy kits do have expiry dates. And taking one which has passed that date may cause false results. This article touches on why checking that date on the kit first is important before you test, how pregnancy kits work, and what dangers such expired kits possess. Supported by expert opinion and scientific knowledge, this guide endeavors to equip you with the knowledge you require for making informed reproductive health choices.

Home pregnancy tests detect the human chorionic gonadotropin (hCG) hormone in your urine, which your body begins making shortly after the fertilized egg implants in your uterus. The test sticks use special antibodies with chemicals that have been treated to respond to hCG and report a positive finding—usually lines, plus symbols, or messages on a display.

With time, though, the delicate components break down. After the test has reached or exceeded its expiration date, the chemical reagents can no longer act dependably. That is, the test might not register hCG when it's actually there, providing you with a false negative result, or—much less often—report a false positive based on poor chemical reactions.

What Happens When a Pregnancy Test Expires?

The date of expiration on a pregnancy test is not merely a courtesy. Companies test their products extensively to find out how long the ingredients will be stable and consistent under normal storage conditions. A pregnancy test will usually be effective for one to three years from the date of manufacture.

Once that time has passed, the antibodies that are employed to identify hCG start to weaken. This weakening is subtle but significant—making the test incapable of giving accurate results. The older the test, the greater the likelihood that you'll leave with a result that doesn't accurately represent your pregnancy status.

Just as important as the expiration date is how the test is stored. According to healthcare professionals, the performance of a pregnancy test can deteriorate even before its listed expiry if it’s stored improperly.

Avoid exposing the test to heat, moisture, or direct sunlight. A bathroom medicine cabinet, while convenient, is often not ideal due to the humidity from showers and temperature fluctuations. Instead, keep pregnancy tests in a cool, dry place, and avoid unwrapping individual tests until you’re ready to use them. Unsealing the protective foil can introduce air and moisture that degrade the chemicals faster.

How to Identify an Expired Test?

Always inspect the outer package and test wrapper individually for a printed expiration date. If it is absent or smudged, better not take a risk. Also, beware of buying tests from third-party retailers or online stores where expired stock may go unnoticed.

It's also good to know that even tests just purchased can be old inventory. If you've had a test kit in your bathroom drawer for more than one year, verify the printed date before you use it.

Can You Trust an Expired Test?

Technically, it's possible for an outdated pregnancy test to return a correct result—but it's not reliable. The odds of false negatives grow more sharply with time, which can cause confusion, worry, and delay in obtaining critical prenatal care.

Under FDA recommendations, most erroneous results from past-due tests are likely to be false negatives. This may lead one to continue habits or drugs that are not best practiced in early pregnancy—or lose the opportunity to start early prenatal supplements or tests.

The effect of depending on an out-of-date pregnancy test isn't only medical—it's psychological as well. Inaccurate results can induce undue distress, confusion, or early rejoicing. Even worse, they may stall time-critical health choices like verifying the pregnancy through a physician, making blood work appointments, or starting lifestyle modifications to facilitate a healthy pregnancy.

In medical situations where time is of the essence—like watching over high-risk pregnancies or starting specific treatments—true, timely information is paramount.

Best Practices for Taking a Home Pregnancy Test

To ensure most accurate results, follow these steps:

• Inspect the expiration date before taking any test, even if the package appears new.
• Take first-morning urine when hCG is most concentrated in the urine.
• Wait until the first day of your missed period to take the test; testing earlier riskily produces a false negative.
• Take directions exactly, including timing when to read the results.
• Dispose of unused tests properly, in a dry, cool environment and in their original sealed package.

How Expired Pregnancy Tests Impact Health and Results?

Taking an expired pregnancy test can result in incorrect results, which might lead to undue confusion or undue delay in taking the appropriate next step. Here's what you should know regarding the effectiveness of an expired pregnancy test:

Increased Chance of False Negatives

One of the most significant problems with using an outdated pregnancy test is the increased likelihood of getting a false negative result. This is where the test will show that you're not pregnant when you actually are. This is due to the chemical compounds, especially the antibodies employed to identify hCG, breaking down over time, thus it becomes hard for the test to give a true result.

Degraded Antibodies

Pregnancy tests detect human Chorionic Gonadotropin (hCG), a hormone that is formed during pregnancy. After a while, the antibodies in the test, which cause a response when hCG is present, become weakened. So even if you are pregnant, the test may fail to measure the hormone at a level that is high enough.

Health Risks

As per the U.S. Food and Drug Administration (FDA), expired pregnancy tests tend to give false negatives rather than false positives. A false positive may also occur but is less so with expired tests.

Exposure to External Factors

The reliability of a pregnancy test is also affected by the way it's stored. Incorrect storage, for example exposure to sunlight, humidity, or heat, causes the components to degrade faster and results in more opportunities for getting incorrect results prior to reaching expiration.

Waste of Time and Money

Using an expired test not only reduces the likelihood of getting an accurate result but also wastes your time and money. It's best to check the expiration date before using the test and, if expired, purchase a new one for peace of mind and more reliable results.

Emotional Stress

The effect of depending on an out-of-date pregnancy test isn't only medical—it's psychological as well. Inaccurate results can induce undue distress, confusion, or early rejoicing.

Though home pregnancy tests are an efficient and convenient means of early pregnancy detection, their accuracy relies on a number of major factors, foremost among them their expiration date. Testing with one that has expired may cause emotional distress and delay medical attention at a time when it's needed most.

Each year, hundreds of people around the world lose their lives waiting for a life-saving organ transplant. The demand for organs far outweighs the supply, leaving many patients with little hope. But what if we could print organs—tailor-made for each patient—using their own cells? While we're not quite there yet, researchers are making significant strides in this futuristic field known as 3d bioprinting.

Though the technology is still far from clinical trials, scientists believe that when 3d-printed organs become a medical reality, the process will likely involve a blend of cutting-edge imaging, personalised cell harvesting, and highly advanced bioprinting methods. Here's what this groundbreaking process could look like.

Step 1: Creating a Personalised 3D Model

To print a functional organ, the process begins with creating a precise 3D blueprint. While generic models can serve as a starting point, personalisation is key. Using imaging technologies like MRI (Magnetic Resonance Imaging) and CT (Computed Tomography) scans, medical professionals can generate a detailed digital model of the organ tailored specifically to the patient’s anatomy. This personalized design enhances the chances of a successful transplant by ensuring the printed organ will fit and function properly in the recipient’s body.

Step 2: Collecting Patient’s Cells And Preparing Bioink

One of the biggest hurdles in organ transplantation is rejection, which happens when the recipient’s immune system attacks the new organ. To reduce this risk, scientists aim to use the patient’s own cells to build the organ. These cells are harvested, cultivated in labs, and combined with a specially designed “bioink”—a gel-like substance engineered to mimic the structure of natural tissues. This bioink becomes the medium through which living cells can be precisely layered and formed into complex biological structures.

Step 3: Printing the Organ

With a personalized 3D model in hand and a supply of bioink rich in the patient’s cells, the actual printing process begins. The organ is built layer by layer, using bioprinters designed to handle delicate biological material. Some methods involve extrusion-based bioprinting, which pushes the bioink through a nozzle to form a structure, similar to how icing is piped onto a cake. Other techniques rely on light-based bioprinting, which uses beams of light to shape the biomaterial with incredible precision.

In some cases, additional cells may be added to the organ after printing to support its development or enhance functionality. Although the exact tools and materials are still being refined, technologies such as the BIO X, BIO X6, and LUMEN X are among those helping to push the boundaries of what’s possible in tissue engineering.

Road Ahead

While researchers are still navigating numerous scientific and ethical challenges, the vision of printing fully functional, transplantable organs is no longer science fiction. With continued innovation and global collaboration, 3D bioprinting could one day eliminate organ shortages altogether, saving countless lives and revolutionizing modern medicine.