People who take methotrexate for different health conditions have been cautioned by the NHS that certain symptoms and side effects should not be ignored and may require urgent medical help, including a visit to A&E or calling 999. Methotrexate works as an immunosuppressant, meaning it dampens the immune system to help control inflammation in the body.

What Is Methotrexate?

Methotrexate belongs to a group of medicines known as antimetabolites. It helps manage rheumatoid arthritis by dampening the body’s immune response, controls psoriasis by slowing the rapid buildup of skin cells, and is used in cancer treatment to limit the growth and spread of cancer cells, as per Mayo Clinic.

Doctors commonly prescribe it for conditions such as rheumatoid arthritis, Crohn’s disease, and psoriasis. In some situations, it is also used as part of cancer treatment. Methotrexate is usually taken as a tablet, a liquid medicine that is swallowed, or as a pre-filled pen or syringe that is injected under the skin. While many people benefit from the drug, it can also cause serious side effects that may be worrying for some patients.

Side Effects Of Methotrexate And When To Call For Emergency?

Certain severe side effects linked to methotrexate are rare and affect fewer than 1 in 10,000 people. Even so, the NHS advises contacting your doctor or calling 111 if you notice any of the following symptoms:

• Swelling in the hands, feet, or ankles along with shortness of breath, which may point to a kidney issue
• A long-lasting cough, chest discomfort, or trouble breathing, which could suggest lung inflammation
• Yellowing of the skin or the whites of the eyes, which can indicate liver damage
• Bleeding gums, vomiting blood, unexplained bruises, or blood in the urine, which may signal a blood disorder
• A high temperature, sore throat, or body aches, which could be signs of an infection

Symptoms of this can include:

• Swelling of the lips, throat, or tongue
• A tight sensation in the throat or difficulty swallowing
• Confusion
• Collapsing or fainting and being hard to wake
• Skin, lips, or tongue turning blue, pale, or grey
• Very rapid breathing or severe difficulty breathing

Methotrexate: What Should You Watch Out For While Taking This Medication?

See your care team regularly so they can monitor how the treatment is working. It may take a while before you notice any improvement. You may be asked to get routine blood tests during the course of treatment.

If your care team has prescribed folic acid along with methotrexate, they may advise you not to take folic acid on the same day as your methotrexate dose.

This medicine can make your skin more sensitive to sunlight. Try to stay out of direct sun exposure. If that is not possible, wear covered clothing and apply sunscreen. Avoid sun lamps, tanning beds, or tanning booths.

Contact your care team if you have severe diarrhea, ongoing nausea or vomiting, or heavy sweating. Losing too much fluid from your body can make this medicine unsafe. This drug can raise your chances of developing an infection. Call your care team if you develop a fever, chills, sore throat, or flu-like symptoms. Do not self-medicate. As far as possible, stay away from people who are unwell.

Discuss your cancer risk with your care team. Long-term use of this medication may increase the risk of certain cancers.

Speak to your care team if you or your partner could become pregnant. Methotrexate can cause serious birth defects if taken during pregnancy or within six months after the last dose. A negative pregnancy test is required before starting treatment. Reliable contraception should be used while on this medication and for six months after stopping it. Your care team can guide you on suitable options.

If your partner can become pregnant, use condoms during sexual activity while taking this medication and for three months after the final dose. Do not breastfeed while using this medication and for at least one week after the last dose.

This medication may affect fertility. If this is a concern, discuss it with your care team.

In a shocking incident, a woman contracted the herpes virus after using shared lipstick samples at a cosmetic store, raising concerns about makeup hygiene.

The incident highlights the risks involved in trying products that come into direct contact with the skin and are shared with a lot of people.

Also Read: World Autism Awareness Day 2026: Can Cell Therapy Be The Future Of Autism Treatment?

What Is Herpes?

The herpes simplex virus (HSV) is very common, and the infection is lifelong. But the symptoms can come and go over different periods of life. Many people never get any symptoms linked to their infection.

The common virus, carried by up to 50 to 80 percent of adults, can cause painful blisters or ulcers. It primarily spreads by skin-to-skin contact. It is treatable but not curable.

There are two types of herpes simplex virus: HSV-1 and HSV-2.

HSV- 1 is the most common and usually spreads by oral contact. It causes infections in or around the mouth (such as oral herpes or cold sores), as well as genital herpes.

Common oral herpes symptoms include

• blisters (cold sores)
• open sores (ulcers) in or around the mouth or lips.

HSV-2 generally spreads by sexual contact and causes genital herpes.

Its symptoms include painful

• bumps,
• blisters,
• open sores (ulcers) around the genitals or anus.

How Makeup Testers Can Spread Infection

Experts warned that makeup testers can become a breeding ground for germs. The repeated use of the open samples can spur their growth and can then spread by “double-dipping” — reusing an applicator after touching the skin. This can transfer viruses and bacteria between users.

“You can absolutely get a herpes infection from a makeup tester," Dr. Whitney Bowe, a dermatologist in New York City, told TODAY. "The more ‘double dipping’ that occurs, the higher the chance of spreading viruses or bacteria at a makeup counter.”

A 2010 study by researchers from Rowan University in New Jersey found that cosmetic samples harbored strep, E.coli, and staph.

For two years, the team examined makeup testers at makeup counters, specialty stores, and drug stores. They found that Saturday is the busiest day of the week, and 100 percent of the samples carried some sort of germ.

How To Stay Safe?

To reduce the risk of infection, experts recommend:

• Much like the toothbrush, personal cosmetics and cosmetic brushes must not be shared.
• Wash and dry your brushes regularly to avoid bacterial growth.
• Avoid applying testers directly to your lips or skin
• Use disposable applicators
• Test products on your hand rather than your face
• Avoid using testers if you have cuts, chapped lips, or active infections.

April 2 is celebrated worldwide as “Autism Awareness Day” and April as Autism month to create awareness and promote inclusivity and acceptance in society for individuals with autism.

So what exactly is Autism, and why do we need to create a culture of awareness and acceptance?

As per DSM V (Diagnostic and Statistical Manual of Mental Disorders) criteria, in simple terms, there is poor eye contact, impaired social communication skills, repetitive patterns (certain movements or fixation on certain toys, objects), difficulties with sensory processing - extreme sensitivity to sensory inputs (dislike loud noises, sensitive to touch), etc.

As a child, these individuals may not respond to name-calling, have poor eye contact/lack gestures like pointing, etc., lack imagination in play, and may not be able to relate and respond to the emotions of others. They have set routines and dislike changes to their routines. All this can cause significant disruption to their day-to-day functioning.

This year’s theme of -Autism and Humanity- Every Life has Value” reiterates the need for inclusion of autism, ensuring equitable representation of these individuals. Ensuring that society not only recognizes them but also treats them with equal respect and dignity.

Educational Support and Inclusive Workplace

Sarva Shiksha Abhiyan (SSA) was one of the Government's flagship programs, along with Action for Autism, to disseminate information in schools regarding inclusive education for autism. Education is a key foundation to ensure children with autism get suitable opportunities as adults. Special educators, with additional support in schools, can go a long way in ensuring their potential is maximized.

Many IT giants like Microsoft, Google, and SAP encourage tapping the potential of individuals with autism and their exceptional skills. In our country, organizations and NGOs, including Action for Autism, offer training for future employment opportunities.

There is a spectrum of Autistic Spectrum Disorders (ASD) known as Asperger’s syndrome, and these individuals have normal to above average intelligence and can have some exceptional skills, and the world includes some living examples of these with a higher IQ, some of whom are the most successful and famous personalities. Even on the other end of the spectrum, autistic individuals have exceptional skills, some of which include great attention to detail, creativity, problem-solving, and lateral out-of-the-box thinking.

Options for flexible working hours (part-time), understanding their need for routines, and explaining them beforehand regarding important changes to schedules can help them adapt better to an otherwise challenging workplace.

The Need For Sensitization

Understanding individuals with autism may need little extra support, being a little flexible with time deadlines, giving simple instructions, especially written/visual ones, and allowing them time to overcome their communication barriers can go a long way in ensuring they feel heard and valued like anyone else in the workplace.

Sensitization of all major organization employees to foster a culture of acceptance and awareness, and an accessible work environment, is the need of the hour. Autistic individuals do well in a variety of job profiles, including IT, technology, finance, art and creativity, and administration.

Environmental modifications like background noise cancellation with headphones help those with sensory processing issues. At the end of the day, none of us is perfect, it's recognizing our special skills and strengthening them.

Possibilities are endless if we wish to encourage and make these individuals heard. So, let’s carry the Autism Awareness Day beyond a mere day of awareness and light it up blue. Let’s value and acknowledge them being different, but also empower them to act on their special skills to earn them a dignified place in society and the workplace.

World Autism Awareness Day is observed every year on April 2. The day is important to raise awareness about autism — a neurodevelopmental condition affecting communication, social interaction, and behavior — affecting millions of people globally.

According to the World Health Organization (WHO), one in 127 people worldwide is diagnosed with the lifelong brain health condition. It is also among the top 10 conditions contributing to health loss globally.

Also Read: Leptospirosis: US health officials flag outbreak risk after floods in Hawaii

The first child diagnosed with autistic symptoms was Donald Grey Triplett. Labelled as Case 1, he went on to become an American banker, demonstrating that, if provided with the right and inclusive support and opportunities individuals with autism be as productive as others.

“Like anyone else, autistic people should be able to shape their own lives — and help to shape our shared future,” said

António Guterres, UN Secretary-General.

World Autism Awareness Day: Date and History

April 2 was designated as World Autism Awareness Day (WAAD) by the United Nations General Assembly in 2007.

The 2007 General Assembly resolution highlighted the need to raise public awareness of autism.

It stated that "children with disabilities should enjoy a full and decent life, in conditions which ensure dignity, promote self-reliance and facilitate the child’s active participation in the community, as well as the full enjoyment of all human rights and fundamental freedoms on an equal basis with other children".

World Autism Awareness Day: Theme

This year, World Autism Awareness Day is held under the theme "Autism and Humanity - Every Life Has Value".

The 2026 theme highlights and affirms the dignity and worth of all autistic people. While there are international human rights conventions safeguarding the rights of people with autism, they continue to face stigma, discrimination, and barriers to participation.

“Access to timely, quality health care and support services remains limited, driving inequalities across the life course," the WHO said. The global health body urged "sustained action and greater investment" to address these challenges. It also called for developing inclusive policies and services that uphold the rights of autistic people.

This year's theme, thus, is a call to action to recognize the inherent dignity and equal rights of all people with autism.

Guterres highlighted the need for "equal education, fair employment, and accessible health systems" for all persons with autism and to provide inclusive opportunities to participate and thrive, along with others.

Also read: Expert Reveals Why Childhood Autism Is Going Undetected In India

What is Autism?

The National Health Service (NHS) UK defines autism as not an illness or a medical condition with treatments or a "cure", but a developmental condition that affects how people communicate, learn, behave, and interact with others.

It is a spectrum, which means "everybody with autism is different".

People with autism spectrum disorder (ASD) may have difficulty with social interaction, exhibit atypical behavior and activities, or find it hard to communicate.

Early Signs Of Autism

Studies show that symptoms of autism are usually diagnosed within the first 3 years of birth. These include:

• Limited to zero eye contact
• Delayed responses
• Repeating words or actions such as hand-flapping
• Being strong-headed about following the same routine
• Easily annoyed, throws tantrums
• Difficulty understanding and expressing emotions
• Sensitive to certain sounds, textures, lights, or smells.