SummaryAs 2025 ends, infectious diseases dominated global health, with COVID-19 variants, flu, measles, tuberculosis outbreaks, and bird flu raising alarms. Antimicrobial resistance worsened worldwide, complicating treatment. Meanwhile, non-communicable diseases like heart disease, cancer, diabetes, and respiratory illnesses continued rising, driven by unhealthy lifestyles, urbanization, and persistent healthcare gaps across the globe.