Your skin is often considered a reflection of your body's inner wellbeing, when it comes to kidney function, the connection goes beyond what may initially be something on the surface. The kidneys are responsible for filtering out wastes and toxins in the blood, balancing electrolytes, and helping to control moisture levels. Once kidney function breaks down, its effects are felt not only overall but also are reflected in discernible skin-related changes—dryness, pigmentation, long-term itching, and even hives.

But when the kidneys are unwell, they do not just impair internal function but also manifest themselves on the outside, and specifically on the skin. In the opinion of Dr. Sreedhar Reddy, Urologist and Urology Surgeon, "Kidney-related ailments frequently cause palpable changes to the skin, which may act as preliminary signals for renal illness."

Link Between Your Kidney Health and your Skin

When the kidneys do not effectively remove waste products and excess water from the body, toxins in the blood buildup. This accumulation manifests as several dermatological manifestations indicating intrinsic renal disease. These are:

Xerosis (Severe Dryness of the Skin): Patients can have very dry, rough, scaly skin, which is usually accompanied by cracking. Dr. Reddy describes, "Extremely dry skin that is tight and tends to crack is frequently seen in patients with end-stage kidney disease who are on dialysis or need a transplant."

Pruritus (Itchy Skin): Itching is one of the most common symptoms of kidney disease. A recent survey of individuals on hemodialysis found that 61% reported experiencing at least a moderate level of itching, with 25% describing it as "very" or "extremely intense." This persistent itch occurs as waste products accumulate in the blood, irritating nerve endings.

Pigment Disorders and Rashes: Inability of the kidneys to function properly can cause the accumulation of metabolic byproducts in the skin, causing color changes and rashes. "Dome-shaped, intensely itchy rashes tend to mean that the kidneys are not clearing toxins well," adds Dr. Reddy.

Effect of Kidney Disease on Overall Appearance

Aside from skin disorders, kidney disease has an effect on a person's overall appearance because of metabolic disturbances and fluid imbalance.

Weight Changes: Kidney disease may result in sudden weight loss from muscle atrophy or sudden weight gain from fluid buildup. "Patients tend to develop swelling of the face, hands, and feet because of too much fluid," explains Dr. Reddy.

Changes in Skin Texture and Color: Kidney impairment can result in pallor, yellowish or grayish complexion, and a dull skin.

Hair and Nail Changes: Thin hair, ridges, and brittle nails are reported by many patients with chronic kidney disease (CKD).

Kidney Disease and Its Link to Other Health Conditions

Some other health disorders linked with kidney disease can cause skin conditions and changes in appearance:

Diabetes and Hypertension: Diabetes and hypertension are major causes of kidney disease, and both diseases can worsen skin conditions like itching and delayed healing of wounds.

Liver Dysfunction: A dysfunctional liver, usually associated with kidney problems, can cause bile salts to pile up beneath the skin, which may cause intense itching.

Blood Diseases and Autoimmune Disorders: Certain cancers, thyroid disease, and autoimmune disorders such as celiac disease may also lead to long-term itching secondary to systemic inflammation and nerve stimulation.

How to Keep Your Kidneys Healthy?

For those of us who care about our skin and our well-being, ensuring that our kidneys are functioning properly is important. Dr. Reddy stresses that making some small lifestyle adjustments can greatly enhance kidney health and stave off overt skin decline.

1. Have a Kidney-Friendly Diet

Reducing the intake of sodium, phosphorus, and potassium while increasing antioxidant-rich foods can protect kidney function and enhance skin health.

2. Stay Hydrated

Adequate water intake helps flush out toxins, reducing the burden on the kidneys and preventing dryness and irritation in the skin.

3. Exercise Regularly

Physical activity improves circulation, enhances waste elimination, and supports overall metabolic function.

4. Avoid Smoking and Excessive Alcohol Consumption

Tobacco and alcohol also add to kidney stress, resulting in fluid buildup and inflammation that may adversely affect the skin.

5. Routine Health Checkups

Routine tests of blood pressure, blood sugar levels, and kidney function may help identify early evidence of kidney disease, averting severe complications.

When to Consult A Doctor?

Early warning signs of kidney disease can be identified and avoided in order to prevent severe complications. If you suddenly notice unexplained itching, a chronic rash, extreme dryness, swelling, or a great weight gain, seek advice from a health expert. Kidney function can be tested by conducting blood tests that eliminate other health conditions like diabetes, anemia, or thyroid disorders.

Your kidneys are also responsible for detoxification, the balance of fluid, and metabolism. When compromised, the effects are not only internal but also evident on your complexion and overall look. By living healthy, keeping an eye on kidney function, and consulting a doctor when needed, one can have healthy kidneys along with maintaining healthy skin's natural sparkle and radiance. Dr. Reddy affirms, "Healthy kidneys mean healthy skin. Paying attention to both can improve overall well-being and quality of life."

Dr. Sreedhar Reddy is a MBBS, MS(Gen sur), DNB (Urology), MNAMS (urology), FRTS, FIMS at Apollo Spectra Hospital, Bangalore in India

Malaria is a life-threatening disease that is spread to humans by a specific type of mosquito. It is preventable and curable, but only if detected on time. People who are at high risk include travellers, pregnant women and those with HIV/AIDS. On Friday, while marking World Malaria Day, the World Health Organisation (WHO) asserted that half of the total global population is at risk of this vector borne disease. So now, the question arises: how does it spread?

Malaria is a vector-borne disease. It is spread through female anopheles mosquitoes. These mosquitoes carry single-cell P. Falciparum, which is a pathogen behind this disease. There are five types of Plasmodium parasite, with P. Falciparum (which is found in the African region) and P. Vivax ( common outside the sub-Saharan region) being the most popular. Left untreated, P. Falciparum malaria can progress to severe illness and death within 24 hours.

Malaria Can Be Spread Through Blood Transfusion

But there is empirical evidence that it can also be transmitted through blood transfusion and contaminated needles. Transfusion-transmitted malaria (TTM) occurs when an uninfected person receives blood from a donor who is infected with malaria parasites. While malaria transmission through transfusion is rare, especially in non-endemic areas, it remains a significant concern in certain regions.

According to a systematic review of studies conducted by National Library of Medicine, Plasmodium parasites were shown to survive in whole blood and plasma when stored at 4°C for up to 18 days, and detectable parasites can present even up to 28 days when frozen, although with diminished infectivity.

How To Identify Malaria?

The early symptoms of Malaria are fever, headache and chills, which can usually start within 10 to 15 days of getting bitten by an infected mosquito. Some types of malaria can cause severe illness and death. Infants, children under 5 years, pregnant women, travellers and people with HIV or AIDS are at higher risk. Severe symptoms include:

• extreme tiredness and fatigue
• impaired consciousness
• multiple convulsions
• difficulty breathing
• dark or bloody urine
• jaundice (yellowing of the eyes and skin)
• abnormal bleeding

People with severe symptoms should get emergency care right away. Getting treatment early for mild malaria can stop the infection from becoming severe. Malaria infection during pregnancy can also cause premature delivery or delivery of a baby with low birth weight.

Disproportionate Share Of Global Malaria Burden

The WHO African Region continues to carry a disproportionately high share of the global malaria burden. In 2023, the region was home to about 94% of all malaria cases and 95% of deaths. Children under 5 years of age accounted for about 76% of all malaria deaths in this region. Over half of these deaths occurred in four countries: Nigeria (30.9%), the Democratic Republic of the Congo (11.3%), Niger (5.9%) and United Republic of Tanzania (4.3%).

If you're trying to conceive or even think you might be pregnant, the wait and anticipation for a pregnancy test can be nerve-wracking—hope, worry, excitement, or fear all in one little plastic stick but before you rip open that foil package, there's something important you may be forgetting: the expiration date.

Yes, pregnancy kits do have expiry dates. And taking one which has passed that date may cause false results. This article touches on why checking that date on the kit first is important before you test, how pregnancy kits work, and what dangers such expired kits possess. Supported by expert opinion and scientific knowledge, this guide endeavors to equip you with the knowledge you require for making informed reproductive health choices.

Home pregnancy tests detect the human chorionic gonadotropin (hCG) hormone in your urine, which your body begins making shortly after the fertilized egg implants in your uterus. The test sticks use special antibodies with chemicals that have been treated to respond to hCG and report a positive finding—usually lines, plus symbols, or messages on a display.

With time, though, the delicate components break down. After the test has reached or exceeded its expiration date, the chemical reagents can no longer act dependably. That is, the test might not register hCG when it's actually there, providing you with a false negative result, or—much less often—report a false positive based on poor chemical reactions.

What Happens When a Pregnancy Test Expires?

The date of expiration on a pregnancy test is not merely a courtesy. Companies test their products extensively to find out how long the ingredients will be stable and consistent under normal storage conditions. A pregnancy test will usually be effective for one to three years from the date of manufacture.

Once that time has passed, the antibodies that are employed to identify hCG start to weaken. This weakening is subtle but significant—making the test incapable of giving accurate results. The older the test, the greater the likelihood that you'll leave with a result that doesn't accurately represent your pregnancy status.

Just as important as the expiration date is how the test is stored. According to healthcare professionals, the performance of a pregnancy test can deteriorate even before its listed expiry if it’s stored improperly.

Avoid exposing the test to heat, moisture, or direct sunlight. A bathroom medicine cabinet, while convenient, is often not ideal due to the humidity from showers and temperature fluctuations. Instead, keep pregnancy tests in a cool, dry place, and avoid unwrapping individual tests until you’re ready to use them. Unsealing the protective foil can introduce air and moisture that degrade the chemicals faster.

How to Identify an Expired Test?

Always inspect the outer package and test wrapper individually for a printed expiration date. If it is absent or smudged, better not take a risk. Also, beware of buying tests from third-party retailers or online stores where expired stock may go unnoticed.

It's also good to know that even tests just purchased can be old inventory. If you've had a test kit in your bathroom drawer for more than one year, verify the printed date before you use it.

Can You Trust an Expired Test?

Technically, it's possible for an outdated pregnancy test to return a correct result—but it's not reliable. The odds of false negatives grow more sharply with time, which can cause confusion, worry, and delay in obtaining critical prenatal care.

Under FDA recommendations, most erroneous results from past-due tests are likely to be false negatives. This may lead one to continue habits or drugs that are not best practiced in early pregnancy—or lose the opportunity to start early prenatal supplements or tests.

The effect of depending on an out-of-date pregnancy test isn't only medical—it's psychological as well. Inaccurate results can induce undue distress, confusion, or early rejoicing. Even worse, they may stall time-critical health choices like verifying the pregnancy through a physician, making blood work appointments, or starting lifestyle modifications to facilitate a healthy pregnancy.

In medical situations where time is of the essence—like watching over high-risk pregnancies or starting specific treatments—true, timely information is paramount.

Best Practices for Taking a Home Pregnancy Test

To ensure most accurate results, follow these steps:

• Inspect the expiration date before taking any test, even if the package appears new.
• Take first-morning urine when hCG is most concentrated in the urine.
• Wait until the first day of your missed period to take the test; testing earlier riskily produces a false negative.
• Take directions exactly, including timing when to read the results.
• Dispose of unused tests properly, in a dry, cool environment and in their original sealed package.

How Expired Pregnancy Tests Impact Health and Results?

Taking an expired pregnancy test can result in incorrect results, which might lead to undue confusion or undue delay in taking the appropriate next step. Here's what you should know regarding the effectiveness of an expired pregnancy test:

Increased Chance of False Negatives

One of the most significant problems with using an outdated pregnancy test is the increased likelihood of getting a false negative result. This is where the test will show that you're not pregnant when you actually are. This is due to the chemical compounds, especially the antibodies employed to identify hCG, breaking down over time, thus it becomes hard for the test to give a true result.

Degraded Antibodies

Pregnancy tests detect human Chorionic Gonadotropin (hCG), a hormone that is formed during pregnancy. After a while, the antibodies in the test, which cause a response when hCG is present, become weakened. So even if you are pregnant, the test may fail to measure the hormone at a level that is high enough.

Health Risks

As per the U.S. Food and Drug Administration (FDA), expired pregnancy tests tend to give false negatives rather than false positives. A false positive may also occur but is less so with expired tests.

Exposure to External Factors

The reliability of a pregnancy test is also affected by the way it's stored. Incorrect storage, for example exposure to sunlight, humidity, or heat, causes the components to degrade faster and results in more opportunities for getting incorrect results prior to reaching expiration.

Waste of Time and Money

Using an expired test not only reduces the likelihood of getting an accurate result but also wastes your time and money. It's best to check the expiration date before using the test and, if expired, purchase a new one for peace of mind and more reliable results.

Emotional Stress

The effect of depending on an out-of-date pregnancy test isn't only medical—it's psychological as well. Inaccurate results can induce undue distress, confusion, or early rejoicing.

Though home pregnancy tests are an efficient and convenient means of early pregnancy detection, their accuracy relies on a number of major factors, foremost among them their expiration date. Testing with one that has expired may cause emotional distress and delay medical attention at a time when it's needed most.

Each year, hundreds of people around the world lose their lives waiting for a life-saving organ transplant. The demand for organs far outweighs the supply, leaving many patients with little hope. But what if we could print organs—tailor-made for each patient—using their own cells? While we're not quite there yet, researchers are making significant strides in this futuristic field known as 3d bioprinting.

Though the technology is still far from clinical trials, scientists believe that when 3d-printed organs become a medical reality, the process will likely involve a blend of cutting-edge imaging, personalised cell harvesting, and highly advanced bioprinting methods. Here's what this groundbreaking process could look like.

Step 1: Creating a Personalised 3D Model

To print a functional organ, the process begins with creating a precise 3D blueprint. While generic models can serve as a starting point, personalisation is key. Using imaging technologies like MRI (Magnetic Resonance Imaging) and CT (Computed Tomography) scans, medical professionals can generate a detailed digital model of the organ tailored specifically to the patient’s anatomy. This personalized design enhances the chances of a successful transplant by ensuring the printed organ will fit and function properly in the recipient’s body.

Step 2: Collecting Patient’s Cells And Preparing Bioink

One of the biggest hurdles in organ transplantation is rejection, which happens when the recipient’s immune system attacks the new organ. To reduce this risk, scientists aim to use the patient’s own cells to build the organ. These cells are harvested, cultivated in labs, and combined with a specially designed “bioink”—a gel-like substance engineered to mimic the structure of natural tissues. This bioink becomes the medium through which living cells can be precisely layered and formed into complex biological structures.

Step 3: Printing the Organ

With a personalized 3D model in hand and a supply of bioink rich in the patient’s cells, the actual printing process begins. The organ is built layer by layer, using bioprinters designed to handle delicate biological material. Some methods involve extrusion-based bioprinting, which pushes the bioink through a nozzle to form a structure, similar to how icing is piped onto a cake. Other techniques rely on light-based bioprinting, which uses beams of light to shape the biomaterial with incredible precision.

In some cases, additional cells may be added to the organ after printing to support its development or enhance functionality. Although the exact tools and materials are still being refined, technologies such as the BIO X, BIO X6, and LUMEN X are among those helping to push the boundaries of what’s possible in tissue engineering.

Road Ahead

While researchers are still navigating numerous scientific and ethical challenges, the vision of printing fully functional, transplantable organs is no longer science fiction. With continued innovation and global collaboration, 3D bioprinting could one day eliminate organ shortages altogether, saving countless lives and revolutionizing modern medicine.