Vitamin B12 is vital for red blood cell formation, DNA production, and nerve function. Deficiency is more common in vegans, vegetarians, and pregnant individuals. In such cases, supplementation may be necessary to maintain adequate levels. Vitamin B9, commonly known as folate, is also very important for DNA synthesis, production of red blood cells, and cell growth.A recent study by Osaka Metropolitan University reveals an important aspect of these two nutrients: their deficiency is directly connected with chronic fatigue. The study published in the journal Nutrient urges for a proper diet and ensuring that all necessary nutrients are present for health and energy levels.The researchers studied over 600 healthy adults to determine whether vitamin deficiency can cause fatigue. They mainly focused on B12 and B9 because these two nutrients are crucial to maintain a natural amino acid called homocysteine in the human body. The research finds that the deficiency of these two nutrients causes an increase in homocysteine in the body, which may be connected to fatigue and low motivation.Notably, these deficiencies can impact you differently because of your gender, as the study found that the low level of these nutrients affects men mostly with fatigue, while women feel low motivation.Professor Hiroaki Kanouchi from Osaka Metropolitan University's Graduate School of Human Life and Ecology said, "This suggested relationship between vitamin B12, folate, and fatigue in healthy individuals may represent the first report of its kind."Also Read: Feeling Tired And Foggy? It Could Be Vitamin B12 DeficiencyWhy Does B12 Deficiency Happen?Vitamin B12 is mainly found in animal-based foods such as meat, fish, eggs, and dairy products. People who follow vegetarian or vegan diets may need fortified foods or supplements to get enough.Absorption is also a key factor. Vitamin B12 requires a special protein in the stomach called intrinsic factor to be absorbed properly. Certain medical conditions, medications, or aging can reduce absorption. This means that even if someone eats enough B12, their body may not absorb it efficiently.Also Read: Space Grown Stem Cells: How Are Expedition 74 Astronauts Helping To Fight Cancer?Why Does B9 Deficiency Happen?Folate is naturally found in foods like leafy green vegetables, citrus fruits, lentils, beans, and whole grains, and a diet low in these can cause deficiency. Though in some cases, certain medical conditions can also be the reason for the problem.When To See A Doctor?If you experience ongoing fatigue, tingling sensations, or noticeable changes in memory or mood, consult a healthcare professional. A simple blood test can measure your B12 or B9 levels.Both deficiencies are usually treatable. Treatment may include dietary changes, oral supplements, or, in more severe cases, injections. When identified early, most people recover well.