People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

A doctor has highlighted the subtle signs he often observes in adults with Attention Deficit Hyperactivity Disorder (ADHD). These are traits people with ADHD may recognise in themselves but that are rarely discussed publicly. A consultant psychiatrist has highlighted subtle signs of Attention Deficit Hyperactivity Disorder (ADHD) that often go unnoticed. Dr. Ali Ajaz, who shares advice with over 97,600 TikTok followers, recently outlined six “hidden features” of ADHD that aren’t as widely discussed as the more familiar symptoms. These lesser-known traits can help adults recognise the condition in themselves or others.

What Is ADHD?

Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental condition that begins in childhood and often continues into adulthood. It involves persistent challenges with attention, hyperactivity, and impulsive behaviour. Children with ADHD may struggle in school, face difficulties in relationships, and experience low self-esteem.

While symptoms can lessen over time, many continue to experience them as adults. Although there’s no cure, early diagnosis and a combination of medication, behavioural therapy, and education can significantly improve daily functioning and long-term outcomes.

ADHD Symptoms

The main symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) include difficulty focusing, impulsive behaviour, and excessive activity levels. Signs of the condition usually appear before the age of 12 and, in some cases, can be noticed as early as age 3. The symptoms can range from mild to severe and must be present in more than one environment, such as home, school, or work to confirm a diagnosis. These behaviours often interfere with growth, learning, and everyday functioning and may persist into adulthood.

ADHD is diagnosed more frequently in boys than in girls, though it can look different between the two. Boys are often more visibly hyperactive, while girls may show quieter patterns of inattention that can easily go unnoticed.

There are three main types of ADHD:

1. Predominantly Inattentive Type:

Individuals mainly struggle with concentration, organisation, and completing tasks. They may appear forgetful or easily distracted

2. Predominantly Hyperactive-Impulsive Type:

This form involves restlessness, excessive movement, and impulsive decisions. The person may act without considering the consequences or have difficulty sitting still.

3. Combined Type:

This type includes a mix of inattentive and hyperactive-impulsive symptoms, meeting the criteria for both categories.

Hidden Signs of Adult ADHD

Dr Ali Ajaz in his recent tiktok video talked about less than the 'classic' signs of the condition.

According to the doctor, people with ADHD often show certain behaviours that are rarely discussed but are quite common. One of them is hyperfocus which is getting so engrossed in something that they completely lose track of time. While this can be an advantage in some situations, it often causes them to ignore other responsibilities or personal needs.

Another sign is having an unusually high or low sex drive. For some, sex serves as a form of stimulation or a way to release tension, while for others, it feels like too much effort and concentration, leading to disinterest.

He also mentioned binge eating, explaining that the ADHD brain constantly seeks stimulation, and food becomes an easy source of instant gratification. Finally, he pointed out rejection sensitivity, where even mild criticism can feel deeply hurtful, often resulting in overthinking and emotional withdrawal.

The doctor went on to explain that low self-esteem and self-doubt are also very common among people with ADHD. These feelings often come from years of struggling with symptoms, either being told they are not trying hard enough or putting in their best effort but still falling short of expectations. Over time, this combination can deeply affect confidence and self-worth.

Lastly, he mentioned chronic gut problems such as bloating, pain, constipation, or diarrhoea. These issues, he said, are closely linked to the gut-brain connection, as ADHD brains often show signs of inflammation. Much of this inflammation, he explained, comes from diet and eating patterns.

Antidepressants side effects weight gain: Antidepressants, widely used to manage mental health conditions, can affect weight, heart rate, and blood pressure, though these changes differ depending on the specific drug. Researchers from King’s College London’s Institute of Psychiatry, Psychology & Neuroscience (IoPPN) conducted one of the most extensive reviews to date, comparing the physical effects of 30 antidepressants. The findings, published in The Lancet, draw on data from over 150 clinical trials involving 58,534 participants who took either antidepressants or placebos for eight weeks.

This Common Antidepressant May Quietly Raise Your Blood Pressure

The researchers observed the biggest differences in weight, heart rate, and blood pressure among those taking antidepressants. They said the results, published in The Lancet, are meant to help patients make informed decisions but advised anyone with concerns to consult their doctor.

Researchers examined how these medications affected patients during the first eight weeks of treatment. Some antidepressants led to weight gains of up to 2 kilograms, while others caused changes in heart rate of as much as 21 beats per minute.

What Is Sertraline?

Sertraline, sold under the brand name Zoloft, is a prescription antidepressant medication that belongs to the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). It works by increasing the levels of serotonin, a natural chemical in the brain that helps regulate mood.

Between 2024 and 2025, about 92.6 million antidepressant prescriptions were issued to roughly 8.89 million people in England, according to data from the NHS Business Services Authority (NHSBSA). Among them, sertraline, taken by an estimated 2.9 million patients, was associated with slight weight loss, averaging about 0.76 kilograms, and a small drop in heart rate. However, it also showed a modest rise in both systolic and diastolic blood pressure.

Sertraline Leads To Increased Blood pressure

An increase in blood pressure can raise the risk of stroke, the researchers noted. However, they also pointed out that the study’s main limitation was its short duration, as it only examined the first eight weeks of treatment. They said more research is needed to understand the longer-term effects of these medications.

Dr. Toby Pillinger, lead researcher and consultant psychiatrist at King’s College London, stressed that the findings are not intended to discourage antidepressant use. Instead, they aim to promote personalised treatment and encourage shared decision-making between doctors and patients, empowering individuals to make more informed choices about their care.

Which Antidepressant Should I Opt For?

The most commonly prescribed antidepressants—SSRIs like paroxetine, citalopram, escitalopram, and sertraline, generally showed fewer physical side effects. Professor Andrea Cipriani from the University of Oxford said it is “impossible” to determine how many of the millions taking antidepressants might benefit from a different medication.

He noted that a focus on “generic, cheap medications” has led to 85% of antidepressant prescriptions in the UK being for just three SSRIs: citalopram, sertraline, and fluoxetine.

According to Cipriani, applying the findings from this study could drastically reduce that 85% figure, allowing more patients to access treatments better suited to their needs.

The research team is also developing a free online tool to help doctors and patients make more informed choices about which antidepressant to use.

An average person takes about 22,000 breaths a day, most of them without any conscious effort. Yet research shows that spending just a few minutes on slow, deliberate breathing can help bring blood pressure down, sometimes lowering the top number, or systolic pressure, by as much as 10 points.

Every night before sleep, you might pause, take a deep breath, and feel your body unwind. But can this calming ritual really lower your blood pressure overnight? Social media posts and wellness videos claim it can. We looked into what science and doctors say about this widely shared belief.

What the Claim Says

The idea is simple: if you practise deep, rhythmic breathing before bed—say inhaling for four seconds, holding for four, and exhaling for eight—you’ll wake up with a lower blood pressure reading the next morning. It sounds effortless, but does the body really respond that fast?

What Research Actually Shows

There is solid evidence that slow, deep breathing can help lower blood pressure, though not necessarily overnight. A review published in the Journal of Human Hypertension found that practising slow breathing for just a few minutes daily lowered both systolic and diastolic pressure by an average of 3 to 6 mmHg over time.

Harvard Health Publishing also notes that deep breathing helps by activating the parasympathetic nervous system, which relaxes blood vessels and slows the heart rate, creating a measurable drop in pressure with regular use. In another 2024 clinical study published on PubMed Central (PMC), people who used the 4-4-8 breathing technique for 10 minutes saw their systolic blood pressure fall by about 5.8 mmHg after 30 minutes.

These numbers are modest but meaningful for heart health. Still, most of these effects appeared after consistent practice over days or weeks, not a single night.

The Missing Evidence for the ‘Overnight’ Effect

The viral claim exaggerates the timeline. Few, if any, studies have examined whether one bedtime session of deep breathing can make a measurable difference by the next morning. Blood pressure naturally fluctuates during sleep, so any temporary dip caused by relaxation is likely to even out by morning.

According to cardiologists, the effect is more about long-term nervous system conditioning than an instant fix. The relaxation you feel is real, but its impact on numbers is subtle and cumulative.

Experts still encourage adding deep breathing to your bedtime routine for its calming and sleep benefits. Try this:

• Sit or lie down comfortably.
• Inhale through your nose for 4 seconds.
• Hold your breath for 2–3 seconds.
• Exhale gently through your mouth for 6–8 seconds.
• Continue for about 5 minutes.

Practising this nightly for 4–6 weeks can help reduce stress and may gradually lower blood pressure. Keep a log of your readings to notice any steady improvement.

Deep breathing is a simple, accessible way to support heart health, but it’s not a quick overnight fix. The science supports its long-term benefits, not the viral promise of an immediate drop after one bedtime session.

So while your nightly breathing habit won’t transform your blood pressure overnight, it may still be one of the gentlest ways to calm both body and mind, if you make it part of your everyday rhythm.