People receiving weight-loss drug Wegovy sustained weight loss for up to four years, shedding an average of 10% of their body weight in that time, as per a new study. Wegrovy is a brand that markets semaglutide injections, that have gained widespread attention for their weight-loss effects. The study also found that Semaglutide injections boost an individual's heart health, even when weight loss doesn't take place.

The study, called SELECT, was published in journal Nature Medicine. "At four years, we see ongoing benefits of semaglutide," said Cheng-Han Chen, MD, interventional cardiologist from Cardiologist, who was not involved in the research. Besides the weight loss, it also lead to a loss in cardiovascular outcomes.

The research was conducted on 17000 adults, who had obesity but did not have diabetes. Overall, people who received once-weekly injections of semaglutide lost on average 10.2% of their body weight over the course of four years. All of the study participants continued to lose weight for about 65 weeks, a year and three months, and then their weight remained at a stable level.

Were There Any Side Effects?

However, people's experience with the medication varied. Researchers found no unexpected safety issues with drug during trial. In fact, most the people who withdrew from the study were those who experienced the known symptsoms of the semaglutide injections like nausea, indigestion etc. This occurred mainly during the beginning of the study, as the dose of the medicine is increased to a maximally tolerated dose.

What Did The Results Say?

Of the people on the highest dose of Wegovy, 68% lost at least 5% of their body weight. This compared to 21% of people on the placebo. Additionally, of the total people on Wegovy about 23% lost at least 15% of their body weight. For those in the placebo group, only 1.7% lost that much body weight.

Semaglutide Shows Heart Benefits Beyond Weight Loss

Researchers found that even individuals who did not experience significant weight reduction while on the drug saw a reduced risk of major heart events. Recent analysis of the SELECT trial data revealed that semaglutide significantly lowers the risk of heart attack, stroke, and cardiovascular-related deaths in adults with obesity or those who are overweight. Notably, the results of this study lead the US FDA to approve Novo Nordisk's Wegovy for reducing heart-related risks in this group.

What Is Semaglutide?

Semglutide is the synthetic version of GLP-1—a natural hormone produced in the intestines that regulates blood sugar, appetite, and digestion. Now, every time you eat, your body produces various hormones, including GLP-1. These are called Post nutrition hormones, and help you absorb the energy you just consumed. GLP-1 travels to your pancreas, prompting it to produce insulin. It also travels to the hypothalamus in your brain, which gives you the feeling of being full or satiated. Ozempic imitates this hormone, thereby, silencing the food chatter in the brain. Interestingly, for some people this food chatter is really quiet ( people with low appetite) and for others it is an outburst, (people who generally binge eat.) So with Ozempic, silencing this self-talk in the brain, people tend to lose their appetite and eventually weight.

Are Their Any Side Effects Of Semaglutide?

Semaglutide, marketed under the brand name Wegovy, is primarily an antidiabetic medication used to treat Type 2 diabetes. It is also an anti-obesity drug used for long-term weight management. While it can be taken as a subcutaneous injection or orally, it has significant side effects. It primarily impacts your gastrointestinal tract and its side effects include constipation, nausea, abdominal pain, diarrhoea, and fatigue amongst others.

Roughly one out of six people globally suffer with infertility according to the World Health Organization. A common issue that affects many, infertility, is a condition where a person is unable to reproduce offsprings. While the condition may be common, it can cause a lot of health problems as well as stress for people who wish to have children. To tackle this, people often opt for fertility treatment including reproductive technology called in vitro fertilization (IVF). However, could your infertility be a sign of impending health issues?

A new evidence review suggests a link between infertility in women and a heightened risk of heart problems, particularly among younger women and those undergoing fertility treatments.

Is Infertility An Early Warning for Heart Health?

Infertility may serve as an early sign for future heart health issues, according to researchers at the National and Kapodistrian University of Athens in Greece. This finding was recently presented in Copenhagen, Denmark, at a joint meeting of the European Society of Pediatric Endocrinology and the European Society of Endocrinology.

Researchers looked at data from many different studies – almost 21 of them! They compared nearly 179,000 women who couldn't get pregnant with about 3.4 million women who didn't have fertility issues. What they discovered was that women who were infertile had a higher chance of facing heart issues:

• They were 17% more likely to get heart disease, which is a general term for problems with the heart itself.
• They had a 16% higher chance of having a stroke, which happens when blood flow to the brain is blocked.
• They were 14% more likely to have problems with their heart or blood vessels in general.

Elevated Risk for Younger Women and Those Undergoing Treatment

The research highlights two groups of women who face an even bigger risk. First, it's younger women. The study found that women under 40 who were infertile had a 20% higher chance of heart disease. That's a significant increase for younger individuals. Second, it also showed that women who went through fertility treatments (like IVF) had an 18% greater risk of heart problems. This suggests that either the treatments themselves or the underlying reasons for needing them could be connected to heart health.

Implications for Clinical Care

Researchers believe that because infertility might be an early sign of heart problems, doctors can use this information. They can identify women who might need extra check-ups or special strategies to prevent heart disease earlier in life. It's like giving doctors a heads-up to be more careful with these patients. She also brought up an important question: what are the long-term effects of fertility treatments on a woman's heart? This is something doctors need to consider.

Researchers want to follow women’s health over time to really understand why infertility might be linked to heart health. They hope to figure out the exact biological reasons behind this connection and identify which specific groups of women are most at risk. The ultimate goal is to use all this information to create better guidelines for preventing heart disease early on and to improve heart care for women who have had infertility.

Headache? Take a painkiller. Joint pain? Take another. For all of us, over-the-counter (OTC) painkillers such as ibuprofen or acetaminophen are as much a part of daily life as a morning cup of coffee. They're fast, efficient, and appear harmless—who needs a prescription, anyway? But what if this blase dependence on painkillers is actually laying the groundwork for a much more devastating health emergency?

If that's your daily mantra, don't worry, you're in good company. In the age of instant gratification, all of us are turning to over-the-counter pain relievers as a quick fix for even mild pain. But what if this ostensibly innocuous habit is silently threatening your kidneys with a major health problem?

Painkillers, or analgesics, are usually a lifeline for individuals with chronic or severe pain. From recovery from surgery and migraines to arthritis and menstrual cramps, these drugs offer relief that ensures our quality of life is not drastically reduced. But beneath the pain relief lies a surprising question: whether the overuse of these drugs may exact too high a price-kidney damage and even kidney cancer.

Dr. Aditya Punamiya, a GI, HPB, and Gynecologic Oncosurgery Consultant, cautions, "The long-term and uncontrolled use of over-the-counter painkillers is emerging as an under-diagnosed but serious risk factor for kidney cancer." Dr Punamiya observations reveal an alarming pattern, numerous patients self-medicate for chronic pains—headaches, joint pains, or back pain—unaware of the additive damage to the kidneys.

Why We Turn to Painkillers So Easily?

Pain is a biological alarm system. Helpful in warning us of injury or sickness, chronic pain can strongly interfere with our functioning on a daily basis. To counter this, painkillers provide a feeling of control and comfort. For acute on-demand pain and chronic inflammatory diseases, drugs like NSAIDs and acetaminophen are not only handy but effective as well.

Sadly, the very ease of use of these drugs has led to their misuse. Painkillers are increasingly being consumed without medical supervision, particularly in nations such as India where OTC availability is prevalent but even within well-regulated economies such as the U.S., long-term use has become an undercurrent of an epidemic.

What Are The Types of Painkillers?

Over-the-Counter (OTC) Medications

Paracetamol (Acetaminophen): Good for fever and light pain, but hepatotoxicity is a serious issue above moderate doses.

NSAIDs (Non-Steroidal Anti-Inflammatory Drugs): Contains ibuprofen, naproxen, and diclofenac. These are useful for pain that is inflammation-related but have gastrointestinal and renal toxicity with long-term use.

Prescription Painkillers

Opioids (Tramadol, Morphine, Oxycodone): For severe pain only but pose the risk of respiratory depression, addiction, and endocrine disruption.

Topical and Alternative Therapies

Topical creams and patches containing drugs such as menthol or capsaicin are localized treatments with fewer systemic hazards.

How Do these Drugs Harm the Kidneys?

How do such drugs damage the kidneys? Dr. Punamiya clarifies, "Drugs such as ibuprofen, diclofenac, and naproxen, if taken in excess, can harm the kidneys in two ways. One, they weaken the kidneys' function to filter blood by cutting off blood supply. Two, they cause chronic interstitial nephritis over time, scarring kidney tissues." This scarring provides a fertile ground for RCC to grow.

The kidneys, essential organs responsible for filtering waste products from the blood, are especially susceptible to chronic exposure to NSAIDs and acetaminophen. Acute kidney injury, chronic kidney disease, and, in severe cases, kidney failure can result from excessive use of these compounds. The transition to kidney cancer is not as sudden but equally alarming, since the cumulative insult changes cellular mechanisms, possibly initiating malignant growth.

A landmark meta-analysis by Toni K Choueiri, Youjin Je, and Eunyoung Cho has again highlighted the relationship between chronic painkiller use and renal cell carcinoma (RCC)—the leading form of kidney cancer.

Non-Aspirin NSAIDs: Chronic use was linked to a 25% enhancement in the risk of RCC. Heavy consumption increased that threat by 56%, long-term consumption for more than 10 years especially concerning for women.

Acetaminophen: Associated with a 21% heightened risk of kidney cancer. Heavy users who took high doses saw their risk rise by 66%.

Aspirin: While most U.S.-based research found no conclusive link, some research from other countries suggested a connection, possibly due to regional variation in formulation or consumption habits.

Why Kidney Cancer Is a Silent Threat?

Kidney cancer is especially stealthy since it usually presents late without any symptoms. "Flank pain, hematuria and weight loss are typically late presentations," states Dr. Punamiya. For patients such as Sarah, who might have been taking painkillers for years, these signs may only manifest by the time cancer has metastasized, and so treatment is less effective.

Risk factors such as smoking, hypertension, diabetes, and obesity increase the risk, particularly in individuals with previous long-term analgesic use. Women also have an increased risk with non-aspirin NSAIDs, possibly because of hormonal or metabolic variation, although further work is required to explain this difference. He describes two principal mechanisms:

Decreased Renal Blood Flow: NSAIDs inhibit prostaglandins, decreasing kidney blood flow and compromising kidney filtration capability.

Chronic Interstitial Nephritis: Long-term NSAID use leads to fibrosis and inflammation of kidney tissue, setting the stage for RCC.

"Most patients self-treat for headaches or joint pain without knowing they're gradually driving their kidneys towards failure," he adds.

Why Early Detection Of Kidney Cancer Symptoms is Difficult?

Kidney cancer is infamous for its asymptomatic nature in the early stages. By the time symptoms such as pain in the flank, hematuria (urine containing blood), or unexplained weight loss appear, the disease is usually advanced. Patients with pre-existing risk factors—such as smoking, hypertension, and diabetes—and with a history of analgesic abuse are particularly susceptible.

Dr. Punamiya advises individuals to consult a doctor for ongoing pain rather than resorting to self-medication. "Routine screening and preventive caution are necessary, especially for vulnerable groups," he points out.

What Are Ways You Can Manage Pain Management Smartly?

Not every use of painkillers is risky. "Short-term, doctor-monitored use is generally safe," says Dr. Punamiya. The trick is not entering into uncontrolled, long-term use. Here's how to handle pain more safely:

Consult a Healthcare Provider

For long-term pain, consult a professional to treat the underlying condition, whether arthritis, neuropathy, or migraines. A customized treatment plan can minimize painkiller dependency.

Try Non-Drug Options

Physical therapy, acupuncture, yoga, and cognitive-behavioral therapy can treat chronic pain without medication risks. For sudden pain, ice, heat, or rest may be enough.

Use Painkillers Wisely

Follow instructions on dosing and avoid prolonged use outside of medical guidance. For NSAIDs, eat food when taking to reduce stomach discomfort, and drink enough fluids to aid kidney function.

Take Precautions

Encourage regular health screening for early detection of kidney problems, particularly among high-risk groups. Dr. Punamiya urges "preventive vigilance" with follow-up visits and attention to early signs such as blood in the urine or recurrent flank pain.

Lifestyle Matters

A balanced diet, exercise, and weight control can cut pain from conditions such as arthritis while reducing kidney cancer risk factors such as obesity and high blood pressure.

There may be the temptation to cover up pain instead of comprehending its cause but swallowing a pill with a glass of water can be an instant solution that might come at a price of long-term health. The growing body of evidence linking commonly used painkillers to kidney cancer is a call for informed, cautious use. As more people take their health into their own hands, the importance of education, medical guidance, and moderation cannot be overstated.

When we talk about men’s health, prostate care rarely enters the conversation before the age of 50 but waiting that long might mean missing early signs of dysfunction. According to leading health experts, the prostate—a walnut-sized gland central to male reproductive health—starts undergoing subtle changes as early as your 30s. While issues like prostate enlargement and cancer are more commonly diagnosed later in life, the foundation for lifelong prostate health is laid much earlier.

So why should men under 35 be concerned? Because learning, know-how, and making a few sensible health decisions today might avoid chronic issues tomorrow.

Your prostate gland is tiny, yet its function in a man's reproductive system is important. It lies beneath the bladder and encases the urethra, the tube that carries urine as well as semen. The major functions of the prostate are:

Producing Prostatic Fluid: It is a significant fraction of semen. Prostatic fluid holds enzymes, zinc, citric acid, and prostate-specific antigen (PSA), keeping the sperm alive by thinning the semen.

Regulating Urine Flow during Ejaculation: During orgasm, the prostate tightens to avoid urine entering into the semen and to facilitate ejaculation smoothly.

Regulating Hormones: Within the prostate, there is an enzyme 5-alpha-reductase that turns testosterone into dihydrotestosterone (DHT). This hormone affects male secondary sex characteristics such as body hair and deepening voice but also has a major role in the growth of the prostate.

Learning about these processes is key to knowing when things may be headed in the wrong direction—and that includes being able to tell different sorts of prostate disorders apart.

Prostate Enlargement vs. Prostate Cancer: What's the Difference?

One of the most prevalent misconceptions among younger men is mixing up benign prostate enlargement with prostate cancer. Dr. Sridhar Reddy Baddam, Senior Consultant Vascular and Oncointerventions at Hyderabad-based Apollo Hospital, says, "One of the key things that young men should know is the distinction between prostate enlargement and prostate cancer. Benign Prostatic Hyperplasia (BPH) is a non-cancerous, benign enlargement that usually starts developing post-30–35 years.". It can lead to symptoms like frequent urination or difficulty starting the stream, but it’s not life-threatening.”

Prostate cancer, by contrast, is a malignant growth that often shows no signs in its early stages, which makes regular screenings vital—especially if you have a family history of the condition.

The signs can overlap," continues Dr. Baddam, "which is why prevention and early detection are so important. If either condition is caught early, there are more treatment options and better results."

What is the Hormonal Connection?

Hormones, specifically testosterone, bear a profound relationship with prostate health—but not necessarily one men suspect. Dr. Virender K Sheorain, Associate Director, Medanta - The Medicity, describes the nuance, "There's widespread confusion about testosterone and prostate health. Testosterone per se is not the issue; it's how the body metabolizes it. When it metabolizes into DHT, it can affect prostate growth. That's why hormonal balance is crucial."

Men in their 30s should have hormone levels regularly checked, particularly if they're finding it hard to urinate or have decreased libido. The best part? Treatment has improved.

"One of those methods is Prostate Artery Embolization (PAE), which lowers the prostate's blood supply and causes it to shrink over time," explains Dr. Sheorain. "It's a non-surgical treatment that provides symptom relief without much downtime."

Can Exercise Prevent Prostate Issues?

At your 30s, prostate health is perhaps still a distant issue—but the habits you form at this stage are important. Dr. Mousam Dey, Senior Intervention Radiologist, Fortis Hospital Kolkata, points out the increased awareness among young men, "Men in their early 30s are more becoming aware of prostate health, and that's a positive change.". Daily exercise aids in hormone regulation, the reduction of inflammation, and weight control, all of which are connected to a decreased chance of developing BPH as well as prostate cancer.

Exercise, particularly strength training and aerobics, has been associated with lower PSA levels and decreased risk of prostate issues. Inactivity, conversely, can cause hormonal disruptions that speed prostate enlargement.

Early Red Flags You Shouldn't Ignore

The majority of prostate disorders start insidiously. However, as the gland enlarges (either through benign hypertrophy or malignancy), symptoms can start to develop. Men under age 35 should be aware of:

• Frequent urination, particularly at night
• Trouble initiating or stopping the stream
• A weakened or interrupted urinary stream
• Painful ejaculation
• Hematuria or hematospermia

Although these symptoms do not necessarily signify cancer, they are worth bringing up with a urologist for early screening and prevention.

How Small Habits Support Long-Term Protection?

So what can men younger than 35 do to safeguard their prostate health today? Use this as your fundamental guide:

• Shoot for at least 30 minutes of exercise five times a week.
• Add zinc-fortified foods (such as pumpkin seeds and seafood), healthy fats, and antioxidants such as lycopene (in tomatoes).
• If you have a family history, begin PSA screenings earlier—sometimes as early as age 35.
• Stress affects hormones and the immune system, both of which influence prostate function.
• Do not smoke and avoid excessive alcohol use since both are associated with worse prostate results and increased cancer risks.

The prostate can't take center stage in the same way as the heart or brain in early adulthood, but neglecting it until midlife will cost you your long-term well-being. Today's 30-something man is juggling career, family, and health aspirations—and that means staying one step ahead of avoidable diseases such as BPH and prostate cancer. As Dr. Baddam points out, "Awareness in your 30s isn't premature—it's proactive.

Start small. Think big. And remember: Prostate health isn't about age—it's about taking responsibility for your health journey early.