The Health and Me had previously reported on how many people faced problems with their pancreas post taking weight loss drugs and diabetes injections. These medicines are mostly Wegovy, Ozempic and other variants of GLP-1 medicines, or the glucagon-like peptide-1 receptor agonists. This has led to an investigation by the authorities.

Not just this, but there are also reports of deaths that have been linked with GLP-1 medicines. Data from the Medicines and Healthcare products Regulatory Agency (MHRA) revealed that ever since these drugs were approved, there have been hundreds of cases of acute and chronic pancreatitis.

The data revealed that 10 people have died and among them, 5 were linked to active ingredients of these popular weight loss jabs.

What Did The Data Reveal?

• A total of 181 cases of acute and chronic pancreatitis have been reported in connection with tirzepatide, the active ingredient in Mounjaro, including five fatalities.
• Liraglutide was associated with 116 such cases, one of which was fatal.
• Semaglutide—the active ingredient in Ozempic and Wegovy—was linked to 113 cases, with one death reported.
• Exenatide was associated with 101 cases, including three deaths.
• Dulaglutide and lixisenatide were linked to 52 and 11 cases respectively, with no reported fatalities for either drug.

Based on the data, the Yellow Card Biobank project, which is launched by MHRA and Genomics England will investigate these instances and check whether these drugs could influence people's genetic make-up.

When we asked Dr Amrit Kaur Kaler, Consultant, Molecular Pathology at Kokilaben Dhirubhai Ambani Hospital, Mumbai about it, she said the "definitive answer to it is no". The doctor explained, "GLP-1 drugs are designed to mimic the body’s own incretin hormone. Once injected, they bind to GLP-1 receptors located on pancreatic β-cells and in regions of the brain that regulate appetite. This action leads to an enhanced insulin secretion, helping the body respond appropriately to rising blood glucose levels." It also leads to appetite suppression, by activating neurocircuits that signal fullness. Furthermore, it delays gastric emptying, which prolongs satiety after meals.

In a nutshell, explained the doctor, the medicines "target receptors, not genes."

Though Dr Kaler also notes, "Although GLP-1 agonists themselves do not rewrite genes, any significant change in metabolism—such as substantial weight loss or improved insulin sensitivity—can lead to epigenetic modifications. These are biochemical tweaks, like adding or removing methyl groups on DNA or changing histone configurations, that influence gene activity without altering the underlying sequence." However, it is also important to note that the drugs do not introduce new mutations or make the pancreas produce abnormal DNA. "Individuals with inherited variants in genes like PRSS1, SPINK1, or CFTR already carry a higher baseline risk for pancreatitis," she explains.

The MHRA is encouraging individuals taking GLP-1 medicines who have been hospitalised with acute pancreatitis to report their experience through the Yellow Card scheme.

Following a report submission, the MHRA will reach out to patients to ask if they are willing to take part in a related study.

Participants will be asked to share further information and provide a saliva sample to help determine whether genetic factors may contribute to the risk of developing acute pancreatitis from specific medications.

What Are GLP-1 Medicines?

GLP-1 agonists, used to lower blood sugar in type 2 diabetes and support weight loss, are currently under increased scrutiny, according to Wales Online.

With an estimated 1.5 million people in the UK using weight loss injections, health authorities recognise their role in tackling obesity but warn against viewing them as a universal solution, citing potential side effects.

Commonly reported reactions include nausea, constipation, and diarrhoea. Recent safety alerts have also highlighted concerns about Mounjaro possibly reducing the effectiveness of oral contraceptives.

Dr. Alison Cave, Chief Safety Officer at the MHRA, stated: “Evidence shows that nearly a third of medicine-related side effects could be avoided through genetic testing. Adverse drug reactions are estimated to cost the NHS over £2.2 billion annually in hospital admissions alone.”

She added that data gathered from the Yellow Card Biobank will help identify patients at increased risk of side effects, enabling more personalised and safer prescribing based on individual genetic profiles.

What Happens To Your Body When GLP-1 Medicines Are Administered?

To understand what our body goes through, we spoke to experts in endocrinology and gastroenterology. Here's what they said.

Dr Pranav Ghody, Consultant Endocrinologist & Diabetologist, Wockhardt Hospitals at Mumbai Central explains that weight loss medications, particularly injectable GLP-1 receptor agonists like semaglutide, have become popular due to their effectiveness. "However, when misused taken without medical supervision, used in high doses, or by people with underlying health issues they can lead to serious side effects. Some complications, like pancreatitis or severe gastrointestinal symptoms, may be life-threatening if not promptly addressed."

Why does it impact the pancreas? Dr Ghody explains that these medicines slow digestion and help control hunger, however, in some individuals, especially those predisposed or with a history of pancreatic issues, they can irritate the pancreas and trigger inflammation, leading to a condition called acute pancreatitis.

He also notes that in rare cases, acute pancreatitis can become severe. "It could lead to serious complications like organ failure of infections. If not diagnosed and managed early, it can be fatal. That said, such outcomes are uncommon and typically occur when early warning signs are ignored or the drug is misused."

Dr Saswata Chatterjee, Gastroentrologist at CMRI Hospital explained, "Cases of pancreatitis is more commonly seen in patient people who take terezaberatide. What occurs is there is a pancreatic duct through which the normal pancreatic secretions flow out of the pancreas and into the small intestine. This medicine has been shown to cause hyperplasia of cells around the pancreatic duct and therefore ductal occlusion occurs which leads to pancreatitis in some situations."

Dr Kashish Gupta, Consultant Endocrinology at PSRI Hospital, Delhi, points out that deaths reported in association with these drugs are usually related to severe complications like pancreatitis, dehydration, electrolyte imbalances, or cardiac issues in patients who were either not properly monitored or had other underlying health risks. "Sometimes, patients also self-medicate or receive these injections without adequate clinical oversight, which adds to the risk."

He further adds, "People should be made aware of early warning signs of pancreatitis such as sudden, severe abdominal pain that radiates to the back, persistent nausea, vomiting, and fever. If such symptoms occur, the medication must be stopped immediately and emergency medical care sought."

So, How Can One Ensure Safe Use Of Weight Loss Drugs?

"Always take these drugs under the guidance of a qualified endocrinologist or physician. A thorough evaluation including your medical history, current health status, and regular monitoring is crucial. Never self-medicate or take someone else’s prescription. Also, report any symptoms like persistent stomach pain, nausea, or vomiting immediately to your doctor," points out Dr Ghody.

Seconding to this. Dr Sachin Chittawar, Endocrinologist notes that drugs should be prescribed by an endocrinologist.

As cough and flu season sweeps across the UK, health expert Dr Xand shared crucial guidance during today’s episode of BBC Morning Live (Jan 19) for anyone struggling with a stubborn cough. The discussion focused on coughs and colds, highlighting new research showing that human rhinovirus, a common cause of cold, can also trigger pneumonia in adults.

Flu Season In UK: Warning Signs To Watch For

Speaking with presenters Helen Skelton and Gethin Jones, as per Mirror, Dr Xand, a specialist in public and global health, explained which symptoms indicate a cough should not be ignored. He noted that a persistent cough is one of the key signs of pneumonia.

Gethin asked, "A cough happens with many illnesses, so when should someone really worry?" Dr Xand replied, "This is a big question, and plenty of people at home might be thinking, 'Is this serious?' because coughs can linger for a long time."

He continued: "Viruses like respiratory syncytial virus (RSV) can cause what’s known as the 'hundred-day cough,' and people can be coughing for weeks wondering what’s going on."

Dr Xand advised viewers to follow the NHS guidelines for coughs, saying, "The NHS recommends consulting your doctor if a cough persists for over three weeks. Many coughs last three to four weeks, and you’ll usually notice if they’re improving. Right now, the most common cause is a virus."

Dr Xand’s Cough Syrup Alert

Addressing people from home about cough syrups, Dr Xand highlighted the latest NHS guidance. He suggested trying more natural remedies, which can be just as effective. "The NHS does not actually recommend cough syrup," he explained. "It advises hot lemon with honey instead."

The official NHS website confirms that "hot lemon with honey has a similar effect to cough medicines." This simple remedy can soothe the throat, calm irritation, and reduce the cough reflex. Some studies even suggest it works as effectively as certain over-the-counter medicines, particularly for children over one year old. However, it’s important to note that it doesn’t treat the underlying illness.

What Do Cough Syrup Studies Show?

Research shows that most over-the-counter cough medicines offer minimal benefits. Studies, including those from the Cochrane Collaboration, reveal that they perform little better than a placebo for short-term cough relief in both adults and children.

While these syrups may temporarily ease throat irritation or provide a sense of relief, ingredients such as dextromethorphan and guaifenesin often do no better than sugar pills. Much of the perceived benefit comes from the placebo effect or the body’s natural recovery.

Instead, simpler measures like honey, staying hydrated, and using painkillers such as paracetamol or ibuprofen are often more effective. Most coughs caused by colds simply need time to resolve.

Cough Syrup: Red Flags To Watch For

Dr Xand shared the warning signs people should be aware of. "There are several red flags worth noting. High fever, chills, or unexplained shortness of breath are all reasons to see a doctor immediately. You should be able to breathe normally, and if you can’t, that’s a concern."

He added, "Any chest pain with a cough, very thick mucus, or extreme fatigue are also serious signs. More severe warning signals include trouble breathing, bluish lips or fingertips, confusion, mental changes, prolonged high fever, and a rapid heart rate."

"It’s crucial to act quickly," Dr Xand continued. "I’ve seen cases in my own family where someone went from a mild cough to being extremely unwell in just a day. Sudden deterioration can be life-threatening, so early medical help is essential."

Pneumonia Can Be Subtle but Serious

Dr Xand emphasized, "Pneumonia can sometimes develop quietly. It isn’t always dramatic, but it can be fatal. That’s why it’s so important to monitor symptoms and seek medical help promptly if things are getting worse."

Vitamin deficiencies are often brushed aside as minor nutritional gaps. Many people assume they can be fixed later or ignored until something feels seriously wrong. According to Dr Prabhat Ranjan Sinha, Senior Consultant, Internal Medicine at Aakash Healthcare, this casual attitude can be risky, especially when it comes to Vitamin D3 and Vitamin B12. Both nutrients play a central role in bone strength, nerve function, immunity, and energy levels. When their levels drop, the damage may build quietly and surface only when daily life starts to feel difficult.

Vitamin D3 and Vitamin B12 are essential for overall wellbeing. Their deficiency may not cause obvious symptoms at first, but over time they can affect how the body functions, how often a person falls sick, and how energetic or mentally sharp they feel.

Vitamin B12 And D3 Deficiencies: The Sunshine Vitamin And Why It Matters

Vitamin D3, often called the sunshine vitamin, is produced by the body when skin is exposed to sunlight. Along with calcium, it helps maintain strong bones and reduces the risk of fractures. Low levels of Vitamin D3 can weaken muscles, increase the risk of falls, and raise the chances of bone disorders such as osteoporosis. In children, severe deficiency can lead to rickets, a condition that affects normal bone growth.

Dr Sinha explains that Vitamin D3 does more than support bone health. It also plays a key role in immune function. People with low levels may fall sick more often and take longer to recover from infections. Research has also linked deficiency to higher levels of inflammation in the body.

Despite living in a country with abundant sunlight, Vitamin D3 deficiency is widespread. Urban lifestyles keep many people indoors for long hours. Regular use of sunscreen, limited outdoor activity, and aging all reduce the body’s ability to produce and absorb this vitamin. Diet alone rarely provides enough Vitamin D3, which is why deficiency remains common even among people who eat well.

Vitamin B12 And Its Silent Impact

Vitamin B12 is equally important but often overlooked. It is essential for nerve health, brain function, and the production of healthy red blood cells. Unlike some deficiencies that show early warning signs, B12 deficiency tends to develop slowly. Its symptoms are often mistaken for stress, aging, or routine fatigue.

Low Vitamin B12 levels can cause weakness, persistent tiredness, tingling or numbness in the hands and feet, memory problems, mood changes, and difficulty concentrating. Over time, untreated deficiency can lead to nerve damage and anemia.

Certain groups are at higher risk. Vegetarians and vegans often do not get enough B12 because it is mainly found in animal-based foods. Older adults may struggle to absorb B12 due to reduced stomach acid. People with digestive disorders and those taking long-term acid-reducing medications are also more vulnerable.

Why These Deficiencies Are Missed?

One of the biggest challenges with Vitamin D3 and B12 deficiencies is that their symptoms overlap with many common health complaints. Ongoing fatigue, joint pain, low mood, or frequent illness are often blamed on work stress, poor sleep, or lifestyle habits. As a result, people delay medical advice until symptoms start interfering with everyday life.

Dr Sinha notes that this delay can make recovery slower and complications more likely.

Vitamin B12 And D3 Deficiencies Diagnosis And Timely Care

Simple blood tests can accurately detect Vitamin D3 and B12 deficiencies. However, many people only get tested once symptoms become severe. Early diagnosis allows for timely treatment, which may include supplements, dietary changes, and lifestyle adjustments under medical guidance.

Addressing these deficiencies early is one of the simplest ways to protect long-term health. Adequate sunlight exposure, balanced nutrition, and routine screening can help maintain healthy levels. Taking Vitamin D3 and B12 deficiencies seriously is a small step that can prevent lasting health problems and support healthier aging.

As winter approaches, many people notice an increase in sinus- and ear-related issues. Symptoms such as nasal congestion, facial pressure, headaches, ear pain, and dizziness become more frequent during this season. According to Dr. Swapnil Brajpuriya, Associate Director & Head Unit II – ENT at Asian Hospital, the combination of cold air, low humidity, and sudden temperature changes are the main reasons why sinus and ear problems worsen in winter.

Why Does Cold Air Cause Sinus Blockage?

The sinuses are air-filled cavities within the facial bones that connect to the nose and play a key role in the breathing process. During winter, the cold, dry air dries out the nasal lining, causing the mucus to thicken. Thickened mucus slows down normal sinus drainage, leading to congestion and blockage.

Dr. Brajpuriya explains, “In winter, the nasal mucous membrane tends to dry out, preventing proper drainage of mucus from the sinuses. This leads to congestion and sinus blockage.”

The Link Between Ear Heaviness, Headache, and Dizziness

The sinuses and ears are connected via the Eustachian tube, which regulates pressure between the middle ear and the environment. When sinus inflammation or blockage occurs, it can create pressure in the ears, causing a feeling of fullness, reduced hearing, headaches, and sometimes dizziness.

“Sinus infections can block the Eustachian tube, causing pressure buildup inside the ear. This pressure is often responsible for the headaches and dizziness experienced by patients,” says Dr. Brajpuriya.

Why Are Infections More Common in Winter?

Winter months often mean spending more time indoors in closed, crowded spaces, which increases the risk of viral and bacterial infections spreading. Additionally, colder temperatures and seasonal changes can weaken the immune system, making common colds and flu more likely to develop into sinusitis or middle ear infections.

Dr. Brajpuriya adds, “If a cold or flu is not treated promptly, it can progress to a sinus or middle ear infection, particularly in children and the elderly.”

Who Should Be Extra Careful?

Certain groups are more susceptible to sinus and ear problems during winter. People with allergies, asthma, frequent colds, weak immunity, or pre-existing sinus conditions need to be extra vigilant. Smokers are also at higher risk, as smoke can irritate the nasal and sinus lining, exacerbating congestion and inflammation.

Sinus Treatment and Prevention Tips

To manage and prevent winter-related sinus and ear issues, Dr. Brajpuriya recommends the following precautions:

• Keep your nose and ears protected from cold air using scarves or masks.
• Stay hydrated by drinking plenty of water to keep mucus thin.
• Minimise exposure to dust and allergens indoors.
• Seek medical advice if nasal congestion, ear pain, or dizziness persists for more than a few days.

He emphasizes, “Neglecting sinus and ear problems can lead to chronic infections. Timely treatment and proper care are essential to prevent complications.”

Cold air, dry weather, and viral or bacterial infections are the key factors behind the increase in sinus and ear problems during winter. With simple preventive measures, adequate hydration, protecting the nose and ears, and seeking early medical care, most people can manage these seasonal issues effectively and reduce the risk of complications.